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GI Insights

Updated about 1 month ago

Health & Fitness
Medicine
Science
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GI Insights is dedicated to advancing the science and clinical practice of gastroenterology. Digest the latest diagnostic and management strategies, clinical data, research updates, and more in this special series.

Read more

GI Insights is dedicated to advancing the science and clinical practice of gastroenterology. Digest the latest diagnostic and management strategies, clinical data, research updates, and more in this special series.

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iTunes Ratings

3 Ratings
Average Ratings
2
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0
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0
Cover image of GI Insights

GI Insights

Latest release on Mar 18, 2020

The Best Episodes Ranked Using User Listens

Updated by OwlTail about 1 month ago

Rank #1: The Motility of the Gut: What Do We Know?

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Guest: Jack Grider, PhD
Host: Mark DeLegge, MD

What is the underlying mechanism of propulsion in the digestive system, and how is motility stimulated? How are some newer pharmacotherapies looking to target serotonin to treat conditions such as IBS and constipation? Dr. Jack Grider, professor in the department of medicine, division of gastroenterology at the Virginia Commonwealth University School of Medicine, talks about future pharmacotherapy directions that either suppress or encourage motility in the digestive system. Hosted by Dr. Mark DeLegge.

Aug 04 2009

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Rank #2: Shifts in Crohn's Disease Treatment Models

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Guest: William J. Sandborn, MD
Host: Mark DeLegge, MD
The current treatment paradigm for Crohn's disease is a pyramid approach, where patients are given the safest medications before pursuing more aggressive strategies. New evidence suggests that Crohn's disease should be treated with the most effective medications first, such as anti-TNF therapies. But is a top-down strategy safe enough for most patients? Dr. William Sandborn, professor of medicine and gastrointestinal research at Mayo Clinic College of Medicine, describes the results of new Crohn's disease trials and research. Is using steroids to treat Crohn's disease an idea of the past, or are steroids still effective for certain patients? Dr. Mark DeLegge hosts.

Nov 18 2008

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Rank #3: The Many Faces of Irritable Bowel Syndrome: Multimodal Treatments for a Complex Disease

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Irritable bowel syndrome is becoming increasingly recognized as a complex interplay of pathologies, from changes in gut microflora to nutrient absorption abnormalities to psychosocial stressors. The ways in which these factors contribute and interact create different profiles of disease, requiring personalized therapeutic plans for IBS patiets. Joining Dr. Barry Mennen to discuss a multimodal model for approaching the root causes of IBS is Dr. Neelesh A. Tipnis, the Paul H. Parker Professor and Chair of Pediatric Gastroenterology and Director of the GI Motility and Functional Bowel Disorders Program at the University of Mississippi Medical Center.

Aug 10 2015

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Rank #4: IBS and Functional GI Disorders (FGIDs)

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Host: Jay Goldstein, MD
Guest: Douglas Drossman, MD

Host Dr. Jay Goldstein discusses the latest in IBS & Functional GI Disorders (FGIDs) with guest expert Dr. Douglas Drossman of the Drossman Center for the Education and Practice of Integrated Care. Dr. Drossman is Professor Emeritus in the departments of Gastroenterology and Psychiatry at the Center for Functional GI and Motility, University of North Carolina at Chapel Hill.

Apr 27 2015

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Rank #5: The New GERD Guidelines

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Guest: Michael Vaezi, MD, PhD
Host: Mark DeLegge, MD

Gastroesophageal reflux disease (GERD) is the most common GI diagnosis. But many aspects of diagnosing and treating GERD and related syndromes vary considerably. Now, the AGA has issued new evidence-based guidelines on this widespread disorder. Some of the recommendations may surprise you. Dr. Michael Vaezi, co-author of the guidelines, discusses the best GERD management strategies with host Dr. Mark DeLegge. To view the AGA's GERD Guidelines, please click here.

Oct 31 2008

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Rank #6: Can Dietary Zinc Help Treat and Prevent Inflammatory Bowel Disease?

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Host: Barnett Mennen, MD

Host Dr. Barry Mennen welcomes Dr. Ashwin Ananthakrishnan, Assistant Professor of Medicine at Harvard Medical School and medical co-director at the MGH Crohn’s and Colitis center. Dr. Ananthakrishnan is involved in several large cohort studies that are attempting to examine established and novel environmental factors, including diet, that influence the risk of development of inflammatory bowel diseases. His recent study focusing on the potential role of dietary zinc in preventing bowel inflammation becomes the focus of this discussion.

Oct 26 2015

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Rank #7: Food Allergies: Fact from Fiction

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Guest: Sheila Crowe, MD
Host: Jay Goldstein, MD

Food allergies are becoming increasingly common. Such allergies are often not easy to diagnose, and can present differently in adults and children. What is the difference between a food allergy and a specific food intolerance? What causes food allergies, and are there effective treatments beyond avoidance? Host Dr. Jay Goldstein probes the truth about food allergies with Dr. Sheila Crowe, professor of medicine in the division of gastroenterology and hepatology at the University of Virginia.

Sep 09 2008

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Rank #8: Crohn's Disease: Latest Diagnosis, Treatment & Management Strategies

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Host Dr. Jay Goldstein welcomes Dr. Sunanda V. Kane, Professor of Medicine in the Department of Gastroenterology & Hepatology at Mayo Clinic, to dicuss the latest in Crohn's disease diagnosis and management. Dr. Kane is author of IBD Self-Management: The AGA Guide to Crohn's Disease and Ulcerative Colitis, now in its second edition.

Apr 20 2015

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Rank #9: Endoscopic Imaging Optics for Assessing Dysplasia

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Guest: Thomas D. Wang, MD, PhD
Host: Mark DeLegge, MD

Microscopic imaging of the digestive tract moves beyond examination of tissue at subcellular levels, helping us identify molecular regions in which to probe for dysplasia. Dr. Thomas Wang, assistant professor of medicine and biomedical engineering at the University of Michigan Medical School, details this 'biopsy inside the body' with host Dr. Mark DeLegge. How could this technology shape the future of GI practice? How does this differ from chromoendoscopy, autofluorescence, and other current technologies?

Sep 10 2008

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Rank #10: Evolving Treatment of Inflammatory Bowel Disease

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Guest: Richard Fedorak, MD
Host: Jay Goldstein, MD

Steroids used to be the standard treatment for inflammatory bowel disease. But now biologic and immunosuppresive therapies are often used. How can we increase the efficacy of these medications? What combinations work best? Dr. Richard Fedorak, professor of medicine in the division of gastroenterology at the University of Alberta in Canada, discusses IBD treatments with host Dr. Jay Goldstein.

Nov 04 2008

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Rank #11: When PPIs Fail: Evaluating and Managing Patients with Refractory GERD

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Guest: Brian Lacy, MD, PhD
Host: Lee Freedman, MD

Resistance to proton pump inhibitors, or PPIs, is not uncommon among patients with gastroesophogeal reflux disease, or GERD. How should physicians initially approach managing patients with suspected GERD, and at what point should physicians classify a patient as a PPI non-responder? Our guest, Dr. Brian Lacy, associate professor of medicine at Dartmouth Medical School, and director of the GI Motility Laboratory at Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire, suggests tests that physicians might use in evaluating patients with refractory GERD, including upper endoscopy and various types of pH monitoring. What therapeutic strategies can physicians use to manage these patients? Hosted by Dr. Freedman.

Sep 16 2010

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Rank #12: Crohn’s & Colitis Congress: Making Sense of IBD Care Guidelines

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Host: Gary R. Lichtenstein, MD
Guest: Marla Dubinsky, MD

Not every IBD patient fits into IBD care guidelines, which is why Dr. Gary Lichtenstein and Dr. Marla Dubinsky discuss the best ways to use these guidelines in your practice at the second annual Crohn’s & Colitis Congress in Las Vegas.

Apr 02 2019

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Rank #13: Novel Perspectives on Inflammatory Bowel Disease: Focus on Microbiomes and Stool Transplants

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Live from the floor of Digestive Disease Week in Washington DC, GI Insights presents two interviews focusing on innovative approaches to inflammatory bowel disease, hosted by Dr. Barry Mennen. Guests on this program include:

  • Dr. Jonathan Braun, Professor and Chair of Pathology and Lab Medicine at the David Geffen School of Medicine at UCLA. His research centers on the biology of mucosal interaction of host immunity with the local microbial community, and its impact on chronic mucosal inflammatory disease and cancer.
  • Michael Hurst, author of Poop Power: How a Man Used a Fecal Transplant at Home to Permanently Cure Himself of Ulcerative Colitis. Mr. Hurst is a known advocate and volunteer for the Fecal Transplant Foundation, whose story of self-designing an unorthodox treatment regimen for ulcerative colitis has since offered new insights on best clinical management practices for IBD.

Jul 27 2015

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Rank #14: Reliability of Measuring Ileo-Colonic Disease Activity in Crohn's Disease by MR Enterography

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Guest: Yash Mittal, MD

Reliability of Measuring Ileo-Colonic Disease Activity in Crohn's Disease by Magnetic Resonance Enterography.

Vipul Jairath, MD, PhD, Ingrid Ordas, MD, PhD, Guangyong Zou, PhD, Julian Panes, MD, Jaap Stoker, MD, PhD, Stuart A Taylor, MD, Cynthia Santillan, MD, Karin Horsthuis, MD, Mark A Samaan, MD, Lisa M Shackelton, PhD, Larry W Stitt, MSc, Pieter Hindryckx, MD, PhD, Reena Khanna, MD, William J Sandborn, MD ,Geert D'Haens, MD, PhD, Brian G Feagan, MD, Barrett G Levesque, MD, and Jordi Rimola, MD, PhD

BACKGROUND:

Magnetic resonance enterography is increasingly utilized for assessment of luminal Crohn's disease activity. The Magnetic Resonance Index of Activity and the London Index are the most commonly used outcome measures in clinical trials. We assessed the reliability of these indices and several additional items.

METHODS:

A consensus process clarified scoring conventions and identified additional items based on face validity. Four experienced radiologists evaluated 50 images in triplicate, in random order, at least 1 month apart, using a central image management system. Intra- and interrater reliability were assessed by calculating and comparing intraclass correlation coefficients.

RESULTS:

Intrarater intraclass correlation coefficients (95% confidence intervals) for the Magnetic Resonance Index of Activity, London, and London "extended" indices and a visual analogue ...

Jan 29 2019

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Rank #15: Comparative Effectiveness of Drug Therapies for Inflammatory Bowel Disease

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Host Dr. Barry Mennen welcomes Dr. Ryan Stidham, Assistant Professor of Internal Medicine at the Inflammatory Bowel Diseases Center of the University of Michigan Health System, to discuss the current therapeutic landscape for IBD based on recent comparative clinical trials.

Jul 20 2015

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Rank #16: Success of Adalimumab Dose Escalation & De-Escalation in Ulcerative Colitis

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Guest: Shail Govani, MD, MSc

Incidence and Predictors of Success of Adalimumab Dose Escalation and De-escalation in Ulcerative Colitis: a Real-World Belgian Cohort Study.

Saartje Van de Vondel, MD, Filip Baert, MD, PhD, Christine Reenaers, MD, PhD, Stijn Vanden Branden, MD, Leila Amininejad, MD, Pieter Dewint, MD, PhD, Wouter Van Moerkercke, MD, Jean-François Rahier, MD, PhD, Pieter Hindryckx, MD, PhD, Peter Bossuyt, MD, Marc Ferrante, MD, PhD, and Belgian IBD Research and Development (BIRD)

BACKGROUND:

Adalimumab (ADM) has been shown efficacious in ulcerative colitis (UC). In randomized controlled trials, dose escalation from 40 mg ADM every other week to 40 mg every week was required in 20%–25% of patients within 1 year. Real-life data suggest higher escalation rates. Attempts for dose de-escalation have not been studied yet. We assessed the need for, outcome of, and predictors of dose escalation and de-escalation in a large retrospective cohort of UC patients treated with ADM.

METHODS:

We included 231 consecutive patients from 10 Belgian centers initiating ADM treatment for active UC before September 1, 2015 (follow-up ≥1 year in each patient). We performed detailed chart review to identify variables associated with short-term clinical benefit (based on physician global assessment and absence of rectal bleeding at week 10), success ...

Jan 29 2019

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Rank #17: Making Dollars and 'Sense' of Physician Quality Reporting Systems in Gastroenterology

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Host: Barnett Mennen, MD

Physician Quality Reporting Systems, or PQRS, are here to stay in clinical medicine. Within the field of gastroenterology, understanding the metrics of PQRS can make a substantial difference in the success of a practice. Joining host Dr. Barry Mennen to detail the ins and outs of PQRS in gastroenterology is Dr. Ziad Gellad, Assistant Professor of Medicine, Director of Quality in the Division of Gastroenterology, and Director of Clinical Improvement in the Department of Medicine at Duke University Medical Center.

Nov 02 2015

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Rank #18: Boosting Awareness of GI Cancers: Focus on Colorectal and Liver Carcinomas

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Live from the floor of Digestive Disease Week in Washington DC, GI Insights presents two interviews focusing on screening, surveillance, and therapeutic updates for colorectal and liver cancers, hosted by Dr. Barry Mennen. Guests on this program include:

  • Dr. Linda Rabeneck, Vice President of Prevention and Cancer Control at Cancer Care Ontario (CCO), Professor of Medicine at the University of Toronto, and Senior Scientist at the Institute for Clinical Evaluative Sciences (ICES) in Toronto. Dr. Rabeneck speaks on global initiatives to increase awareness about colorectal cancer screening and surveillance.
  • Dr. Kris Kowdley, Director of the Liver Care Network and Research Director of the Organ Care Program at Swedish Medical Center in Seattle, WA. Dr. Kowdley summarizes key takeaways on recognition of liver cancer and other related diseases of the liver in American populations today.

Aug 03 2015

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Rank #19: What GI Physicians Need to Know About Probiotics

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Guest: Richard Fedorak, MD
Host: Jay Goldstein, MD

What are probiotics, and how do strains differ? How can they be used most effectively? Dr. Richard Fedorak, professor of medicine in the division of gastroenterology at the University of Alberta in Canada, probes the potential of probiotics with host Dr. Jay Goldstein. Can they be used to replace medications for certain patients with gastrointestinal disorders? Find out what you should you tell your patients about probiotics.

Nov 04 2008

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Rank #20: Evaluating Performance: The Physician Quality Reporting Initiative

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Guest: Mary Igo, MBA, RN
Host: Mark DeLegge, MD

The Physician Quality Reporting Initiative (PQRI) is a CMS-based program designed to help medical professionals measure performance outcomes in their practice. How does the PQRI define quality, and how can it provide more concrete measurements of quality? What do GI practices need to know when becoming involved in the PQRI? Mary Igo, MBA, CEO of Minnesota Gastroenterology, a GI practice based in St. Paul, and an expert in medical group management, assesses the pros and cons of implementing the PQRI system with host Dr. Mark DeLegge.

Oct 07 2008

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