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The Beacon

Dr. Jack West reviews emerging new information and controversial topics in health care in general, cancer treatment in particular.

Ranked #1

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Overall Survival Benefit for Local Ablative Therapy as Consolidation for Oligometastatic Stage IV NSCLC: Where Does it Fit in Practice Now? (BMIC-070)

Overall Survival Benefit for Local Ablative Therapy as Consolidation for Oligometastatic Stage IV NSCLC: Where Does it Fit in Practice Now? (BMIC-070)

Dr. Jack West describes recently updated results of a small randomized trial of consolidation local ablative therapy (LA... Read more

9 Dec 2018

9mins

Ranked #2

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Is Durvalumab (Imfinzi) in Stage III NSCLC Curing Patients or Just Treating Metastatic Disease Earlier? Importance of Overall Survival and Implications for Duration of Treatment (BMIC-025)

Is Durvalumab (Imfinzi) in Stage III NSCLC Curing Patients or Just Treating Metastatic Disease Earlier? Importance of Overall Survival and Implications for Duration of Treatment (BMIC-025)

Dr. Jack West explores the importance of following the overall survival of patients on the PACIFIC trial and considers s... Read more

22 Feb 2018

6mins

Ranked #3

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What is Positive Predictive Value of PET PSMA in Biochemical Recurrence of Prostate Cancer? Highlights in GU Oncology from ASCO 2018 (BMIC-059)

What is Positive Predictive Value of PET PSMA in Biochemical Recurrence of Prostate Cancer? Highlights in GU Oncology from ASCO 2018 (BMIC-059)

Dr. Daniel Goldstein reviews data on the positive predictive value of PET PSMA imaging in patients with biochemically re... Read more

27 Aug 2018

2mins

Ranked #4

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IMpower133: Is there Finally a New Standard of Care for Extensive Stage SCLC? (BMIC-064)

IMpower133: Is there Finally a New Standard of Care for Extensive Stage SCLC? (BMIC-064)

Dr. Jack West reviews the IMpower133 trial that integrated atezolizumab with first line chemo for extensive stage SCLC a... Read more

6 Nov 2018

7mins

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Ranked #5

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Updated Results on PACIFIC Trial: Should we Revise Who Should Receive Consolidation Immunotherapy after Chemo/Radiation? (BMIC-065)

Updated Results on PACIFIC Trial: Should we Revise Who Should Receive Consolidation Immunotherapy after Chemo/Radiation? (BMIC-065)

Dr. Jack West discusses the trial design of the PACIFIC trial of consolidation durvalumab (Imfinzi) after chemo/radiatio... Read more

8 Nov 2018

7mins

Ranked #6

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Nivolumab/Ipilimumab vs. Chemo in High TMB Advanced NSCLC: Key Results from CheckMate 227 (BMIC-034)

Nivolumab/Ipilimumab vs. Chemo in High TMB Advanced NSCLC: Key Results from CheckMate 227 (BMIC-034)

Dr. Jack West reviews the CheckMate 227 trial, summarizing highlights from efficacy & side effects of nivolumab/ipil... Read more

10 May 2018

13mins

Ranked #7

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Chemo-Immunotherapy in Non-Squamous NSCLC: Has the KEYNOTE-189 Trial Defined a Clear Standard of Care? (BMIC-022)

Chemo-Immunotherapy in Non-Squamous NSCLC: Has the KEYNOTE-189 Trial Defined a Clear Standard of Care? (BMIC-022)

Dr. Jack West reviews the results and pending questions of the KEYNOTE-189 trial of chemotherapy with or without pembrol... Read more

20 Jan 2018

8mins

Ranked #8

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Durvalumab (Imfinzi) FDA Approved for Stage III NSCLC: Should It Become Standard of Care Without Overall Survival Benefit Demonstrated? (BMIC-024)

Durvalumab (Imfinzi) FDA Approved for Stage III NSCLC: Should It Become Standard of Care Without Overall Survival Benefit Demonstrated? (BMIC-024)

Dr. Jack West reviews key results of the PACIFIC trial of the immunotherapy agent durvalumab (Imfinzi) vs. placebo in st... Read more

20 Feb 2018

7mins

Ranked #9

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Immunotherapy with Pembrolizumab in Metastatic Prostate Cancer: Highlights in GU Oncology from ASCO 2018 (BMIC-055)

Immunotherapy with Pembrolizumab in Metastatic Prostate Cancer: Highlights in GU Oncology from ASCO 2018 (BMIC-055)

Dr. Daniel Goldstein summarizes key data in genitourinary oncology from ASCO 2018, including new results on pembrolizuma... Read more

17 Aug 2018

2mins

Ranked #10

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Is Chemotherapy More Effective After Prior Immunotherapy? (BMIC-029)

Is Chemotherapy More Effective After Prior Immunotherapy? (BMIC-029)

Dr. Jack West presents early data suggesting that chemotherapy may be more effective after prior immunotherapy than othe... Read more

12 Apr 2018

5mins

Ranked #11

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KEYNOTE-189: Key Summary of a Practice-Changing Trial in Advanced Non-Squamous NSCLC (BMIC-030)

KEYNOTE-189: Key Summary of a Practice-Changing Trial in Advanced Non-Squamous NSCLC (BMIC-030)

Dr. Jack West reviews the trial design, efficacy endpoints, and toxicity results of the KEYNOTE-189 trial of pembrolizum... Read more

27 Apr 2018

13mins

Ranked #12

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New Data & Context for a PARP Inhibitor/Abiraterone Combination in Metastatic Prostate Cancer: Highlights in GU Oncology from ASCO 2018 (BMIC-058)

New Data & Context for a PARP Inhibitor/Abiraterone Combination in Metastatic Prostate Cancer: Highlights in GU Oncology from ASCO 2018 (BMIC-058)

Dr. Daniel Goldstein considers new data by Clarke & colleagues on a combination of the PARP inhibitor olaparib with ... Read more

24 Aug 2018

3mins

Ranked #13

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My Top 5 ASCO 2018 Abstracts in Stage I-III NSCLC, Small Cell Lung Cancer, & Mesothelioma (BMIC-037)

My Top 5 ASCO 2018 Abstracts in Stage I-III NSCLC, Small Cell Lung Cancer, & Mesothelioma (BMIC-037)

Dr. Jack West reviews his top 5 abstracts in stage I-III non-small cell lung cancer, small cell lung cancer, and mesothe... Read more

23 May 2018

7mins

Ranked #14

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My Top 5 ASCO 2018 Abstracts in Advanced NSCLC (BMIC-036)

My Top 5 ASCO 2018 Abstracts in Advanced NSCLC (BMIC-036)

Dr. Jack West reviews his top 5 abstracts in the advanced NSCLC track at ASCO 2018, explaining why each is poised to cha... Read more

21 May 2018

10mins

Ranked #15

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T Effector Gene Signature on IMpower150: Is There a Better Biomarker than PD-L1 for Immunotherapy? (BMIC-021)

T Effector Gene Signature on IMpower150: Is There a Better Biomarker than PD-L1 for Immunotherapy? (BMIC-021)

Dr. Jack West reviews provocative biomarker results on the IMpower150 trial that tested atezolizumab with carboplatin/pa... Read more

21 Dec 2017

10mins

Ranked #16

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Is More Better with Radium-223 for Metastatic Prostate Cancer? Highlights in GU Oncology from ASCO 2018 (BMIC-056)

Is More Better with Radium-223 for Metastatic Prostate Cancer? Highlights in GU Oncology from ASCO 2018 (BMIC-056)

Dr. Daniel Goldstein reviews data in genitourinary oncology from ASCO 2018, including a study of higher dose or prolonge... Read more

20 Aug 2018

1min

Ranked #17

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Are Tumor Mutation Burden and Nivolumab/Ipilimumab Ready for Clinical Use? Insights from CheckMate 227 (BMIC-035)

Are Tumor Mutation Burden and Nivolumab/Ipilimumab Ready for Clinical Use? Insights from CheckMate 227 (BMIC-035)

Dr. Jack West reviews the CheckMate 227 trial, summarizing highlights from efficacy & side effects of nivolumab/ipil... Read more

11 May 2018

9mins

Ranked #18

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"Best Treatment First": Implications for front-Loading Combinations in Lung Cancer (BMIC-063)

"Best Treatment First": Implications for front-Loading Combinations in Lung Cancer (BMIC-063)

Dr. Jack West describes an emerging theme that the best outcomes for patients with lung cancer and likely other cancer a... Read more

7 Sep 2018

9mins

Ranked #19

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Atezolizumab in First Line NSCLC: Early Clinical Results from the IMpower150 Trial (BMIC-020)

Atezolizumab in First Line NSCLC: Early Clinical Results from the IMpower150 Trial (BMIC-020)

Dr. Jack West reviews the preliminary clinical results on the IMpower150 trial that tested the value of adding the immun... Read more

18 Dec 2017

11mins

Ranked #20

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KEYNOTE-189: Clinical Implications in Patients with Advanced Non-Squamous NSCLC and High (≥50%) Tumor PD-L1 Expression (BMIC-031)

KEYNOTE-189: Clinical Implications in Patients with Advanced Non-Squamous NSCLC and High (≥50%) Tumor PD-L1 Expression (BMIC-031)

Dr. Jack West reviews clinical results in patients with advanced non-squamous NSCLC and high tumor PD-L1 on the KEYNOTE-... Read more

30 Apr 2018

7mins

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