Originally developed to treat diabetes, SGLT2 inhibitors are potentially groundbreaking in slowing the progression of chronic kidney disease. Recent studies indicate SGLT-2 inhibitors hold promise for slowing CKD progression and for treating heart failure and other cardiovascular conditions. Dr. Michael Anger, Fresenius Medical Care’s chief medical officer for the Renal Therapies Group, joins this episode to discuss how SGLT-2 inhibitors can be used to intervene earlier with kidney disease patients and improve overall patient health.

Originally developed to treat diabetes, SGLT2 inhibitors are potentially groundbreaking in slowing the progression of chronic kidney disease. Recent studies indicate SGLT-2 inhibitors hold promise for slowing CKD progression and for treating heart failure and other cardiovascular conditions. Dr. Michael Anger, Fresenius Medical Care’s chief medical officer for the Renal Therapies Group, joins this episode to discuss how SGLT-2 inhibitors can be used to intervene earlier with kidney disease patients and improve overall patient health.

The benefit of SGLT2 Inhibitors in kidney disease patients with Michael Anger, MD

Including patient-reported outcomes (PROs), in clinical trials, opens new and meaningful pathways to understanding medical care from the patient’s point of view. By combining clinical and patient-reported end points, trials featuring PROs can identify opportunities to improve patient health status and define treatment goals.   Krister Cromm, Fresenius Medical Care’s expert director of patient experience for clinical research, is leading the company’s evolution from disease-centered to person-centered integrated trial design. 

Including patient-reported outcomes (PROs), in clinical trials, opens new and meaningful pathways to understanding medical care from the patient’s point of view. By combining clinical and patient-reported end points, trials featuring PROs can identify opportunities to improve patient health status and define treatment goals.  Krister Cromm, Fresenius Medical Care’s expert director of patient experience for clinical research, is leading the company’s evolution from disease-centered to person-centered integrated trial design.

PROMS – Patient Reported Outcomes KRISTER CROMM

Jennifer Flythe

People with kidney disease receiving dialysis have poor health-related quality of life. By considering biomedical and patient-reported outcomes when conducting research and measuring care quality, we can enrich our understanding of patient experiences and identify opportunities to improve patient health status by aligning treatment goals with issues important to patients.    In this episode of GMO Dialogues, Dr. Jennifer Flythe, Associate Professor of Medicine at UNC School of Medicine, discusses Patient Related Outcome Measures and how they can improve the quality of patient care. 

People with kidney disease receiving dialysis have poor health-related quality of life. By considering biomedical and patient-reported outcomes when conducting research and measuring care quality, we can enrich our understanding of patient experiences and identify opportunities to improve patient health status by aligning treatment goals with issues important to patients.  In this episode of GMO Dialogues, Dr. Jennifer Flythe, Associate Professor of Medicine at UNC School of Medicine, discusses Patient Related Outcome Measures and how they can improve the quality of patient care.

How Patient Reported Outcomes Can Improve Patient Care Jennifer Flythe, MD

Felicia Speed

The Covid 19 pandemic has taken a large psychological toll on physicians and other healthcare workers worldwide.  This global crisis has brought Mental Health concerns into our everyday conversations.    Dr. Felicia Speed, Fresenius Medical Care’s vice president of social work services, has seen first-hand the cascading impact burnout has on physicians, clinical staff, and patients.  She has worked with the American Society of Nephrology to develop mental health modules for healthcare professionals and shares her insights in this episode. 

The Covid 19 pandemic has taken a large psychological toll on physicians and other healthcare workers worldwide.  This global crisis has brought Mental Health concerns into our everyday conversations.  Dr. Felicia Speed, Fresenius Medical Care’s vice president of social work services, has seen first-hand the cascading impact burnout has on physicians, clinical staff, and patients.  She has worked with the American Society of Nephrology to develop mental health modules for healthcare professionals and shares her insights in this episode.

Addressing Mental Health for Healthcare Professionals with Dr. Felicia Speed

The Chinese Mainland with a population of more than 1.4 billion people faces a huge, growing burden of kidney diseases. Significant advances in nephrology have been made over the past 40 years in clinical practice, research, and academic development.  Nephrologist Grace Yan, Chief Medical Officer for Fresenius Kidney Care China, discusses the challenges and future of renal care in China.

The Chinese Mainland with a population of more than 1.4 billion people faces a huge, growing burden of kidney diseases. Significant advances in nephrology have been made over the past 40 years in clinical practice, research, and academic development.  Nephrologist Grace Yan, Chief Medical Officer for Fresenius Kidney Care China, discusses the challenges and future of renal care in China.

Nephrology in China - Grace Yan, MD, PhD

End-stage kidney disease significantly impacts an individual’s quality of life, morbidity, and mortality. There is a growing body of evidence to support that patients with chronic conditions, who take an active role in their care report better clinical outcomes. Nephrologist Kolitha Basnayake is Fresenius Medical Care’s Country Medical Director for the United Kingdom and Ireland. He is a champion for the transformation and delivery of home dialysis in the United Kingdom. Dr. Bosnayake discusses how quality improvement programs must address barriers to shared hemodialysis care for the individual.

End-stage kidney disease significantly impacts an individual’s quality of life, morbidity, and mortality. There is a growing body of evidence to support that patients with chronic conditions, who take an active role in their care report better clinical outcomes. Nephrologist Kolitha Basnayake is Fresenius Medical Care’s Country Medical Director for the United Kingdom and Ireland. He is a champion for the transformation and delivery of home dialysis in the United Kingdom. Dr. Bosnayake discusses how quality improvement programs must address barriers to shared hemodialysis care for the individual.

Shared Care and the Transformation of Dialysis Treatment - Kolitha Basnayake, MD, PhD, FRCP

Preclinical and epidemiological studies have shown an association between acidosis and the progression of chronic kidney disease. Emerging evidence suggests that bicarbonate treatment may slow the progression of CKD and reduce the risk of kidney failure. Nephrologist Nilufar Mohebbi, Fresenius Medical Care’s Chief Medical Director for Switzerland, is investigating the effect of alkali therapy on graft function in kidney transplant recipients with metabolic acidosis. The goal is to extend the life of transplanted organs in renal patients.

Preclinical and epidemiological studies have shown an association between acidosis and the progression of chronic kidney disease. Emerging evidence suggests that bicarbonate treatment may slow the progression of CKD and reduce the risk of kidney failure. Nephrologist Nilufar Mohebbi, Fresenius Medical Care’s Chief Medical Director for Switzerland, is investigating the effect of alkali therapy on graft function in kidney transplant recipients with metabolic acidosis. The goal is to extend the life of transplanted organs in renal patients.

Metabolic Acidosis and its effect on transplanted organs - Prof. Nilufar Mohebbi, MD

Anjana Harve

Healthcare’s use of digital technology has changed significantly in the past decade. From on-line patient records, to telemedicine, to connected health.  As the healthcare industry evolves with new technology and legislation, identifying security threats and keeping patient data safe, is a top priority. Anjana Harve, Fresenius Medical Care’s Chief Information Office, talks about cybersecurity and the use of health information systems to improve the quality of care for patients.

Healthcare’s use of digital technology has changed significantly in the past decade. From on-line patient records, to telemedicine, to connected health.  As the healthcare industry evolves with new technology and legislation, identifying security threats and keeping patient data safe, is a top priority. Anjana Harve, Fresenius Medical Care’s Chief Information Office, talks about cybersecurity and the use of health information systems to improve the quality of care for patients.

Cybersecurity - Anjana Harve 

Nwamaka Eneanya

Current equations that use serum creatinine incorporate age, sex, and race to estimate measured Glomerular Filtration Rate. Inclusion of race in these equations and other medical algorithms is facing increased scrutiny because race is a social, not a biologic construct. Its inclusion may contribute to systemic racism in medicine. Nephrologist Amaka Eneanya, assistant professor of Medicine and Epidemiology at the University of Pennsylvania’s, Perelman School of Medicine, is an advocate for eliminating race from the formula, and the author of a wave-making paper that helped propel the issue to a national stage.

Current equations that use serum creatinine incorporate age, sex, and race to estimate measured Glomerular Filtration Rate. Inclusion of race in these equations and other medical algorithms is facing increased scrutiny because race is a social, not a biologic construct. Its inclusion may contribute to systemic racism in medicine. Nephrologist Amaka Eneanya, assistant professor of Medicine and Epidemiology at the University of Pennsylvania’s, Perelman School of Medicine, is an advocate for eliminating race from the formula, and the author of a wave-making paper that helped propel the issue to a national stage.

Disparities in Healthcare - Nwamaka Eneanya

Fluid management is a critical component of dialysis and has come a long way. The Renal Research Institute developed its own Ultrafiltration Controller which continuously compares the patient’s Relative Blood Volume profile to the target curve and makes Ultrafiltration rate adjustments. Dr. Lemuel Fuentes, Supervisor of Clinical Research at RRI discusses this innovation and its designation as a US Food and Drug Administration 21st Century Breakthrough Device.

Fluid management is a critical component of dialysis and has come a long way. The Renal Research Institute developed its own Ultrafiltration Controller which continuously compares the patient’s Relative Blood Volume profile to the target curve and makes Ultrafiltration rate adjustments. Dr. Lemuel Fuentes, Supervisor of Clinical Research at RRI discusses this innovation and its designation as a US Food and Drug Administration 21st Century Breakthrough Device.

Evolution of Fluid Management - Lemuel Rivera Fuentes, MD

Global Medical Office Dialogues, is an interview feature podcast.  Frank Maddux, MD, FACP, Global Chief Medical Officer for Fresenius Medical Care, talks with a diverse group of thought leaders in science, medicine and current events.  Through in-depth dialogue and discussion, we take a deeper look at important topics from many different angles and perspectives.

Improving vascular access care is key to improving outcomes for people receiving hemodialysis.   In this edition of Global Medical Office Dialogues our guest is Dr. Walead Latif, an interventional nephrologist and vascular access care expert.  A Medical Director at Azura Vascular Care in the United States, Dr. Latif weighs in on improving patient outcomes by addressing challenges and opportunities in vascular access. 

Improving vascular access care is key to improving outcomes for people receiving hemodialysis.   In this edition of Global Medical Office Dialogues our guest is Dr. Walead Latif, an interventional nephrologist and vascular access care expert.  A Medical Director at Azura Vascular Care in the United States, Dr. Latif weighs in on improving patient outcomes by addressing challenges and opportunities in vascular access.

Vascular Access - Dr. Walead Latif

Improving access to kidney transplantation on a worldwide basis is a vital next step for global healthcare. In this episode of Dialogues, transplant expert, Dr. Ben Hippen, MD, FASN, FAST, Senior Vice President of Transplant Medicine for Fresenius Medical Care, discusses the challenges and opportunities facing global transplantation and why transplantation remains a vital therapy option for people living with advanced kidney disease. 

Improving access to kidney transplantation on a worldwide basis is a vital next step for global healthcare. In this episode of Dialogues, transplant expert, Dr. Ben Hippen, MD, FASN, FAST, Senior Vice President of Transplant Medicine for Fresenius Medical Care, discusses the challenges and opportunities facing global transplantation and why transplantation remains a vital therapy option for people living with advanced kidney disease.

Transplants - Benjamin Hippen, MD, FASN, FAST

Expanding our scientific understanding of the effectiveness and safety of interventions for individuals with End Stage Kidney Disease is an important goal of researchers.   In this episode of Dialogues, we’ll talk with Dr. Linda Ficociello and Dr. Anke Winter, two Fresenius Medical Care experts in epidemiology and research.   They discuss ways Real World Evidence can complement existing research in gaining new and valuable insights that improve kidney disease care. 

Expanding our scientific understanding of the effectiveness and safety of interventions for individuals with End Stage Kidney Disease is an important goal of researchers.   In this episode of Dialogues, we’ll talk with Dr. Linda Ficociello and Dr. Anke Winter, two Fresenius Medical Care experts in epidemiology and research.   They discuss ways Real World Evidence can complement existing research in gaining new and valuable insights that improve kidney disease care.

Evolving Product Research - Dr. Linda Ficociello & Dr. Anke Winter 

In this episode of Dialogues, we talk with two of the world’s leading authorities on chronic kidney disease, Drs. Bernard Canaud and Allan Collins, Senior Chief Scientists at Fresenius Medical Care. We discuss how addressing common, manageable complications through personalized renal replacement therapy can improve cardiac outcomes in hemodialysis patients.

In this episode of Dialogues, we talk with two of the world’s leading authorities on chronic kidney disease, Drs. Bernard Canaud and Allan Collins, Senior Chief Scientists at Fresenius Medical Care. We discuss how addressing common, manageable complications through personalized renal replacement therapy can improve cardiac outcomes in hemodialysis patients.

Cardioprotection, Dr. Allan Collins & Dr. Bernard Canaud

Nephrology has been under-represented in clinical research, even as rapid progress in gene sequencing and analysis has led to precision medicine advances in other medical areas like oncology and cardiology. Ali Gharavi, MD, Chief of the Division of Nephrology at Columbia University Irving Medical Center and Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons, discusses how genomic and phenotypic research can help scientists better understand how genetic variations in patients with chronic kidney disease can lead to more precise diagnoses and therapies that help improve outcomes by individualizing care.

Nephrology has been under-represented in clinical research, even as rapid progress in gene sequencing and analysis has led to precision medicine advances in other medical areas like oncology and cardiology. Ali Gharavi, MD, Chief of the Division of Nephrology at Columbia University Irving Medical Center and Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons, discusses how genomic and phenotypic research can help scientists better understand how genetic variations in patients with chronic kidney disease can lead to more precise diagnoses and therapies that help improve outcomes by individualizing care.

Personalized, Precise Medicine: Using Genomic and Phenotypic Research to Individualize Care and Improve Outcomes for Patients with Chronic Kidney Disease with Ali Gharavi

The evidence for genetic drivers in kidney diseases is substantial, but much larger data sets will be needed to untangle the complex interactions that lead to kidney injury. Kurt Mussina, President of Frenova Renal Research, talks about Frenova’s efforts to develop the largest renal-focused genomic registry in the world. Containing genetic sequencing data from chronic kidney disease patients around the globe, data from the registry will be used by researchers to improve understanding of kidney disease.

The evidence for genetic drivers in kidney diseases is substantial, but much larger data sets will be needed to untangle the complex interactions that lead to kidney injury. Kurt Mussina, President of Frenova Renal Research, talks about Frenova’s efforts to develop the largest renal-focused genomic registry in the world. Containing genetic sequencing data from chronic kidney disease patients around the globe, data from the registry will be used by researchers to improve understanding of kidney disease.

Data-Driven Precision Medicine: Building the World's Largest Kidney-Disease Focused Genomic Registry with Kurt Mussina

Allison Hess

In part two of our exploration of Food Is Medicine, veteran health and wellness expert Allison Hess, Vice President of Health Innovations at Geisinger, discusses the company’s successful Fresh Foods Farmacy.  By providing fresh, healthy food to those most in need, Allison and team are shining a light on the vital role healthy foods play in improving patient outcomes.

In part two of our exploration of Food Is Medicine, veteran health and wellness expert Allison Hess, Vice President of Health Innovations at Geisinger, discusses the company’s successful Fresh Foods Farmacy.  By providing fresh, healthy food to those most in need, Allison and team are shining a light on the vital role healthy foods play in improving patient outcomes.

Translating Science into Medicine: Food is Medicine Part II, Allison Hess

Dr. Amir Sapkota, professor at the University of Maryland, talks about the effects climate change has on health outcomes.  He discusses the relationships between frequency of extreme events, changes in plant phenology, and increased risk of respiratory diseases.  Dr. Sapkota is developing public health strategies to combat the effects of a changing climate. 

Dr. Amir Sapkota, professor at the University of Maryland, talks about the effects climate change has on health outcomes.  He discusses the relationships between frequency of extreme events, changes in plant phenology, and increased risk of respiratory diseases.  Dr. Sapkota is developing public health strategies to combat the effects of a changing climate.

Translating Science into Medicine: Climate Change, Amir Sapkota

Biochemist Nadja Grobe, supervisor of lab research at the Renal Research Institute, discusses how metabolomic signatures can be used to deliver more personal, precise care for patients living with kidney disease.  By learning from these unique biomarkers, researchers are at the forefront of developing the future of personalized medicine.

Biochemist Nadja Grobe, supervisor of lab research at the Renal Research Institute, discusses how metabolomic signatures can be used to deliver more personal, precise care for patients living with kidney disease.  By learning from these unique biomarkers, researchers are at the forefront of developing the future of personalized medicine.

Translating Science into Medicine: Metabolomics, Nadja Grobe

We continue our look at Translating Science Into Medicine by talking with Dr. Doris Fuertinger, Director of Biomathematical Modeling and Simulation at Fresenius Medical Care.  Dr. Fuertinger and her team are using complex mathematics and real-life data to create patient Avatars that can help predict an individual’s physiological response to a certain treatment.  These realistic simulations of clinical trials can help overcome the limitations of traditional approaches and lead to new improvements in patient outcomes.

We continue our look at Translating Science Into Medicine by talking with Dr. Doris Fuertinger, Director of Biomathematical Modeling and Simulation at Fresenius Medical Care.  Dr. Fuertinger and her team are using complex mathematics and real-life data to create patient Avatars that can help predict an individual’s physiological response to a certain treatment.  These realistic simulations of clinical trials can help overcome the limitations of traditional approaches and lead to new improvements in patient outcomes.

Translating Science into Medicine: Virtual Clinical Trials, Doris Fuertinger

Global Medical Office Dialogues

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