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Translational Medicine

Research in Medicine needs to ultimately translate into better treatment of patients. Researchers at the Nuffield Department of Medicine, University of Oxford, collaborate to develop better care and improved preventive measures. Findings in the laboratory are translated into changes in clinical practice, from Bench to Bedside.

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The best episodes ranked using user listens.

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Cancer and regenerative medicine

Professor Xin Lu talks about the links between cancer and regenerative medicine. Professor Xin Lu is the Director of the Oxford branch of the Ludwig Institute for Cancer Research. Her lab works toward identifying molecular mechanisms that suppress tumour growth and metastasis and focuses on understanding the factors that lead to uncontrollable cell growth.

4mins

22 Mar 2013

Rank #1

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Human Genetics

Professor Peter Donnelly tells us how genetics helps us to understand common diseases and develop new drugs. Understanding which variations in our DNA affect susceptibility to diseases can provide new insights into the disease process and lead to new treatments. Professor Peter Donnelly leads large collaborative human genetic studies, and his group develops and applies statistical methods to extract maximal information from the large datasets generated by genomic studies.

5mins

9 Jul 2013

Rank #2

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Psychiatric genetics

Professor Jonathan Flint talks about his research on psychiatric genetics. It is now known that genetic variants can form the basis of psychiatric disorders, such as depression and anxiety. Professor Jonathan Flint is investigating the genetics behind psychiatric disorders, in particular the origins of stress-related conditions, such as anxiety and depression, for which we have relatively ineffective treatments.

4mins

21 May 2013

Rank #3

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Cancer Immunlogy

Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments. Immunotherapy stimulates the bodys immune system and can be a powerful treatment for cancer. With the aim of developing better treatment strategies for cancer patients, Professor Vincenzo Cerundolo is working to gain a better understanding of the cell-to-cell interplay required for optimal expansion and activation of tumour-specific T cell populations.

7mins

25 Mar 2013

Rank #4

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Universal Flu Vaccine

Dr Richard Antrobus talks about his research in the development of a universal flu vaccine. Dr Antrobus has been conducting a Phase I study of a Universal Vaccine for Influenza. Progress so far indicates that this approach induces a potent T cell response, and Dr Antrobus is currently assessing whether this response is equally potent in the elderly - one of the 'at risk' groups of the Influenza virus.

6mins

26 Jun 2012

Rank #5

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Lowering cholesterol in chronic kidney disease

The largest trial investigating the benefits of cholesterol lowering in kidney patients. The Study of Heart and Renal Protection (SHARP) concluded that around a quarter of all heart attacks, strokes, and operations to open blocked arteries could be avoided in people with chronic kidney disease by using the combination of ezetimibe and simvastatin to lower blood cholesterol levels.

5mins

3 Apr 2012

Rank #6

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Immune System in the Gastrointestinal tract

Dr Holm Uhlig talks about the role of the immune system in our gastrointestinal tract. Dr Holm Uhlig is based at the Translational Gastroenterology Unit and studies defects in the immune response and regulation leading to immunopathology. Dr Uhlig is interested in children with inflammatory bowel disease, and aims to understand the complex puzzle of molecular mechanisms involved.

5mins

12 Sep 2012

Rank #7

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Liver Fat Metabolism

Dr Leanne Hodson talks about her research on liver fat metabolism. Dr Leanne Hodson's research focuses on fatty liver disease, defined as having over 5 percent liver fat, and a 'silent disease' as many people are not diagnosed. Dr Hodson aims to find targets for new medications which will help lower the risk of accumulating liver fat.

7mins

1 May 2012

Rank #8

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The genetics of metabolic diseases

A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function. Professor Wyatt Yue explores how genetic defects lead to disease at the molecular level, by determining 3D structures and biochemical properties of enzymes and protein complexes linked to congenital genetic errors. Professor Yue works closely with clinicians and paediatricians to decipher the underlying genetic, biochemical and cellular mechanisms of these diseases. His long-term aim is to help design novel therapeutic approaches for metabolic diseases.

4mins

28 Jul 2015

Rank #9

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Pharmacogenomics

Dr Sebastian Nijman develops new approaches to study signalling networks in cancer cells and uncover specific weaknesses, particularly in breast and lung cancer. This can be used to develop more effective drugs and to better guide treatment decisions. In the context of cancer, genetic diversity means that we respond differently to various treatments. Pharmacogenomics sits at the intersection between genetics and drugs. Better understanding of the genetic landscape of cancer and the recent increase of targeted drugs allow us to better match patients with the best treatments, improving care.

4mins

9 Feb 2015

Rank #10

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Cancer Informatics

Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us better tailor treatments to individual cancer patients. Dr Benjamin Schuster-Böckler heads the computational group at the Ludwig Institute for Cancer Research. His work has demonstrated that epigenetic modifications influence the mutational landscape in cancer cells. He studies the effects of DNA-binding proteins on transcription factors, with the aim to understand the regulation (and mis-regulation) of the transcription of important oncogenes and tumour suppressors.

6mins

9 Feb 2015

Rank #11

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Biological imaging

Video microscopy aims to improve target discovery and drug development and to do so generates large volumes of data. Professor Jens Rittscher has a joint appointment between the Ludwig Institute for Cancer Research, the Target Discovery Institute and the Department of Engineering Science. His research aims to enhance our understanding of complex biological processes through the analysis of image data acquired at the microscopic scale.

7mins

9 Feb 2015

Rank #12

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Chemistry, epigenetics and drugs

Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug. Professor Paul Brennan research focusses on epigenetics: the mechanisms that control gene expression. He studies how chemical probes interfere with epigenetic enyzmes that can be targeted to treat various diseases. Epigenetics combined with disease biology will ultimately accelerate drug discovery.

3mins

28 Jul 2015

Rank #13

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Personalised Diabetes Treatment

Professor Stephen Gough talks about the development of personalised diabetes treatment. Prof. Stephen Gough believes that you cannot give every patient affected by diabetes the same treatment; where people react differently to treatments provides a background to his research. Prof. Gough aims to provide the right treatment to the right person at the right time in their disease for optimum results.

5mins

17 May 2012

Rank #14

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Diabetes in Young Adults

Dr Katharine Owen talks about the different types of Diabetes in young adults. There are more forms of diabetes than the commonly known type 1 and type 2. Dr Katherine Owen investigates the different characteristics of monogenic diabetes with the aim of creating systematic diagnostics for aetiology of diabetes, and implementing that in clinical care. The ultimate aim is to promote personalized medicine for everybody with diabetes.

5mins

17 Jul 2012

Rank #15

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Respiratory Medicine

Dr Najib Rahman talks about his research on respiratory medicine. The Pleura are thin membranes that cover the surface of the lungs. Dr Najib Rahman specialises in areas of respiratory medicine including pleural disease and the conduct and analysis of respiratory trials. Dr Rahman is currently conducting clinical studies in malignant and infectious pleural disease, and is Clinical Director of the Oxford Respiratory Trials Unit.

5mins

28 May 2013

Rank #16

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Autoimmunity

Professor Richard Cornall tells us about his research on autoimmunity. Professor Richard Cornall aims to understand the causes of autoimmune diseases. Autoimmunity occurs when the immune system which is normally designed to attack pathogens ends up attacking the body. Professor Cornall is also interested in how people differ in their inherited susceptibility and why these differences are sustained in human populations by natural selection.

8mins

12 Sep 2012

Rank #17

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Wider Statin Use Saves Lives

Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives.

5mins

18 Jun 2012

Rank #18

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Clinical Trials in Gastroenterology

Dr Simon Travis tells us how clinical trials bring tomorrows treatments to patients today. Before translating basic research into the clinic it is important first to undergo clinical trials in order to identify safe treatments and therapies for disease. Led by Dr Simon Travis the Gastroenterology Clinical Trials Facility at Oxford University works to translate basic research into clinical trials of novel therapies for gastrointestinal and liver diseases.

4mins

25 Mar 2013

Rank #19

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Membrane proteins and drug development

Dr Liz Carpenter talks about her research on membrane proteins and drug development. Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.

5mins

29 Apr 2013

Rank #20