Host: Alka Goyal, MD  Higher Postinduction Infliximab Serum Trough Levels Are Associated With Healing of Fistulizing Perianal Crohn’s Disease in Children.  Wael El-Matary, MD, MSc Thomas D Walters, MD Hien Q Huynh, MDJennifer deBruyn, MD David R Mack, MD Kevan Jacobson, MD Mary E Sherlock, MDPeter Church, MD Eytan Wine, MD, PhD Matthew W Carroll, MD, Eric I Benchimol, MD, PhD Sally Lawrence, MD Anne M Griffiths, MD Background: There is some evidence in adults that higher serum infliximab (IFX) levels are needed to adequately treat fistulizing perianal Crohn's disease (CD). However, data in children are lacking. We aimed to determine postinduction serum trough IFX levels that are associated with healing of fistulizing perianal CD (PCD) at week 24. Methods: In a multicenter inception cohort study, consecutive children younger than age 17 years with fistulizing perianal CD treated with IFX between April 2014 and June 2017 who had serum trough IFX titers measured before the fourth infusion were included. Area under the receiver operating characteristic curve (AUROC) was calculated to determine the best cutoff to predict fistula …

Host: Alka Goyal, MD Higher Postinduction Infliximab Serum Trough Levels Are Associated With Healing of Fistulizing Perianal Crohn’s Disease in Children. <a>Wael El-Matary, MD, MSc</a> <a>Thomas D Walters, MD</a> <a>Hien Q Huynh, MD</a><a>Jennifer deBruyn, MD</a> <a>David R Mack, MD</a> <a>Kevan Jacobson, MD</a> <a>Mary E Sherlock, MD</a><a>Peter Church, MD</a> <a>Eytan Wine, MD, PhD</a> <a>Matthew W Carroll, MD, </a><a>Eric I Benchimol, MD, PhD</a> <a>Sally Lawrence, MD</a> <a>Anne M Griffiths, MD</a> <h4>Background:</h4> There is some evidence in adults that higher serum infliximab (IFX) levels are needed to adequately treat fistulizing perianal Crohn's disease (CD). However, data in children are lacking. We aimed to determine postinduction serum trough IFX levels that are associated with healing of fistulizing perianal CD (PCD) at week 24. <h4>Methods:</h4> In a multicenter inception cohort study, consecutive children younger than age 17 years with fistulizing perianal CD treated with IFX between April 2014 and June 2017 who had serum trough IFX titers measured before the fourth infusion were included. Area under the receiver operating characteristic curve (AUROC) was calculated to determine the best cutoff to predict fistula …

Assessing the Correlation Between Perianal Fistula Healing & Trough Levels of Infliximab in Children with IBD


Host: Brian P. McDonough, MD, FAAFP   Guest: Teresa Gil, PhD  Since about 21 million mothers in America experienced sexual abuse in their childhood, there’s a good chance that some of these women are our patients. So as their physicians, how can we provide them with the best possible care as they continue to cope with the lifelong effects of sexual abuse? That’s what Dr. Brian McDonough explores with Dr. Teresa Gil, author of Women Who Were Sexually Abused as Children: Mothering, Resilience, and Protecting the Next Generation.

Host: Brian P. McDonough, MD, FAAFP Guest: Teresa Gil, PhD Since about 21 million mothers in America experienced sexual abuse in their childhood, there’s a good chance that some of these women are our patients. So as their physicians, how can we provide them with the best possible care as they continue to cope with the lifelong effects of sexual abuse? That’s what Dr. Brian McDonough explores with Dr. Teresa Gil, author of Women Who Were Sexually Abused as Children: Mothering, Resilience, and Protecting the Next Generation.

The Lasting Effects of Childhood Sexual Abuse: Fighting the Lifelong Battle


Host: Paul Rokuskie  Did you know that in just 10 years, the national prevalence rate for autism spectrum disorder (ASD) has nearly tripled, going from 1 in 166 to 1 in 59? Or that 2 percent of the US population under the age of 18 now carries a diagnosis of ASD? Join Paul Rokuskie as he speaks with Dr. Stuart Shapira, Associate Director for Science at CDC’s National Center on Birth Defects and Developmental Disabilities, about these and other findings from the 2018 study regarding prevalence rates for ASD. 

Host: Paul Rokuskie Did you know that in just 10 years, the national prevalence rate for autism spectrum disorder (ASD) has nearly tripled, going from 1 in 166 to 1 in 59? Or that 2 percent of the US population under the age of 18 now carries a diagnosis of ASD? Join Paul Rokuskie as he speaks with Dr. Stuart Shapira, Associate Director for Science at CDC’s National Center on Birth Defects and Developmental Disabilities, about these and other findings from the 2018 study regarding prevalence rates for ASD.

Why Has the Prevalence Rate of Autism Tripled in Recent Years?


Host: Paul Rokuskie   Guest: David S. Mandell, ScD  As prevalence rates for autism spectrum disorder (ASD) increase, so do economic costs. On average, medical expenditures for individuals with an ASD were 4 to 6 times greater than those without an ASD. Join Paul Rokuskie and his guest Dr. David Mandell, Associate Director of the Center for Autism Research at the Children’s Hospital of Philadelphia, as they dive into the economic impact of ASD.

Host: Paul Rokuskie Guest: David S. Mandell, ScD As prevalence rates for autism spectrum disorder (ASD) increase, so do economic costs. On average, medical expenditures for individuals with an ASD were 4 to 6 times greater than those without an ASD. Join Paul Rokuskie and his guest Dr. David Mandell, Associate Director of the Center for Autism Research at the Children’s Hospital of Philadelphia, as they dive into the economic impact of ASD.

What is the Economic Impact of Autism Spectrum Disorder?


Host: Paul Rokuskie  As diagnostic information becomes more readily available, the importance of early diagnosis cannot be underestimated when it comes to helping those with autism spectrum disorder (ASD) and their families. Join Paul Rokuskie and his guest Dr. Stuart Shapira, Associate Director for Science at CDC’s National Center on Birth Defects and Developmental Disabilities, as they discuss the diagnosis criteria for ASD.

Host: Paul Rokuskie As diagnostic information becomes more readily available, the importance of early diagnosis cannot be underestimated when it comes to helping those with autism spectrum disorder (ASD) and their families. Join Paul Rokuskie and his guest Dr. Stuart Shapira, Associate Director for Science at CDC’s National Center on Birth Defects and Developmental Disabilities, as they discuss the diagnosis criteria for ASD.

Autism: The Critical Importance of Early, Individualized Diagnosis


Host: Jennifer Caudle, DO   Guest: Sarah E. Domoff, PhD  To address the growing issue of prolonged screen time and media use among children, Dr. Jennifer Caudle speaks with Dr. Sarah Domoff, Director of the Family Health Lab at Central Michigan University, about the tools available to help physicians identify and curb screen addiction.

Host: Jennifer Caudle, DO Guest: Sarah E. Domoff, PhD To address the growing issue of prolonged screen time and media use among children, Dr. Jennifer Caudle speaks with Dr. Sarah Domoff, Director of the Family Health Lab at Central Michigan University, about the tools available to help physicians identify and curb screen addiction.

Impacts of Prolonged Screen Time on Children's Health


Host: Brian P. McDonough, MD, FAAFP   Guest: Tanya Altmann, MD  To investigate the concerning rise in both asthma and allergies in children, Dr. Brian McDonough is joined by Dr. Tanya Altmann, pediatrician and Editor in Chief of the American Academy of Pediatrics parenting books, to discuss why a missing component of the gut microbiome may be the potential cause and how nutrition and probiotics play a vital role in a child's growth and development. 

Host: Brian P. McDonough, MD, FAAFP Guest: Tanya Altmann, MD To investigate the concerning rise in both asthma and allergies in children, Dr. Brian McDonough is joined by Dr. Tanya Altmann, pediatrician and Editor in Chief of the American Academy of Pediatrics parenting books, to discuss why a missing component of the gut microbiome may be the potential cause and how nutrition and probiotics play a vital role in a child's growth and development.

Is the Rise of Allergies Due to Missing Gut Microbiomes?


Host: Jennifer Caudle, DO   Guest: Jean Bennett, MD, PhD   Guest: Albert Maguire, MD  Power couple Drs. Jean Bennett and Albert Maguire discuss how their new therapy for the RPE65 gene, which causes retinal blindness, was recently approved by the FDA to become the first gene therapy treatment for a genetic disease in the United States and the first worldwide treatment for inherited blindness. Not only do they delve into the mechanics of the corrected gene injection, but they also explain what this milestone means for patient eligibility and how their marriage has played a role in the success of their research partnership. Dr. Jean Bennett is the F.M. Kirby Professor of Ophthalmology at the Perelman School of Medicine at the University of Pennsylvania, and Dr. Albert Maguire is a Professor of Ophthalmology at the Hospital of the University of Pennsylvania and Attending Physician in the Division of Pediatric Ophthalmology at Children’s Hospital of Philadelphia.

Host: Jennifer Caudle, DO Guest: Jean Bennett, MD, PhD Guest: Albert Maguire, MD Power couple Drs. Jean Bennett and Albert Maguire discuss how their new therapy for the RPE65 gene, which causes retinal blindness, was recently approved by the FDA to become the first gene therapy treatment for a genetic disease in the United States and the first worldwide treatment for inherited blindness. Not only do they delve into the mechanics of the corrected gene injection, but they also explain what this milestone means for patient eligibility and how their marriage has played a role in the success of their research partnership. Dr. Jean Bennett is the F.M. Kirby Professor of Ophthalmology at the Perelman School of Medicine at the University of Pennsylvania, and Dr. Albert Maguire is a Professor of Ophthalmology at the Hospital of the University of Pennsylvania and Attending Physician in the Division of Pediatric Ophthalmology at Children’s Hospital of Philadelphia.

FDA-Approved Gene Therapy Reverses Blindness in Children & Adults


Host: Philip Stein, MD   Guest: Neilanjan Nandi, MD   Guest: Susan Peck, MSN, CRNP  From the ReachMD studios in Fort Washington, Pennsylvania, host Dr. Philip Stein talks with Dr. Neilanjan Nandi and nurse practitioner Susan Peck about their respective experiences with The Crohn’s &amp; Colitis Foundation's Camp Oasis. This camp gives children with IBD the opportunity to meet other kids with the same chronic illness, teaching them how to cope with their disease, manage their own medical needs, try new sports and activities, build confidence and independence, and most importantly, spend quality time just being a kid.

Host: Philip Stein, MD Guest: Neilanjan Nandi, MD Guest: Susan Peck, MSN, CRNP From the ReachMD studios in Fort Washington, Pennsylvania, host Dr. Philip Stein talks with Dr. Neilanjan Nandi and nurse practitioner Susan Peck about their respective experiences with The Crohn’s &amp; Colitis Foundation's Camp Oasis. This camp gives children with IBD the opportunity to meet other kids with the same chronic illness, teaching them how to cope with their disease, manage their own medical needs, try new sports and activities, build confidence and independence, and most importantly, spend quality time just being a kid.

The Crohn’s & Colitis Foundation's Camp Oasis: A Clinician's Perspective


Host: John J. Russell, MD   Guest: Thomas Doyle, MD  About 40,000 babies are born with Congenital Heart Disease each year, making it one of the most common birth defects and causes of infant death in the US. CHD is usually present at birth but shows very few outward signs and, in most cases has no known cause or origin.  New and evolving surgical techniques, along with the dawn of pediatric heart transplant, are transforming the field of pediatric cardiology and offer new options for CHD patients. Host Dr. John Russell talks with Dr. Thomas Doyle about how continued research, improved surgical treatments and, emerging technology have altered the course of treatment for CHD, resulting in approximately 69% of children with CHD now living to age 18. Dr. Thomas Doyle is the Ann and Monroe Carell Jr. Family Associate Professor of Pediatrics at Vanderbilt University. Dr. Doyle was a 2016 Project Heart CHD research grant recipient.

Host: John J. Russell, MD Guest: Thomas Doyle, MD About 40,000 babies are born with Congenital Heart Disease each year, making it one of the most common birth defects and causes of infant death in the US. CHD is usually present at birth but shows very few outward signs and, in most cases has no known cause or origin. New and evolving surgical techniques, along with the dawn of pediatric heart transplant, are transforming the field of pediatric cardiology and offer new options for CHD patients. Host Dr. John Russell talks with Dr. Thomas Doyle about how continued research, improved surgical treatments and, emerging technology have altered the course of treatment for CHD, resulting in approximately 69% of children with CHD now living to age 18. Dr. Thomas Doyle is the Ann and Monroe Carell Jr. Family Associate Professor of Pediatrics at Vanderbilt University. Dr. Doyle was a 2016 <a href="https://projectheart.org/" rel="nofollow" target="_blank">Project Heart </a>CHD research grant recipient.

Heart of the Matter: Emerging Treatment Options for Congenital Heart Disease


Every generation strives to make the lives of our children happier, healthier and more productive. From cases of otitis media and current lipid management strategies, to the latest treatment options for traumatic brain injury, and the manifestation of rare chromosomal abnormalities, ReachMD explores the realm of children's health with a balanced lineup of leading medical experts in pediatrics and adolescent medicine. Join us to learn more!

Focus on Children's Health

Host: Jennifer Caudle, DO  Sleep apnea in children can lead to many behavioral, school and social problems. Recent research has even suggested that children who snore loudly were found to be twice as likely to have learning problems as children who don’t snore. What can be done to minimize sleep apnea in children?   On this episode of Everyday Family Medicine, Dr. Jennifer Caudle speaks with Dr. Diana Batoon, dentist and founder of Bonita Dental in Scottsdale, Arizona. Dr. Batoon has devoted much of her dental practice and public education efforts around identifying and treating sleep apnea in children.

Host: Jennifer Caudle, DO Sleep apnea in children can lead to many behavioral, school and social problems. Recent research has even suggested that children who snore loudly were found to be twice as likely to have learning problems as children who don’t snore. What can be done to minimize sleep apnea in children? On this episode of Everyday Family Medicine, Dr. Jennifer Caudle speaks with Dr. Diana Batoon, dentist and founder of Bonita Dental in Scottsdale, Arizona. Dr. Batoon has devoted much of her dental practice and public education efforts around identifying and treating sleep apnea in children.

Sleep Apnea in Children: Identification and Treatment Pathways


Guest: Roy Sanders, MD   Host: Bill Rutenberg, MD  Dr. Roy Sanders, author of How To Talk to Parents About Autism, speaks frankly with host Dr. Bill Rutenberg about his own family experience in learning of his son's autistic spectrum disorder. He discusses his family's journey and the dynamics involved in caring for a child with special needs. Dr. Sanders also talks about his professional work as director of psychiatric services at the Marcus Institute in Atlanta, an organization which works with children who have developmental disabilities.

Guest: Roy Sanders, MD Host: Bill Rutenberg, MD Dr. Roy Sanders, author of How To Talk to Parents About Autism, speaks frankly with host Dr. Bill Rutenberg about his own family experience in learning of his son's autistic spectrum disorder. He discusses his family's journey and the dynamics involved in caring for a child with special needs. Dr. Sanders also talks about his professional work as director of psychiatric services at the Marcus Institute in Atlanta, an organization which works with children who have developmental disabilities.

How To Talk to Parents About Autism


Guest: Jennifer Christner, MD   Host: Michael Benson, MD  Patients requesting early prescription refills, reporting lost medication, and other deviations from a standard dosing regimen are certainly worth noting. Given the frequency with which we prescribe medications for ADD, ADHD and other illnesses to our young patients, these irregularities may serve as warning signs of a larger problem. Host Dr. Michael Benson discusses prescription stimulant abuse in children with Dr. Jennifer Christner, an adolescent medicine specialist and a clinical assistant professor in the department of pediatrics and communicable diseases at the University of Michigan Medical School.

Guest: Jennifer Christner, MD Host: Michael Benson, MD Patients requesting early prescription refills, reporting lost medication, and other deviations from a standard dosing regimen are certainly worth noting. Given the frequency with which we prescribe medications for ADD, ADHD and other illnesses to our young patients, these irregularities may serve as warning signs of a larger problem. Host Dr. Michael Benson discusses prescription stimulant abuse in children with Dr. Jennifer Christner, an adolescent medicine specialist and a clinical assistant professor in the department of pediatrics and communicable diseases at the University of Michigan Medical School.

Prescription Stimulant Abuse in Young Patients


Guest: William J. Bryan, MD   Host: Sherwin Ho, MD  One of the lessons of Little League is that injuries are almost inevitable— particularly for overworked young pitchers. Dr. Bill Bryan, orthopedic surgeon and former team physician for Major League Baseball’s Houston Astros, talks with host Dr. Sherwin Ho about the best approaches to evaluating and treating shoulder and elbow injuries. Some injuries are only temporary, but Dr. Bryan says other arm troubles may force a pitcher to choose a new position on the field, at least until the patient is older and stronger. 

Guest: William J. Bryan, MD Host: Sherwin Ho, MD One of the lessons of Little League is that injuries are almost inevitable— particularly for overworked young pitchers. Dr. Bill Bryan, orthopedic surgeon and former team physician for Major League Baseball’s Houston Astros, talks with host Dr. Sherwin Ho about the best approaches to evaluating and treating shoulder and elbow injuries. Some injuries are only temporary, but Dr. Bryan says other arm troubles may force a pitcher to choose a new position on the field, at least until the patient is older and stronger. <a href="https://md.sermo.com/medical/article/news?pid=4282" rel="nofollow" target="_blank"></a>

Little League Pitching Injuries


Host: Bruce Bloom, DDS, JD   Guest: David Teachey, MD  Dr. David Teachey, a practicing pediatric hematologist-oncologist, laboratory and clinical researcher, and instructor in the department of pediatrics, division of oncology, at the Children’s Hospital of Philadelphia, explains to host Bruce Bloom his breakthrough research that may resolve symptoms for children saddled with the rare genetic disorder, Autoimmune Lymphoproliferative Syndrome.

Host: Bruce Bloom, DDS, JD Guest: David Teachey, MD Dr. David Teachey, a practicing pediatric hematologist-oncologist, laboratory and clinical researcher, and instructor in the department of pediatrics, division of oncology, at the Children’s Hospital of Philadelphia, explains to host Bruce Bloom his breakthrough research that may resolve symptoms for children saddled with the rare genetic disorder, Autoimmune Lymphoproliferative Syndrome.

Autoimmune Lymphoproliferative Syndrome


[Read the Article] Autism Spectrum Disorder (ASD) represents a diverse group of neurodevelopmental conditions. If researchers can better understand the genetics of ASD, it may be possible to identify and diagnose at-risk children sooner. A new study looked at the results of two newer genetic testing technologies, chromosomal microarray and whole-exome sequencing, in children diagnosed with ASD.Researchers from Newfoundland, Canada studied more than 250 children diagnosed with ASD. All participants underwent the chromosomal microarray analysis, however, only 95 randomly selected participants had whole-exome sequencing. Results found that sixteen percent of the children had an ASD related genetic finding on either microarray or whole-exome sequencing.In addition to the new tests, researchers also closely examined the children for subtle physical differences and screened them for birth defects. Based on these exams, they were put into three groups of increasing physical severity: essential, equivocal, and complex. Researchers found that thirty-five percent of children in the complex group had a positive genetic test. In that group, the diagnosis of autism was more delayed than in the children of the other groups. [Watch more videos of The JAMA Report] JAMA Report videos provided pursuant to license. ©2015 American …

<a href="http://jama.jamanetwork.com/article.aspx?articleid=2432161" rel="nofollow" target="_blank">[Read the Article]</a> Autism Spectrum Disorder (ASD) represents a diverse group of neurodevelopmental conditions. If researchers can better understand the genetics of ASD, it may be possible to identify and diagnose at-risk children sooner. A new study looked at the results of two newer genetic testing technologies, chromosomal microarray and whole-exome sequencing, in children diagnosed with ASD. Researchers from Newfoundland, Canada studied more than 250 children diagnosed with ASD. All participants underwent the chromosomal microarray analysis, however, only 95 randomly selected participants had whole-exome sequencing. Results found that sixteen percent of the children had an ASD related genetic finding on either microarray or whole-exome sequencing. In addition to the new tests, researchers also closely examined the children for subtle physical differences and screened them for birth defects. Based on these exams, they were put into three groups of increasing physical severity: essential, equivocal, and complex. Researchers found that thirty-five percent of children in the complex group had a positive genetic test. In that group, the diagnosis of autism was more delayed than in the children of the other groups. <a href="https://reachmd.com/programs/the-jama-report/" rel="nofollow" target="_blank">[Watch more videos of The JAMA Report]</a> JAMA Report videos provided pursuant to license. ©2015 American …

Newer Genetic Tests May Help Identify Some Children with Autism Spectrum Disorder


Host: Mark Nolan Hill, MD   Guest: Joseph Muenzer, MD  Hunter syndrome is a rare but serious genetic disorder that inhibits the body’s ability to break down specific complex carbohydrates. Initial onset symptoms include inguinal hernias, recurrent otitis, and the common cold, frequently manifesting concurrently as part of a multi-system failure sometime after the first year of life. Because many of these symptoms are common in infants, physicians often do not suspect Hunter syndrome, yet treatment for the disease is much more effective when administered early in its progression. How can we minimize the delay typically associated with diagnosis of Hunter syndrome? Dr. Joseph Muenzer, professor of pediatrics and genetics at the University of North Carolina School of Medicine, and one of the world’s leading authorities in Hunter syndrome research, joins host Dr. Mark Nolan Hill to share his expertise.

Host: Mark Nolan Hill, MD Guest: Joseph Muenzer, MD Hunter syndrome is a rare but serious genetic disorder that inhibits the body’s ability to break down specific complex carbohydrates. Initial onset symptoms include inguinal hernias, recurrent otitis, and the common cold, frequently manifesting concurrently as part of a multi-system failure sometime after the first year of life. Because many of these symptoms are common in infants, physicians often do not suspect Hunter syndrome, yet treatment for the disease is much more effective when administered early in its progression. How can we minimize the delay typically associated with diagnosis of Hunter syndrome? Dr. Joseph Muenzer, professor of pediatrics and genetics at the University of North Carolina School of Medicine, and one of the world’s leading authorities in Hunter syndrome research, joins host Dr. Mark Nolan Hill to share his expertise.

Delayed Diagnosis of Hunter Syndrome


[Read the Article] Preschool children who experience repeated episodes of severe lower respiratory tract infections (LRTI) often present with symptoms like wheezing and difficulty breathing. A new study looked at whether the use of the common antibiotic, azithromycin, would help prevent progression of the illness, if given early enough in the episode.Researchers from Washington University in Saint Louis School of Medicine, studied more than 600 children, ranging from ages one to six years old, with a history of repeated episodes of severe respiratory illness. Children were randomly assigned to either receive azithromycin or a placebo early in these episodes.They found that children in the antibiotic group experienced a lower risk of progressing to severe LRTI than the placebo group. [Watch more videos of The JAMA Report]

<a href="http://jama.jamanetwork.com/article.aspx?articleid=2470445" rel="nofollow" target="_blank">[Read the Article]</a> Preschool children who experience repeated episodes of severe lower respiratory tract infections (LRTI) often present with symptoms like wheezing and difficulty breathing. A new study looked at whether the use of the common antibiotic, azithromycin, would help prevent progression of the illness, if given early enough in the episode. Researchers from Washington University in Saint Louis School of Medicine, studied more than 600 children, ranging from ages one to six years old, with a history of repeated episodes of severe respiratory illness. Children were randomly assigned to either receive azithromycin or a placebo early in these episodes. They found that children in the antibiotic group experienced a lower risk of progressing to severe LRTI than the placebo group. <a href="https://reachmd.com/programs/the-jama-report/" rel="nofollow" target="_blank">[Watch more videos of The JAMA Report]</a>

Early Antibiotic Use May Halt Progression of Severe Respiratory Illness in Young Children


Host: Leslie P. Lundt, MD   Guest: Diann Ackard, PhD  When we hear that a patient has an eating disorder, we almost always think of a female. Yet adolescent boys do have disordered eating. Might knowing the risk factors help us target our interventions? Eating disorders expert Dr. Diann Ackard joins host Dr. Leslie Lundt as they discuss gender differences in eating disorders.

Host: Leslie P. Lundt, MD Guest: Diann Ackard, PhD When we hear that a patient has an eating disorder, we almost always think of a female. Yet adolescent boys do have disordered eating. Might knowing the risk factors help us target our interventions? Eating disorders expert Dr. Diann Ackard joins host Dr. Leslie Lundt as they discuss gender differences in eating disorders.

Eating Disorders and Sexuality in Boys


Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease in Patients Naïve to or Who Have Failed Tumor Necrosis Factor Antagonist Therapy. Sands BE1, Sandborn WJ, Van Assche G, Lukas M, Xu J, James A, Abhyankar B, Lasch K. BACKGROUND: Vedolizumab is a gut-selective α4β7 integrin antagonist for the treatment of moderately to severely active Crohn's disease (CD). Aims of this study were to characterize the efficacy and safety of vedolizumab induction and maintenance therapy in patients who were naïve to tumor necrosis factor-alpha (TNF-α) antagonist therapy (TNF-naïve) or who had discontinued TNF-α antagonist therapy because of inadequate response (i.e., primary nonresponse), loss of response, or intolerance (collectively classified as the TNF-failure population). METHODS: Post hoc analyses of the efficacy data for 516 TNF-naïve and 960 TNF-failure patients from the GEMINI 2 and GEMINI 3 trials were evaluated at weeks 6, 10, and 52 and included clinical remission (CD Activity Index [CDAI] score ≤150), enhanced clinical response (≥100-point decrease from baseline in CDAI score), durable clinical remission (remission at ≥80% of visits), and corticosteroid-free remission. Adverse events were summarized for the TNF-naïve and TNF-failure subgroups by treatment received. RESULTS: Among patients who responded to vedolizumab induction at week 6, 48.9% …

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease in Patients Naïve to or Who Have Failed Tumor Necrosis Factor Antagonist Therapy. Sands BE1, Sandborn WJ, Van Assche G, Lukas M, Xu J, James A, Abhyankar B, Lasch K. <h4>BACKGROUND:</h4> Vedolizumab is a gut-selective α4β7 integrin antagonist for the treatment of moderately to severely active Crohn's disease (CD). Aims of this study were to characterize the efficacy and safety of vedolizumab induction and maintenance therapy in patients who were naïve to tumor necrosis factor-alpha (TNF-α) antagonist therapy (TNF-naïve) or who had discontinued TNF-α antagonist therapy because of inadequate response (i.e., primary nonresponse), loss of response, or intolerance (collectively classified as the TNF-failure population). <h4>METHODS:</h4> Post hoc analyses of the efficacy data for 516 TNF-naïve and 960 TNF-failure patients from the GEMINI 2 and GEMINI 3 trials were evaluated at weeks 6, 10, and 52 and included clinical remission (CD Activity Index [CDAI] score ≤150), enhanced clinical response (≥100-point decrease from baseline in CDAI score), durable clinical remission (remission at ≥80% of visits), and corticosteroid-free remission. Adverse events were summarized for the TNF-naïve and TNF-failure subgroups by treatment received. <h4>RESULTS:</h4> Among patients who responded to vedolizumab induction at week 6, 48.9% …

Vedolizumab as Induction and Maintenance Therapy for Crohn’s Disease in Patients Naïve to or Who Have Failed Tumor Necrosis Factor Antagonist Therapy


Host: Andrew Krakowski, MD   Guest: Bari Cunningham, MD  Imagine that you have a rare condition called Xeroderma Pigmentosum (XP) in which even the slightest amount of UV radiation from the Sun turns your skin to cancer; left untreated, you can expect to die within the first 10 years of your life. Also imagine that your brothers and sisters suffer from this same affliction, but your family lacks the resources to do anything about it. Join Dr. Andrew Krakowski as he joins Dr. Bari Cuningham to discuss her remarkable journey through the wilderness of Guatemala to a small town where an autosomal recessive disease has dominated the local population and cast a shadow on life in this village. Then hear how a new day may be dawning for these special people thanks to a support team that is now championing their cause.

Host: Andrew Krakowski, MD Guest: Bari Cunningham, MD Imagine that you have a rare condition called Xeroderma Pigmentosum (XP) in which even the slightest amount of UV radiation from the Sun turns your skin to cancer; left untreated, you can expect to die within the first 10 years of your life. Also imagine that your brothers and sisters suffer from this same affliction, but your family lacks the resources to do anything about it. Join Dr. Andrew Krakowski as he joins Dr. Bari Cuningham to discuss her remarkable journey through the wilderness of Guatemala to a small town where an autosomal recessive disease has dominated the local population and cast a shadow on life in this village. Then hear how a new day may be dawning for these special people thanks to a support team that is now championing their cause.

Xeroderma Pigmentosum in the Crosshairs: A Dermatologist's Journey to Guatemala, Part 2


Host: Michael Greenberg, MD   Guest: Hugh Rienhoff, MD  Dr. Michael Greenberg speaks with Dr. Hugh Rienhoff about www.mydaughtersdna.org, a website he created to help children with rare or difficult-to-diagnose genetic diseases find proper diagnoses and help.

Host: Michael Greenberg, MD Guest: Hugh Rienhoff, MD Dr. Michael Greenberg speaks with Dr. Hugh Rienhoff about <a href="http://www.mydaughtersdna.org" rel="nofollow" target="_blank">www.mydaughtersdna.org</a>, a website he created to help children with rare or difficult-to-diagnose genetic diseases find proper diagnoses and help.

Searching for a Genetic Diagnosis for Rare Diseases: The Story of MyDaughtersDNA.org


Guest: KT Park, MD  Recorded on location at the Crohn’s &amp; Colitis Foundation's Annual Meeting in Orlando, host Dr. Sophie Balzora, Crohn's &amp; Colitis Foundation Reach-IBD member and faculty advisor of the Greater New York Chapter Fellows' Education Committee, discusses general strategies for clinicians and families to optimize growth in pediatric IBD with Dr. K.T. Park, Assistant Professor of Pediatric Gastroenterology at Stanford University School of Medicine &amp; Co-Director of Stanford Children’s Inflammatory Bowel Disease Center. 

Guest: KT Park, MD Recorded on location at the Crohn’s &amp; Colitis Foundation's Annual Meeting in Orlando, host Dr. Sophie Balzora, Crohn's &amp; Colitis Foundation Reach-IBD member and faculty advisor of the Greater New York Chapter Fellows' Education Committee, discusses general strategies for clinicians and families to optimize growth in pediatric IBD with Dr. K.T. Park, Assistant Professor of Pediatric Gastroenterology at Stanford University School of Medicine &amp; Co-Director of Stanford Children’s Inflammatory Bowel Disease Center.

Optimizing Growth in Pediatric Inflammatory Bowel Disease


[Read the Article] Electronic cigarettes (e-cigarettes) are becoming increasingly popular among teens. A new study looks at whether younger teens who never smoked cigarettes and who begin using e-cigarettes might be more likely to go on to use conventional tobacco products.Researchers from the University of Southern California, Los Angeles surveyed more than 2,300 Los Angeles area high school students who reported never using tobacco products at the beginning of 9th grade. The students were surveyed again six months later and also when entering the 10th grade.In a comparison of teens who had used e-cigarettes to those who had not, the researchers found that those who had used e-cigarettes were four times more likely to have gone on to use conventional tobacco products, including cigarettes and cigars. The researchers acknowledge that their findings, while suggestive, cannot prove that e-cigarette use directly causes subsequent tobacco use. [Watch more videos of The JAMA Report]  JAMA Report videos provided pursuant to license. ©2015 American Medical Association, publisher of JAMA® and The JAMA Network® journals.

<a href="http://jama.jamanetwork.com/article.aspx?articleid=2428954" rel="nofollow" target="_blank">[Read the Article]</a> Electronic cigarettes (e-cigarettes) are becoming increasingly popular among teens. A new study looks at whether younger teens who never smoked cigarettes and who begin using e-cigarettes might be more likely to go on to use conventional tobacco products. Researchers from the University of Southern California, Los Angeles surveyed more than 2,300 Los Angeles area high school students who reported never using tobacco products at the beginning of 9th grade. The students were surveyed again six months later and also when entering the 10th grade. In a comparison of teens who had used e-cigarettes to those who had not, the researchers found that those who had used e-cigarettes were four times more likely to have gone on to use conventional tobacco products, including cigarettes and cigars. The researchers acknowledge that their findings, while suggestive, cannot prove that e-cigarette use directly causes subsequent tobacco use. <a href="https://reachmd.com/programs/the-jama-report/" rel="nofollow" target="_blank">[Watch more videos of The JAMA Report]</a> JAMA Report videos provided pursuant to license. ©2015 American Medical Association, publisher of JAMA® and The JAMA Network® journals.

Teens Who Use Electronic Cigarettes Are More Likely to Start Smoking


Guest: Marlene Schwartz, MS, PhD   Host: Leslie P. Lundt, MD  Studies show that people who eat breakfast have better overall nutrition, improved cognitive functioning and are less likely to be overweight. What should we advise our pediatric patients to eat for breakfast? Up to 50% of school-aged children eat cereal for breakfast. How much nutritional value is present in cereal? How best can we advise parents on feeding their children? Dr. Marlene Schwartz, deputy director for the Rudd Center for Food Policy and Obesity at Yale University, describes her research into children's nutrition with host Dr. Leslie Lundt.

Guest: Marlene Schwartz, MS, PhD Host: Leslie P. Lundt, MD Studies show that people who eat breakfast have better overall nutrition, improved cognitive functioning and are less likely to be overweight. What should we advise our pediatric patients to eat for breakfast? Up to 50% of school-aged children eat cereal for breakfast. How much nutritional value is present in cereal? How best can we advise parents on feeding their children? Dr. Marlene Schwartz, deputy director for the Rudd Center for Food Policy and Obesity at Yale University, describes her research into children's nutrition with host Dr. Leslie Lundt.

The Most Important Meal of the Day: What Should Children Eat for Breakfast?


Host: Maurice Pickard, MD   Guest: Elijah Nealy, PhD  These days, it is practically impossible not to hear about some aspect of transgender life, and kids are coming out as trans at younger and younger ages. But what resources are available to parents, teachers, and mental health professionals who need to support these children? Host Dr. Maurice Pickard chats with Elijah C. Nealy, therapist and former deputy executive director of New York City’s LGBT Community Center. Mr. Nealy is the author of Transgender Children and Youth: Cultivating Pride and Joy with Families in Transition, which provides insights about the physical, social, and emotional aspects of transition and the best practices to support trans kids.

Host: Maurice Pickard, MD Guest: Elijah Nealy, PhD These days, it is practically impossible not to hear about some aspect of transgender life, and kids are coming out as trans at younger and younger ages. But what resources are available to parents, teachers, and mental health professionals who need to support these children? Host Dr. Maurice Pickard chats with Elijah C. Nealy, therapist and former deputy executive director of New York City’s LGBT Community Center. Mr. Nealy is the author of Transgender Children and Youth: Cultivating Pride and Joy with Families in Transition, which provides insights about the physical, social, and emotional aspects of transition and the best practices to support trans kids.

Transgender Children & Youth: Cultivating Pride & Joy with Families in Transition


Guest: Jill Grimes, MD   Host: Jennifer Shu, MD, FAAP  The Centers for Disease Control (CDC) has indicated that 19 million Americans — including one in four teenage girls — are infected with at least one sexually transmitted disease (STD). As physicians, we know that these diseases are far more common than most people think. But are we doing our best to educate our patients and provide appropriate screening measures? How can physicians work to debunk common public misconceptions about STDs? Dr. Jill Grimes, a practicing family physician in Austin, Texas, and author of Seductive Delusions: How Everyday People Catch STDs, addresses a series of erroneous beliefs about STDs and offers counsel on the most effective ways for physicians to help tackle this critical public health problem. Dr. Jennifer Shu hosts.

Guest: Jill Grimes, MD Host: Jennifer Shu, MD, FAAP The Centers for Disease Control (CDC) has indicated that 19 million Americans — including one in four teenage girls — are infected with at least one sexually transmitted disease (STD). As physicians, we know that these diseases are far more common than most people think. But are we doing our best to educate our patients and provide appropriate screening measures? How can physicians work to debunk common public misconceptions about STDs? Dr. Jill Grimes, a practicing family physician in Austin, Texas, and author of Seductive Delusions: How Everyday People Catch STDs, addresses a series of erroneous beliefs about STDs and offers counsel on the most effective ways for physicians to help tackle this critical public health problem. Dr. Jennifer Shu hosts.

Teenagers and STDs: A Too-Common Pairing


Host: Brian P. McDonough, MD, FAAFP   Guest: Howard Spiva  Wearing a helmet is an overlooked but critical safety precaution, particularly among children. Attorney Howard Spiva knows the lifelong struggle of individuals recovering from traumatic brain injuries, having devoting much of his career to providing helmet safety education for children. Joined by host Brian McDonough, Mr. Spiva discusses important details about helmet safety, the current status of helmet laws, and continuing efforts to reduce traumatic brain injuries nationwide.

Host: Brian P. McDonough, MD, FAAFP Guest: Howard Spiva Wearing a helmet is an overlooked but critical safety precaution, particularly among children. Attorney Howard Spiva knows the lifelong struggle of individuals recovering from traumatic brain injuries, having devoting much of his career to providing helmet safety education for children. Joined by host Brian McDonough, Mr. Spiva discusses important details about helmet safety, the current status of helmet laws, and continuing efforts to reduce traumatic brain injuries nationwide.

Head's Up! Why Wearing Bike Helmets Can't Be Overlooked


Host: Prathima Setty, MD  A couple of extra minutes attached to the umbilical cord at birth may translate into a significant boost in neurodevelopment several years later, research suggests. Dr. Prathima Setty is joined by Dr. Kecia Gaither, a perinatal consultant at St. Lukes Hospital in Kansas City, MO as they talk about how delaying cutting the umbilical cord can be beneficial. 

Host: Prathima Setty, MD A couple of extra minutes attached to the umbilical cord at birth may translate into a significant boost in neurodevelopment several years later, research suggests. Dr. Prathima Setty is joined by Dr. Kecia Gaither, a perinatal consultant at St. Lukes Hospital in Kansas City, MO as they talk about how delaying cutting the umbilical cord can be beneficial.

'Cutting the Cord' on Outdated L&D Practices: The Benefits of Delayed Umbilical Cord Cutting


The best podcast episodes on Startups. For anyone working in a startup, or anyone interested in the incredible stories behind how people built companies like Instagram, and Facebook. Offering both practical advice and insights, as well as the stories for how many of the biggest startups got to where they are today. Add episodes you're interested into your queue below!

OwlTail

Best Startups Podcasts

The best podcast episodes of the most interesting stories and things. From skyping someone while they're in space, to tracking down and meeting a telephone scammer in person, to the story of a Galapagos. These episodes will keep you and all your friends entertained and captivated for hours. Learn something new in every episode! Add episodes you're interested into your queue below!