Hassan Samee's guest appearances

Hassan Samee

the bioinformatics chat

David Kelley

Irineo Cabreros

Romain Lopez

Gabriel Misrachi

Kristina Grigaityte

Jacob Schreiber

Simeon Carstens

Trevor Pesout

HoJoon Lee

Seung Woo Cho

Kaushik Panda

Keith Slotkin

Fernando Portela

Chang Xu

Andrey Ziyatdinov

OwlTail

Even though the double-stranded DNA has the famous regular helical shape,there are small variations in the geometry of the helix depending on whatexact nucleotides its made of at that position. In this episode of the bioinformatics chat, Hassan Samee talks about therole the DNA shape plays in recognition of the DNA by DNA-binding proteins,such as transcription factors. Hassan also explains how his algorithm, ShapeMF,can deduce the DNA shape motifs from the ChIP-seq data. Links:  A De Novo Shape Motif Discovery Algorithm Reveals Preferences of Transcription Factors for DNA Shape Beyond Sequence Motifs (Md. Abul Hassan Samee, Benoit G. Bruneau, Katherine Pollard) ShapeMF on GitHub A picture explaining some of the DNA shape features  If you enjoyed this episode, please consider supporting the podcast on Patreon!

Even though the double-stranded DNA has the famous regular helical shape, there are small variations in the geometry of the helix depending on what exact nucleotides its made of at that position. In this episode of the bioinformatics chat, <a href="https://www.bcm.edu/research/labs/hassan-samee" rel="nofollow" target="_blank">Hassan Samee</a> talks about the role the DNA shape plays in recognition of the DNA by DNA-binding proteins, such as transcription factors. Hassan also explains how his algorithm, ShapeMF, can deduce the DNA shape motifs from the ChIP-seq data. Links: <ul> <li><a href="https://www.cell.com/cell-systems/fulltext/S2405-4712(18)30475-7" rel="nofollow" target="_blank">A De Novo Shape Motif Discovery Algorithm Reveals Preferences of Transcription Factors for DNA Shape Beyond Sequence Motifs</a> (Md. Abul Hassan Samee, Benoit G. Bruneau, Katherine Pollard)</li> <li><a href="https://github.com/h-samee/shape-motif" rel="nofollow" target="_blank">ShapeMF on GitHub</a></li> <li><a href="https://en.wikipedia.org/wiki/Nucleic_acid_double_helix#/media/File:CCF10292011_00000.jpg" rel="nofollow" target="_blank">A picture explaining some of the DNA shape features</a></li> </ul> If you enjoyed this episode, please consider supporting the podcast on <a href="https://www.patreon.com/bioinfochat" rel="nofollow" target="_blank">Patreon</a>!

#35 The role of the DNA shape in transcription factor binding with Hassan Samee