Paul Spagnuolo's guest appearances

Paul Spagnuolo

humanOS Radio

The Natural Health Influencer Podcast

Avocatin B

Aaron Alexander

David Katz

Dan Siegel

Todd White

James Clear

Ben Miller

Chris Kresser

Andrew Hill

Jeff Chilton

Stephan Guyenet

Richard Lin

Gary Taubes

Judith Campisi

Noelle Martin

OwlTail

If you're someone who is struggling with blood sugar levels or weight loss, this episode is for you! Today, we delve into new research about avocados and the tiny molecule found in them that, according to scientists at the University of Guelph, can do great things for your insulin levels and your health! We’re joined by Dr. Paul Spagnuolo, food scientist, renowned expert in nutraceuticals, and acclaimed researcher from the University of Guelph, who has affectionately been nicknamed ‘The Avocado Guy’. Dr. Spagnuolo gives us a detailed breakdown of what insulin resistance is and how it affects our health before explaining the research that he has been doing on avocados for the past 10 years. Tuning in, you’ll hear about Avocatin B, how it works on the mitochondria of our cells, and how it has been proven to reduce insulin resistance. Dr. Spagnuolo also talks about the Metavo supplement he has developed and how it may benefit you. To find out more about this nutraceutical breakthrough that may help you manage your blood sugar levels, stop cravings, and even get rid of that afternoon crash, tune in today!Key Points From This Episode:An introduction to today’s guest, Dr. Paul Spagnuolo, and his impressive credentials. What insulin resistance is and how it affects our health. Insight into Dr. Paul Spagnuolo’s decade of avocado research.What Avocatin B is and how it works on the mitochondria of our cells.Results from a lab study on mice to improve how their bodies metabolize fats and sugars.How they applied these findings to human subjects.Some of the benefits they saw in humans.  How Avocatin B helps reverse insulin resistance. The Metavo product that Dr. Paul Spagnuolo developed. Why just consuming avocado is not enough.Who would benefit from taking Metavo.The importance of diet and exercise and why this is not a magic pill.Some of the other nutrients in Metavo and the benefits of chromium. What an A1C test is and how Avocatin B affects test results.Success stories of how the product has impacted people’s lives.Where you can find Metavo. What Dr. Paul Spagnuolo believes to be the next big thing in nutraceuticals.  Links Mentioned in Today’s Episode:Dr. Paul Spagnuolo on LinkedInMetavoDeliciously GeekyAllison Tannis on LinkedInAllison Tannis on InstagramNatural Health Influencer on Instagram Natural Health Influencer Facebook GroupPure-Lē NaturalVista MagazineVista Magazine on Instagram

If you're someone who is struggling with blood sugar levels or weight loss, this episode is for you! Today, we delve into new research about avocados and the tiny molecule found in them that, according to scientists at the University of Guelph, can do great things for your insulin levels and your health! We’re joined by Dr. Paul Spagnuolo, food scientist, renowned expert in nutraceuticals, and acclaimed researcher from the University of Guelph, who has affectionately been nicknamed ‘The Avocado Guy’. Dr. Spagnuolo gives us a detailed breakdown of what insulin resistance is and how it affects our health before explaining the research that he has been doing on avocados for the past 10 years. Tuning in, you’ll hear about Avocatin B, how it works on the mitochondria of our cells, and how it has been proven to reduce insulin resistance. Dr. Spagnuolo also talks about the Metavo supplement he has developed and how it may benefit you. To find out more about this nutraceutical breakthrough that may help you manage your blood sugar levels, stop cravings, and even get rid of that afternoon crash, tune in today! Key Points From This Episode:<ul><li>An introduction to today’s guest, Dr. Paul Spagnuolo, and his impressive credentials. </li><li>What insulin resistance is and how it affects our health. </li><li>Insight into Dr. Paul Spagnuolo’s decade of avocado research.</li><li>What Avocatin B is and how it works on the mitochondria of our cells.</li><li>Results from a lab study on mice to improve how their bodies metabolize fats and sugars.</li><li>How they applied these findings to human subjects.</li><li>Some of the benefits they saw in humans.  </li><li>How Avocatin B helps reverse insulin resistance. </li><li>The Metavo product that Dr. Paul Spagnuolo developed. </li><li>Why just consuming avocado is not enough.</li><li>Who would benefit from taking Metavo.</li><li>The importance of diet and exercise and why this is not a magic pill.</li><li>Some of the other nutrients in Metavo and the benefits of chromium. </li><li>What an A1C test is and how Avocatin B affects test results.</li><li>Success stories of how the product has impacted people’s lives.</li><li>Where you can find Metavo. </li><li>What Dr. Paul Spagnuolo believes to be the next big thing in nutraceuticals.  </li></ul> Links Mentioned in Today’s Episode:<a href="https://www.linkedin.com/in/paul-spagnuolo-55532813/" rel="nofollow" target="_blank">Dr. Paul Spagnuolo on LinkedIn</a><a href="http://metavo.com" rel="nofollow" target="_blank">Metavo</a><a href="https://allisontannis.com/" rel="nofollow" target="_blank">Deliciously Geeky</a><a href="https://ca.linkedin.com/in/allison-tannis-msc-rhn-2621162b" rel="nofollow" target="_blank">Allison Tannis on LinkedIn</a><a href="https://www.instagram.com/deliciouslygeeky/?hl=en" rel="nofollow" target="_blank">Allison Tannis on Instagram</a><a href="https://www.instagram.com/naturalhealthinfluencer/?hl=en" rel="nofollow" target="_blank">Natural Health Influencer on Instagram</a> <a href="https://facebook.com/groups/naturalhealthinfluencer/" rel="nofollow" target="_blank">Natural Health Influencer Facebook Group</a><a href="https://purele.ca/" rel="nofollow" target="_blank">Pure-Lē Natural</a><a href="https://vistaglobalmarket.com/" rel="nofollow" target="_blank">Vista Magazine</a><a href="https://www.instagram.com/vistamagcanada/" rel="nofollow" target="_blank">Vista Magazine on Instagram</a>

Ep 70: Avocatin B and Insulin Resistance with Dr. Paul Spagnuolo A.K.A The Avocado Guy

On this episode of humanOS Radio, Dan speaks with Paul Spagnuolo. Dr. Spagnuolo has a PhD in Applied Health Sciences from the University of Waterloo, and is currently a Professor at the Department of Food Science at the University of Guelph in Ontario Canada. His lab has been focused on identifying and developing nutraceuticals as novel therapeutic agents, and figuring out the molecular and cellular mechanisms through which these food-derived bioactive compounds influence cell biology. To that end, the Spagnuolo lab has created a unique, in-house nutraceutical library that is conducive for high-throughput screening. This is useful because it allows the lab to efficiently search for compounds with potent and selective toxicity against cancer cells.When screening this natural health product library for potential therapeutics, they discovered avocatin B, a mixture of polyhydroxylated fatty alcohols that is found exclusively in avocados. Avocatin B is a potent inhibitor of fatty acid oxidation (FAO), which makes it a promising candidate as a drug to block or delay some of the cellular processes that lead to insulin resistance and diabetes. In theory, reducing FAO in skeletal muscle and in pancreatic beta cells would force cells to burn glucose instead of fatty acids. This boost in glucose oxidation would be expected to lower blood sugar levels and restore insulin sensitivity. But of course, the only way to know whether it actually works is to put it to the test.Paul and his team wanted to explore whether this avocado compound could indeed help with metabolic syndrome. To that end, they recently performed a series of experiments testing avocatin B in rodent models of obesity and insulin resistance, as well as a randomized controlled clinical trial in humans. To learn what they found, check out the interview!

On this episode of humanOS Radio, Dan speaks with Paul Spagnuolo. Dr. Spagnuolo has a PhD in Applied Health Sciences from the University of Waterloo, and is currently a Professor at the Department of Food Science at the University of Guelph in Ontario Canada. His lab has been focused on identifying and developing nutraceuticals as novel therapeutic agents, and figuring out the molecular and cellular mechanisms through which these food-derived bioactive compounds influence cell biology. To that end, the Spagnuolo lab has created a unique, in-house nutraceutical library that is conducive for high-throughput screening. This is useful because it allows the lab to efficiently search for compounds with potent and selective toxicity against cancer cells. When screening this natural health product library for potential therapeutics, they discovered avocatin B, a mixture of polyhydroxylated fatty alcohols that is found exclusively in avocados. Avocatin B is a potent inhibitor of fatty acid oxidation (FAO), which makes it a promising candidate as a drug to block or delay some of the cellular processes that lead to insulin resistance and diabetes. In theory, reducing FAO in skeletal muscle and in pancreatic beta cells would force cells to burn glucose instead of fatty acids. This boost in glucose oxidation would be expected to lower blood sugar levels and restore insulin sensitivity. But of course, the only way to know whether it actually works is to put it to the test. Paul and his team wanted to explore whether this avocado compound could indeed help with metabolic syndrome. To that end, they recently performed a series of experiments testing avocatin B in rodent models of obesity and insulin resistance, as well as a randomized controlled clinical trial in humans. To learn what they found, check out the interview!

#088 - Avocatin B and Obesity - Paul Spagnuolo