Kristine Yaffe's guest appearances

Kristine Yaffe

BrainStorm by UsAgainstAlzheimer's

GeriPal

Richard Isaacson

Mark Hyman

Wendy Suzuki

Bruce Miller

Scott Turner

David Morgan

Lisa Genova

Lisa Mosconi

Mary Newport

Ellen Goodman

Jill Smith

Mark Shriver

Jonathan Jackson

Diane Rehm

Amy Bloom

OwlTail

We’ve had multiple GeriPal episodes about treatments for dementia, including aducanumab (here,  here, and  here) and lecanemab (here).  As today’s guest, Kristine Yaffe notes, part of the reason for that emphasis is that in the US we prioritize treatment, whereas other countries are ahead of us in prioritizing prevention.  Deb Barnes and Kristine Yaffe published a landmark paper in Lancet Neurology finding that up to half of dementia risk is due to modifiable factors.  If we focused on prevention, from a public health standpoint, we would achieve far more than spending millions billions on treatment. Today we talk about steps we can and should take to reduce the risk of dementia, including:   Education and cognitive games (I reveal my embarrassingly poor average time on the NYT mini cross word)   Physical activity   Sleep   Depression   Smoking   Social isolation   Blood pressure control (listen also to our podcast on Sprint Mind with Jeff Williamson)    We also delve into an exciting new trial Kristine led with others on the impact of risk factor reduction on cognition - here’s a link to press about the trial from a fall meeting presentation - article forthcoming.  And because we can’t resist, we dip into aducanumab and lecanemab at the end.   -@AlexSmithMD

We’ve had multiple GeriPal episodes about treatments for dementia, including aducanumab (<a href="https://geripal.org/all-things-amyloid-including-aducanumab/" rel="nofollow" target="_blank">here</a>, <a href="https://geripal.org/aducanumab-aduhelm-for-the-treatment-of-alzheimers-a-podcast-with-aaron-kesselheim-and-jason-karlawish/" rel="nofollow" target="_blank"> here</a>, and <a href="https://geripal.org/real-world-eligibility-for-aducanumab-a-podcast-with-tim-anderson-and-marco-canevelli/" rel="nofollow" target="_blank"> here</a>) and lecanemab (<a href="https://geripal.org/is-it-time-for-geriatricians-to-get-on-board-with-lecanemab-jason-karlawish-and-ken-covinsky/" rel="nofollow" target="_blank">here</a>).  As today’s guest, Kristine Yaffe notes, part of the reason for that emphasis is that in the US we prioritize treatment, whereas other countries are ahead of us in prioritizing prevention.  Deb Barnes and Kristine Yaffe published a landmark paper in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647614/" rel="nofollow" target="_blank">Lancet Neurology</a> finding that up to half of dementia risk is due to modifiable factors.  If we focused on prevention, from a public health standpoint, we would achieve far more than spending millions billions on treatment. Today we talk about steps we can and should take to reduce the risk of dementia, including: <ul> <li> Education and cognitive games (I reveal my embarrassingly poor average time on the NYT mini cross word) </li> <li> Physical activity </li> <li> Sleep </li> <li> Depression </li> <li> Smoking </li> <li> Social isolation </li> <li> Blood pressure control (listen also to our podcast on <a href="https://geripal.org/does-intensive-blood-pressure-lowering/" rel="nofollow" target="_blank">Sprint Mind with Jeff Williamson</a>) </li> </ul> We also delve into an exciting new trial Kristine led with others on the impact of risk factor reduction on cognition - here’s a link to <a href="https://www.cbsnews.com/sanfrancisco/news/ucsf-dementia-scientists-findings-show-adults-can-reduce-alzheimers-risks-through-lifestyle/" rel="nofollow" target="_blank">press</a> about the trial from a fall meeting presentation - article forthcoming.  And because we can’t resist, we dip into aducanumab and lecanemab at the end.  -@AlexSmithMD

Prevention of Dementia: Kristine Yaffe

David Holtzman

Difficulty sleeping affects many people with Alzheimer's: sleeping longer than usual, trouble falling asleep or staying asleep, or sleeping during the day and being awake at night. For those who do not have Alzheimer's, regularly getting inadequate sleep can increase your risk for the disease.What does research tell us about the link between insomnia and Alzheimer's? And are there steps we can take to help manage the risk created by poor sleep?Host Meryl Comer speaks with two experts on these questions: David Holtzman, MD, of Washington University in St. Louis has led studies linking sleep disorders to greater amyloid-beta and tau accumulation in the brain and thus to an increased risk of developing Alzheimer's.Kristine Yaffe, MD, of the University of California, San Francisco, is an expert on populations studies as well as sleep and Alzheimer’s disease.Support the show (https://www.usagainstalzheimers.org)

Difficulty sleeping affects many people with Alzheimer's: sleeping longer than usual, trouble falling asleep or staying asleep, or sleeping during the day and being awake at night. For those who do not have Alzheimer's, regularly getting inadequate sleep can increase your risk for the disease.What does research tell us about the link between insomnia and Alzheimer's? And are there steps we can take to help manage the risk created by poor sleep? Host Meryl Comer speaks with two experts on these questions:<ul><li> David Holtzman, MD, of Washington University in St. Louis has led studies linking sleep disorders to greater amyloid-beta and tau accumulation in the brain and thus to an increased risk of developing Alzheimer's.</li><li>Kristine Yaffe, MD, of the University of California, San Francisco, is an expert on populations studies as well as sleep and Alzheimer’s disease.</li></ul><a href="https://www.usagainstalzheimers.org" rel="payment nofollow" target="_blank">Support the show</a> (<a href="https://www.usagainstalzheimers.org" rel="nofollow" target="_blank">https://www.usagainstalzheimers.org</a>)

[AlzTalks-Archive] Insomnia and Alzheimer's - Dr. David Holtzman & Dr. Kristine Yaffe