Rank #1: The Blueprint for Everything with Amanda Poholek, PhD
The cells in our body work together as a system to help us function and Amanda Poholek, assistant professor in the Department of Pediatrics and Department of Immunology, is interested in what happens when these cell interactions “go wrong” and result in diseases. Dr. Poholek discusses transcription factors, the proteins that help direct our genetic information, and the breakthrough technology of Next Generation Sequencing (NGS or NextGen), which provides rapid and accurate genome analysis.
Rank #2: The Unique Microbiome of Premature Infants with Michael Morowitz, MD
Michael Morowitz, MD, is an associate professor of Surgery and an attending physician in the Division of Pediatric and General Thoracic Surgery. Dr. Morowitz’s research focuses on Necrotizing Enterocolitis (NEC), a mysterious disorder of intestinal inflammation in premature newborn infants. His lab studies the microbiome, the vast collection of microorganisms that cover our bodies, inside and out.
Rank #3: Spreading Access to Pediatric Care with Kristin Ray, MD
Kristin Ray, MD, director of Health Systems Improvements with Children’s Community Pediatrics (CCP), and a Mellon Scholar with the Richard King Mellon Foundation Institute for Pediatric Research, aims to improve the pediatric health care delivery system to make quality care more readily available to all. Dr. Ray discusses two interventions that can help with these challenges, telemedicine and electronic consultations, and the future of this specialty care delivery.
Rank #4: Neonatal Cardiovascular Research with Thomas Diacovo, MD
Thomas Diacovo, MD, is chief of the UPMC Newborn Medicine Program and director of Neonatal Cardiovascular Research at the Heart Institute. Dr. Diacovo discusses how he became interested in Thrombosis research, his journey to Pittsburgh, and his research testing new drugs for neonatal intensive care patients, particularly those with congenital heart disease who are at high risk for forming blood clots. Dr. Diacovo also credits the parents of our patients for the success of his clinical trials.
Rank #5: In Pursuit of the Self-Healing Heart with Bernhard Kühn, MD
Bernhard Kühn, MD, is the director of research in Cardiology and an associate director for the Richard King Mellon Institute for Pediatric Research. The Kühn Lab focuses on cardiomyocytes and creating therapies that can help the heart muscle heal itself to recover from a heart attack or to help it restore a congenital heart defect to normal cardiac function without requiring surgery. He also reflects on the helpful collaboration with the cardiac surgery team here at UPMC Children’s Hospital of Pittsburg
Rank #6: Let’s Talk About Ears with Alejandro Hoberman, MD
Alejandro Hoberman, MD, chief of the Division of General Academic Pediatrics and president of Children’s Community Pediatrics, has contributed research on urinary tract infections and acute otitis media, and in this episode, the focus is on the ears. He discusses the role of antibiotics, duration of treatment, resistance, adverse outcomes, allergies, and more. Dr. Hoberman also talks about the role that new technologies and multimedia tools play in treatment and discussions with parents.
Rank #7: A Passion for Pediatric Emergency Medicine with Mioara Manole, MD
After six years of medical school in Romania, Mioara Manole, MD, came to the U.S. and discovered a passion for pediatric emergency medicine. In addition to seeing patients, she is also the director of Basic and Translational Research in the Division of Pediatric Emergency Medicine. Learn how her research translates to clinical work, including the creation of the FLO2 NeuroCap, a noninvasive device that measures brain oxygenation and neuronal activity in children after cardiac arrest or other brain injuries.
Rank #8: A History of Pediatric Liver Transplantation with George Mazariegos, MD
In the late ’80s, George Mazariegos, MD, had a one-month rotation with transplant pioneer Thomas E. Starzl, MD. Today, he is chief of Pediatric Transplantation at UPMC Children’s Hospital of Pittsburgh and director of Pediatric Transplantation at the Thomas E. Starzl Transplantation Institute. Our hosts cover all things pediatric liver transplantation: What conditions require a transplant, what our center has accomplished, growing our transplant network, and improving care after transplantation.
Rank #9: From the U.S. Navy to UTIs with Tim Shope, MD
Tim Shope, MD, professor of Pediatrics, has lived in many places, but common pediatric infections, including urinary tract infections (UTIs) are everywhere. His team created the UTICalc, available at uticalc.ptt.edu. This user-friendly tool prompts the clinician with five questions, providing an estimated risk of UTI to help reduce unnecessary catheterization and improve outcomes. Also, learn about Dr. Shope’s time with the U.S. Navy, and his famous family member in the world of infectious disease researc
Rank #10: The First Handshake with Tim Hand, PhD
Tim Hand, PhD, assistant professor with the Richard King Mellon Foundation Institute for Pediatric Research, takes samples from the neonatal intensive care unit (NICU) to look at how antibodies in a mother’s breast milk may shape the relationship between an infant and their microbiome. Listen in as Dr. Hand discusses the unique microbiome of premature infants, necrotizing enterocolitis (NEC), and how maternal IgA, an active component in a mother’s breast milk, can shape a child’s immune system.