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Rank #150 in Medicine category

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ERCAST

Updated 3 days ago

Rank #150 in Medicine category

Education
Health & Fitness
Medicine
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A short, focused discussion of emergency medicine topics with perspectives from emergency physicians as well as other specialties. Here's the problem: When I listen to a 45 minute lecture that goes through about 15 different studies and has 50 slides, I come out feeling like a genius. An hour later, I have forgotten 95% of it. Here's the solution: ercast. We cover a single issue and try to tease out all the relevant elements without overstuffing your frontal cortex. It's for physicians and anyone interested in a bare bones look at emergency care.

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A short, focused discussion of emergency medicine topics with perspectives from emergency physicians as well as other specialties. Here's the problem: When I listen to a 45 minute lecture that goes through about 15 different studies and has 50 slides, I come out feeling like a genius. An hour later, I have forgotten 95% of it. Here's the solution: ercast. We cover a single issue and try to tease out all the relevant elements without overstuffing your frontal cortex. It's for physicians and anyone interested in a bare bones look at emergency care.

iTunes Ratings

384 Ratings
Average Ratings
358
12
6
3
5

ūüĎć

By ati90116 - Dec 07 2018
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Plz use number for episodes ūüôŹ

Great!

By hosehead1423 - Feb 13 2016
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Sad to see the episodes stopping though

iTunes Ratings

384 Ratings
Average Ratings
358
12
6
3
5

ūüĎć

By ati90116 - Dec 07 2018
Read more
Plz use number for episodes ūüôŹ

Great!

By hosehead1423 - Feb 13 2016
Read more
Sad to see the episodes stopping though
Cover image of ERCAST

ERCAST

Updated 3 days ago

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A short, focused discussion of emergency medicine topics with perspectives from emergency physicians as well as other specialties. Here's the problem: When I listen to a 45 minute lecture that goes through about 15 different studies and has 50 slides, I come out feeling like a genius. An hour later, I have forgotten 95% of it. Here's the solution: ercast. We cover a single issue and try to tease out all the relevant elements without overstuffing your frontal cortex. It's for physicians and anyone interested in a bare bones look at emergency care.

Rank #1: How to master CPR

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Little things can make a big difference when it comes to running a code. EMS director and CPR aficionado Bill Reed gives a primer on High Performance CPR.

  High Performance CPR core principles
  • Rate = 110 (100-120).
  • Metronome set at 110.
  • Depth = 2.0-2.5 inches.
  • Full recoil (no leaning).
  • Focus on rate & depth.
  • Listen for 15 second countdown warning of upcoming compressor switch.
  • Change compressors at 2-minute intervals/cycles.
  • Whenever possible, compressions performed from patient‚Äôs right side and new compressor comes in from the previous compressors right side.¬† Opposite is true for left sided compressions.
  • New compressor to ‚Äúhover‚ÄĚ over chest during rhythm check and/or defibrillation.
  • No more than 5 second pauses for compressor change or rhythm checks.
  • Immediately resume CPR after defibrillation (no pulse checks) or when rhythm check is complete.

Airway/Respiratory

  • NRB or nasal cannula at max flow initially.
  • BVM when available.
  • Rate = 1 breath every 10 compressions (unsynchronized).
  • Volume = no more than ¬Ĺ ambu bag.
  • ETI when feasible or if no ROSC by 6-8 minutes as resources allow.
  • ETCO2 monitor connected as soon as feasible.
  • ETI should be accomplished by a provider other than code lead.
  • Hands off patient and/or airway device at 2-minute check.
 Monitor/Defibrillator
  • Attach as soon as possible.
  • Standard pad placement.
  • If witnessed VF while pads were in place for another reason, immediate charge and defibrillate.¬† Otherwise, ensure CPR for at least 30 seconds before delivering any defibrillations.
  • Pre-charge defibrillator 15 seconds prior to 2-minute checks.
  • If non-shockable rhythm at 2-minute check, ‚Äúdump‚ÄĚ charge by pressing the decrease energy selection button.
  • If shockable rhythm at 2-minute check, immediately defibrillate & resume CPR (no pulse checks).
  • If VF on rhythm check at 6 minutes (third cycle), immediately defibrillate, then roll patient 30 degrees towards new compressor, attach new posterior pad slightly below and medial to the patients left scapula, roll patient back and resume CPR.¬† Attach new anterior pad over left superior chest.¬† Connect new AP pads to new monitor/defibrillator.
  • At 8 and 10-minute checks (fourth & fifth cycles), pre-charge and defibrillate with new AP pads & monitor/defibrillator set at max joules.
  • At 12-minute check (sixth cycle), pre-charge both defibrillators to max joules and defibrillate both ‚Äúsimultaneously‚ÄĚ if patient is still in VF.¬† One operator, two fingers.
  • Caveats
    • Changing to AP pads and/or double sequential defibrillation (DSD) is only for refractory VF.
    • If VF converts with standard pad placement, AP pad placement, or DSD, use that pad placement and energy setting for recurrent VF defibrillations

Venous Access

  • IO is faster than IV.
  • IV can follow IO.
  • Central venous access should be accomplished by a provider other than the code lead.
Drugs
  • Know your rhythm before giving drugs! ¬†That tachycardia might be SVT or something that might not take kindly to a bolus of epinephrine
    • Epinephrine
      • Goal is for 3 doses in first 10 minutes.
      • Can give at 2,4, & 6-minute checks or whatever time interval is most easily accomplished.
      • After 10 minutes, goal is for Epi every 5 minutes.
    • Amiodarone (for VF)
      • Goal is for 2 doses in first 10 minutes.
      • 300mg first dose and 150mg second dose.
      • Can give at 2 & 6-minute checks or whatever time interval is most easily accomplished.
Code Lead & Code Scribe/Time Keeper
  • Confirm/ensure metronome use & appropriate CPR depth & rate.
  • Confirm/ensure appropriate BVM or BV ET Tube rate and volume.
  • Confirm/ensure ETCO2 connected and documented.
  • Notify team of impending compressor change and rhythm check 15 seconds prior to the end of the 2-minute cycle.
  • Confirm/ensure defibrillator is pre-charged.
  • Interpret rhythm.
  • Instruct defibrillator operator to deliver shock (or deliver shock if code lead is the operator) after confirming no team member is touching the patient.
  • Confirm/ensure resumption of CPR and BVM after rhythm check and/or defibrillation.
  • Request and confirm drug delivery at appropriately intervals.
  • Confirm/ensure documentation of rhythm(s) and drug doses.
  • Ensure all pauses are less than or equal to 5 seconds (use 5 sec verbal count down).

Dec 06 2017

41mins

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Rank #2: ZDoggMD

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Zubin Damania (ZDoggMD) is an internist and founder of Turntable Health, an innovative healthcare startup that was part of an urban revitalization movement in Las Vegas.¬†During a decade-long hospitalist career at Stanford, he experienced our dysfunctional health care system firsthand leading to burnout and depression. He created videos under the¬†pseudonym ZDoggMD as an outlet to find his voice. This launched a grassroots movement¬†‚ÄĒ¬†half a billion youtube views and a passionate tribe¬†dedicated to improving health care¬†for everyone.

 

ERcast 2.0 Launches May 1

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In this interview we cover a wide range of topics including

  • Underwear
  • How ZDogg went from hospitalist to rapper to Medicine 3.0evanaglist
  • Meditation
  • The Mind Illuminated
  • The roots of anxiety
  • Mental preparation before giving a talk
  • ZDogg's response to criticism, antipathy, and negative feedback from the anti-vaccine movement
  • Nurse practitioners

A Smattering of Performance Improvement, Stress Management, and Wellness Episodes

  Full Video Interview Below

https://www.youtube.com/watch?v=bujZmXEtuHA

 

My Favorite Zdogg Song

https://www.youtube.com/watch?v=NAlnRHicgWs

Apr 24 2018

44mins

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Rank #3: What you don't know about Wernicke's encephalopathy

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Megan Spyres, toxicologist and emergency physician at LA County-USC, gives a primer on diagnosing and treating Wernicke's encephalopathy. The title of this post "What you don't know about Wernicke's encephalopathy" is more from my perspective than a commentary on what you, the listener, may know. After all, you might be a genius when it comes to this disease. For me, this has always been confusing and difficult to diagnose. So let's sharpen our clinical acumen and learn why neglecting thiamine can be a really bad thing. Special thanks to Dr. Anand Swaminathan for his journalistic excellence in putting together this interview.

  Pathophysiology
  • secondary to thiamine deficiency (vitamin B1). Thiamine is a cofactor for pyruvate dehydrogenase. This enzyme is needed to take glucose from anaerobic glycolysis into the Krebs cycle (where we make the majority of our ATP)
  • pyruvate dehydrogenase converts pyruvate (the end product of glucose metabolism in glycolysis) to acetyl co-A. Acetyl co-A is the entry point into the Krebs Cycle.
  • if there is no thiamine, there is no Acetyl co-A... no Krebs Cycle... no ATP.
  • The heart and brain get quite upset and function poorly when they don‚Äôt have ATP
  • we only have a few weeks of thiamine reserves (best case scenario)
Clinical Presentations

Cardiac: Wet beriberi

  • high output heart failure. Fatigue SOB, peripheral edema

CNS: Wernicke's encephalopathy

  • ophthalmoplegia
  • ataxia
  • altered mental status/confusion/memory problems

Extra nuggets

  • It would be nice, in a clinical sense,¬†if patients presented with all elements of this triad, but the overwhelming majority do not (there may be just one or two)
  • Wernicke's encephalopathy¬†can progress to Korsakoff syndrome -¬†an irreversible anterograde¬†amnesia. May also include confabulation, apathy, lack of insight.
  • In addition to the above findings, there may also be absent reflexes on physical exam

How common is Wernicke's encephalopathy?

  • estimated to be present in 2% of the US population

Who is at risk?

  • insufficient intake
  • insufficient absorption
  • enhanced elimination

Specific groups who are at risk for thiamine deficiency

  • Chronic Alcoholics:¬†poor nutrition,¬†poor absorption
  • Bariatric surgery, AIDS, malignancy, hyperemesis gravidarum
  • Insufficient¬†intake:¬†eating disorders, prisoners, institutionalized elderly
  • Enhanced elimination:¬†patients on furosemide

Evaluating for Wernicke's encephalopathy

  • It‚Äôs an easy disease to overlook. Consider in¬†an alcoholic patients with multiple presentations with confusion
  • Do a good neurologic exam. Don‚Äôt blow off persistent ataxia, especially when the intoxication has resolved to the point where the patient can be discharged
  • In 1997, Caine et al suggested that the diagnosis could be made with two or more of the following:
  1. dietary deficiencies
  2. oculomotor abnormalities
  3. cerebellar dysfunction
  4. either an altered mental state or mild memory impairment

Treatment

  • give thiamine
  • in the presence of ETOH, thiamine absorption is reduced by up to 50%. Don't think you will be able to rapidly correct this disease with PO treatment alone
  • 100mg IV is good for prevention and might protect patients for at least a week. This dose is not, however, considered sufficient for treatment
  • treat with¬†¬†500mg IV thiamine three times daily¬†¬†for 2-3 days, then¬†250mg IV TID for 3-5 days

Does thiamine need to be given before glucose?

  • a glucose load will increase thiamine requirements.
  • historically,¬†it has¬†been thought that giving a load of glucose (or dextrose) might ‚Äėpush patients¬†over the edge‚Äô into encephalopathy. There‚Äôs no evidence that this occurs in patients who aren‚Äôt already overtly thiamine deficient.

Bottom Line: Wernickes encephalopathy is easy to treat but also easy to miss. When we miss it, our patients can suffer

Sep 30 2017

17mins

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Rank #4: Cellulitis

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Recorded at Essentials of Emergency Medicine 2017, Greg Moran, MD reviews current thinking on cellulitis diagnosis and management. Greg is a professor of emergency medicine at Olive View-UCLA medical center who, in addition to emergency medicine, is fellowship trained in infectious disease and has over 100 publications in journals including: New England Journal of Medicine, British Medical journal, JAMA, Lancet, and Annals of Emergency Medicine. Greg is a thought leader in the field of emergency infectious disease and a super nice guy. In this segment, Greg covers: a common cellulitis mimic; admit vs discharge of patients with cellulitis; what bugs cause cellulitis and, taking that into account, what antibiotic should I use- double coverage, single coverage?

 

The great cellulitis mimic: Stasis Dermatitis
  • Similar in appearance to cellulitis
  • Often bilateral (where cellulitis is usually unilateral)
  • Risk factors include venous stasis, lymphedema
  • Fluid goes into the interstitial space -> into the dermis -> and then causes superficial redness and irritation

Treatment

  • Many recommendations out there, many of them consensus, opinion or based on weak data
  • Elevation
  • Compression if the patient can tolerate it
  • Wet dressings if there is crusting and exudative eczema
  • Topical steroids (medium to high potency) such as triamcinolone, fluocinonide, fluticasone ointments
  • If you think there could be infection at play, consider a short course of oral antibiotics (also consider topical if there‚Äôs a break in the skin or part of the leg is looking particularly red and angry)

 

Admit or go home?
  • Inpatient mortality for cellulite is low (somewhere in the low single digits percent)
  • No validated decision instruments regarding admission or discharge
  • 2014 study¬†Predictors of Failure of Empiric Outpatient Antibiotic Therapy in Emergency Department Patients With Uncomplicated Cellulitis¬†¬†found that fever, chronic leg ulcers, edema, lymphedema, cellulitis at a wound site or recurrent in the same area were risk factors for outpatient treatment failure
  • Does this mean that patients with these risk factors need mandatory admission? It doesn‚Äôt, but it gives an inkling of who might do poorly or at least fail¬†outpatient antibiotics
  • Bottom line: no clear consensus on who can be discharged but low inpatient mortality suggests we may be over-admitting
  • A nice review of the admit or discharge cellulitis question can be found here
  Single or double antibiotic coverage

Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis. JAMA May 2017 PMID:28535235

  • 500 patients with cellulitis
  • Treated cephalexin alone or cephalexin plus TMP/Sulfa
  • No significant difference in outcome

Comparative effectiveness of cephalexin plus trimethoprim-sulfamethoxazole versus cephalexin alone for treatment of uncomplicated cellulitis: a randomized controlled trial. Clinical infectious diseases 2013 PMID:23457080

  • 150 patients with cellulitis
  • Treated cephalexin alone or cephalexin plus TMP/Sulfa
  • No significant difference in outcome

Bottom line: In uncomplicated cellulitis without abscess or significant co-morbidities, current evidence suggests no advantage of adding TMP/Sulfa to cephalexin

 

Check out Essentials of Emergency Medicine. Well, I guess if you're against fun education and hate puppies, then disregard that recommendation.   References
  • Weng, Qing Yu, et al. "Costs and consequences associated with misdiagnosed lower extremity cellulitis." Jama dermatology 153.2 (2017): 141-146.¬†PMID:27806170
  • Weiss, Stefan C., et al. "A randomized controlled clinical trial assessing the effect of betamethasone valerate 0.12% foam on the short-term treatment of stasis dermatitis." Journal of drugs in dermatology: JDD 4.3 (2005): 339-345.¬†PMID:15898290
  • Talan, David A., et al. "Factors associated with decision to hospitalize emergency department patients with skin and soft tissue infection." Western Journal of Emergency Medicine 16.1 (2015): 89.¬†PMID:25671016
  • Peterson, Daniel, et al. "Predictors of failure of empiric outpatient antibiotic therapy in emergency department patients with uncomplicated cellulitis." Academic Emergency Medicine21.5 (2014): 526-531.¬†PMID:24842503
  • Khachatryan, Alexandra, et al. "Skin and Skin Structure Infections in the Emergency Department: Who Gets Admitted?." Academic Emergency Medicine 21 (2014): S50. Abstract from 2014 SAEM
  • Carratala, J., et al. "Factors associated with complications and mortality in adult patients hospitalized for infectious cellulitis." European Journal of Clinical Microbiology and Infectious Diseases 22.3 (2003): 151-157.¬†PMID:12649712
  • Pallin, Daniel J., et al. "Clinical trial: comparative effectiveness of cephalexin plus trimethoprim-sulfamethoxazole versus cephalexin alone for treatment of uncomplicated cellulitis: a randomized controlled trial." Clinical infectious diseases 56.12 (2013): 1754-1762.¬†PMID:23457080
  • Moran, Gregory J., et al. "Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial." Jama 317.20 (2017): 2088-2096. PMID:28535235
  • Original Kings of County Analysis of Admit or Discharge Cellulitis

Jan 29 2018

17mins

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Rank #5: Massive GI Bleed on Anticoagulants

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Rob and Tom Deloughery discuss management of actively bleeding patients who have been prescribed anticoagulation medications.

May 04 2018

30mins

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Rank #6: When can you shower after stitches?

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In this episode
  • When is showering OK after stitches?
  • What type of ointment should be placed on a laceration to promote healing?
  • Is there an advantage to using antibiotic ointment over petroleum jelly on a non infected laceration?
  • How¬†much of an extensor tendon needs to be cut for you to either repair it yourself or refer to a hand surgeon?
  • What type suture to use for extensor tendon repair.

 

How long does one have to wait to take a shower after getting stitches?
  • There is limited data addressing this question, but based on the data we do have, showering after 48 hours is probably OK.
  • Even the NHS thinks so.
  • It may be perfectly fine to shower even sooner, but there's no evidence that gives a time cutoff for optional showering.
  • Note- showering does not mean submersion and it certainly doesn't mean getting in a hot tub. Second note- ¬†the intent of this podcast it for medical providers to understand the medical literature and differing opinions on this question, not direct medical advice to patients.

 

What should you use to dress a wound?
  • Keep it moist. Don't let the wound dry. Lungs do the breathing, the wound needs to be smothered.
  • Petroleum jelly is fine. Antibiotic ointment on a non infected wound does not confer extra benefit and may actually lead to worse outcomes (hypersensitivity)
  • A 1995 study found that using antibiotic ointment on acutely sutured traumatic lacerations decreased the incidence of 'stitch abscess' but otherwise did not improve outcome for more severe infectious, such as cellulitis
  • Non adherent dressing, absorptive dressing, then overwrap. Many dressings incorporate all three of these in one product

 

How much of an extensor tendon needs to be cut for you to either repair it yourself or refer to a hand surgeon?
  • Our interviewed expert says he repairs anything 25% or greater
  • In Roberts and Hedges it says repair is optional if the laceration is less than 50% of the cross-sectional area of the tendon.
  • A study that surveyed hand surgeons on flexor tendons found that some surgeons repair all of tendon lacerations, some only if they were more than 50%¬†PMID:¬†7606610
  • If you‚Äôre wondering if that injured tendon needs repair, if it‚Äôs a little divot, probably not. When you get into the 25-50% range, possibly. If in doubt, splint and refer.¬†
What type suture to use for extensor tendon repair
  • Many options
  • Avoid Vicryl. It will break down too fast (2-3 weeks, not long enough for the tendon to heal)
  • Nylon commonly used
  • Our consultant prefers 4-0 Monocryl or PDS II. They will both dissolve but maintain tensile strength for a long enough the for the tendon to heal

 

References

Showering after laceration repair 

  1. Hsieh, Pei-Yin, et al. "Postoperative showering for clean and clean-contaminated wounds: a prospective, randomized controlled trial." Annals of surgery 263.5 (2016): 931-936. PMID:26655923
  2. Toon, Clare D., et al. "Early versus delayed post‚Äźoperative bathing or showering to prevent wound complications." The Cochrane Library (2015). Full text link
  3. Harrison, Conrad, Cian Wade, and Sinclair Gore. "Postoperative washing of sutured wounds." Annals of Medicine and Surgery 11 (2016): 36-38. Full text link

Keeping the wound moist to promote healing

  1. Dyson, Mary, et al. "Comparison of the effects of moist and dry conditions on dermal repair." Journal of investigative dermatology 91.5 (1988): 434-439. Full text link
  2. Dire, Daniel J., et al. "Prospective Evaluation of Topical Antibiotics for Preventing Infections in Uncomplicated Soft‚Äźtissue Wounds Repaired in the ED."¬†Academic Emergency Medicine¬†2.1 (1995): 4-10.¬†PMID:¬†7606610

Contact Dermatitis Offenders

  1. Fransway, Anthony F., et al. "North American contact dermatitis group patch test results for 2007‚Äď2008."¬†Dermatitis24.1 (2013): 10-21¬†PMID:¬†23340394
  2. Common contact allergens explained The Dermatologist 2014

Nov 27 2017

14mins

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Rank #7: Alcohol, c-spines, and lots of pus

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A day late and a dollar short, but here it is, the Ercast summer Journal Club. As per usual, boy genius Adam Rowh, MD is in the house to give his take on the medical literature. In this episode, we discuss

  • Cervical spine clearance in the intoxicated patient (can you remove the collar if they have a negative CT?)
  • Is there utility to giving antibiotics to patients with simple cutaneous abscess?
  • Thrombolytics don't give long term benefit to patients with submissive pulmonary embolism
  • Haloperidol is good for what ails you (if you have gastroparesis)
  • Steroids for bronchitis

Also mentioned in this show

  • Boneyard RPM IPA
  • Follow us on Facebook. It's the new information portal for updates, questions, etc. If you want to contact me personally, use the contact link on this webstie
  • Now on to the education....

 

Do patients with simple abscesses need antibiotics?

The answer for much of the antibiotic era has been no. I and D is sufficient treatment. But with the rise of MRSA, that thinking has been questioned. A paper by Talan in 2016 investigating TMP-Sulfa vs placebo for uncomplicated skin abscess suggested that TMP-Sulfa conferred a higher cure rate after I and D. Now comes a study of similar ilk but an additional treatment arm.

Study Basics

  • Title: Daum, Robert S., et al. "A placebo-controlled trial of antibiotics for smaller skin abscesses."¬†New England Journal of Medicine376.26 (2017): 2545-2555.PMID:¬†28657870
  • The patients:¬†786 patients with abscesses 5 cm diameter or less.
  • The treatment: After I and D placebo, patients received either placebo, clindamycin, or TMP-Sulfa
  • Primary endpoint: Clinical cure. This includes improvement of the treated abscess but ALSO no new abscesses forming elsewhere (that will come into play later)
  • The results:¬†Compared to placebo, both clindamycin and TMP-Sulfa improved short-term outcome.¬†Clinical cure was 83% clinda, 81% TMP-Sulfa, and 69% placebo. NNT of 8. There was not much difference between the different antibiotics, but big a difference compared to placebo

Looking under the hood (examining the details)

  • Treatment effect was only when staph was the culprit. When there was no staph isolated, the outcome was not influenced by antibiotics
  • Average surrounding erythema was over 2cm. This suggests that there was some cellulitis in these patients. Prior to this study, the common practice was to treat these patients with antibiotics. We recognize that it's not always easy to delineate between redness from the abscess itself and spreading cellulitis. Our point of contention, that these abscesses also had cellulitis, may be making a big deal out of a small thing (or it could be the most legitimate criticism of the paper).
  • Treatment¬†failure was mostly formation of new abscess and not worsening of the original abscess. While this is certainly a measurable effect, is it really a treatment failure? We argue that it is not. What's probably happening here is decolonization on some level. That is pure conjecture, of course, and it's certainly possible that there was autioinfection from the main abscess.¬†
  • Our bias: ¬†We don‚Äôt want to give extra antibiotics. Coming into this paper, we were looking for any faults in the study that could confirm an 'antibiotic stewardship' approach. ¬†If this was a paper showing even a small benefit for thrombolysis in the treatment of pulmonary embolism, we would look at in the exact opposite manner-where is the signal of benefit that says we might help patients. ¬†
  • Will this change our management? Both Rob and Adam say it will not. We will continue to treat simple cutaneous abscesses (without surrounding erythema) with I and D alone. If the¬†abscess is a recurrence or it is a patient with multiple abscesses, we will consider antibiotics.

 

C-spine clearance in the intoxicated patient

An intoxicated patient with moderate trauma has a pristine looking, completely normal, CT of the cervical spine. Do we need them to continue wearing their cervical collar until clinical sobriety? Enter our next study

Study Basics

  • Title: Schreiber, Martin, et al. "Cervical spine evaluation and clearance in the intoxicated patient: a prospective western trauma association multi-institutional trial and survey." (2017).¬†PMID:¬†28723840
  • The patients: About 10,000 moderate trauma patients, of who approx ¬†3000 were TOX positive ¬†(alcohol, drugs, or both).¬†The average injury severity score was 11 (moderate trauma).
  • Intervention: CT cervical spine
  • Primary outcomes: Incidence and type of cervical spine injuries, accuracy of CT scan, and the impact of TOX+ on the time to cervical spine clearance
  • The results: In the TOX positive ¬†group, CT had a sens=94%, spec=99.5%, and NPV=99.5% for all Csp injuries. For clinically significant injuries, the NPV was 99.9%, and there were no unstable cervical spine injuries missed by CT (NPV=100%). One patient in the Tox + but CT negative group had a central cord injury. When CT cervical spine was negative, TOX + led to longer immobilization vs sober patients (mean 8 hrs vs 2 hrs, p12hrs) in 25%.
  • Author take home: CT-based clearance in TOX+ patients appears safe and may avoid unnecessary prolonged immobilization

This conclusion mirrors the EAST guidelines on cervical spine collar clearance in the obtunded adult blunt trauma patient:

In obtunded adult blunt trauma patients, we conditionally recommend cervical collar removal after a negative high-quality C-spine CT scan result alone. This conditional recommendation is based on very low-quality evidence but places a strong emphasis on the high negative predictive value of high quality CT imaging in excluding the critically important unstable C-spine injury.

Haloperidol for Vomiting

The lament for droperidol's absence from our pharmacopeia continues unabated, yet there is another shining star: haloperidol. What's old is new when it comes to treating severe nausea and vomiting. Long recognized in the palliative care world as the cat's pajamas for management of nausea, haloperidol is finally getting the recognition it deserves.

Study Basics:

The study: Ramirez, R., et al. "Haloperidol undermining gastroparesis symptoms (HUGS) in the emergency department." The American journal of emergency medicine (2017). PMID:28320545

The patients: Retrospective study of 52 patients with diabetic gastroparesis treated with 5mg IM haloperidol.

The comparator group: The SAME PATIENTS on ED visits when they didn’t get haloperidol! You can't get better matching characteristics than that.

The results: Using haloperidol in this group of patients decreased amount of opiates given and admissions but not ED or hospital length of stay. There were no complications seen in patients given haloperidol

Systemic lytics don't work for intermediate risk PE

This has been a subject of much debate over the past decade and there has been signal that there may be a benefit in function outcome when thrombolytics are given to so-called intermediate risk pulmonary emboli- not hypotensive but right ventricular dysfunction and a positive biomarker. The biggest research article to date says lytics don't improve outcome.

Study Basics

The study: Konstantinides, Stavros V., et al. "Impact of thrombolytic therapy on the long-term outcome of intermediate-risk pulmonary embolism." Journal of the American College of Cardiology 69.12 (2017): 1536-1544. PMID:28335835

The patients: About 700 patients with intermediate risk PE given either Tenecteplase of placebo. Intermediate risk PE defined as RV dysfunction confirmed by echocardiography or spiral computed tomography of the chest. Myocardial injury confirmed by a positive troponin I or T test result.

The results: At 3 year follow up, there was no significant difference in mortality, functional limitations, pulmonary HTN, or RV dysfunction.

Our take home: When we first saw this paper, we were giddy because here was evidence that would show, once and for all, that lytics were an effective treatment for this cohort. The cold hard data says quite the opposite: lytics don’t make a difference in long term outcome. The best evidence we have to date suggests that there is no justification to give systemic thrombolysis to a stable patient with intermediate risk PE. Will catheter directed lysis prove any better, or are there certain high risk groups under the 'intermediate' umbrella who would benefit? Time will tell. 

 

Prednisone for cough

Study Basics

The study: Hay, Alastair D., et al. "Effect of oral prednisolone on symptom duration and severity in nonasthmatic adults with acute lower respiratory tract infection: a randomized clinical trial." Jama 318.8 (2017): 721-730. PMID:28829884

The patients: 400 patients with cough for less than a month and at least 1 lower tract symptom like phlegm, chest pain, wheezing or SOB in the past day. Patients received either 40 mg of prednisolone or placebo daily for 5 days. The primary outcomes were duration of cough and mean severity of symptoms on days 2 to 4.

The results: Steroids did not make a difference

Our take home: WTF!? Of course steroids didn’t work! Only 6 percent of patients had wheezing and only a handful had crackles.  Does a patient with an undifferentiated acute viral respiratory infection benefit from steroids? Apparently not. We tend to prescribe patients to these patients who DO have wheezing, but this supports our practice of not using them in patients who don't. 

Oct 20 2017

43mins

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Rank #8: The White Coat Investor

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The White Coat Investor (AKA Jim Dahle, MD) talks debt, investing, philanthropy, investment philosophy, and investment strategies for different stages of your career.

Key Links from this episode

When Jim was an intern, he didn't know much about finance. His education started with this book

Books Jim recommends as foundational reading to understand personal finance

White Coat Investor advice for a medical student

  • Try to spend as little as possible. Every dollar you spend in medical school is going to be 3 dollars you¬†pay back later
  • This is they time you're expected to be poor. Be frugal
  • Your specialty choice has a huge effect on your future financial life. Pick the one you will be able to work at the longest that makes you the happiest.

Advice to a young doctor

  • The year that matters most in your financial life is your first year as an attending physician. That year sets habits.
  • In med school and residency, have a plan in place for your first 12 attending paychecks.
  • In the first few years after residency, live the lifestyle of a resident while earning like an attending. This can lead to rapid savings and loan repayment
  • Embrace the habit of saving
  • Calculate your annual savings rate/what you're putting toward retirement. Amount of annual savings divided by gross income. That number should be around 20%
  • Look at your purchases from the point of view, "Will this make me happy?" The is the essence of budgeting: attaching your values to how you spend your money
  • Each month, review where your money is going. Is that where you want it to be going? If it's not, make some changes.
  • Don't buy on credit. Spending your money on payments is not what you want to be doing

Financial Advisors

  • Most doctors want or need a good financial advisor
  • The problem is that what we want is just to have a 'money guy' that takes care of all the money and we don't have to pay attention to it
  • To make sure you're getting good advice at a fair price, you'll need at least a basic level of financial education (or at least get a second opinion)
  • Be aware of the fees your advisor is charging. Expect at least 4 figure amounts

Starting residency. Buy or rent?

  • Buy a home when you are in a stable professional and social situation
  • there are high transit costs. It costs about 15% of the value of the home to make the 'round trip in and out of the home.About 5% to get in and 10 % to get out. If you're not there long enough for the home's appreciation¬†to make up for that 15% loss, you're probably going to come out behind
  • Homes appreciate about 3% per year
  • If you're in a 3 year recency, changes are you won't break even
  • White Coat Investor recommends most residents NOT buy a home and rent

New Attending. Buy or rent?

  • There is a good chance you will change jobs in the first few years
  • This is not the most stable professional time
  • Make sure the job work for you before you buy a house
  • Rent for the first 6-12 months
  • You should still be living like a resident during this first ¬†year
  • Buy a home when you are in a stable professional and social situation

The "Point of Enough"

  • If you don't define it, it will always seem like a number that's twice what you have
  • Take how much you spend in a year and multiply it by 25. When you have that in assets, you have reached finically independence.

Real estate investing

  • Owning actual property is to the only way to do it. Other options include.....
  • The easiest way is the REIT. Real Estate Investment Trust index fund.
  • Syndicated real estate

Pay Down Debt vs Invest in the Market

  • Doing either one will increase your net worth (unless the market tanks)
  • Focus on what percentage of your income is going toward building wealth rather than what compartment that wealth building is going into
  • Student loans have a few negative aspects: You can't deduct the interest when you're an attending; student loans tend to have high interest rates. Try to get rid of student loan debt within 2-5 years after residency

Jim's Ideas on Giving/Philanthropy

  • Good for the soul
  • Develops a stewardship mentality
  • Giving money away sends a message to the subconscious that you have enough - you can give some away and still be OK
  • It keeps you connected to the rest of the world
  • It can make your portfolio more tax efficient

Dec 12 2017

1hr 2mins

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Rank #9: Haloperidol for Analgesia

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One of the stress points when a patient taking chronic opioids presents with acute pain is that we feel we have little to offer them. Are more opioids the answer? That's often what happens, but might not be the best next step. In this episode, Reuben Strayer presents the argument in favor of haloperidol for analgesia and why more opioids can do more harm than good.

  

Episode Guide

In the introduction, preview of a project we're working on for Essentials of Emergency Medicine (May 15-17).

Opioid induced hyperalgesia: compared to those not taking opioids, patients on chronic opioids may have a more unpleasant experience when exposed to painful stimuli. In other words, they are more sensitive pain. The meds used to treat pain, actually worsen pain.

A patient who uses chronic opioids will have marginal gains in analgesia with escalating doses while getting closer to potentially lethal adverse effects.

Haloperidol is an analgesic option for patients taking chronic opioids.

Reuben's strategy for using haloperidol for analgesia in chronic opioid patients: 10 mg IM haloperidol if there is no IV,  5 mg IV if they have a line. If they don't fall asleep shortly after (or have improvement of pain) he repeats the dose.  If that doesn’t work, he uses analgesic dose ketamine.

For analgesic dose ketamine in these patients, Reuben uses 30 mg IV. This may cross over into the 'recreational' or 'partial dissociation' dose where the patient can have disturbing psycho-perceptual effects. He has found that the pretreatment with haloperidol leads to less distress from these psycho-perceptual effects. For more information on ketamine dosing, see Reuben's post on the Ketamine Brain Continuum.

Haloperidol and the prolonged QTc: Butyrophenones (of which haloperidol is one) are known to prolong the QTc. Should we get an EKG prior to giving haloperidol to see if the QTc is already prolonged? Reuben feels that the negative effects of butyrophenone QTc prolongation are overblown and does not routinely get an EKG prior to giving haloperidol. This includes initial and subsequent doses.  Take that with a grain of salt because there are many docs who do get an EKG before the first or second dose of haloperidol, especially if there is a known QTc prolonging drug on the patient's med list (like methadone). Some hospitals even have policies that before a second dose is given, there is a hard stop for EKG and QTc check.

Check out Reuben's blog Emergency Medicine Updates and follow him on Twitter

 

References

Opioid Hyperalgesia

  • Marion Lee, M., et al. "A comprehensive review of opioid-induced hyperalgesia."¬†Pain physician¬†14 (2011): 145-161 Full text link.¬†PMID:¬†21412369¬†
  • Hooten, W. Michael, et al. "Associations between heat pain perception and opioid dose among patients with chronic pain undergoing opioid tapering."¬†Pain Medicine¬†11.11 (2010): 1587-1598 Full text link. ¬†PMID:¬†21029354

Droperidol for analgesia

  • Richards, John R., et al. "Droperidol analgesia for opioid-tolerant patients."¬†Journal of Emergency Medicine¬†41.4 (2011): 389-396. ¬†PMID:¬†20832967
  • Amery, W. K., et al. "Peroral management of chronic pain by means of bezitramide (R 4845), a long-acting analgesic, and droperidol (R 4749), a neuroleptic. A multicentric pilot-study."¬†Arzneimittel-Forschung¬†21.6 (1971): 868.¬†PMID:¬†5109279
  • Admiraal, P. V., H. Knape, and C. Zegveld. "EXPERIENCE WITH BEZITRAMIDE AND DROPERIDOL EN THE TREATMENT OF SEVERE CHRONIC PAIN."¬†British journal of anaesthesia¬†44.11 (1972): 1191-1196.¬†PMID:¬†4119073

Early studies on Haloperidol for analgesia

  • Maltbie, A. A., et al. "Analgesia and haloperidol: a hypothesis."¬†The Journal of clinical psychiatry¬†40.7 (1979): 323-326.¬†PMID:¬†222741
  • Cavenar, Jo, and A. A. Maltbie. "The analgesic properties of haloperidol."¬†US Navy Med¬†67 (1976): 10.
  • Cavenar, Jesse O., and Allan A. Maltebie. "Another indication for haloperidol."¬†Psychosomatics¬†17.3 (1976): 128-130.

Haloperidol for pain

  • Seidel, Stefan, et al. "Antipsychotics for acute and chronic pain in adults."¬†Cochrane Database Syst Rev¬†4 (2008).¬†PMID:¬†18843669
  • Ramirez, R., et al. ‚ÄúHaloperidol undermining gastroparesis symptoms (HUGS) in the emergency department.‚Ä̬†The American journal of emergency medicine¬†(2017).¬†PMID:28320545¬†Reviewed in this ERCast episode
  • Salpeter, Shelley R., Jacob S. Buckley, and Eduardo Bruera. "The use of very-low-dose methadone for palliative pain control and the prevention of opioid hyperalgesia."¬†Journal of palliative medicine¬†16.6 (2013): 616-622.¬†PMID:¬†23556990
  • Afzalimoghaddam, Mohammad, et al. "Midazolam Plus Haloperidol as Adjuvant Analgesics to Morphine in Opium Dependent Patients: A Randomized Clinical Trial."¬†Current drug abuse reviews¬†9.2 (2016): 142-147.¬†PMID:¬†28059034

Feb 18 2018

25mins

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Rank #10: Evidence Based Hyperkalemia Management

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Hyperkalemia is one of, if not the most, common electrolyte abnormalities we see. But much of what we do in treatment is what someone told us to do when we were young learners. In this episode we debunk hyperkalemia myths and discuss an evidence based approach to management. For more great content check out 

https://www.hippoed.com/em/ercast/

Nov 07 2018

34mins

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Rank #11: How to Use the Pulse Ox Like a Boss

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From Essentials of Emergency Medicine NYC 2017, Reuben Strayer explains how the pulse ox might be the most useful bit of tech in the ED.

Pearls:

  • The pulse ox waveform is an excellent indicator of mechanical heart rate and peripheral perfusion.

  • For patients ¬†breathing room air, pulse oximetry can be used to monitor for hypoventilation. ¬†
  • Nail polish has minimal impact on the accuracy of pulse oximetry.
  • If you are unable to get a good pulse ox waveform by adjusting or repositioning the probe, be concerned that the patient is poorly perfused.

  • ‚ÄúThe respiratory rate is the most vital of the vital signs.‚ÄĚ ¬†¬†¬†Experienced doctors look at a patient who seems well, but understands that they‚Äôre not truly well, because they subconsciously notice tachypnea. Subconsciously is the only way to notice tachypnea, because respiratory rate is often not measured accurately. ¬†Since we don‚Äôt always have access to reliable respiratory rate, Strayer‚Äôs go-to vital sign is the oxygen saturation.
  • ‚ÄúReusable pulse oximeter probes are gross.‚ÄĚ ¬†One study found that even when these probes are cleaned by standard procedure, ‚ÖĒ had bacteria cultured from them. Strayer recommends using single use probes in your department.
  • Wilkins MC. Residual bacterial contamination on reusable pulse oximetrysensors. Respir Care. 1993 Nov;38(11):1155-60. PubMed PMID: 10145923.
  • Data is conflicting about the effect of nail polish on pulse oximetry readings, but overall it is felt that the impact is minimal. ¬†
  • Earlier data suggested that nail polish decreased sat readings by 2-10%, but more recent studies found minimal effect. ¬†
  • If it seems that the waveform is affected by nail polish, you can remedy the situation by turning the probe 90 degrees, so it goes sideways through the finger.
  • Yamamoto LG, et al. Nail polish does not significantly affect pulse oximetry measurements in mildly hypoxic subjects. Respir Care. 2008 Nov;53(11):1470-4. PubMed PMID: 18957149.
  • As long as a patient is breathing room air, pulse ox can monitor ventilation and function as a hypoventilation alarm.

  • Significantly hypercapnic patients saturate less than 95% when they‚Äôre breathing room air. So if you need to monitor a patient for hypoventilation, such as due to intoxication or procedural sedation, the pulse ox will do a great job of telling you if the patient is still breathing.
  • If you need to give supplemental oxygen, then use capnography to monitor respirations.

  • The pulse oximeter does so much more than provide oxygen saturation. ¬†

  • It provides the photoplethysmogram (PPG) which is a waveform that tells you the ‚Äúmechanical‚ÄĚ heart rate. While telemetry gives the electrical heart rate, what really matters to your organs is the mechanical rate. This can be especially helpful during transvenous or transcutaneous pacing. When you have reliable tracing, the pulse ox heart rate is more reliable than the telemetry heart rate.

  • The pulse ox can measure the peripheral perfusion index which is a more sensitive and earlier indicator of hypoperfusion than blood pressure. This is a numerical value which indicates the strength of the pulsations read by the pulse oximeter. It is based on the amplitude of the pulse ox waveform and expressed as a number between 1 (low) and 10 (high). ¬†The perfusion index dips before the stroke volume drops and long before the heart rate rises. Many monitors will report the perfusion index in tiny print after the word PERF.
  • Lima AP, Beelen P, Bakker J. Use of a peripheral perfusion index derived from the pulse oximetry signal as a noninvasive indicator of perfusion. Crit Care Med.2002 Jun;30(6):1210-3. PubMed PMID: 12072670.
  • van Genderen ME, et al. Peripheral perfusion index as an early predictor for central hypovolemia in awake healthy volunteers. Anesth Analg. 2013 Feb;116(2):351-6. PubMed PMID: 23302972.
  • What if you don‚Äôt have a reliable pulse ox tracing?

  • Most of the time this is because the probe is poorly positioned, the patient is moving too much, or there‚Äôs a lot of ambient light.
  • If you‚Äôve corrected for these problems and you still don‚Äôt have a good tracing, you should be concerned that the patient is poorly perfused.
  • One study of 20,000 anesthesia cases showed that pulse ox failure was directly related to worsening physical status. ¬†
    • Moller JT, et al. Randomized evaluation of pulse oximetry in 20,802 patients: I. Design, demography, pulse oximetry failure rate, and overall complication rate. Anesthesiology. 1993 Mar;78(3):436-44. PubMed PMID: 8457044.

  • How does the pulse ox measure oxygen saturation and what is the best way to position the oximeter probe on the finger?

  • One side of the pulse ox puts emits visible (red) light and infrared light. On the other side is the detector. The percent oxygen saturation is calculated based on the different way in which oxyhemoglobin absorbs visible and infrared light compared with deoxyhemoglobin. ¬†
  • The pulse ox measures carboxyhemoglobin as if it were oxyhemoglobin, giving a falsely elevated pulse ox reading for a victim of carbon monoxide poisoning.
  • The best spot for a peripheral pulse ox is a place with a lot of capillaries and arterioles, like the fingertips, earlobes, nose, or forehead.
  • Functionally, ¬†it doesn‚Äôt seem to matter whether the emitter is on the dorsum, volar aspect, or even side of the finger. ¬†For convenience sake, most find it ergonomically superior to have the cord and emitter on the dorsum of the finger.

  • Mannheimer PD. The light-tissue interaction of pulse oximetry. Anesth Analg.2007 Dec;105(6 Suppl):S10-7. Review. PubMed PMID: 18048891
  • Vegfors M, Lennmarken C. Carboxyhaemoglobinaemia and pulse oximetry. Br JAnaesth. 1991 May;66(5):625-6. PubMed PMID: 2031826

  • DeMeulenaere, Susan. "Pulse oximetry: uses and limitations." The Journal for Nurse Practitioners 3.5 (2007): 312-317. Link.
  • Chan ED, et al. Pulse oximetry: understanding its basic principles facilitates appreciation of its limitations. Respir Med. 2013 Jun;107(6):789-99. PMID: 23490227

Mar 11 2019

20mins

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Rank #12: Internal Medicine in the Emergency Department

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Internist Neda Freyha sprinkles some IM in the ED - how to interpret TSH levels and why aspirin is no longer recommended for a-fib thromboprophylaxis.

Jun 03 2018

25mins

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Rank #13: Mind of an Addict

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Our guest today is Joe Polish. Unlike most guests on this show, Joe is not involved in medicine- heis one of the best known marketing minds on the planet. He is the creator of the Genius Network which is the place high level entrepreneurs go to get their next big breakthrough with access to connection, contribution, and collaboration. Joe is also a best selling author and renown podcaster with I Love Marketing, genius network, Rich Cleanerand 10x Talk. But none of those things are why Joe is on the show today. Joe is also an addict, but deeper than that, he’s turning his experience with addiction into a force for change with Genius Recovery and Artists for Addicts.

In this episode

  • Open Letter¬†to Anyone Struggling with Addiction
  • Joe's ¬†story of addiction and how he's dealt with it on the path to recovery
  • The roots of addiction, why punishing addicts doesn't work and what we can do instead
  • Sex addiction and connection¬†
  • The Craving Brain: Why addiction may not be a choice and what we need to understand about it
  • How to bring more compassion and empathy to addicts and help them recover
  • Gabor Mate:"Not why the addiction, but why the pain?"
  • Be transformational, not transactional

Apr 30 2018

22mins

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Rank #14: Why Epi Might (and might not) Work in Cardiac Arrest

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The pendulum never seems to stop swinging when it comes to the efficacy of epinephrine in cardiac arrest.  

20-25 years ago, the push was to use escalating doses of epinephrine starting at 1 mg and increasing to 3 mg, then 5 mg, and continuing at 5 mg as needed.  Some protocols started directly with 5 mg and continued with 5 mg thereafter. These protocols were based on early studies which suggested that higher doses of epi resulted in improved survival to hospital admission.

Subsequent analyses, 5-10 years later, showed that many of the people who got high doses of epi were dying at the same rate, or perhaps even higher rate.  Also, amongst the survivors, the neurologic outcome was worse.

Over the past few years, a few studies have reported that epi, even in 1 mg doses, could be potentially harmful and not helpful.

The most recent literature seems to be coming back to a middle zone whereby there probably is some benefit to epinephrine, but only if given in a certain time period.  These studies suggest that epi is most beneficial if given in the first 15-20 minutes after cardiac arrest. Continued dosing of epi beyond the 20 minute mark (post cardiac arrest) seems to produce more rapid deterioration and is not supported by the literature.

Jul 01 2018

22mins

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Rank #15: Infected and Obstructing Nephrolithiasis

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Patients with infected ureteral stones present a true medical emergency. I very well may be obvious what's going on but, often, it's not so clear. Maybe the patient has no fever but a few white cells in the urine, or maybe they look sick but have a negative UA. In this wide-ranging discussion, we interview urologist Nora Takla about her approach to infected stones, how she manages those with equivocal presentations, as well as the logistics following up non-infected stones, the significance of extravasation on CT scan, and the sometimes surprisingly complicated decision making when it comes to admitting ureteral colic patients.

Subscribe and hear the rest of the show.  CLICK HERE! For access to more incredible education and 2.25 hours of CME each month. 

Apr 13 2019

33mins

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Rank #16: Pseudoseizures (PNES)

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Walker Foland is an emergency physician practicing in Michigan and in this episode breaks down why pseudoseizures, now termed PNES (Psychogenic Nonepileptic Seizures), are a real disease.

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Are patients with PNES ‚Äėfaking it‚Äô?
  • PNES is a conversion disorder: an unconscious manifestation of psychological trauma.
  • Walker treats PNES patients with haloperidol or olanzapine with the thinking that this is psychological, not true epilepsy
  • PNES is not ‚Äėfaking it‚Äô or lying

 

Challenges
  • Patients with PNES may also have true epileptic seizures
  • Diagnosing PNES, or separating it from epilepsy, may take video EEG monitoring, a neurologist, and sometimes prolonged periods of time to figure things out

 

How to tell the difference between an grand mal epileptic seizure vs PNES vs faking it?

PNES

  • Seizures related to a specific stimulus (sound foods, body movement)
  • Frequency and amplitude of concussions: same frequency through the seizure with varying amplitude.
  • Maintenance of consciousness and may have some of the below
    • may guard the face with passive hand drop
    • resist eyelid opening
    • visual fixation on a mirror
    • Whit Fisher, Dr Procedurettes, squirts water in the face of patients where there is thought of PNES. ¬†If they grimace, probably not an epileptic seizure.

Faking Seizures

  • Talking
  • Purposeful movement
  • Avoids injury
  • May use convulsions as a way of harming staff
  • Intermittently awake and vocal during the episode

Epileptic seizure

  • Convulsive frequency decreases, amplitude increases as seizure progresses
  • No response to pain
  • Allow passive eye opening

A 2010 article from the Journal of Neurology Neurosurgery and Psychiatry broke down the evidence of what other elements can help distinguish PNES from epileptic seizures.

  • Duration over 2 minutes suggests PNES, but we‚Äôve all seen epileptic seizures last for a long time, status, and some PNES can be super short
  • Happens in sleep. Evidence suggests that if the event happens in sleep, that is probably episode. PNES episodes happen when awake
  • Fluctuating course such as a pause in the rhytmic movement, epileptic seizures usually don‚Äôt pause and then restart, a pause favors PNES
  • Flailing. You‚Äôd think the flailing patient has PNES for sure because epilepsy doesn‚Äôt flail, but it does! Flailing is much more common in PNES, but not so much so that it‚Äôs a clear distinguishing factor
  • Urinary incontinence, more common in epilepsy, but does happen in PNES.
  • Post-ictal recovery period. Surely, this is the sine qua non of epilepsy. ¬†It is way way more common following generalized epileptic seizures but happens in around 15% of PNES.
  • The sterterous breathing (noisy, labored) that we see after generalized tonic clonic epileptic seizures suggests epilepsy and is not a characteristic of PNES

 

Walker’s take home points
  • PNES patients aren‚Äôt ‚Äėfaking it‚Äô
  • This is a real disorder, it's just not epilepsy

References

Chen, David K., and W. Curt LaFrance Jr. "Diagnosis and treatment of nonepileptic seizures." CONTINUUM: Lifelong Learning in Neurology 22.1, Epilepsy (2016): 116-131. PMID:26844733

Avbersek, Andreja, and Sanjay Sisodiya. "Does the primary literature provide support for clinical signs used to distinguish psychogenic nonepileptic seizures from epileptic seizures?." Journal of Neurology, Neurosurgery & Psychiatry 81.7 (2010): 719-725.Full Text PMID:20581136 

Shen, Wayne, Elizabeth S. Bowman, and Omkar N. Markand. "Presenting the diagnosis of pseudoseizure." Neurology 40.5 (1990): 756-756. Full Text PMID:2330101

Mar 21 2018

15mins

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Rank #17: C Diff Treatment Changes

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A few weeks ago, a post on Clay Smith’s Journal Feedabout the new IDSA C diff guidelines caught my attention (specifically, that metronidazole is no longer recommended as first line therapy). Whuut? I tweeted this and @medquestioningtweeted back, "Need to dig to see why they dropped metro in the bucket." Yes, @medquestioning, my thoughts exactly.

 

Mentioned in this episode

 

New IDSA C Diff Guideline Treatment Recommendations  

Initial Episode, Non Severe (WBC ‚ȧ 15k, creatinine < 1.5)

First Line

  • Vancomycin 125 mg PO QID for 10 days
  • Fidaxomicin 200mg PO ¬†BID for 10 days

Second line

  • Metronidazole 500mg TID PO for 10 days

Initial Episode, Severe (WBC >15k, creatinine >1.5)

  • Vancomycin 125 mg PO QID for 10 days
  • Fidaxomicin 200mg PO ¬†BID for 10 days

Initial Episode, Fulminant (Hypotension or shock, ileus, megacolon)

  • Vancomycin 500 mg 4 times per day by mouth or by nasogastric tube.
  • If ileus, consider adding rectal instillation of vancomycin.
  • Intravenously administered metronidazole (500 mg every 8 hours) should be administered together with oral or rectal vancomycin, particularly if ileus is present

First Recurrence

‚ÄĘ Vancomycin 125 mg given 4 times daily for 10 days if metronidazole was used for the initial episode, OR

‚ÄĘ Use a prolonged tapered and pulsed vancomycin regimen if a standard regimen was used for the initial episode (eg, 125 mg 4 times per day for 10‚Äď14 days, 2 times per day for a week, once per day for a week, and then every 2 or 3 days for 2‚Äď8 weeks), OR

‚ÄĘ ¬†Fidaxomicin 200 mg given twice daily for 10 days if Vancomycin was used for the initial episode

Photo Credit Photo by Gabor Monori on Unsplash

The Guidelines

  • McDonald, L. Clifford, et al. "Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)." Clinical Infectious Diseases66.7 (2018): e1-e48.¬†PMID:29462280

Original Studies

  • Teasley, DavidG, et al. "Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitis." The Lancet322.8358 (1983): 1043-1046.¬†PMID:6138597
  • Wenisch, C., et al. "Comparison of vancomycin, teicoplanin, metronidazole, and fusidic acid for the treatment of Clostridium difficile‚ÄĒassociated diarrhea." Clinical infectious diseases22.5 (1996): 813-818.¬†PMID:8722937
  • New Evidence Favoring Vancomycin
  • Zar, Fred A., et al. "A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile‚Äďassociated diarrhea, stratified by disease severity." Clinical Infectious Diseases45.3 (2007): 302-307.¬†PMID:17599306
  • Johnson, Stuart, et al. "Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials."¬†Clinical Infectious Diseases¬†59.3 (2014): 345-354.¬†PMID:¬†24799326

CDC C. Diff Statistics

New York Times article on the association of the rise of new sweeteners and the rise of C. diff.

The Germs That Love Diet Soda

Apr 17 2018

12mins

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Rank #18: Performance Coach Jason Brooks

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Jason Brooks PhD is a performance coach helping health care providers, athletes, and other high level performers live better, work better, and be better. In this episode Jason gives his strategies and tactics on myriad topics including: three techniques for stress inoculation, improving test taking, the unseen costs of hiding ignorance, and what habits are common among high level performers.

 

Episode Contents
  • A look back at ERCast episode one on Rectal Foreign Bodies
  • Jason's work with physicians through Phenomenal Docs
  • You can't stop the waves but you can learn to surf - Jon Kabat Zinn
  • Who consults a performance coach? Those who are stuck and want to become unstuck. Those who are excelling and want to excel at an even higher level. These forces can exist simultaneously in the same person
  • What's easier to accomplish? Moving from a perception of low-level performance or getting to a higher level of excellence?
  • Answering the question, "Why is this happening to me?"
  • Start with Why by Simon Sinek Book TED Talk
  • Having an internal yardstick to gauge how decisions align with your values
  • Making time for periodic reflection
  • The importance of adversity
  • It's not what we do that causes burnout, it's losing sight of why we do it
  • Common habits of top performers that transcend a particular career
  • Humility is a common attribute in high level and respected performers driven to be the best I can be, but I don't have all the answers
  • Expectations of a master physician to learners: make me better by contributing to my knowledge base, and I expect you let me know if you think I'm making a mistake
  • Shedding the fear of exposing ignorance. What is the real cost of not exposing ignorance? Leaving knowledge on the table
  • Three techniques for stress inoculation
  • Practice through visualization
  • Breathing techniques to trigger parasympathetic response and mitigate sympathetic fight/flight/flee
  • Using a trigger word to de-escalate stress (mine is "level down")
  • Improving test taking performance
  • How an Olympic archer recalibrates after missing a shot
  • Connect with Jason: Facebook, Twitter, email doctorjbro at gmail dot com

Jan 22 2018

1hr 6mins

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Rank #19: Beating Stress and the Hot Offload with Ashley Liebig

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Ashley Liebig is a HEMS Flight Nurse and Helicopter Rescue Specialist with Austin Travis County STAR Flight. Prior to her flight and rescue career, Ashley served in the US Army as a combat medic with the 101st Airborne Division. She is known around the world as a teacher of managing the stress response, both as someone who has approached it analytically as well as developed tools to mitigate the detrimental aspects of stress out of sheer necessity.

 

The Hot Offload

Following an intense or stressful situation, employ the 'hot offload'. This is different from a formal debriefing where all of the steps are reviewed, improvements considered, etc.

Hot offload Principles

  • A quick moment of diffusion
  • Get out the facts of what happened
  • What did you see, hear, taste, touch, smell immediately after the event
  • Reaffirming the memories and also exploring potentially false thought processes
  • Discuss feelings of guilt within the confines of the small unit that was involved

Hot Offload Steps

  • Bad thing happens
  • Team leader gets the group together
  • Group goes through what they saw-the raw facts of the event
  • In the hot offload, there isn‚Äôt time for could have, should have, would have. We usually don‚Äôt know if one particular action would have really made a difference
  • Team leader does a quick check in - are you OK to continue working?
  • The team leader may have to pull someone out of work if they observe that that person is not functioning well after the event

 

Ashley's three techniques for managing stress

Cognitive reframing

  • Change¬†your perspective/mindset to make a negative situation into a positive situation. Finding opportunities in what at first appears to be something negative
  • When bad things happen, there is a void created¬†for you to fill with new opportunities
  • Ashley recommends this 2 minute podcast clip by Jocko Willink on how to deal with failure and bad situations. In summary, when someone (and the someone can be you) presents you with a problem, respond with, "Good." When things are going badly, there will be some good that comes from it.

Visualization and rehearsal

  • This can inoculate you against the stress that arises in critical and high stakes situaitons

Mindfulness meditation

 

Ashley’s Credo Work Hard, Be Respectful, Be Kind

Also mentioned in this podcast

Liz Crowe- we talk a lot about burnout but little regarding how to prevent it

Jocko Willink Podcast Clip

https://www.youtube.com/watch?v=IdTMDpizis8

Jocko Willink on the 12 aspects of an effective leader

Nov 13 2017

35mins

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Rank #20: Gunshot to the Groin with Kenji Inaba

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Dr Kenji Inaba is a trauma surgeon at the University of Southern California. He is also the director of their surgical ICU,  one of the most widely published trauma researchers with over 400 publications, and a reserve officer with the Los Angeles police department. You'd think with that kind of background, he would be macho, arrogant, and in your face about how awesome he is but, in fact, he’s just the opposite. Humble, kind, thoughtful and just about the greatest guy you’ll ever meet. In today's episode, we discuss junctional bleeding:  Bleeding from an area that is a junction of an extremity and the torso (and neck) that is not amenable to hemorrhage control by tourniquet.

 

A patient arrives with a gunshot wound to the groin. The paramedic is holding pressure with a stack of gauze but it's obvious that bleeding isn't controlled. Here are the next steps
  • Remove the gauze
  • Assess the injury
  • Where is the hole and what kind of bleeding is coming up?
  • If there is sustained bleeding, apply pressure to the specific point of bleeding ¬†- ideal if you can compress proximal to the hemorrhage site. Using diffuse pressure with the palm of your hand in the general vicinity of bleeding may be less effective.
  • If bleeding continues or you need to free up your hands, consider placing a Foley catheter in the wound.
  • The best kind of wound for a foley catheter is one that's just big enough to allow entry of the catheter (so it balloon stays in the cavity once it's inflated)

 

Placement of a Foley catheter to control junctional bleeding as described by Kenji Inaba
  • Use the largest Foley catheter that you have. It's not the size of the catheter that's so important, it's that larger catheters will have more balloon volume
  • Ask for mulipies catheters because one might not provide hemostasis
  • Place the Foley in the hole (bullet or stab wound) and go all the way into the bleeding cavity. Slip the catheter in as deep as it will go
  • Inflate the balloon with saline (or some sort of fluid). If the bleeding hasn't stopped after 20-30 cc of fluid in the balloon, you may need to place a second catheter
  • Clamp across the Foley tube (so blood doesn't come back through the catheter)
  • May need to stitch the skin so the balloon doesn't pop out
  • Another option that Kenji uses are the XSTAT pellets

 

Kenji's opinion on junctional tourniquets (examples Combat ready clamp, SAM junctional tourniquet )
  • They work
  • Some are quite bulky, a lot of material in your way during a resuscitation
  • If you work in a place were you need to apply pressure and get your hands free and have the capacity to store them, not a bad idea.
  • In Kenji's ED, OR, and ICU, he doesn't see much return on investment

Nov 06 2017

23mins

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