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#32 Earning Your Stripes with Patrick Collison. On this episode of the Knowledge Project Podcast, I chat with Patrick Collison, co-founder and CEO of the leading online payment processing company, Stripe. If you’ve purchased anything online recently, there’s a good chance that Stripe facilitated the transaction. What is now an organization with over a thousand employees and handling tens of billions of dollars of online purchases every year, began as a small side experiment while Patrick and his brother John were going to college. During our conversation, Patrick shares the details of their unlikely journey and some of the hard-earned wisdom he picked up along the way. I hope you have something handy to write with because the nuggets per minute in this episode are off the charts. Patrick was so open and generous with his responses that I’m really excited for you to hear what he has to say. Here are just a few of the things we cover: The biggest (and most valuable) mistakes Patrick made in the early days of Stripe and how they helped him get better The characteristics that Patrick looks for in a new hire to fit and contribute to the Stripe company culture What compelled he and his brother to move forward with the early concept of Stripe, even though on paper it was doomed to fail from the start The gaps Patrick saw in the market that dozens of other processing companies were missing — and how he capitalized on them The lessons Patrick learned from scaling Stripe from two employees (he and his brother) to nearly 1,000 today How he evaluates the upsides and potential dangers of speculative positions within the company How his Irish upbringing influenced his ability to argue and disagree without taking offense (and how we can all be a little more “Irish”) The power of finding the right peer group in your social and professional circles and how impactful and influential it can be in determining where you end up. The 4 ways Patrick has modified his decision making process over the last 5 years and how it’s helped him develop as a person and as a business leader (this part alone is worth the listen) Patrick’s unique approach to books and how he chooses what he’s going to spend his time reading ...life in Silicon Valley, Baumol’s cost disease, and so, so much more. Patrick truly is one of the most warm, humble and down to earth people I’ve had the pleasure to speak with and I thoroughly enjoyed our conversation together. I hope you will too! *** For comprehensive show notes on this episode, including a full edited transcript, go to https://www.fs.blog/podcast/ My free weekly Brain Food digest helps you upgrade your thinking. Don't miss out, sign up at https://www.fs.blog/newsletter/ Follow Shane on Twitter (https://twitter.com/farnamstreet)
Airbnb's Brian Chesky in Handcrafted. If you want your company to truly scale, you first have to do things that don't scale. Handcraft the core experience. Get your hands dirty. Serve your customers one-by-one. And don't stop until you know exactly what they want. That's what Brian Chesky did. As CEO of Airbnb, Brian’s early work was more akin to a traveling salesman. He takes us back to his lean years – when he went door-to-door, meeting Airbnb hosts in person – and shares the imaginative route to crafting what he calls an "11-star experience.”
I've Had Better. [Contains mature themes] He reached out because a year after the discovery of his affair, they aren’t fighting anymore, but they certainly haven’t moved on. Esther guides them towards a more honest conversation, and a revelation about their communication.
01: John Gottman - How to Be a Master of Relationship. Welcome! My guest today is Dr. John Gottman, one of the world's leading experts on how to have an amazing relationship. He and his wife Julie currently operate The Gottman Institute in Seattle, offering numerous resources and training. Join us for a deep dive into their work! Dr. Gottman’s findings are largely based on the conclusions he has made over many years of research and observations of couples. He and his team have how to be a master (and avoid being a disaster) at relationship. Dr. Gottman discusses the following topics: “The Sound Relationship House” - what is the foundation for a relationship that lasts? Learn the importance of having high expectations in relationship, and also uncover ways in which what you'd *think* would be good for your relationship is actually counterproductive. Dr. Gottman identifies Styles of Confronting Conflict: Volatile, Validating, and Conflict-Avoiding. All of these conflict styles can lead to successful relationships. Learn what to do if you and your partner are mismatched in your conflict style. Dr. Gottman discusses “bids” we make with our partner as an attempt to connect. Are you a "yes" to your partner's bids? Are they a yes to yours? “Bids” that fail are often the beginnings of conflict. How do things change if you start paying attention and responding to your partner's bids in a positive way? Mindfulness is the key to noticing these bids and avoiding conflict. “Small Things Often” - a reminder to turn toward these bids in the small moments of life. Dr. Gottman's concept of startup is a way of thinking about what you bring to your interactions with your partner. Do you start in a place that's already positive, and thinking highly of your partner? Or do you start in a place where you are suspecting the worst of your partner? Build up your emotional bank account with small compliments (deposits). According to John, there are three phases of any relationship: Falling in Love (initial), Building Trust (middle), and Cherishing Your Partner (long-term intimacy). What phase are you in? The key to success is using strategies that are appropriate for where you are in your relationship. The key to more sex is having the freedom to say "no" without being punished for it. If refusing sex can actually have a positive payoff, then it will actually lead to a couple having a more satisfying (and frequent) sex life. Do you ever wonder how to make a good relationship GREAT? Focus on cherishing your partner. What if YOU are the only partner who wants to make changes? Can you make a difference? Absolutely. Learn how shifts in your approach can have a profound affect on your relationship. The key to success in a relationship isn't that nothing bad ever happens. It's how well you as a couple learn how to repair after those things occur. John discusses how you can learn to repair, and the positive effects that has on long-term relationships. Do you know how to decide if you’re in a bad relationship? When you're with your partner, are you at your best? Or are you veering off towards your worst? Gottman offers this simple guideline for how to know whether to stay or go. Also what to think about BEFORE you decide that you're on the wrong path. Join us for these topics and more. Dr. Gottman has practical information that can improve your relationship TODAY! Links and Resources: What Makes Love Last: How to Build Trust and Avoid Betrayal by Dr. John Gottman The Gottman Institute, Seattle www.gottman.com www.neilsattin.com/gottman (visit to download a .pdf of this episode guide along with John Gottman's "Dreams in Conflict" exercise to help couples who seem to have irreconcilable differences. You can also text “PASSION” to 33444 for instructions on how to download the guide. If you download the guide within the first week of this show's airing, you will also qualify for a chance to win a free signed copy of Dr. Gottman’s book "What Makes Love Last".) The Relationship Alive Community on Facebook Amazing intro/outro music provided courtesy of: The Railsplitters - Check them Out!
Rank #1: Beyond the Abstract: Reporting on the STS Intermacs and Pedimacs Databases. Hosted by Thomas K. Varghese Jr., MD, MS, Annals Deputy Editor, Digital Media and Digital Scholarship, the “Beyond the Abstract” program explores the “whys” behind an article in The Annals of Thoracic Surgery and discusses next steps with authors and thought leaders. In the latest episode, Drs. Robert Kormos and David Morales join host Dr. Thomas K. Varghese Jr. to explore the motivation for developing registries that examine clinical outcomes and quality-of-life metrics for patients who received FDA-approved durable mechanical circulatory support devices. They also discuss how these data will impact future devices, patient selection, and outcomes. Read the related Annals articles online: “The Society of Thoracic Surgeons Intermacs Database Annual Report: Evolving Indications, Outcomes, and Scientific Partnerships” (http://bit.ly/2NmLNPs)“Third Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report: Preimplant Characteristics and Outcomes” (http://bit.ly/2J5vSzY)
Rank #2: Anticoagulation During Cardiopulmonary Bypass. In January, The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiologists, and the American Society of ExtraCorporeal Technology released a clinical practice guideline on the use of blood thinning medication (anticoagulants) during heart surgery. In this episode, guideline coauthor John Hammon, MD speaks with two cardiothoracic surgeons (Gaetano Paone, MD and Richard Engelman, MD) and a perfusionist (Theron Paugh, CCP) about how the guideline will change clinical practice.
Rank #1: ABSITE Breast Oncology Review. https://media.blubrry.com/surgoncfiles/www.surgoncfiles.com/wp-content/uploads/2017/11/ABSITE-Review-Cyr-Interview-LXJ-Edit-11-19.mp3 On this episode of the SO files, Brad and Linda welcome Assistant Professor of Surgery at Washington University in St. Louis/ Siteman Cancer Center, and co-author of the NCCN Clinical Practice Guidelines for Breast Cancer, Dr. Amy Cyr . We will take you through both benign, pre-malignant, and malignant breast oncology, with a focus on ABSITE relevant information. Background Reading NCCN Clinical Practice Guidelines in Breast Cancer, Revised Nov. 2017 A high-yield, recently updated review of the standard of care guidelines for non-invasive and invasive breast cancer. Includes updated AJCC 7th edition TNM staging tables. Sabistons Textbook of Surgery, Chapter 34: Disease of the Breast Kelly K Hunt and Elizabeth A Mittendorf. Great review of breast pathology, with an overview of all facets of breast cancer–with tables and text highlighting key practice changing articles. Papers/Resources we Mention in the Episode NCCN Clinical Practice Guidelines in Breast Cancer, Revised Nov. 2017 A high-yield, recently updated review of the standard of care guidelines for non-invasive and invasive breast cancer. Includes updated AJCC 7th edition TNM staging tables. Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society Kevin C. Oeffinger, Elizabeth T. H. Fontham, Ruth Etzioni, Abbe Herzig, James S. Michaelson, Ya-Chen Tina Shih, Louise C. Walter, Timothy R. Church, Christopher R. Flowers, Samuel J. LaMonte, Andrew M. D. Wolf, Carol DeSantis, Joannie Lortet-Tieulent, Kimberly Andrews, Deana Manassaram-Baptiste, Debbie Saslow, Robert A. Smith, Otis W. Brawley, Richard Wender. ACS updated recommendations for breast cancer screening for average risk women. Recommendations: Annual screening from 45-54, 55+ biennial screening or have the opportunity to continue annual screening. Screening should continue as long as the women has good overall health, and a life expectancy of 10+ years. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, Leitch AM, Saha S, McCall LM, Morrow M. A practice changing article that established that for patients with clinical T1-2 N0 breast cancer with <3 SLN metastases found on SLN biopsy, there is no benefit of completion axillary lymph node dissection over no further surgical treatment of the axilla. This is high yield for the ABSITE, and a good thing to know for any medical student scrubbing in on a breast cancer operation during their surgical rotation. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, Cataliotti L, Westenberg AH, Klinkenbijl JH, Orzalesi L, Bouma WH, van der Mijle HC, Nieuwenhuijzen GA, Veltkamp SC, Slaets L, Duez NJ, de Graaf PW, van Dalen T, Marinelli A, Rijna H, Snoj M, Bundred NJ, Merkus JW, Belkacemi Y, Petignat P, Schinagl DA, Coens C, Messina CG, Bogaerts J, Rutgers EJ. AMAROS Phase III Trial: For patients with clinical T1-2 N0 breast cancer and 1 or more positive SLNs identified during surgery, axillary radiotherapy results in statistically equivalent axillary recurrence at 5 years vs. completion axillary lymph node dissection (1.19% and 0.43%, respectively, at 5 years). No significant differences in disease free or overall survival. Of note, at 5 years significantly more patients in the completion axillary lymph node dissection group had ipsilateral arm lymphedema than the axillary radiotherapy group (23% vs. 11%, respectively, p<0.0001). Gail Model to Predict Breast Cancer Risk. A commonly used model to predict future breast cancer risk for patients with no history of invasive breast cancer, DCIS or LCIS. Patients with a 5 year risk of >1.7% are candidates for chemoprevention.
Rank #2: Gastric Cancer Review- Resident geared, ABSITE friendly. https://media.blubrry.com/surgoncfiles/www.surgoncfiles.com/wp-content/uploads/2017/12/Gastric-ABSITE-review-.mp3 Happy new years from SO Files! Ring in 2018 with an algorithm based review of gastric cancer management! We released this all out of order so excuse our Thanksgiving banter but the great news is that bad jokes never go out of style, so enjoy some useful review while adhering to your gym goals for at least the first week of January. Resources NCCN Guidelines – Gastric Cancer An updated, evidence based overview of gastric cancer management. Workup, and surgical/ medical treatment algorithms discussed. 7th Edition of the AJCC Cancer Staging Manual: Stomach Updated AJCC staging information for gastric cancer. Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial. Songun I, Putter H, Kranenbarg EM, Sasako M, van de Velde CJ. 15 year follow-up data from the Dutch D1D2 trial for gastric cancer. D2 lymphadenectomy resulted in a 29% overall survival for the D2 group vs. 21% for the D1 group (p=0.34). Gastric cancer related death was higher in the D1 group than the D2 group (48% vs. 37%, respectively, p=0.01). In this trial a D2 gastrectomy included a splenectomy as standard protocol.
Rank #1: Aortic Root Surgery Procedure: Columbia Bioroot. Allan Stewart, MD, Director of the Aortic Surgery Program at NewYork-Presbyterian Hospital, provides an excellent introduction the aortic valve, aortic valve disease, and aortic valve.
Rank #2: Surgery for Hypertrophic Cardiomyopathy. Hiroo Takayama, MD, PhD, surgeon at NewYork-Presbyterian Hospital/Columbia University Medical Center, narrates a surgery video of a hypertrophic cardiomyopthy procedure.
Rank #1: Topics in 10: Wilms Tumor. Topics in 10: Drs Andrew Davidoff and Todd Ponsky come together to provide you the essentials on the diagnosis and management of Wilms Tumor.Contributing editor: Rachel (Rae) Hanke, MD00:00:00:00 Introduction 00:00:15:24 What is Wilms tumor? 00:01:16:27 How does it present? 00:01:41:05 What do you do to work up suspected renal mass?00:02:55:00 Staging (1 through 5) 00:04:03:13 Management 00:04:08:09 Unilateral disease 00:06:49:00 Bilateral disease 00:07:26:07 Solitary kidney or unilateral tumor but predisposed to developing second tumor 00:08:37:04 Intravascular tumor extension 00:09:52:29 Metastasis00:11:03:14 Wilms Tumor Clinical Pearls Intro and outro tracks are adapted from "I dunno" by grapes, featuring J Lang, Morusque. Artist URL: ccmixter.org/files/grapes/16626
Rank #2: Spontaneous Pneumothorax. This podcast is an interactive discussion about the management of spontaneous pneumothorax between Dr. Todd Ponsky and Dr. Dan Ostlie.Dr. Ostlie is Surgeon-in-Chief, Chair of Surgery, and Executive Vice-President at Phoenix Children’s Hospital, and has helped carry out multiple studies looking at the optimal way to manage spontaneous pneumothorax in pediatric patients.00:00:00:00 Introduction00:01:24:19 Case Scenario: 16-year-old male with right-sided chest pain00:02:21:12 Historical Management of Spontaneous Pneumothorax00:05:01:18 What We Know Now00:07:29:03 Option of Immediate VATS00:08:58:07 Midwest Consortium00:10:27:03 Rationale of Aspiration00:12:16:03 Aspiration Study from Midwest Consortium00:17:30:26 Algorithm from the Aspiration Study00:17:53:20 Outcomes in Patients Discharged Home after Aspiration Alone00:20:18:14 How would you counsel a family based on this study?00:22:07:23 Technique for Aspiration00:22:59:07 Technical Considerations for VATS00:23:21:21 Is there a role for pleurodesis?00:24:55:15 Talc or Chemical Pleurodesis00:26:00:17 Role of CT00:27:22:16 Management of Multiply Recurrent Pneumothorax00:29:46:27 Small Recurrence after VATS with Pleurodesis00:31:16:24 Conclusion and Future Steps00:32:48:23 TeaserIntro and outro tracks are adapted from "I dunno" by grapes, featuring J Lang, Morusque.Artist URL: ccmixter.org/files/grapes/16626
Rank #1: Basics of Small Cell Lung Cancer. Expert oncologists provide brief, distilled summaries of the most central issues in cancer management and emerging approaches for patients and caregivers. The Global Resource for Advancing Cancer Education (GRACE) is committed to providing the knowledge that will help enable the general public to be informed participants in their own care. Visit CancerGRACE.org for more info.
Rank #2: Adjuvant Chemotherapy for Elderly and Frail Patients. Expert oncologists provide brief, distilled summaries of the most central issues in cancer management and emerging approaches for patients and caregivers. The Global Resource for Advancing Cancer Education (GRACE) is committed to providing the knowledge that will help enable the general public to be informed participants in their own care. Visit CancerGRACE.org for more info.
Rank #1: DC&R November 2015. Hear Dr. Traci Hedrick discuss her article "Defining Surgical Site Infection in Colorectal Surgery: An objective analysis using serial photographic documentation" with commentary by reviewer Dr. Scott Regenbogen.
Rank #2: DC&R October 2015. Interview with Dr. Michael Stamos (senior author of Moghadamyeghaneh et al. -Variations in laparoscopic colectomy utilization in the United States) and DC&R reviewer Kurt Davis.
Rank #1: Association of Surgical Work Measures and Specialty With Relative Value Units. Interview with Christopher P. Childers, author of Association of Work Measures and Specialty With Assigned Work Relative Value Units Among Surgeons
Rank #2: AAES Guidelines for Primary Hyperparathyroidism Management. Interview with Sally Carty, MD, author of The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism.
Rank #1: Episode 79 - Cracking the Chest: The Brief History of Resuscitative Thoracotomy. There are few surgical interventions more dramatic than the thoracotomy - a desperate last-ditch effort to save a failing heart by manual compression. The history of the procedure is a fascinating one, dating back to the 19th century. This became the procedure of choice when a heart stopped, typically during surgery, but was eventually replaced by what we now call CPR. The history of the development of CPR is also covered, and of course, we'll take some interesting tangents.
Rank #2: Episode 80 - Ambroise Pare, Renaissance Surgeon. In this episode, we will explore the life and impact of French surgeon Ambroise Pare, who has been described as "one of the most luminous figures in the dark period of the late sixteenth century in France". A true Renaissance man, so to speak, Pare impacted a wide range of surgical practices. But his most significant impact was felt on the battlefields of Europe, as he modernized the treatment of gunshot wounds and amputations. All that, and more, in this episode!
Rank #1: Episode 10: Optimal ICU rounding. How good are you at rounding? How could you making it better? Whats in your ICU rounding checklist? My own checklist. Selected References: The JAMA paper. The Attitudes at Rounds paper. The exploirative discriptive paper. The two Cochrane Reviews: https://www.ncbi.nlm.nih.gov/pubmed/10796485 https://www.ncbi.nlm.nih.gov/pubmed/19588316 The Diffusion of Evidence Based Practice statewide paper. The checklist paper. The computer bsed decision making algorithim paper.
Rank #2: Episode 9: Not All MTP's Are Equal ..... . What is Massive Transfusion? What's in an MTP? When to Trigger? What's in the box? New trends and controversies. When to halt your MTP. Selected References: Early high ratio platelet transfusion in trauma resuscitation and its outcomes. Trauma resuscitation requiring massive transfusion: a descriptive analysis of the role of ratio and time. Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survival. Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. Improvement of Treatment Outcomes after Implementation of a Massive Transfusion Protocol: A Level I Trauma Center Experience. Massive transfusion policies at trauma centers participating in the American College of Surgeons Trauma Quality Improvement Program. Use of prothrombin complex concentrate as an adjunct to fresh frozen plasma shortens time to craniotomy in traumatic brain injury patients. Plus the PROMTT and PROPPR Trials ofcourse.
Rank #1: Pectus Excavatum. Pectus excavatum is an abnormal development of the chest wall in which several ribs and the sternum grow abnormally, resulting in a caved-in, or sunken appearance. It is considered be a relatively common congenital deformity and occurs more often in males than in females. Approximately 40% of pectus excavatum patients have one or more family members with the defect.
Rank #2: 3D Bronchoscopy. Bronchoscopy is a diagnostic procedure used to obtain a small amount of lung tissue and fluid samples, which are then examined under a microscope to help in diagnosing a change in your lung function.
Rank #1: Laparoscopic Cystogastrostomy for Pancreatic Pseudocyst. Laparoscopic Cystogastrostomy
Rank #2: Lap L hepatic lobectomy. Lap L hepatic lobectomy
Rank #1: The Science Behind Happiness. Episode 23: Dr. Richard Davidson In this episode, we’re joined by Dr. Richard Davidson, Professor of Psychology and Psychiatry here at the University of Wisconsin and the founder of UW’s Center for Healthy Minds. Dr. Davidson discusses his research on what it means to be happy, an academic pursuit that was inspired by the Dali Lama. He delves into some of the scientific data behind his work and offers advice on how you can improve your mindfulness to create a happier life. Recorded 3/29/2017
Rank #2: When Death Becomes Life: Notes from a Transplant Surgeon. Episode 60: Dr. Joshua Mezrich John Mezrich, MD, from UW’s Department of Surgery discusses his new book When Death Becomes Life: Notes from a Transplant Surgeon. The book chronicles his own journey to become a transplant surgeon, along with an insightful history of the field. It will be published January 15, 2019. Dr. Mezrich was also the first guest on the Surgery Sett. He tells the "Story of Big Daddy," which was the original title of his book. Listen to Episode 60 to find out why he changed the title.
Rank #1: Life as a Military Surgeon. Join us for an in depth look at life as a military surgeon. How did they get involved? What motivates them to re-enlist? How do they prepare for combat surgery? Drs. Ben Miller, Pam Choi and Matt Martin (as a guest!) share their experiences.
Rank #2: EAST Master Class Webinar - Correction of Coagulopathy: Factor-based vs. Plasma. In this special episode of Traumacast, we present the audio portion of our recent EAST Master Class Webinar. We had a pro con debate of the utility of clotting factor concentrates in resuscitation and reversal of anticoagulation, with Matt Martin and Bellal Joseph arguing in favor of factor concentrates and Macky Neal and Babak Sarani in favor of plasma-based resuscitation.Click here to watch the webinar held on February 13, 2019. This Traumacast and Webinar was sponsored by a grant from CSL Behring, makers of K-Centra.
Rank #1: June 2019 Episode 87. Journal of Trauma Editor in Chief, June 2019 issue of the Journal of Trauma and Acute Care Surgery
Rank #2: March 2019 Episode 84. Journal of Trauma Editor in Chief, March issue of the Journal of Trauma and Acute Care Surgery
Rank #1: JAMA Surgery, 2014-02-19 Online First articles, Editor's Audio Summary. Julie Ann Freischlag, MD, Editor of JAMA Surgery, discusses Online First articles published on February 19, 2014
Rank #2: JAMA Surgery, 2014-01-15 Online First articles, Editor's Audio Summary. Julie Ann Freischlag, MD, Editor of JAMA Surgery, discusses Online First articles published on January 15, 2014