Rank #1: Ep 3 Gnarlypox
This week we pay tribute to one of the gnarliest diseases of all time, and the only human disease that's ever been eradicated (thus far). That's right, people- we're talking smallpox! It's gonna get grody. Smallpox has a depressing history, a fascinating biology, a moderately uplifting present, and a precarious future. We'll cover it all.
Rank #2: Ep 5 Plague Part 1: The GMOAT
That's right y'all... Today we're talking the GMOAT: The GREATEST MORTALITY OF ALL TIME: BLACK DEATH. This episode we'll cover the biology and history of one of the most epic diseases of all time- Yersinia pestis the causative agent of plague. It's such an epic topic in fact, that you'll have to tune in next week to catch up on the current status of plague around the world!
Rank #3: Ep 20 Prions: Apocalypse Cow
This week's episode is nothing like any of our past episodes, and there will never be another quite like it. How can we be so sure, you ask? Because this week, we're covering prions, the terrifying, genetic material-less infection that is 100% fatal and caused by nothing more than a humble protein. And not just any protein, a protein you already have in your body. Are you sweating yet? Good. Then settle in and listen to the amazing biology of this terrifying twisted proteinacious particle, the fascinating and fraught history that led to its discovery, and the current research on just how scared you need to be of prions in your brain.
Rank #4: Ep 14 Rabies: Don't dilute me, bro
After a long hiatus we are back with a much anticipated look at one of the most feared diseases of all time: rabies. We cover everything from its evolutionary history to its massive case fatality rate, from why it makes you slobber so much to how Pliny the Elder thought you should treat it (spoiler: don't try it at home, folks). Sit back with a foam-topped quarantini in hand and enjoy our first episode of season 2.
Rank #5: Ep 15 MRSA: Make Resistance Susceptible Again
We've gotten pretty graphic on this podcast before, but this episode takes it to a whole new level. The omnipresent Staphylococcus aureus is a bacterium that wears many faces. Often that face is harmless, but Staph has the power to invade and infect nearly every organ of the body, leaving destruction (and a lot of pus) in its wake. While Staphylococcus aureus has been wreaking havoc on humans since well before the discovery of antibiotics, Methicillin-resistant Staph aureus (MRSA) has risen to terrifying prominence as resistance becomes the new norm. If any disease could make you run out (or stay in) and wash your hands, it’s this one. As always, you can find all of our sources at thispodcastwillkillyou.com/episodes.
Rank #6: Ep 11 Ebola: The New Kid on the Block
Let's face it. This is the episode you've been waiting for. Are you ready for one of the most publicized epidemics of the century? Because we're ready to tell you about it. Ebola has been in the scientific consciousness since 1976, but why did it take an outbreak of epic proportions for you, dear listeners, to hear about it? Well, listen closely for the answer. Special guests this episode include badass scientists Lauren Cowley, Nell Bond, and Sarah Paige, who will share their first-hand experiences with the 2014 Ebola epidemic.
Rank #7: Ep 12 HIV/AIDS: Apathy Will Kill You
This is it, y'all: the season finale. This week we’re talking about HIV/AIDS, one of the biggest pandemics of modern times. We were fortunate enough to speak with three individuals who have had vastly different experiences with HIV/AIDS. Frank Iamelli, who took care of many of his friends throughout the epidemic, Hillel Wasserman, who has been living with HIV since 1987, and Brryan Jackson who was diagnosed with AIDS when he was only 5 years old. In this episode, you'll get a glimpse into their stories and then we'll fill you in on all of the biology, history, and present state of HIV in the world. Don’t forget to tune in next week for our special bonus episode where you will get to hear more of Frank, Hillel, and Brryan's stories in depth. In the meantime, here are a couple of links to Brryan's website and Being Alive LA which you'll hear more about next week!
Rank #8: Ep 4 The Poop Show
That's right.. this is the poop show! Today we talk cholera- the bacterial disease that makes you liquid-poop your pants (and then some). Travel back in time with us to when London was a sewage-filled cesspool until the Original John Snow stepped in to save the day and created the field of epidemiology. But is cholera a thing of the past? Not so much.
Rank #9: Ep 19 Scurvy: Thanks a lot, evolution.
Arr, mateys, climb aboard for a swash-buckling tale of when the high seas were full of disease! Today we’re covering a non-infectious but no less terrifying scourge that has wrecked millions of lives and sent even the bravest of sailors quivering in their boots: Scurvy. From the open ocean to the California gold rush to modern times, scurvy has been causing collagen breakdown throughout human history, and we can blame it all on...evolution?
Rank #10: Ep 10 Yellow Fever: Is there a Hamilton song about this?
Today we're talking about yellow fever, a disease with a history as colorful as its name, and a vector as pretty as a picture (depending on whom you ask, I suppose). From an epidemic that decimated Memphis, Tennessee in the late 1800s, to the development of the vaccine, to where the offending mosquito hangs out today, we'll cover everything you need to know about this disease. Like for example did you know that A. Ham The Man himself was infected?! Yeah, me neither. Let's learn things together.
Rank #11: Ep 7 Hit Me With Your Best (Polio) Shot
A scientific rivalry for the ages, a president with a closely kept secret, and a summertime with no pool time. What do all these things have in common? Well step right up and take a listen- today we're talking about polio, that virus that just won't quit.
Rank #12: Ep 18 Hantavirus: The Real Rat Race
What do Korea, Slovenia, Finland, and the southwestern US all have in common? If you guessed Hantaviruses, you’d be quite correct. Today we bring you all the details on hantaviruses, from the deadly and terrifying hantavirus pulmonary syndrome, to the less lethal but still horrifying hemorrhagic fever with renal syndrome. From its long road to discovery, through the infamous 1993 outbreak and up to the present day, you’ll never look at an adorable little deer mouse the same way again.
Rank #13: Ep 6 Plague Part 2: TGFA
We're back with another episode all about plague-TGFA: Thank Goodness For Antibiotics! Today we'll focus on the status of plague in the modern world: where it is, where it isn't, and what we can do about it. And as always, we'll let you know whether or not to put on your scaredy pants.
Rank #14: Ep 8 ABRACADABRA - Go Away Malaria!
It's both a disease of dinosaurs and a plague of people. A gin and tonic might make you forget how much those bites itch, but it won't protect you much from this mosquito-borne monster. That's right people, today we're talking about malaria! We're super excited to tell you about this parasite since it's one of EAU's personal favs (are we allowed to have favorite horrible diseases?). Come along as we travel back millions of years to explore malaria's wee beginnings, trace its path as it shaped human evolution, take a short botanical detour to make that G & T, and end up where we first began--in 2017. Turns out that monster hasn't released humanity from its clutches quite yet.
Rank #15: Ep 9 Tuberculosis: A Slow Burn
Today, we’re taking a page straight out of Dickens and talking about tuberculosis- a disease as rich in history as it is in bloody sputum. We'll travel the path of an individual Mycobacterium tuberculosis as it makes it way down the respiratory tract of its victim and waits patiently, hidden and untouchable. We’ll learn why Nicole Kidman's skinny physique was so en vogue in Moulin Rouge, talk about ‘The Royal Touch’, which isn’t quite as creepy as it sounds, cover enough of Koch's postulates that you can give yourself an honorary microbiology degree, and oh so much more.
Rank #16: Ep 16 Scratch and Sniff Diphtheria Membrane
This episode is so good that we’re putting it out a full day early. Pour yourself a quarantini and cozy up with us as we tell you a story of a bacterium that slowly strangles children to death, a scientific quest that helped shape the understanding of infectious diseases, and a great dog sled race across wild and frozen lands to stop death in its tracks. The main character of this story is, you guessed it, Diphtheria. This dreaded disease still lingers, infecting children throughout the world today with its stinking pseudomembrane. But don't worry, it's not all bad news... we have a vaccine.
Rank #17: Don't Tread on my Monkshood: Crossover w/ IDOP
What's the difference between a physician and a pretender, a magician and a poisoner? That's a question we'll try and answer in today's episode! We are very excited to bring you our first botanical poison crossover episode with our good friend Matt Candeias of the awesome podcast and website, In Defense of Plants. This week, we'll talk about Wolfsbane, or Monkshood, or Aconitum, or any of its various common names. The point is, get ready to learn about a pretty gnarly poison, its history, how it affects your body, and why on earth a plant would make such deadly compounds from an ecological and evolutionary perspective. Don't forget to check out our guest spot on In Defense of Plants where we talk about two plants commonly used in herbal remedies. You can find it on itunes or wherever you are listening to this pod. Check out Matt's website indefenseofplants.com and follow him on twitter @indfnsofplnts!
Rank #18: Ep 17 Oh No Tetrodo: Crossover w/ TBOSP
Are you hungry for braaaaiiiinnnnssss? Or for fugu at the very least? We hope so, because this week we’re talking zombies and tetrodotoxin. In this crossover episode with Dr. Shane Campbell-Staton from The Biology of Superheroes Podcast, we trace the origin of the modern pop culture zombie back to its Haitian roots. We explore the outrageous evolutionary arms races in which tetrodotoxin, the principal component of so-called ‘zombie powder’, has played a major part. And finally, we answer the age-old question: can a pufferfish make you into a zombie? Be sure to check out Part 1 of this crossover episode, Episode 7 of The Biology of Superheroes Podcast, where we discuss the biological basis of death, whether we’re prepared for a zombie outbreak, and behavior-manipulating parasites. You can follow Shane @superbiopodcast on Twitter.
Rank #19: Bonus Episode HIV/AIDS
The cherry on top of our first season, this bonus episode features more of Frank, Hillel, and Brryan's stories. Frank and Hillel, who live on opposite coasts of the US, share what it was like for them to live through through the AIDS crisis in the 1980s and 90s. Brryan and Hillel also share their experiences living with HIV today. We were incredibly moved by all three of their stories and are so honored to get to share them with you. We hope you enjoy it! If you'd like to hear more from Brryan, you can find him on social media @BrryanJackson, and also find his website here. If you'd like to learn more about Being Alive LA, the speaker's organization Hillel mentioned, you can find their website here.
Rank #20: Ep 25 Put your hands together for: Gonorrhea!
This bug deserves a big round of applause and not just because it’s nicknamed “The Clap”. Check out this week’s episode to gasp in wonder at the tricks that Neisseria gonorrhoeae uses to tiptoe past your immune system. Then prepare to cringe at some old-timey treatments for the disease while we trace the history of this ancient pathogen. Finally, make sure you have a quarantini or placeborita in hand for when we chat about the not-so-cheery outlook for this particular sexually-transmitted infection. Believe us, this is one episode you’re not gonn(orrhe)a want to miss.