Rank #1: Screening for diabetes mellitus
Rank #2: Choice of basal insulin for management of diabetes; Evaluation of children with febrile seizures
Rank #3: Vaccination to prevent herpes zoster
Dr. Schmader is a Professor of Medicine and Chief of the Division of Geriatrics at Duke University. He is Section Editor in Primary Care and Editor-in-Chief of the Geriatrics specialty at UpToDate.
Reference: Dooling KL, Guo A, Patel M, et al. Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines. MMWR Morb Mortal Wkly Rep 2018; 67:103.
Contributor Disclosure: Grant/Research/Clinical Trial Support: Merck [Herpes zoster (Zoster vaccine)]; GlaxoSmithKline [Herpes zoster (Zoster vaccine)].
Rank #4: Goal blood pressure in older adults; Dexamethasone and acute pharyngitis pain in adults
Rank #5: SPRINT Trial; Recurrent Wheezing in Children; HTN in Pregnancy and Risk of Congenital Heart Defects
Rank #6: Revised recommendations for endoscopy in dyspepsia; New hypertension criteria in ACC/AHA guidelines
Rank #7: Metformin use in diabetes; Flexible sigmoidoscopy and colorectal cancer screening in older women
Rank #8: Glucocorticoids and sepsis; HPV vaccination in young adolescents
Rank #9: Sexual dysfunction in women; Pediatric gastroenteritis; Childhood obesity
Rank #10: Severe asymptomatic hypertension; Endovascular vs. open abdominal aneurysm repair
Rank #11: Zika virus; Therapy for chronic asthma; Stroke prevention in sickle cell disease
Rank #12: Treatment for acute otitis media in young children; Tenofovir alafenamide for chronic hepatitis B
Rank #13: Frequency for dosing of oral iron; Risk of late recurrence after endocrine therapy for breast cancer
Figure on hepcidin in UpToDate: https://www.uptodate.com/contents/image?imageKey=HEME%2F105245
Rank #14: Indications for surgery after a first episode of acute diverticulitis
Dr. Pemberton is Professor of Surgery at the Mayo Clinic and Mayo Medical School, and authors several topics on diverticular disease for UpToDate.
Reference: El-Sayed C, Radley S, Mytton J, et al. Risk of Recurrent Disease and Surgery Following an Admission for Acute Diverticulitis. Dis Colon Rectum 2018; 61:382.
Contributor Disclosure: Nothing to disclose
Rank #15: Spirometry and asthma diagnosis; Baricitinib for the treatment of rheumatoid arthritis
Rank #16: Evidence-Based Medicine and UpToDate
Rank #17: Syncope and pulmonary embolus; Treatment of vulvovaginal atrophy
Rank #18: Multi-drug resistant tuberculosis; Ischemic cardiomyopathy; Chronic insomnia
Rank #19: Naltrexone versus buprenorphine for opioid use disorder
Dr. Saxon is a Professor in the Department of Psychiatry and Behavioral Sciences at the University of Washington in Seattle, and he is Chair of the American Psychiatric Association's Council on Addiction Psychiatry.
Lee JD, Nunes EV Jr, Novo P, et al. Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial. Lancet 2018; 391:309.
Tanum L, Solli KK, Latif ZE, et al. Effectiveness of Injectable Extended-Release Naltrexone vs Daily Buprenorphine-Naloxone for Opioid Dependence: A Randomized Clinical Noninferiority Trial. JAMA Psychiatry 2017; 74:1197.
Contributor Disclosure: Grant/Research/Clinical Trial Support: Medicasafe [Medication dispensing]. Consultant/Advisory Boards: Neurocrine Biosciences [Tardive dyskinesia (Valbenazine)].
Rank #20: Catheter ablation for atrial fibrillation with heart failure
Dr. Olshansky is Professor Emeritus of Internal Medicine at the University of Iowa, Adjunct Professor of Medicine at Des Moines University, and Section Editor for UpToDate cardiology topics.
Reference: Marrouche NF, Brachmann J, Andresen D, et al. Catheter Ablation for Atrial Fibrillation with Heart Failure. N Engl J Med 2018; 378:417.
Contributor Disclosure: Speaker’s Bureau: Lundbeck [Orthostatic hypotension (Droxidopa)]; CryoLife [Heart Valve Replacement (On-X Aortic Valves)]. Consultant/Advisory Boards: Lundbeck [Orthostatic hypotension (Droxidopa)]; CryoLife [Heart Valve Replacement (On-X Aortic Valves)]. Other Financial Interest: Amarin [Hypertriglyceridemia (EPA; Chair, Data and Safety Monitoring Board)]; Boerhringer Ingelheim [Atrial fibrillation (GLORIA AF trial)].