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Alternative Health
Health & Fitness

Mastering Nutrition

Updated 5 days ago

Alternative Health
Health & Fitness
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Hi, I'm Chris Masterjohn and I have a PhD in Nutritional Sciences. I am an entrepreneur in all things fitness, health, and nutrition. In this show I combine my scientific expertise with my out-of-the-box thinking to translate complex science into new, practical ideas that you can use to help yourself on your journey to vibrant health. This show will allow you to master the science of nutrition and apply it to your own life like a pro.

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Hi, I'm Chris Masterjohn and I have a PhD in Nutritional Sciences. I am an entrepreneur in all things fitness, health, and nutrition. In this show I combine my scientific expertise with my out-of-the-box thinking to translate complex science into new, practical ideas that you can use to help yourself on your journey to vibrant health. This show will allow you to master the science of nutrition and apply it to your own life like a pro.

iTunes Ratings

251 Ratings
Average Ratings
223
16
2
5
5

Excellent content

By AZ2020 - Jan 20 2018
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Packed with so much information about nutrition, thank you.

Great Detail

By Z Health - Aug 25 2017
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A lot of info it would take months to look up. Well done.

iTunes Ratings

251 Ratings
Average Ratings
223
16
2
5
5

Excellent content

By AZ2020 - Jan 20 2018
Read more
Packed with so much information about nutrition, thank you.

Great Detail

By Z Health - Aug 25 2017
Read more
A lot of info it would take months to look up. Well done.
Cover image of Mastering Nutrition

Mastering Nutrition

Updated 5 days ago

Read more

Hi, I'm Chris Masterjohn and I have a PhD in Nutritional Sciences. I am an entrepreneur in all things fitness, health, and nutrition. In this show I combine my scientific expertise with my out-of-the-box thinking to translate complex science into new, practical ideas that you can use to help yourself on your journey to vibrant health. This show will allow you to master the science of nutrition and apply it to your own life like a pro.

Rank #1: 003: The Sugar Conspiracy -- Trading One Nutritional Boogeyman for Another

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In his April 7, 2016 piece in The Guardian, "The Sugar
Conspiracy" Ian Leslie argues that the politics of nutrition has
blinded us to the fact that sugar is more deserving than saturated
fat of the status of dietary arch-villain and that the politics
continue but the status of sugar and saturated fat are starting to
switch. But we need to move beyond nutritional boogeymen, not
switch one for another. Our sense of history and physiology -- key
concepts about the historical role of Ancel Keys, the rate at which
sugar is converted to fat in a process called de novo lipogenesis,
and whether insulin's stimulation of fat storage can offer a
plausible explanation of obesity -- get distorted when we try to
make a public enemy out of sugar, just as they do when we make a
public enemy out of saturated fat. It's time for a more nuanced
view.

Apr 26 2016
27 mins
Play

Rank #2: Ask Me Anything About Nutrition, March 4, 2019 | Mastering Nutrition #63

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On March 4, members of the CMJ Masterpass joined me in a live Zoom meeting to ask me anything about nutrition, and here’s the full recording!

We talk about things like:

  • How much spinach, broccoli, and kale is too much?
  • Can frozen vegetables be trusted for their folate?
  • Do cooked legumes lose folate when frozen?
  • I go on an extended rant about the harm done by exaggerating the harms of synthetic folic acid.
  • We use labs to identify a probable genetic defect in glutathione synthesis.
  • When to think about supplementing with calcium.
  • When a drug makes histamine intolerance and blood sugar dysregulation collide.
  • My thoughts on root canals.
  • Should you take leucine to gain muscle mass, or just eat protein?
  • A GREAT discussion on how our detoxification system evolved to handle fruits and vegetables, and why eating them can help us out through the principle of "hormesis."
  • Could low LDL levels compromise female fertility?

All this and much more!

If you’d like to participate in the next Q&A, consider joining the CMJ Masterpass. Use this link to get a 10% lifetime discount: https://chrismasterjohnphd.com/masterpass/masteringnutrition

This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.”

This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

In this episode, you will find all of the following and more:

AMA About Nutrition Show Notes

00:40 Cliff Notes

03:44 Introduction

06:48 How much spinach, broccoli, and kale is too much? And why frozen vegetables cannot be trusted as a source of folate.

12:21 Do cooked legumes lose folate when frozen?

16:09 The difference between folic acid and folate, including a rant about the over exaggeration of the harms of folic acid.

34:02 Thoughts on myasthenia gravis and Epstein-Barr virus?

35:20 In the context of hemochromatosis and iron overload, why would ferritin be low when transferrin saturation is high?

43:04 What to do when the lab says that your pyroglutamate levels are the highest that they've ever seen? Could it be a glutathione synthetase deficiency?

52:43 Can you use a high GGT, gamma-glutamyltransferase, to indicate that the body is trying to make more glutathione?

54:40 What if taking collagen at night causes you to wake up and pee?

01:00:08 Does high serum B12 have any relation to cancer?

01:05:06 Should you take a calcium supplement if dietary calcium intake is low, blood calcium is normal, PTH is midrange, and vitamin D is 48 nanograms per milliliter?

01:11:07 What does it mean when after taking a drug, histamine intolerance and blood sugar dysregulation collide?

01:15:53 What are my thoughts on root canals?

01:25:58 What do I think of Layne Norton's suggestion to take 3 grams of leucine with every meal?

01:30:00 Are liver pills really as good as eating cooked liver?

01:34:08 How much vitamin C should be taken with a standard daily dose of collagen?

01:37:41 What do I think causes fibromyalgia?

01:41:33 Is folate also unstable in frozen liver, or does it just apply to greens?

01:42:37 Is there a potential for adverse effects for someone who supplements with 5 or 10 milligrams of folic acid or methylfolate based on a heterozygous MTHFR SNP?

02:00:05 What to do when serum magnesium is high, but the magnesium doesn't make it into the cells.

02:05:00 Any recommendations on increasing DHEA?

02:05:29 Are thyroid nodules similar to goiter in some cases?

02:06:23 Is it a problem if arginine, citrulline, and beta-alanine are elevated in the Genova ION Profile while supplementing with beta-alanine and citrulline malate?

02:08:56 A discussion of plant polyphenols and hormesis.

02:20:22 Is it safe to take creatine when nursing?

02:29:02 Is vitamin E supplementation harmful if you have a GSTP1 polymorphism?

02:33:25 Could low LDL levels compromise female fertility?

Mar 30 2019
2 hours 54 mins
Play

Rank #3: Nutrition in Neuroscience Part 1 | Mastering Nutrition #53

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Nutrition has a HUGE impact on your brain!

Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements.

Join me as I lead you in a safari through the textbook, “Neuroscience,” pointing out along the way all the interesting connections to nutrition. Listen in for part 1 on the basic cellular functions of neurons!

This episode is brought to you by US Wellness Meats. I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as well as a wide array of other meat products, all from animals raised on pasture. Head to grasslandbeef.com and enter promo code “Chris” at checkout to get a 15% discount on any order that is at least 7 pounds and is at least $75 after applying the discount but under 40 pounds (it can be 39.99 lbs, but not 40). You can use this discount code not once, but twice!

This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

To get all four episodes RIGHT NOW, ad-free, and with transcripts, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

In this episode, you will find all of the following and more:

00:37 Cliff Notes

14:55 The primary type of cell in the nervous system is the neuron.

16:32 Glial cells are the assistants of the nervous system.

17:22 Cells in the nervous system are polarized.

18:54 Mitochondria are typically only located at the synapse of neurons and in the middle of photoreceptors; creatine is important for transporting energy in a cell where ATP production is highly polarized.

26:43 Sources of creatine

28:13 Brief overview of how to support methylation

31:06 The polarization of astrocytes and the obligate need for glucose in the brain

37:33 Electrical signaling, resting membrane potential, depolarization, threshold potential, hyperpolarization, and the importance of sodium, potassium, and chloride

45:13 How to get enough sodium, chloride, and potassium in the diet

53:51 The sodium-potassium ATPase uses ATP to pump three sodium ions out of the cell and two potassium ions into the cell, so magnesium and all of the nutrients involved in energy metabolism are important.

58:44 How action potentials propagate

01:03:40 Myelin and the importance of cholesterol

01:06:53 Smith-Lemli-Opitz Syndrome is a rare genetic disorder of cholesterol synthesis that results in neurological problems that are corrected by dietary cholesterol.

01:09:32 Calcium acts as a second messenger in the nervous system, and the cytosolic calcium concentration has to be kept very low for this to work, which requires ATP energy.

01:14:22 Other roles of calcium in the nervous system

01:15:34 Sufficient dietary calcium and ATP energy are needed to support the second messenger roles of calcium.

Jan 11 2019
1 hour 24 mins
Play

Rank #4: What to Do About High Cholesterol | 38

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If you're concerned about your cholesterol, or confused about what to do, this episode is for you. In this episode, I list the four key factors that control blood cholesterol levels and outline the simplest dietary or lifestyle changes we can make to have the biggest impact.

This episode is brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice.

In this episode, you will find all of the following and more: 

00:33 Cliff notes; 09:22 Targeting the low-hanging fruit; 11:50  The total-to-HDL-C ratio as a fingerprint of low LDL receptor activity; 13:20  Other markers such as particle size, particle count, and ApoB as fingerprints of low LDL receptor activity; 16:30  The four factors that control the LDL receptor; 18:50  Intracellular free cholesterol (effects of dietary fiber, cholestyramine, statins, and polyunsaturated fatty acids or PUFAs); 20:37  Thyroid hormone (effects of micornutrients, body fat, and carbohydrate intake); 23:50  Insulin (via PCSK9, effects of the fasting-feeding cycle and carbohydrate intake); 27:00  Inflammation (via PCSK9, effects of acute infection and chronic inflammation); 29:15  Practical approaches to maximizing LDL receptor activity; 29:22  Nutrient-dense whole food diets; 34:00  Thyroid disorder; 37:15   Adrenal stress, circadian stress, inflammatory stress; 39:05  Insulin resistance, body composition, and fatty liver disease; 42:00  Weight loss will improve insulin sensitivity, and for many a low-carb diet is a tool to achieve that, but in an insulin-sensitive person, carbohydrate stimulation of insulin has a powerful beneficial effect on LDL receptor activity; 46:20  Inflammation and PCSK9; 47:00  C-Reactive Protein levels, body composition, diet quality, and exercise; 49:25  Replacing fat with carbohydrate.

Mar 19 2017
58 mins
Play

Rank #5: Kresser/Kahn Vegan Debate on Joe Rogan: My Post-Game Analysis

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Please head on over to the YouTube video and like it, share it, or comment on it to help me promote this! 

It would also be great if you're on Twitter if you could like, retweet, or reply to the tweet about the analysis.

The links mentioned in the podcast can all be found in the description of the YouTube video.

Enjoy!

Oct 04 2018
1 hour 17 mins
Play

Rank #6: Urinary Organic Acid Tests | MWM Energy Metabolism Cliff Notes #11

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Now we take it clinical: how do we use what we’ve learned so far to interpret the section of a urinary organic acids test that reports the citric acid cycle metabolites?

We begin by looking at the underlying chemistry to explain the curious absence of oxaloacetate on these tests. We conclude by mastering the ability to spot three unique patterns: energy overload, oxidative stress, and thiamin deficiency.

For the full lesson go to chrismasterjohnphd.com/mwm/2/11

Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.

Sep 06 2017
11 mins
Play

Rank #7: Pantothenic Acid, Part 1 (What It Is and Why We Need It) | Mastering Nutrition #64

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Pantothenic acid is vitamin B5. You use it to make coenzyme A, a molecule that is central to energy metabolism, most famous for forming acetyl CoA, which lies at the intersection of all anabolic (building up) and catabolic (breaking down) reactions.

Alex Leaf and I team up again, this time to tackle B5.

This is what happens when you don’t have enough:

  • You get fatigue apathy, discomfort, uneasiness, or pain.
  • You get numbness and tingling in the hands and feet.
  • You may get depressed, quarrelsome, childish, or want to spend all day in bed.
  • Your pulse gets higher than you’d expect after minor exertion.
  • Your sleep gets trashed.
  • You get muscle cramps and abdominal cramps, you fart more, and when things get real bad you might throw up.

Much of this can be explained by pantothenic acid’s role in working all of this magic:

  • We use it break down fat, protein, and carbohydrate for energy.
  • We use it to synthesize fatty acids, ketones, and cholesterol.
  • We use it to synthesize all of the steroid hormones, including the sex hormones, the glucocorticoids that regulate blood sugar, and the mineralcorticoids that regulate electrolyte balance and blood pressure.
  • We use it to regulate our use of iron properly, including preventing its accumulation in the brain, where it can cause neurological damage.
  • We use it to make melatonin, which tells our body it’s time to sleep.
  • We use it to make acetylcholine, a neurotransmitter involved in learning, memory, and cognitive performance during periods of sustained, focused attention.
  • We use it to make mucin, which lubricates the eyes, ears, nose, mouth, vagina, penis, and internal organs.
  • We use it to regulate the fasting/feeding cycle by flipping on the genes for autophagy during fasting and flipping on the genes for repair and antioxidant defense during feeding.
  • We use it for quite a few other things too, like the detoxification of some drugs; the synthesis of hemoglobin to prevent anemia; switching on the urea cycle to help us burn protein for energy cleanly; using folate to synthesize DNA, all the major vitamin-derived carriers in the system of energy metabolism, and glycine, an amino acid that acts as a calming, sleep-promoting neurotransmitter, stabilizes blood sugar, and supports collagen synthesis to make your bones strong and your skin smooth.

Burning fat only requires 20% more B5 than burning carbs, which is small compared to how these macros affect riboflavin requirements, However, under conditions of stress you can burn carbohydrate without any B5 at all and you cannot do that with fat. In mice with severe deficiencies of coenzyme A, ketogenic diets dramatically worsen the neurological effects of deficiency.

Although pantothenic acid is named for its presence everywhere and in everything using the Greek word “pantos,” and the common dogma is that no one is deficient, Alex and I make the case in this two-part podcast that suboptimal pantothenic acid status might just be the norm.

And the crazy thing? Official recommendations suggest we only need about 5 milligrams per day. In the podcast we discuss why some people might need GRAMS per day.

Plus, why the FOOD forms might be superior to anything you can get in any supplements on the market.

In part 2, to be released on July 5, we’ll cover how to get pantothenic acid in foods, blood tests, and supplements.

This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

In this episode you will find all of the following and more:

00:37 Cliff Notes

14:02 Symptoms of experimentally induced pantothenic acid deficiency

15:57 It is thought that pantothenic acid deficiency doesn’t occur naturally.

18:59 Experiments inducing pantothenic acid deficiency

26:06 Signs and symptoms of suboptimal pantothenic acid status

26:54 Is there pantothenic acid toxicity?

30:52 Hypothetical problems of taking high doses of pantothenic acid

31:53 What pantothenic acid is

35:28 Comparisons to niacin and riboflavin

37:14 Roles of coenzyme A

46:02 Roles of 4’-phosphopantetheine

48:12 Burning fat requires 20% more vitamin B5 than burning carbohydrate; and why in the context of severe deficiency of B5 or impairment in the metabolism of B5 a high-fat diet could have devastating consequences.

53:09 The importance of the ratio of acetyl-CoA to free CoA in regulating many metabolic pathways

01:01:02 There are metabolic disorders, such as fatty acid oxidation disorders, that compromise the pool of coenzyme A.

01:03:03 Synthesis of coenzyme A

01:06:47 How coenzyme A synthesis is regulated

01:11:38 Degradation of coenzyme A

01:15:44 The physiology of pantothenic acid absorption

01:25:29 A 2015 paper showed that 4’-phosphopantetheine can cross cell membranes via passive diffusion.

01:29:00 The physiology of pantothenic acid transport in the blood

01:32:11 Cellular uptake of pantothenic acid from the blood

01:33:21 Tissue distribution of pantothenic acid

01:36:00 There may be a particularly high need for pantothenic acid in adolescence.

01:37:01 Mothers actively transfer pantothenic acid to their fetuses and into their milk at their own expense.

01:39:29 Pharmacokinetics of supplementation

01:48:20 A case for why food is superior to supplements for vitamin B5

01:52:41 Inborn errors of coenzyme A metabolism include pantothenate kinase-associated neurodegeneration (PKAN).

Jun 19 2019
2 hours 15 mins
Play

Rank #8: How to Gain Muscle Without Gaining Fat | Chris Masterjohn Lite #56

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How do you put on muscle without risking gaining fat? You need the right workout, enough protein, and a gentle caloric surplus. Watch the video for more details!

This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off.

To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

Aug 02 2018
7 mins
Play

Rank #9: Creatine: Far More Than a Performance Enhancer

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Creatine, best known for its ability to build muscle and enhance athletic performance, is also critical for digestion, mental health, protecting your hearing, and keeping your skin vibrant and youthful.    From among the various options for creatine supplementation, I recommend Optimized Nutrition micronized creatine powder. If you are using creatine while traveling, try Optimized Nutrition creatine caps. Click here for the only searchable database of the creatine content of foods on the internet. It has over 140 entries! This episode is brought to you by Paleovalley. I use their beef sticks as a convenient yet nutritious snack. They are made from 100% grass-fed beef and preserved through traditional fermentation. The fermentation makes them more digestible and gives them a fresher mouthfeel and texture compared to most other meat snacks I’ve tried, which tend to be too dry for me to fully enjoy. They also have a grass-fed organ complex that contains a blend of liver, heart, kidney, and brain, all stuffed into gel caps for those who can’t bring themselves to eat these incredibly nutritious meats with a fork. Head to paleovalley.com and enter the promo code masterjohn at checkout for 30% off your order. This is a huge savings available for only a limited time. You can get 30% off everything on the site, ordering as much as you want, but only for the duration of the next three podcast episodes. Check it out now to make sure you get your discount!  

This episode is brought to you by US Wellness Meats. I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as well as a wide array of other meat products, all from animals raised on pasture. Head to grasslandbeef.com and enter promo code “Chris” at checkout to get a 15% discount on any order that is at least 7 pounds and is at least $75 after applying the discount but under 40 pounds (it can be 39.99 lbs, but not 40). You can use this discount code not once, but twice!

Dec 21 2017
1 hour 33 mins
Play

Rank #10: 031: Why You Should Manage Your Glutathione Status and How to Do It

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Glutathione is central to recovery from exercise, feeling good, looking good, aging gracefully, and preventing or overcoming both infectious diseases and chronic degenerative diseases. Episode 31 covers everything you need to know about why and how to manage your glutathione status.

This episode is brought to you by Kettle and Fire Bone Broth. Use the link kettleandfire.com/chris to get $10 off your first order.

This episode is also brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice.

In this episode, you will find all of the following and more: 00:35 Cliff Notes; 10:45  Introducing my new health and wellness packages; 13:25 The health benefits of glutathione: master antioxidant, central to liver detoxification and the defense against glycation, master controller of hundreds of proteins, mucus fluidity, bronchodilation, anti-aging, protection against diabetes and its complications including cataracts and cardiovascular disease, protection against Hashimoto's thyroiditis and other thyroid disorders, protection against infectious diseases by supporting the immune system's respiratory (oxidative) burst, protection against congestion, COPD, asthma, and other lung problems; 25:15 How to measure glutathione status, the importance of measuring it in both is reduced (GSH) and oxidized disulfide (GSSG) forms, and using those to calculate your redox status using my glutathione redox status calculator; 30:28 The synthesis, recycling, and regulation of glutathione; 37:00      Practical strategies to improve glutathione status: protein, vitamin B6, carbohydrate, whey protein and raw milk, bone broth and collagen, magnesium, metabolic rate (ATP), polyphenols (e.g. EGCG and other green tea catechins) and other phytonutrients (e.g. sulforaphane) as Nrf2 inducers, glutathione in foods, N-acetyl-cysteine and glutathione supplements, insulin and insulin resistance, MTHFR mutations, glucose 6-phosphate dehydrogenase deficiency, niacin, riboflavin, and thiamin, why Jarrow oral glutathione is my current choice of supplement 1:04:24      Tying it all together.

Jan 13 2017
1 hour 19 mins
Play

Rank #11: Living With MTHFR | 46

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MTHFR is an enzyme that allows folate (vitamin B9) to support the cellular process of methylation, which is important for the synthesis of creatine and phosphatidylcholine, the regulation of gene expression, neurotransmitter metabolism, and dozens of other processes. There are two common polymorphisms that decrease its activity, A1298C and C677T, with C677T having the stronger effect. Genetic decreases in MTHFR activity are associated with cardiovascular disease, neurologic and psychiatric disorders, pregnancy complications and birth defects, and cancer.

While discussions of these polymorphism tend to focus on repleting methyl-folate, this should only be a small piece of the puzzle. The bigger pieces of the puzzle are restoring choline, creatine, and glycine. 

In this episode, I describe how the methylation system works, how it's regulated, and how it's altered with MTHFR variations. I then use this to develop a detailed dietary strategy and an evaluative strategy to make sure the dietary strategy is working.

Show notes coming soon!

This episode is brought to you by Ample Meal. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides a balance of fat, protein, and carbohydrate, plus all the vitamins and minerals you need in a single meal, all from a blend of natural ingredients. The protein is from whey and collagen. The fat is from coconut oil and macadamia nut oil. The carbohydrates, vitamins, and minerals come exclusively from food sources like sweet potatoes, bananas, cocoa powder, wheat and barley grass, and chlorella. I use Ample on Mondays when I have 12 hours of appointments with breaks no longer than 15 minutes. It keeps my brain going while I power through the long day, never letting food prep make me late for an appointment. Head to amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.

This episode is brought to you by US Wellness Meats. I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as well as a wide array of other meat products, all from animals raised on pasture. Head to grasslandbeef.com and enter promo code “Chris” at checkout to get a 15% discount on any order that is at least 7 pounds and is at least $75 after applying the discount but under 40 pounds (it can be 39.99 lbs, but not 40). You can use this discount code not once, but twice!

Aug 12 2017
2 hours 1 min
Play

Rank #12: Thiamin, Ketones, and Microbes | MWM Energy Metabolism Cliff Notes #14

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Did you realize that thiamin deficiency can be caused by your environment? In the old days, beriberi was associated with the consumption of white rice. Nowadays, refined foods are an unlikely cause of thiamin deficiency because they are fortified. We associate deficiency syndromes such as Wernicke’s encephalopathy and Korsakoff’s psychosis primarily with chronic alcoholism. Yet there are regional outbreaks of thiamin deficiency among wildlife attributed to poorly characterized thiamin antagonists in the environment. Thiamin-destroying amoebas can pollute water, thiamin-destroying bacteria have been isolated from human feces, and thiamin-destroying fungi have also been identified. Could toxic indoor molds and systemic infections play a role as well?

Thiamin deficiency is overwhelmingly neurological in nature and hurts the metabolism of carbohydrate much more than fat. Indeed, preliminary evidence suggests thiamin supplementation can help mitigate glucose intolerance. Ketogenic diets are the diets that maximally spare thiamin and are best characterized as treatments for neurological disorders. Anecdotally, ketogenic diet-responsive neurological problems sometimes arise as a result of infection. Could ketogenic diets be treating problems with thiamin or thiamin-dependent enzymes? One must exercise caution here: fat contains little thiamin, and ketogenic diets can actually cause thiamin deficiency if they don’t contain added B vitamins. The relationships between thiamin, glucose metabolism, and neurological health are remarkable and desperately need our attention.

For the full lesson, go to chrismasterjohnphd.com/mwm/2/14

Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.

Sep 10 2017
9 mins
Play

Rank #13: Five Rules for a Healthy Diet | Chris Masterjohn Lite #72

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Here is a healthy diet, boiled down into five simple rules.

Tune in to learn the rules!

This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com.

This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off.

To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

Sep 27 2018
7 mins
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Rank #14: 032: Why You Need to Manage Your Iron Status and How to Do It

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In episode 32, I tell the story of my personal story with iron overload, and weigh in on the proper use of blood tests and strategies to manage anemia, hemochromatosis, and everything in between. It's important to realize that these are the extremes, and there is a large middle space where we need to not only manage how much iron we accumulate, but how we direct it away from its disease-promoting roles and into its health-promoting roles.

This is a great primer on iron as well as a source of insights you may not have encountered elsewhere, such as the importance of oxidative stress as an independent regulator of ferritin, and the potential dangers of supplements designed to protect against oxidative stress like milk thistle, Protandim, sulforaphane, and green tea extract, for people at risk of anemia.

You can find the show notes to this episode at chrismasterjohnphd.com/32.

This episode is also brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice.

This episode is brought to you by Kettle and Fire Bone Broth. Use the link kettleandfire.com/chris to get $10 off your first order.

In this episode, you will find all of the following and more: 0:33 Cliff Notes; 10:30 Introduction; 13:12 My personal story with iron overload; 30:12 The physiological roles of iron: hemoglobin, myoglobin, nitric oxide synthase, iron-sulfur clusters in the cytochromes of the electron transport chain, guanylyl cyclase, thyroid peroxidase (TPO), myeloperoxidase (MPO), oxygen transport, energy and ATP production, cellular regulation, thyroid hormone production, immunity; 38:20 Iron as a source of oxidative stress: free iron, hydrogen peroxide, and the hydroxyl radical, oxidative stress as an independent regulator of ferritin; 41:10 Regulation of iron status; Ferritin, long-term storage, protector against pathogens, protector against oxidative stress; Transferrin, short-term iron storage; Hepcidin, master coordinator of iron metabolism; HFE, communicator between transferrin and hepcidin; 49:10 Regulation of dietary absorption of plant and animal iron; 51:00 Measuring and assessing iron status: complete blood count (MCH, MCV, RDW, CHr), full iron panel, sensitivity and specificity of transferrin saturation versus ferritin, differential interpretation of ferritin as a marker of iron overload, inflammation, or oxidative stress; 1:11:43 What to do for anemia: differentiate potential causes, iron in foods (heme, nonheme, vitamin C, polyphenols, phytate, calcium), iron in supplements (iron-saturated lactoferrin, heme iron, liposomal iron), avoid Nrf2-stimulating supplements (like Protandim, sulforaphane, milk thistle, green tea extract), importance of followup measurements of ferritin 01:21:03 What to do for iron overload: blood donation, dietary management, phlebotomy, chelation, importance of followup

Jan 27 2017
1 hour 38 mins
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Rank #15: Nutrition in Neuroscience Part 4 | Mastering Nutrition #56

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Part 4 of how NUTRITION has a HUGE impact on your BRAIN!

Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements.

Join me as I lead you in a safari through the textbook, “Neuroscience,” pointing out along the way all the interesting connections to nutrition. Listen in for part 2 on the COGNITIVE FUNCTIONS! Mental and emotional health, cognitive performance, and sleep!

Ads

This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.”

In this episode, you will find all of the following and more:

00:39 Cliff Notes

12:08 Anatomy of the brain

16:41 The role of the basal ganglia in suppressing the investment of energy in any type of program until there is a worthwhile reason not to suppress it, and how dopamine acts as a signal of value in the basal ganglia via disinhibition

24:56 Why we can view Parkinson’s as fundamentally not a problem with movement but as a problem with a perception of the value of investing energy in controlling movement

28:23 Tonic and phasic dopamine and the importance of COMT-mediated methylation for regulating the tonic level of dopamine

36:34 The importance of GABA in suppressing the programs that dopamine doesn't signal has value in order to make the dopamine signal of value meaningful

37:28 Overview of the autonomic nervous system; the sympathetic nervous system mediates the fight-or-flight response, and the parasympathetic nervous system mediates the rest-and-digest response.

41:11 The roles of acetylcholine and norepinephrine in the autonomic nervous system, and the importance of nitric oxide to the sexual functions of the autonomic nervous system

44:28 Sleep and circadian rhythms, the importance of vitamin A, morning sun exposure, and avoiding blue light at night

48:12 Melatonin synthesis, the importance of vitamin B6, BH4, oxidative stress, vitamin B5, methylation, and tryptophan uptake into the brain

51:10 Why you can't mimic your natural melatonin rhythm with melatonin supplements

52:55 Antidiuretic hormone, the importance of light hygiene for preventing you from getting up to pee in the middle of the night, and why salt might also help

56:14 Whether the timing of carbohydrate, protein, and choline supplements makes a difference for your daytime wakefulness, your nighttime sleepiness, your deep sleep, and your REM sleep

01:00:44 The possibility that glycine and magnesium could help get rid of conditioned fear responses

01:01:30 Thoughts on consciousness; are we a ghost in the machine, or are we just a machine?

01:06:25 The default mode network is fundamentally about our inward, introverted-directed processes, contrasted with the executive control network, which is fundamentally about our relationship to the outside world and our extraverted functions.

01:10:52 How activities that had nothing to do with people skills but allowed me to flex my extroverted muscles, like exploring the outside world on my own, helped me with my people skills

01:16:48 Nutrition cannot replace the cognitive work necessary to have a healthy mindset and life, but nutrition does make it easier to do the right thing for your mental health.

Feb 01 2019
1 hour 26 mins
Play

Rank #16: Ask Me Anything About Nutrition, Feb 1, 2019

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Here’s the recording of the February 1 Ask Me Anything!

30 CMJ Masterpass subscribers sat in on a Zoom session with me last Friday and asked me whatever they wanted about nutrition.

We talk about bone meal for calcium, K2 and heart palpitations, low white blood cell counts, lowering anxiety at night and getting better deep sleep, probiotic cycling, fat intake and familial hypercholesterolemia, negative consequences of taking baking soda too much for too long and what to do instead, the lymphatic system and fat metabolism, intolerances to food and supplements, electrolytes after sauna use, heart rate variability, SIBO, H. pylori, protein on keto, hair mineral analysis, SpectraCell, and more.

Listen in to hear my answers!If you’d like to participate in the next Q&A, consider joining the CMJ Masterpass. Use this link to get a 10% lifetime discount: https://chrismasterjohnphd.com/masterpass/masteringnutrition

This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.”

This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

In this episode, you will find all of the following and more:

Ask Me Anything Show Notes

13:20 Alternative bone meal powders to Whole Bone Calcium from Traditional Foods Market

15:54 Nutritional causes of low white blood cell count and possible solutions

18:09 Supplements that may lower anxiety at night and improve heart rate variability during sleep

24:40 Brands, forms, and dosage recommendations for nicotinamide riboside and nicotinamide mononucleotide

27:08 Dosage recommendations for berberine

27:50 Supplements that may increase deep sleep

31:18 Brands and dosage recommendations for CBD oil

31:31 Probiotics brand and cycling recommendations

33:19 Is Theracurmin as effective as Meriva Curcumin for arthritis?

39:19 Best clinical way to monitor COMT function if you have already tested for SNPs

43:10 How would you address normal TSH but low T4?

47:38 Should you be more concerned about overall fat intake or saturated fat intake with familial hypercholesterolemia?

50:59 Concerns about long-term bicarbonate supplementation and other suggestions for raising pH

58:08 Could magnesium hydroxide be absorbed via skin and cause hypermagnesemia?

58:40 The relationship between Lp(a) and cardiovascular disease

01:00:23 The role of the lymphatic system in fat metabolism

01:01:41 If your cholesterol is high, how do you avoid having a large burden of oxidized LDL?

01:08:16 Bovine colostrum for those with dairy sensitivities, and what to do about food sensitivities in general

01:17:24 Heart palpitations as a result of vitamin K2 supplementation and whether increasing calcium intake could help

01:21:10 Best formula and dosage of no-carb electrolytes to take at night to optimize sleep, especially after sauna use

01:22:35 Can a low-carb diet cause waking up in the middle of the night?

01:30:24 Why would a male have low blood levels of calcium?

01:32:21 What to do about low cortisol

01:33:19 What supplements would you recommend for a ketogenic diet?

01:35:09 Recommended brands of resveratrol and whether or not you should take resveratrol

01:38:55 Recommendations for treating SIBO and H. Pylori

01:44:26 What do you think about taking clomid to boost testosterone?

01:44:38 How do you determine if you’re getting enough protein?

01:48:14 Avmacol and sulforaphane

01:50:22 How to address edema

01:55:07 What do you think of alternative testing like hair mineral analysis or SpectraCell?

01:57:49 How to lower your calcium score

02:01:45 Recommendations on magnesium supplements and dosage

02:04:09 How to improve LDL receptor activity

02:05:48 Is milk thistle beneficial?

02:06:16 Do you have any concerns with taking 400 milligrams of phosphatidylserine supplements before bed to lower cortisol?

02:06:33 What would cause low platelet count, and how would you fix it?

02:06:53 Recommendations for peripheral neuropathy

02:08:22 What are your top three non-nutrient factors that prevent beta-oxidation or ketogenesis?

Feb 09 2019
2 hours 20 mins
Play

Rank #17: Why You Need Glycine: A Panel Discussion | Mastering Nutrition #49

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Glycine can you sleep, stabilize your blood sugar, improve your joint health, keep your skin beautiful, and do much more. It's a little amino acid with a big impact on your health.

This episode is a panel discussion between Dr. Chris Masterjohn, Alex Leaf of Examine.Com, and Vladimir Heiskanen, covering everything you need to know about glycine.

The best way to get glycine is from hydrolyzed collagen. Great Lakes offers the best balance of quality, transparency, and price. Vital Proteins, while more expensive, uses enzymatic digestions rather than heat to hydrolyze the collagen, and some people find that their digestion tolerates Vital Proteins but not other brands.

Some people respond better to pure glycine. For these cases I recommend Bulk Supplements pure glycine powder. It has the same sweetness as sugar and can be used as a sweetener.

You can view the show notes for this episode at chrismasterjohnphd.com/49.

This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. I wrote this to make everything you could possibly need to measure and manage your nutritional status all one click away. If you purchase it by Wednesday, January 9, you can turn in your proof of purchase at any point in the future while my consultations are available to get $30 back on a single consultation or $100 back on a Health and Wellness Package. Get it now!

This episode is brought to you by Paleovalley. I use their beef sticks as a convenient yet nutritious snack. They are made from 100% grass-fed beef and preserved through traditional fermentation. The fermentation makes them more digestible and gives them a fresher mouthfeel and texture compared to most other meat snacks I’ve tried, which tend to be too dry for me to fully enjoy. They also have a grass-fed organ complex that contains a blend of liver, heart, kidney, and brain, all stuffed into gel caps for those who can’t bring themselves to eat these incredibly nutritious meats with a fork. Head to paleovalley.com and enter the promo code masterjohn at checkout for 30% off your order. This is a huge savings available for only a limited time. You can get 30% off everything on the site, ordering as much as you want, but only for the duration of the next three podcast episodes. Check it out now to make sure you get your discount!

This episode is brought to you by US Wellness Meats. I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as well as a wide array of other meat products, all from animals raised on pasture. Head to grasslandbeef.com and enter promo code “Chris” at checkout to get a 15% discount on any order that is at least 7 pounds and is at least $75 after applying the discount but under 40 pounds (it can be 39.99 lbs, but not 40). You can use this discount code not once, but twice!

To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

Jan 08 2018
1 hour 50 mins
Play

Rank #18: 7 Ways to Keep Your Blood Sugar Stable | Chris Masterjohn Lite #55

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Here are seven ways to keep your blood sugar in control: vinegar; glycine, proper balance and eating order within your meals, walking after your meal, putting your carbs after exercise, managing your glycemic load per meal, and focusing on meals that have a low glycemic index for you personally.

The video covers these recommendations in more detail.

This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off.

To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

Jul 31 2018
9 mins
Play

Rank #19: Carbs and Sports Performance: The Principles | MWM Energy Metabolism Cliff Notes #17

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Can athletes fat-adapt their workouts? This lesson lays down the principles of exercise biochemistry and physiology needed to understand the importance of the three energy systems supporting energy metabolism in skeletal muscle: the phosphagen system (ATP and creatine), anaerobic glycolysis (dependent on carbs), and oxidative phosphorylation (dependent on carbs, fat, or protein). We discuss why maximal intensity always depends on carbs if the intensity and duration are sufficient to deplete phosphocreatine concentrations, and clarify the window of time and intensity that can be fat-adapted. This sets the foundation for the next lesson, which looks at the evidence of how carbohydrate restriction and ketogenic diets impact sports performance.

For the full episode, go to chrismasterjohnphd.com/mwm/2/17

Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.

Sep 25 2017
11 mins
Play

Rank #20: 012: What is Measuring Our Hba1c REALLY Telling Us About our Blood Glucose and Diabetes Risk?

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In response to popular demand, this week is glycation week. In this episode, I discuss the strengths and limitations of using Hba1c to measure our cumulative recent exposure to blood glucose and diabetes risk. Many people will be familiar with the fact that variation in red blood cell turnover confounds this measurement. Less well known is that variations in the deglycating enzyme fructosamine 3-kinase (FN3K) also confound the measurement. Counter-intuitively, if you have a higher rate of this deglycating enzyme but a lower rate of downstream metabolism of 3-deoxyglucosone, your lower Hba1c could actually mean MORE glycation. I conclude that Hba1c is a useful test, but only in the context of a bigger picture put together with more information.

Jun 07 2016
46 mins
Play

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