OwlTail

Cover image of Epigenetics and cellular memory

Epigenetics and cellular memory

Edith Heard was born on March 5th, 1965 in London (United Kingdom)She studied Natural Sciences at Cambridge University, graduating in genetics, and then carried out her PhD at the Imperial Cancer Research Fund (London), working on gene amplification in cancer. During her post doc at the Pasteur Institute in Paris, she began her work on the epigenetic process of X-chromosome inactivation. Since 2001 she has led the Mammalian Developmental Epigenetics team at the Institut Curie and has been director of the Unit of Genetics and Developmental Biology Department since 2010.She has been awarded several prizes and honours, including the Silver Medal of the CNRS in 2008, the Jean Hamburger Prize (Ville de Paris) in 2009, an ERC Advanced Investigator Award in 2010 and the Grand Prix de la FRM in 2011. She was elected as EMBO member in 2005. In 2012, she was appointed Professor of the Collège de France.Edith Heard has made many important contributions to the emerging field of epigenetics through her work on one of its most classic examples, X-chromosome inactivation. This process entails the silencing of one of the two X chromosomes during early development in female mammals, enabling dosage compensation between the sexes. This phenomenon of chromosome-wide gene silencing that can be stably propagated during cell division, was discovered more than half a century ago and represents a paradigm for epigenetics. The pioneering work of Edith Heard, using X inactivation as a model system, has shed light on epigenetic mechanisms at multiple timescales: over the cell cycle, during development, across generations and in evolution. Her team revealed the dynamics of this epigenetic process during development - being established early on, then rapidly reversed in a subset of cells that give rise to the embryo-proper. This finding had important general implications for the plasticity of epigenetic states in the embryo, in stem cells and during induced pluripotency. It also had implications in cancer, where dedifferentiation is commonly found and epigenetic plasticity seems to be a hallmark. Edith Heard and her colleagues were also the first to discover the evolutionary diversity of events underlying X inactivation, with striking differences in the timing and manner in which this process is set up between even closely related mammals during early embryogenesis. Her group have also made several discoveries on the mechanisms of X inactivation. They have demonstrated the importance of the spatial organization and dynamics of the two X chromosomes in the nucleus during the initiation of X inactivation. They have also defined some of the first changes in the chromatin status of the X chromosome which can be considered as potential epigenetic marks ensuring the cellular memory of the inactive state.

Popular episodes

All episodes

The best episodes ranked using user listens.

Warning: This podcast data isn't working.

This means that the episode rankings aren't working properly. Please revisit us at a later time to get the best episodes of this podcast!

Podcast cover

05 - Reprogramming in Development and Disease

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2013-2014iPs Cells Used as Therapeutic Tools or as Models to Understand Various PathologiesLecture 5

1hr 40mins

7 Apr 2014

Rank #1

Podcast cover

04 - Reprogramming in Development and Disease

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2013-2014Molecular Mechanisms Involved in ReprogrammingLecture 4

1hr 51mins

31 Mar 2014

Rank #2

Similar Podcasts

Podcast cover

03 - Reprogramming in Development and Disease

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2013-2014Experimental Reprogramming - Induced Pluripotent CellsLecture 3

1hr 29mins

24 Mar 2014

Rank #3

Podcast cover

02 - Reprogramming in Development and Disease

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2013-2014Reprogramming Phases during Development in MammalsLecture 2

1hr 24mins

17 Mar 2014

Rank #4

Most Popular Podcasts

Podcast cover

01 - Reprogramming in Development and Disease

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2013-2014Reprogramming in Development and DiseaseCell Identity Reprogramming: A Historical IntroductionLecture 1

1hr 42mins

10 Mar 2014

Rank #5

Podcast cover

06 - Epigenetics and Heredity

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2012-2013Epigenetics, development and heredityEpigenetics and HeredityLecture 6

1hr 34mins

18 Mar 2013

Rank #6

Podcast cover

05 - Genomic Imprinting - an example of paternal or maternal origin-specific gene expression

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2012-2013Epigenetics, development and heredityEnvironmentally induced epigenetic changesLecture 5

1hr 32mins

11 Mar 2013

Rank #7

Podcast cover

04 - Genomic Imprinting - an example of paternal or maternal origin-specific gene expression

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2012-2013Epigenetics, development and heredityGenomic Imprinting - an example of paternal or maternal origin-specific gene expressionLecture 4

1hr 32mins

25 Feb 2013

Rank #8

Podcast cover

03 - Mammalian X–Chromosome Inactivation – an example of mitotic cellular memory

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2012-2013Epigenetics, development and heredityMammalian X–Chromosome Inactivation – an example of mitotic cellular memoryLecture 3

1hr 36mins

18 Feb 2013

Rank #9

Podcast cover

02 - Molecular Mechanisms of Epigenetic processes : how to read the genome

Edith HeardCollège de FranceEpigenetics and cellular memoryLectures 2012-2013Epigenetics, development and heredityMolecular Mechanisms of Epigenetic processes : how to read the genome and memorize gene expression patterns genome partitioningLecture 2

1hr 41mins

11 Feb 2013

Rank #10