In this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc. (PA, USA), walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also addresses the safety and efficacy of these cell therapies as well as the ethical considerations around them.

Talking Techniques | CAR-T and CAR-NK cell therapies

Phalgun Lolur

AI Summit 2023: an interview with Phalgun Lolur by Future Science Group

AI Summit 2023: an interview with Phalgun Lolur

Uthman Ali

Brain-computer interfaces and neuroethics with Uthman Ali by Future Science Group

Brain-computer interfaces and neuroethics with Uthman Ali

In this Tech Blast episode, we explore preparing 3D cell cultures with Sartorius’ (Goettingen, Germany) Sandra Söderholm, Application Development Specialist, and Maria Voutilainen, Product Manager. Sandra and Maria give us an introduction to 3D cell cultures and how to prepare them, and then delve into a foundational technique that is often overlooked: pipetting. We discuss pipetting techniques, common mistakes and their pipetting dos and don’ts. Contents:Introduction: 00:00–01:30An introduction to 3D cell cultures: 01:30–02:48Preparing 3D cell cultures: 02:48–03:25Don’t overlook your pipetting technique: 03:25–05:45Common pipetting mistakes and how to overcome them: 05:45–08:30Reproducibility of 3D cell cultures: 08:30–10:30

In this Tech Blast episode, we explore preparing 3D cell cultures with Sartorius’ (Goettingen, Germany) Sandra Söderholm, Application Development Specialist, and Maria Voutilainen, Product Manager. Sandra and Maria give us an introduction to 3D cell cultures and how to prepare them, and then delve into a foundational technique that is often overlooked: pipetting. We discuss pipetting techniques, common mistakes and their pipetting dos and don’ts. Contents: Introduction: 00:00–01:30 An introduction to 3D cell cultures: 01:30–02:48 Preparing 3D cell cultures: 02:48–03:25 Don’t overlook your pipetting technique: 03:25–05:45 Common pipetting mistakes and how to overcome them: 05:45–08:30 Reproducibility of 3D cell cultures: 08:30–10:30

Tech Blast | Preparing 3D cell cultures

Gaudry Troché

In our new podcast series, we're joined by a Bioanalysis author to review their publication's biggest challenges, wider implications and next steps. In episode two, Ellen is joined by Research Assistant Gaudry Troché to discuss conventional sampling and microsampling for the comparison of pharmacokinetic study profiles of insulin. Gaudry discusses life as an early career scientist, his plans for the future and his poster presentation at the Health Benefits and Leadership conference in Las Vegas.

Beyond the Abstract: an interview with Gaudry Troché

In this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc., walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also addresses the safety and efficacy of these cell therapies as well as the ethical considerations around them.

Sino Biological IF Podcast

Lance - Interview - FINAL by Future Science Group

Lance - Interview - FINAL

Luciano Floridi

Luciano Floridi Interview Final by Future Science Group

Luciano Floridi Interview Final

Future Science Group

Doris Doudet

Whilst at Society for Neuroscience's annual meeting (Washington DC, USA, 11–15 November 2017), Lauren Pulling (Editor) sat down with Doris Doudet (University of British Columbia, Canada) to hear more about her recent research, which has demonstrated elevated inflammation in the gut of a Parkinson's disease rat model.

NCTalks at SfN17: Doris Doudet on Parkinson's, inflammation and the gut

Eric Bonner

Eric Bonner (Eurofins) discusses the techniques he uses for assessing immunogenicity, key challenges and what the future may hold for the field in this podcast, exclusive to the Bioanalysis Zone Spotlight on immunogenicity. You can find many more resources on immunogenicity via the immunogenicity Spotlight pages on Bioanalysis Zone: http://bit.ly/2J6w15F

Eric Bonner (Eurofins) discusses the techniques he uses for assessing immunogenicity, key challenges and what the future may hold for the field in this podcast, exclusive to the Bioanalysis Zone Spotlight on immunogenicity. You can find many more resources on immunogenicity via the immunogenicity Spotlight pages on Bioanalysis Zone: <a href="http://bit.ly/2J6w15F" rel="nofollow" target="_blank">http://bit.ly/2J6w15F</a>

Immunogenicity with Eric Bonner (Eurofins)

Theo Roth

BioTechniques Digital and Assistant Editors Abigail Sawyer and Tristan Free talk to Theo Roth from the University of California San Francisco Marson Lab (CA, USA). Having recently made headlines for his work in T-cell engineering, Theo takes us through his groundbreaking CRISPR research, its potential impacts in CAR-T cell therapy and further afield, whilst also tackling the evolving ethics in gene editing and the potential benefits of using ssDNA over dsDNA for CRISPR techniques.

Talking Tech News | Theo Roth on CRISPR, CAR-T and gene editing ethics

Greg Michelotti

BioTechniques Digital and Assistant Editors Abigail Sawyer and Tristan Free talk to Greg Mitchelotti of Metabolon about metabolomics, its potential applications in precision medicine and the new $4 million research collaboration with the Canadian Longitudinal Study of Aging and other Canadian institutions to identify biomarkers for frailty.

Talking Techniques | Greg Michelotti on metabolomics, precision medicine and frailty biomarkers

Patrick Connor

Jade Parker, Senior Editor of Oncology Central is joined by Patrick Connor from AstraZeneca to discuss the Lung Ambition Alliance to find out how the Lung Ambition Alliance is looking to one day eliminate lung cancer as a cause of death and double the 5-year survival rate for the disease by 2025.Date of preparation: July 2019 Date of expiry: July 2020 Document ID: Z4-18671

Jade Parker, Senior Editor of Oncology Central is joined by Patrick Connor from AstraZeneca to discuss the Lung Ambition Alliance to find out how the Lung Ambition Alliance is looking to one day eliminate lung cancer as a cause of death and double the 5-year survival rate for the disease by 2025. Date of preparation: July 2019 Date of expiry: July 2020 Document ID: Z4-18671

OCTALKS l Breaking through limits in lung cancer survival with Patrick Connor

Joanne Hackett

Joanne Hackett, Chief Commercial Officer at Genomics England, discusses their goals, completing major milestones in genomics research and approaching precision medicine.

Joanne Hackett on DNA sequencing, 5 million genomes & precision medicine

In this podcast, senior scientists from Alturas Analytics (ID, USA), Katherine Yahvah, Chad Christianson and Michael Williams discuss some of the challenges they have faced and some of the solutions they have successfully implemented.

Expert discussion: challenges facing the modern bioanalyst

Georgi Makin, Editor of 3DMedNet, is joined by Jacob Koffler (University of California San Diego; CA, USA) as they discuss how 3D printing is being used in spinal cord injury research. As part of 3DMedNet’s special feature - 3D in focus: applications in neuro R&amp;D – Georgi and Jacob explore 3D printing in neurology and neuroscience.Find out more: Georgi Makin is the Editor of 3DMedNet (www.3dmednet.com), a community website that unites the diverse and multifaceted world of medical 3D printing with the aim of advancing the field, together.Jacob Koffler is a Bioengineer Neuroscientist working at the Center for Neural Repair within the School of Medicine at the University of California San Diego. Find out more about his work in the full interview on 3DMedNet: http://bit.ly/2LeBTLF Find out more about the neuro applications of 3D printing via 3DMedNet (http://bit.ly/2UhRRJc) and discover more about neurology, neuroscience and regenerative medicine via our supporting sister sites, Neuro Central (www.neuro-central.com) and RegMedNet (www.regmednet.com).

Georgi Makin, Editor of 3DMedNet, is joined by Jacob Koffler (University of California San Diego; CA, USA) as they discuss how 3D printing is being used in spinal cord injury research. As part of 3DMedNet’s special feature - 3D in focus: applications in neuro R&amp;D – Georgi and Jacob explore 3D printing in neurology and neuroscience. Find out more: Georgi Makin is the Editor of 3DMedNet (<a href="http://www.3dmednet.com" rel="nofollow" target="_blank">www.3dmednet.com</a>), a community website that unites the diverse and multifaceted world of medical 3D printing with the aim of advancing the field, together. Jacob Koffler is a Bioengineer Neuroscientist working at the Center for Neural Repair within the School of Medicine at the University of California San Diego. Find out more about his work in the full interview on 3DMedNet: <a href="http://bit.ly/2LeBTLF" rel="nofollow" target="_blank">http://bit.ly/2LeBTLF</a> Find out more about the neuro applications of 3D printing via 3DMedNet (<a href="http://bit.ly/2UhRRJc" rel="nofollow" target="_blank">http://bit.ly/2UhRRJc</a>) and discover more about neurology, neuroscience and regenerative medicine via our supporting sister sites, Neuro Central (<a href="http://www.neuro-central.com" rel="nofollow" target="_blank">www.neuro-central.com</a>) and RegMedNet (<a href="http://www.regmednet.com" rel="nofollow" target="_blank">www.regmednet.com</a>).

3DMedTALKS l 3D printing for spinal cord injury research

Mark Wrona

In this podcast, Mark Wrona (Principal Scientist at Waters Corporation; MA, USA) discusses his experience with HRMS and the current trends in the field of drug metabolism and pharmacokinetics (DMPK). He discusses the role HRMS plays in the analysis of biopharmaceuticals and compares the advantages of HRMS compared to triple quad.

The role of HRMS in DMPK analysis: a podcast with Mark Wrona

Jason Causon

In this podcast, Jason Causon (Technical Product Manager at SCIEX, Canada) discusses his experience with HRMS and the current research focuses at SCIEX. He also details how SCIEX are using HRMS, the biggest challenges that have had to be overcome and future opportunities that he hopes HRMS software will bring.

Challenges and applications of HRMS: a podcast with Jason Causon

David Harris

In this interview, David Harris (Charles River Laboratories; NC, USA) discusses the current global landscape for cell therapy, associated safety concerns and challenges, and preclinical animal models that are used to evaluate cellular therapies.

Cell therapy: an interview with David Harris

In this interview, we talk to Mary Lame, Principal Applications Scientist who supports discovery bioanalysis for both large and small molecules, providing application development and support with Waters Corporation (Milford, MA, USA). Mary will discuss the key challenges scientists face developing robust peptide bioanalytical assays and introduces Waters approach for large molecule bioanalytical quantification method development including: pre-analytical sample preparation, as well as offering tips &amp; tricks to help avoid the most common pitfalls working with peptides to help improve peptide assay performance and to streamline assay development. She also discusses how to enable highly sensitive and robust quantification of biomolecules from complex biomatrices.

Key challenges in Peptide Bioanalysis Sample Preparation

Neil Walsh

Hear more about the recent mass spectrometry product launches from SCIEX announced at ASMS 2019, including the new Acoustic Ejection Mass Spectrometry technology, in this interview with Neil Walsh (SCIEX; MA, USA).

Advancing mass spectrometry technologies: an interview with Neil Walsh

Hans Keirstead

Hans Kierstead, CEO and founder of Aivita Biomedical, Speaks to Tristan Free, Digital Editor of BioTechniqes. Hans delves into his company's exciting new precision immunotherapy, currently undergoing phase II trials and discusses his 2018 run for US Congress, explaining why he is passionate about the need for scientists in politics.

Talking Techniques| Hans Keirstead on precision therapeutics for cancer and science in politics

Szabolcs Szarka

Szabolcs Szarka (LGC) discusses the challenges, benefits and what the future may hold for HRMS in this podcast, exclusive to the Bioanalysis Zone Spotlight on HRMS in DMPK.You can find many more resources on HRMS via the HRMS in DMPK Spotlight pages on Bioanalysis Zone.

Szabolcs Szarka (LGC) discusses the challenges, benefits and what the future may hold for HRMS in this podcast, exclusive to the Bioanalysis Zone Spotlight on HRMS in DMPK. You can find many more resources on HRMS via the HRMS in DMPK Spotlight pages on Bioanalysis Zone.

HRMS in DMPK: an interview with Szabolcs Szarka

Michael Schwenkert

Discover more about the development of CAR-T cell therapies, their bioanalytical challenges and specialized antibody reagents that can be ustilized to overcome these in this interview with Michael Schwenkert (Bio-Rad Laboratories).

CAR-T cell development: an interview with Michael Schwenkert

BioTechniques Digital Editor Tristan Free, speaks to Application Scientist Theresa Thompson and Strategy Director Jay Pasquantonio (both Phoseon Technology) about their UV LEDs. We cover the best wavelengths for disrupting nucleotides and proteins, the challenges associated with some of these wavelengths, and the promising potential of UV LEDs to disinfect inorganic surfaces of SARS-CoV-2. Theresa and Jay also detail the safety procedures required while using this technology and deliver a clear warning against the irradiation of organic matter with UV LEDs.

Talking Techniques | UV LEDs for disinfection and potential protection from SARS-CoV-2

Donald Ingber

In the first installment of this two-part episode with Donald Ingber, Founding Director of the Wyss Institute (MA, USA), we discuss his invention of organ-on-a-chip technology, how he is utilizing them in the fight against COVID-19 and the Wyss Institute's response to the pandemic. Donald touches on the performance of the much-discussed chloroquine in his lung-on-a-chip models. We also discuss the pros and cons of organ-on-a-chip technology verses organoids, exploring their use in combination, before Donald examines the possible replacement of animal models with organ-on-a-chip technology.

Talking Techniques: Donald Ingber on COVID-19, organ-on-a-chip technology and the Wyss Institute

In this episode BioTechniques Digital Editor, Tristan Free speaks to Annie Evans, Director of R&amp;D and David Foster, Vice President of Data and Informatics at Metabolon about the latest developments in microbiome studies, including big data analysis, LCMS, alpha diversity and at-home fecal sample collection.

Talking Techniques | Microbiome studies; big data analysis, LCMS and at-home fecal sample collection

Paul Brennan

In this episode BioTechniques Digital Editor, Tristan Free, speaks to Paul Brennan, President and CEO of NervGen, about the company's new technique, currently under development, for repairing nerve damage and it's potential for treating Alzheimer's. Paul also covers some of the gaps in Alzheimer's research and wades in on the Tau vs Amyloid Beta debate.

Talking Techniques | Paul Brennan: repairing nerve damage and addressing Alzheimer's

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