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Childhood Cancer 2016

Childhood Cancer 2016

Weekly hand curated podcast episodes for learning

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Diet, transplacental carcinogenesis and risk to children: results from the NewGeneris project

Prof Kyrtopoulos speaks with ecancertv at Childhood Cancer 2016 about the NewGeneris project, monitoring maternal diet and establishing biomarkers associated with childhood disease.He outlines the presence of micronuclei, among other biomarkers, as a 'warning sign' for childhood disease, and discusses food groups known to contain oncogenic chemicals.In summary, Prof Kyrtopoulos describes dietary awareness and changes by customers and food manufacturers that can reduce exposure.

7mins

10 Aug 2017

Rank #1

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Making sense of genetic associations with childhood leukaemia risk

Prof Dorak meets with ecancertv at Childhood Cancer 2016 to discuss correlations between genetic markers and the risk of childhood leukaemia.He summarises current research into paediatric leukaemia from across Europe and America, and introduces his own work in a pilot study determining the influence of gender on risk through signalling associated with the RAS pathway.Prof Dorak sets out the future expansion of this research, including collaborations and replication studies with other teams, and discusses other genetic markers for research.

15mins

10 Aug 2017

Rank #2

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Can we reduce exposure to risk factors associated with childhood leukaemia and other cancers?

Dr Miller meets with ecancertv at Childhood Cancer 2016 to discuss a survey of healthcare providers that revealed a gap in information about environmental risk factors for childhood cancer.Air pollution, folate levels and tobacco use are among the factors that affect family's risk even pre-conception.Dr Miller describes the need for wider awareness and public engagement by oncologists on regional and national levels to communicate preventative behaviours more fully.

5mins

10 Aug 2017

Rank #3

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miRNA screening for germ cell tumours

Dr Murray speaks with ecancertv at Childhood Cancer 2016 about his research, made possible by a grant from Children with Cancer UK.He sets out how miRNA profiles of malignant germ cell tumours identified conserved clusters in patients, which have informed screening and targeting for these 'red flags'.Dr Murray outlines the diagnostic significance of screening and possible combined therapies against these conserved mutant miRNAs for both high and low risk patient subgroups.

5mins

10 Aug 2017

Rank #4

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Risk factors for childhood cancer: what are the challenges in research?

Dr Straif meets with ecancertv at Childhood Cancer 2016 to discuss risk factors of childhood leukaemia.

4mins

10 Aug 2017

Rank #5

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ALK mutations in paediatric tumours

Dr Turner speaks with ecancer at Childhood Cancer 2016 about her work, made possible by a project grant from Children with Cancer UK.She describes the role of ALK activity in the aetiology anaplastic large cell lymphoma, and as a target for paediatric therapies following the success of crizotinib in treating ALK lung cancer.Considering the mechanisms of resistance, Dr Turner outlines how her research into screening for 'bypass tracks' might circumvent resistance in childhood disease.

6mins

10 Aug 2017

Rank #6

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Genetic polymorphisms associated with childhood AML

Dr Brisson speaks with ecancertv at Childhood Cancer 2016 about polymorphisms in enzymes required for the benzene processing pathway resulting in variable susceptibility to acute myeloid leukaemia (AML).She highlights NQO1 and GSTM1 polymorphisms were associated with increased risk to differing subtypes of childhood leukaemia.

3mins

10 Aug 2017

Rank #7

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The CAR T cell revolution in cancer therapy

Dr Grupp meets with ecancertv at Childhood Cancer 2016 to discuss how engineered T cells are changing therapy of paediatric tumours.

3mins

10 Aug 2017

Rank #8

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Childhood Cancer 2016: Conference review

Prof Amrolia meets with ecancertv at Childhood Cancer 2016 to discuss novel immunotherapies.

3mins

10 Aug 2017

Rank #9

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Vaccination to improve the persistence of CD19 CAR T cells in relapsed ALL

Dr Ghorashian speaks with ecancertv at Childhood Cancer 2016 about results from a European trial of CD19 CAR T cells to treat relapsed ALL.She describes the creation, transduction and activation of the T cell line, and that vaccination of patients did result in short term benefit.Dr Ghorashian considers that broader impact of engineered T cells, and looks forward to a second generation of CAR cells for her further research.

2mins

10 Aug 2017

Rank #10