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Cell Culture Dish Podcast

The Cell Culture Dish (CCD) podcast covers areas important to the research, discovery, development, and manufacture of disease and biologic therapeutics. Key industry coverage areas include: drug discovery and development, stem cell research, cell and gene therapy, recombinant antibodies, vaccines, and emerging therapeutic modalities.

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New Advancements in Cell and Gene Therapy Implementing Precision Medicine

In this podcast and accompanying article, we talked with Dr. Paul Wotton, Chief Executive Officer, Obsidian Therapeutics about the evolution of cancer therapy and new advancements in the space including precision medicine. Our discussion included Obsidian's cytoDRiVE™ platform that provides a technology, in which the level and timing of protein activity are fully controlled in a dose-dependent manner by an FDA-approved small molecule.


10 Dec 2019

Rank #1

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Viral Vector Manufacturing for Gene Therapy

In this podcast and accompanying article, we interviewed Dr. Mats Lundgren, PhD Customer Applications Director, Life Sciences, GE Healthcare, Sweden about developing platform processes for viral vector manufacturing and Mats describes a recently developed platform process for adenovirus production.


23 Jan 2019

Rank #2

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Expediting cell and gene therapy workflows

In this podcast and accompanying article, we interviewed Mr. Dave Eansor President of the Protein Sciences Segment at Bio-Techne and Dr. Sean Kevlahan, Senior Director of Cell and Gene Therapy at Bio-Techne about new technologies that can be implemented to expedite cell therapy and gene therapy workflows and facilitate the path from bench to clinic.


6 Feb 2019

Rank #3

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Improved gene therapy analytics permit monitoring of critical quality attributes and increased manufacturing efficiency

In this podcast and accompanying article, we interviewed Jonathan Royce, Director, Instruments Business Unit, Vironova about analytics in gene therapy manufacturing. Specifically Jonathan details new technologies to monitor critical quality attributes, reduce development time and increase the number of projects that can be run.


11 Dec 2019

Rank #4

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Key Considerations in Gene Therapy Manufacturing for Commercialization – A panel discussion

Panel discussion that I moderated at this year’s Cell and Gene Therapy Bioprocessing and Commercialization Conference. The discussion covers the latest in gene therapy manufacturing strategies, analytical analysis, cost of goods and key regulatory considerations.


10 Dec 2018

Rank #5

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Innovative vaccine manufacturing enables the delivery of vaccines to the developing world

In this podcast and accompanying article, we interviewed Dr. Alex Chatel, Product Manager, Viral Applications, Univercells about the biggest challenges facing vaccine manufacturing today, why it is so difficult to manufacture and deliver vaccines to the developing world and how a novel technology with the support of the Gates Foundation is poised to address these challenges.


19 Jun 2019

Rank #6

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Antibody Drug Conjugate (ADC) Development and Manufacturing Challenges and Solutions

In this podcast, we interviewed Dr. J.J. Luo, Executive Director and Dr. Lily Yin, Head of Biologics Conjugation Development, at WuXi Biologics about the state of the ADC marketplace and the challenges in developing antibody drug conjugates. We then dove into reasons behind why they built a dedicated manufacturing facility for ADCs and other bioconjugates and how a single-source development platform can benefit bioconjugate drug development efforts.


9 Sep 2019

Rank #7

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Using 3D cell-based human liver microtissue models in predicting adverse effects caused by chronic exposure to engineered nanomaterial

In this podcast and accompanying article, we interviewed Dr. Shareen Doak, Professor of Genotoxicology and Cancer at Swansea University Medical School and Dr. Wolfgang Moritz, Co-founder and Head of External Collaborations and IP, InSphero about the use of 3D cell-based human liver microtissue models to predict the adverse effects of chronic exposure to nanomaterial. We also discussed the use of liver microtissue models for drug discovery and development.


13 Oct 2019

Rank #8

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Closed System Cell Therapy Manufacturing – Moving from the lab to clinical and commercial production

Panel discussion on key considerations for moving cell therapies from lab to commercial manufacturing, including the benefits of manufacturing in a closed system. We also discussed what were some of the key hurdles and possible solutions associated with transitioning to clinical and commercial cell therapy manufacturing.


26 Jul 2018

Rank #9

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How Live Cell Analysis Technology is Meeting the Needs of Ever Evolving Advanced Cell Models

In this podcast and accompanying article, we interviewed Dr. Kimberly Wicklund, Head of Product Management for the IncuCyte® at Sartorius about how live cell analysis is meeting the needs of advanced cell models and how the launch of the new IncuCyte SX1 is providing scientists more options when it comes to using live cell analysis in their workflows.


26 Jun 2019

Rank #10

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Successful Methods for Perfusion Process Optimization

In this podcast, we interviewed Dr. Andreas Castan, Principal Scientist at GE Healthcare Life Sciences about the best methods for optimizing perfusion processes. This included a discussion of tools for media optimization and innovative cell separation techniques.


24 Jul 2019

Rank #11

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Integrating bioprocessing steps to improve efficiency and reduce cost

In this podcast, we interviewed Dr. Rick Morris, Senior Vice President, R&D, Biotech, Pall Life Sciences, about integrating bioprocessing steps to improve efficiency, reduce cost and address current challenges in the industry.  Specifically we looked at how upstream and downstream can be more integrated and how to increase integration in existing facilities.


21 Feb 2019

Rank #12

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Optimizing Fed Batch Culture – Developing New Tools and Methods to Improve Production

In this podcast and accompanying article, we interviewed Dr. Aline Zimmer, Head of R&D, Advanced Cell Culture Technologies at Merck about the importance of optimizing fed batch cell culture for successful biomanufacturing. Aline discussed how her team has developing new tools and methods for optimizing fed batch culture and the impact this has had on productivity and product quality.


29 May 2019

Rank #13

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Successful Mesenchymal Stem Cell Manufacturing for Cell Therapy Applications

Dr. Ross Macdonald, CEO Cynata Therapeutics, talks about the use of mesenchymal stem cells for Cell Therapy applications and key criteria for successful mesenchymal stem cell manufacturing.


31 May 2018

Rank #14

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Mustang Bio’s gene therapy has tremendous potential to cure XSCID or Bubble Boy Disease based on study results from St. Jude

In this podcast, we interviewed Dr. Manny Litchman, President and CEO, Mustang Bio and Dr. Knut Niss, Chief Technology Officer, Mustang Bio about the exciting study results for their gene therapy candidate to treat X-SCID, why this disease is a good fit for gene therapy and next steps.


31 Jul 2019

Rank #15

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FBS – It’s Not All Created Equal – What Consumers Need to Know

Alyssa Master, Ph.D., Senior Manager of Science and Applications, Nucleus Biologics talks about some of the challenges of working with FBS, why not all FBS is created equal and suggestions for FBS customers who are trying to navigate these issues.


9 Nov 2017

Rank #16

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Raw Material Quality – Identifying and Mitigating Variation

In this podcast, we interviewed Cory Card, Principal Scientist Life Sciences, GE Healthcare about raw material quality, its impact on cell culture and technologies to identify and mitigate raw material variation.


24 Sep 2019

Rank #17

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Using cell culture models of endocrine resistance to improve triple positive breast cancer treatment options.

Gibco Cell Culture Hero, Dr. Hillary Stires discusses her work researching better treatment options for triple positive breast cancer patients. She explains how the use of cell culture modeling helps drive her research. She also talks about her experience as a cell culture hero and her passion for the scicomm movement on social media platforms.


1 Apr 2019

Rank #18

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Live Cell Analysis for Neuroscience Research

In this podcast, we talk with Susana Alcantara, Senior R&D Scientist and Neuroscience Program Leader, BioAnalytics, Sartorius about the ways real-time live cell analysis is enabling neuroscience research. We also discussed how real-time cell analysis can be used in neurological disease model development and in studying disease pathology to enable drug discovery.Show Notes:I began the interview by asking Susana what she saw as the biggest challenges surrounding neuroscience research as it relates to cell monitoring and analysis. She explained that she saw the main challenges as being intrinsic to the type of research, specifically that the cells themselves are precious, difficult to obtain, costly and sensitive to handling. Researchers need to be able to sustain these cultures for long periods of time to analyze changes that occur, but common techniques use end point technologies and these aren't able to capture changes in culture over time and they can introduce artifacts.To overcome these challenges, researchers need to avoid unnecessary handling of cells and minimize plate movement thereby providing a stable environment. They also need robust assays to maximize data obtained within each culture, including multiplexing or miniturizing assays. Lastly the development of live cell kinetic approaches is needed to model and monitor these complex neural systems.Next, we discussed the platform that Sartorius has developed to enable cell research. Susana explained that the IncuCyte™ live cell analysis system is an imaging and analysis platform designed to minimize cell disturbance. The camera is on a mobile optical train allowing the culture to remain stationary. Images are then segmented by software that allows quantification in real-time and permits non-invasive measurements. The IncuCyte is flexible and enables the study of many aspects of neuroscience research including cell health and function. Sartorius has created several turnkey solutions including reagents, protocols and advanced software to support researchers.We then talked about the advantages of real-time analysis as it relates to neuroscience research. Susana described that the brain is a complex system and its function depends on dynamic interplay between cells. In neuroscience research you must be able to evaluate temporal changes to understand how the brain functions in healthy and disease states. Researchers can evaluate these developments via temporal changes monitored using live cell analysis. Another important capability is repeated measurements to capture significant and subtle changes. Being able to do this in real-time permits real-time decisions to be made. For example, researchers can have a better understanding of when the culture is ready to be treated and this can enable method optimization. In addition, when an experiment fails, you can go back to the images and can quantify them retrospectively to see what went wrong and why.Next I asked Susana about the assays that Sartorius has developed to assist in neuroscience research and workflows. She explained how the IncuCyte provides flexible analysis of multiple cell types using a combination of applications that have been developed. There has been a plethora of real-time protocols to look at cell health, morphological changes, and cell function.These assays provide unprecedented access to cellular changes over time.I then brought up a white paper that I had read on how real-time live cell analysis can be used in neurological disease model development and in studying disease pathology to enable drug discovery. Susana said that the white paper had great real life examples of the applications developed for the IncuCyte. The applications covered in the white paper fell into three areas of study: neurodynamics, neuronal action and neuroimmunology research.Another area that I wanted to touch on was how live cell analysis can compliment other end point technologies currently being us...


29 Oct 2019

Rank #19

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Cell Therapy Manufacturing – Opportunities and Challenges

Dr. Robert Preti talks about the past, present, and future of global Cell Therapy manufacturing. We also discussed major industry milestones, manufacturing challenges, and opportunities for further improvements.


20 Mar 2018

Rank #20