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Discovery Matters

A collection of stories and insights on matters of discovery that advance life sciences. Brought to you by the curious people at Cytiva.

Weekly hand curated podcast episodes for learning

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The best episodes ranked using user listens.

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4. The role of AI in pandemics

A pandemic starts with a picnic.  But can pandemics be prevented without cancelling feel-good gatherings? Enter Artificial Intelligence into the world of healthcare and life sciences.  Dodi meets up with an expert panel on the topic and gets examples of the real potential of this very trendy topic.

13mins

30 Jul 2019

Rank #1

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6. CAR-T cell therapy: the story of 2 brave young women fighting cancer

This episode is a more immediately serious story than previous topics we've covered.  This story is about a discovery where a number of people had to go through unimaginable pain so that it can become useful for others.  This is the story of Emily Whitehead, the first pediatric patient enrolled in a clinical trial investigating CAR T-cell therapy CTL019, now known as tisagenlecleucel, at Children’s Hospital of Philadelphia (CHOP). Emily is now a happy, healthy 14 year old in remission for the past 7 years.  This is also the story of Nicole Gularte, the leukemia patient who beat cancer 8 times (!!!) and is the recipient of no less than 3 rounds of CAR-T cell therapy for acute lymphoblastic leukemia (ALL). On Nov 23rd she will walk 8 km ahead of Philadelphia Marathon to raise money and awareness for the Emily Whitehead Foundation. You can help by donating here: www.bit.ly/nicolecart 

21mins

18 Oct 2019

Rank #2

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1. Tea and jam and protein separation

Dodi and Conor discover how jam played a part in paving the way for biopharmaceutical drugs. 60 years ago, Swedish scientists happened upon a new method of protein separation through chromatography. The very same technique continues to be the foundation for modern biomedical manufacturing.

17mins

12 Jul 2019

Rank #3

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9. Innovation inside-the-box, cyborgs and jugaad (जुगाड)

Follow Dodi as she dives into the world of innovation. More specifically, the difference between talking innovation and being innovative. Meet Tobias the cyborg that likes thinking inside the box and learn what Gaud has to say about the concept of jugaad in India.

19mins

29 Nov 2019

Rank #4

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8. Microbiome transplant: cooties can cure you

Conor has, what he calls "microbiomania". Whatever the topic, he is able to bring it back to microbiomes in about 3 sentences. So imagine how excited he was to interview Colleen Cutcliffe, CEO of Pendulum whose mission is to make millions healthier through microbiome-targeted medical solutions. Another guest on this episode is Jacques Ravel, professor extraordinaire of The Human Microbiome and Women's Health at the Institute for Genome Sciences, University of Maryland.  Enjoy ! (We sure did!) Interested in Conor's microbiomania? He writes regularly on his LinkedIn account. You can also read more Discovery Matters on our Medium publication. (with the same name).

18mins

18 Nov 2019

Rank #5

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7. Fitness trackers in the 1940s: The Framingham Heart Study

During a lively lunch chat about the popularity of wearable fitness trackers, the curious question came up: with all this data we are generating, what if we were able to do it 50-70 years ago - where would medicine and healthcare be now? Hearing the question Dodi immediately remembered The Framingham Heart Study. Its objective was to identify the common factors or characteristics that contribute to cardiovascular disease (CVD) by following its development over a long period of time in a large group of participants who had not yet developed overt symptoms of CVD or suffered a heart attack or stroke. The research is still ongoing after 70 years and has now added Alzheimers and diabetes to their list. Tune in to listen to Dr. Vasan Ramachandran, Principal Investigator and Director Framingham Heart Study; Professor, Boston University School of Medicine and Tom Gracia, a participant of the study for more than 40 years.

14mins

1 Nov 2019

Rank #6

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10. Perspectives for health - learning about blockchain

Blockchain is everywhere.  Is it the technology we've all been waiting for? Sometimes, and sometimes not. Dodi and Conor talk with Dr. Catherine Mulligan about what blockchain is, and how it's most useful for us.

22mins

13 Dec 2019

Rank #7

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5. A map of humankind from the inside out

We humans have been mapping things since the beginning of time. In our endless quest to figure ourselves and our world out, there are projects galore. Does the 150 year old periodic table ring any bells?  In this episode Dodi takes Conor on an explorer’s journey, destination: Human Protein Atlas project.  Strap on your seatbelt, it’s a bumpy ride connecting the dots between explorers, chemists, geneticists…and even sociologists! 

21mins

21 Aug 2019

Rank #8

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18. Quantum biology: going subatomic

How do birds know where to go in the winter? And why are plants so efficient at making food? Conor and Dodi chat with researchers studying whether quantum biology might offer answers.

18mins

11 May 2020

Rank #9

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17. How does your brain discover what it wants

In this episode Dodi and Conor take 2 minutes to celebrate the birth of Cytiva, company formerly part of GE Healthcare Life Sciences. Yes, only 2 minutes because they're immediately more interested in the science behind choices our brains make. They are joined by Uma Karmarkar, Assistant Professor in Marketing at UCSD focusing on Decision Neuroscience and Tim Arthur, currently a radio presenter for the BBC and an expert in helping organisations through change. 

25mins

23 Apr 2020

Rank #10

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16. The artistry of vaccine development

"Vaccines are a way to educate our immune system to recognize foreign and dangerous stuff." - says Daria Donati, Director of Business Development and Innovation at Cytiva. Dodi and Conor embark on a journey in this episode of Discovery matters: the journey of a vaccine.  They are joined by Adrian Hill, Professor of Human Genetics at the University of Oxford and Consultant Physician and Rebecca Chandler, Senior Contributor at WHO's Uppsala Monitoring Center. 

22mins

27 Mar 2020

Rank #11

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15. How to: Small biotechs into big companies

How do big companies stay at the forefront of the industry? How do small companies "make it big" ? In this episode of Discovery Matters, Conor and Dodi chat with 3 guests to find some answers.  Please welcome Kath Mackay, managing director at Alderley Park, Steve Bates, CEO of the BioIndustry Asociation (BIA) and Oliver Hardick, board member of the BIA and business leader at Cytiva. 

25mins

12 Mar 2020

Rank #12

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14. The story of oligonucleotides and spinal muscular atrophy

In this episode Conor tells Dodi the story of Roy Muhrbeck. It all started 4 years ago when new parents, Hugo Muhrbeck and Maja Ödmann brought home their first child. They were excited and nervous as so many first time parents are. But after a short while, they started to think that maybe everything wasn’t exactly how it should be. Soon after, their son Roy was diagnosed with spinal muscular atrophy (SMA).  Stay tuned to find out how oligonucleotides (oligos) help Roy and where he is today. 

21mins

27 Feb 2020

Rank #13

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13. Scratched knees, smelly yogurt, and speedy wound healing

So, what does yogurt have to do with wound healing? In this episode, Evelina Vågesjö from Ilya Pharma helps Conor and Dodi see the connection. It’s all about getting help from our small bacterial friends, lactic acid, and chemokines. Tune in to learn how it all connects.

18mins

30 Jan 2020

Rank #14

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12. School’s never out: Educating the next gen biopharma talents

Education matters for sure. But what is special about biopharmaceutical education? And what does the future hold? Dodi and Conor are about to find out. Their guides in this episode are Killian O’Driscoll at NIBRT, Ireland, and Ron Kander at Thomas Jefferson University, US.

19mins

10 Jan 2020

Rank #15