 ISCHEMIA trial hailed as practice changing The largest-ever RCT of initial invasive versus conservative management of stable ischemic heart disease makes waves.  DAPA-HF: Dapagliflozin’s HFrEF efficacy confirmed in nondiabetics Further analyses from the DAPA-HF trial showed dapagliflozin cut death and heart failure events in HFrEF patients with no diabetes.  Colchicine cut post-MI CVD events Colchicine fulfilled the promise first seem in CANTOS that anti-inflammatory treatment can reduce cardiovascular disease events.  Getting high heightens stroke, arrhythmia risks Cannabis use or abuse among the young was associated with adverse cardiovascular consequences in two studies. Editor's note: This is the final episode of the MDedge Cardiocast. On behalf of Dr. Jim Dwyer and all of us at MDedge, thank you for supporting Cardiocast. For more MDedge podcasts, go to www.mdedge.com/podcasts.  Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeTweets

<a href="https://www.mdedge.com/cardiology/article/212450/interventional-cardiology-surgery/ischemia-trial-hailed-practice-changing" rel="nofollow" target="_blank"> ISCHEMIA trial hailed as practice changing</a> The largest-ever RCT of initial invasive versus conservative management of stable ischemic heart disease makes waves. <a href="https://www.mdedge.com/cardiology/article/212449/heart-failure/dapa-hf-dapagliflozins-hfref-efficacy-confirmed-nondiabetics" rel="nofollow" target="_blank"> DAPA-HF: Dapagliflozin’s HFrEF efficacy confirmed in nondiabetics</a> Further analyses from the DAPA-HF trial showed dapagliflozin cut death and heart failure events in HFrEF patients with no diabetes. <a href="https://www.mdedge.com/cardiology/article/212986/acute-coronary-syndromes/colchicine-cut-post-mi-cvd-events?channel=39313" rel="nofollow" target="_blank"> Colchicine cut post-MI CVD events</a> Colchicine fulfilled the promise first seem in CANTOS that anti-inflammatory treatment can reduce cardiovascular disease events. <a href="https://www.mdedge.com/cardiology/article/211970/pulmonology/getting-high-heightens-stroke-arrhythmia-risks" rel="nofollow" target="_blank"> Getting high heightens stroke, arrhythmia risks</a> Cannabis use or abuse among the young was associated with adverse cardiovascular consequences in two studies. Editor's note: This is the final episode of the MDedge Cardiocast. On behalf of Dr. Jim Dwyer and all of us at MDedge, thank you for supporting Cardiocast. For more MDedge podcasts, go to <a href="http://www.mdedge.com/podcasts" rel="nofollow" target="_blank">www.mdedge.com/podcasts</a>.  Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="https://www.twitter.com/MDedgeTweets" rel="nofollow" target="_blank">@MDedgeTweets</a>

Vascepa gains event-reduction nod; diabetes ups ischemic risks

 Women have fewer cardiovascular events after non–ST-segment elevation ACS But they also remain undertreated with guideline-directed therapies. *  *  *   Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 *  *  *    FDA panel rejects vernakalant bid for AFib cardioversion indication Eleven years after the first attempt of the antiarrhythmic agent, the FDA panel voted resoundingly against approval.  Bariatric surgery tied to fewer cerebrovascular events The incidence of cerebrovascular events was 65% lower in obese people who underwent bariatric surgery compared with those without surgery  Intensive BP control cut dementia but increased brain atrophy and hurt cognitionThe small but significant ill effects worried some researchers at the Clinical Trials on Alzheimer's Disease conference. *  *  *   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeTweets

<a href="https://www.mdedge.com/cardiology/article/213818/acute-coronary-syndromes/women-have-fewer-cardiovascular-events-after-non?channel=39313" rel="nofollow" target="_blank"> Women have fewer cardiovascular events after non–ST-segment elevation ACS</a> But they also remain undertreated with guideline-directed therapies. *  *  *   Help us make this podcast better! Please take our short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> *  *  *   <a href="https://www.mdedge.com/cardiology/article/214099/arrhythmias-ep/fda-panel-rejects-vernakalant-bid-afib-cardioversion" rel="nofollow" target="_blank"> FDA panel rejects vernakalant bid for AFib cardioversion indication</a> Eleven years after the first attempt of the antiarrhythmic agent, the FDA panel voted resoundingly against approval. <a href="https://www.mdedge.com/cardiology/article/213981/stroke/bariatric-surgery-tied-fewer-cerebrovascular-events?channel=39313" rel="nofollow" target="_blank"> Bariatric surgery tied to fewer cerebrovascular events</a> The incidence of cerebrovascular events was 65% lower in obese people who underwent bariatric surgery compared with those without surgery <a href="https://www.mdedge.com/cardiology/article/213633/alzheimers-cognition/intensive-bp-control-reduced-dementia-increased-brain?channel=39313" rel="nofollow" target="_blank"> Intensive BP control cut dementia but increased brain atrophy and hurt cognition</a>The small but significant ill effects worried some researchers at the Clinical Trials on Alzheimer's Disease conference. *  *  *   For more MDedge Podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>

Post-STEMI events less likely in women; bariatric surgery may lower stroke risk

 Icosapent ethyl cost effective in REDUCE-IT analysis Treatment with the fish-derived drug Vascepa for CV event reduction is more effective and less costly than placebo. *  *  *   Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 *  *  *    DAPA-HF: Dapagliflozin benefits regardless of age, HF severity The SGLT2 inhibitor had similar efficacy in the elderly and across the spectrum of baseline symptom status.  Colchicine cut post-MI CVD events Colchicine fulfilled the promise first seem in CANTOS that anti-inflammatory treatment can reduce cardiovascular disease events.  Cardiac arrests peak with pollution in Japan The incidence of out-of-hospital cardiac arrests in Japan increased on days when counts of particulate matter spiked from the day before. *  *  *   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeTweets

<a href="https://www.mdedge.com/cardiology/article/213302/cad-atherosclerosis/icosapent-ethyl-cost-effective-reduce-it-analysis" rel="nofollow" target="_blank"> Icosapent ethyl cost effective in REDUCE-IT analysis</a> Treatment with the fish-derived drug <a href="https://www.vascepa.com/assets/pdf/Vascepa_PI.pdf" rel="nofollow" target="_blank">Vascepa</a> for CV event reduction is more effective and less costly than placebo. *  *  *   Help us make this podcast better! Please take our short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> *  *  *   <a href="https://www.mdedge.com/cardiology/article/213090/heart-failure/dapa-hf-dapagliflozin-benefits-regardless-age-hf-severity?channel=39313" rel="nofollow" target="_blank"> DAPA-HF: Dapagliflozin benefits regardless of age, HF severity</a> The SGLT2 inhibitor had similar efficacy in the elderly and across the spectrum of baseline symptom status. <a href="https://www.mdedge.com/cardiology/article/212986/acute-coronary-syndromes/colchicine-cut-post-mi-cvd-events?channel=39313" rel="nofollow" target="_blank"> Colchicine cut post-MI CVD events</a> Colchicine fulfilled the promise first seem in CANTOS that anti-inflammatory treatment can reduce cardiovascular disease events. <a href="https://www.mdedge.com/cardiology/article/213410/acute-coronary-syndromes/cardiac-arrests-peak-pollution-japan" rel="nofollow" target="_blank"> Cardiac arrests peak with pollution in Japan</a> The incidence of out-of-hospital cardiac arrests in Japan increased on days when counts of particulate matter spiked from the day before. *  *  *   For more MDedge Podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>

New trick for old drug; Vascepa cost effective for CV reduction

This week’s Cardiocast is devoted entirely to Card Talk with cardiologist brothers Jim and Jerry Dwyer. They welcome two structural interventionalists at the Structural Heart and Valve Center at Emory Healthcare,  Kendra J. Grubb, MD, and  Isida Byku, MD. Both followed a unique track, training in both cardiac surgery and interventional cardiology and practicing in the fast-moving field of structural heart disease. *  *  *   Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 *  *  *   From the “picture that went around the world” of an all-female transcatheter aortic valve replacement team at Emory to advances in structural heart disease treatment, this interview includes expanding TAVR beyond the aortic valve and interventional heart failure treatment using “hooks and anchors and pulleys” to reshape the heart. Dr. Grubb is assistant professor in surgery and medicine at Emory University in Atlanta and surgical director of the Structural Heart and Valve Center at Emory Healthcare. On Twitter @KendraGrubb. She is an adviser, consultant, and/or speaker for Boston Scientific, Edwards, and Medtronic. She is also a principal investigator in Medtronic’s Optimize PRO trial and Ancora’s CorCinch PMVI studies. Dr. Isida Byku is an assistant professor at Emory University. On Twitter @IsidaByku. She has no disclosures.  *  *  *   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeTweets

This week’s Cardiocast is devoted entirely to Card Talk with cardiologist brothers Jim and Jerry Dwyer. They welcome two structural interventionalists at the Structural Heart and Valve Center at Emory Healthcare, <a href="http://www.surgery.emory.edu/about-us/faculty_directory/faculty_profile_kendra_grubb.html" rel="nofollow" target="_blank"> Kendra J. Grubb, MD</a>, and <a href="http://medicine.emory.edu/cardiology/emory-first-faculty-directory/profile.html?f=IBYKU" rel="nofollow" target="_blank"> Isida Byku, MD</a>. Both followed a unique track, training in both cardiac surgery and interventional cardiology and practicing in the fast-moving field of structural heart disease. *  *  *   Help us make this podcast better! Please take our short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> *  *  *   From the “<a href="https://twitter.com/KendraGrubb/status/1174770359293419528" rel="nofollow" target="_blank">picture that went around the world</a>” of an all-female transcatheter aortic valve replacement team at Emory to advances in structural heart disease treatment, this interview includes expanding TAVR beyond the aortic valve and interventional heart failure treatment using “hooks and anchors and pulleys” to reshape the heart. Dr. Grubb is assistant professor in surgery and medicine at Emory University in Atlanta and surgical director of the Structural Heart and Valve Center at Emory Healthcare. On Twitter <a href="https://twitter.com/kendragrubb?lang=en" rel="nofollow" target="_blank">@KendraGrubb</a>. She is an adviser, consultant, and/or speaker for Boston Scientific, Edwards, and Medtronic. She is also a principal investigator in Medtronic’s <a href="https://clinicaltrials.gov/ct2/show/NCT04091048?term=kendra+grubb&amp;draw=2&amp;rank=2" rel="noopener nofollow" target="_blank">Optimize PRO</a> trial and Ancora’s CorCinch PMVI studies. Dr. Isida Byku is an assistant professor at Emory University. On Twitter <a href="https://twitter.com/isidabyku?lang=en" rel="nofollow" target="_blank">@IsidaByku</a>. She has no disclosures.  *  *  *   For more MDedge Podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>

Card Talk: TAVR and glass ceilings

In this special meeting edition of the Cardiocast, MDedge Cardiology editor Catherine Hackett is joined by MDedge reporters Mitchel L. Zoler, Bruce Jancin, and Richard Mark Kirkner.  The MDedge cardiology team reviews three big stories from the 2019 annual scientific sessions of the American Heart Association in Philadelphia.  * * *  Help us make this podcast better! Please take this short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * ISCHEMIA trial hailed as practice changing The results of the ISCHEMIA trial were emphatically declared practice changing by interventional cardiologists and noninterventionalists alike at the AHA meeting.  Bruce Jancin discusses the story. DAPA-HF: Dapagliflozin's HFrRF efficacy confirmed in nondiabetes The results in nondiabetics from the practice-changing DAPA-HF trial gives clinicians strong evidence that the diabetes drug dapagliflozin is equally effective at reducing cardiovascular death and acute exacerbations in heart failure patients regardless of diabetes status.  Mitchel L. Zoler discusses this report.  Weakness exposed in valsartan recall ED visits for hypertension in the month after the 2018 recall spiked 55%. The 2018 recall of generic forms of the antihypertensive drug valsartan exposed weaknesses in the recall systems for generics in both the U.S. and Canada that caused many patients who were on the drug to fall through the cracks.  Richard Mark Kirkner goes deeper into this story.  *  *  *   For full coverage of AHA 2019 visit MDedge Cardiology For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeCardio

In this special meeting edition of the Cardiocast, MDedge Cardiology editor Catherine Hackett is joined by MDedge reporters Mitchel L. Zoler, Bruce Jancin, and Richard Mark Kirkner.  The MDedge cardiology team reviews three big stories from the 2019 annual scientific sessions of the American Heart Association in Philadelphia.  * * *  Help us make this podcast better! Please take this short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> * * * <a href="http://bit.ly/37BCEZx" rel="nofollow" target="_blank">ISCHEMIA trial hailed as practice changing</a> The results of the ISCHEMIA trial were emphatically declared practice changing by interventional cardiologists and noninterventionalists alike at the AHA meeting.  Bruce Jancin discusses the story. <a href="http://bit.ly/2KQDmsj" rel="nofollow" target="_blank">DAPA-HF: Dapagliflozin's HFrRF efficacy confirmed in nondiabetes</a> The results in nondiabetics from the practice-changing DAPA-HF trial gives clinicians strong evidence that the diabetes drug dapagliflozin is equally effective at reducing cardiovascular death and acute exacerbations in heart failure patients regardless of diabetes status.  Mitchel L. Zoler discusses this report.  <a href="http://bit.ly/2rmklqE" rel="nofollow" target="_blank">Weakness exposed in valsartan recall</a> ED visits for hypertension in the month after the 2018 recall spiked 55%. The 2018 recall of generic forms of the antihypertensive drug valsartan exposed weaknesses in the recall systems for generics in both the U.S. and Canada that caused many patients who were on the drug to fall through the cracks.  Richard Mark Kirkner goes deeper into this story.  *  *  *   For full coverage of AHA 2019 visit <a href="http://bit.ly/2pQ7jkX" rel="nofollow" target="_blank">MDedge Cardiology</a> For more MDedge Podcasts, go to <a href="http://mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: @MDedgeCardio

ISCHEMIA trial, DAPA-HF, and valsartan recall: AHA Special

 ISCHEMIA trial hailed as practice changing The largest-ever RCT of initial invasive versus conservative management of stable ischemic heart disease makes waves. *  *  *    Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 *  *  *    DAPA-HF: Dapagliflozin’s HFrEF efficacy confirmed in nondiabetics Further analyses from the DAPA-HF trial showed dapagliflozin cut death and heart failure events in HFrEF patients with no diabetes.  The TWILIGHT of aspirin post-PCI for ACS? Patients do better post-PCI for non-ST-elevation ACS with ticagrelor monotherapy  Weaknesses exposed in valsartan recall ED visits for hypertension in month after the 2018 recall spiked 55% *  *  *   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeTweets

<a href="https://www.mdedge.com/cardiology/article/212450/interventional-cardiology-surgery/ischemia-trial-hailed-practice-changing" rel="nofollow" target="_blank"> ISCHEMIA trial hailed as practice changing</a> The largest-ever RCT of initial invasive versus conservative management of stable ischemic heart disease makes waves. *  *  *   Help us make this podcast better! Please take our short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> *  *  *   <a href="https://www.mdedge.com/cardiology/article/212449/heart-failure/dapa-hf-dapagliflozins-hfref-efficacy-confirmed-nondiabetics" rel="nofollow" target="_blank"> DAPA-HF: Dapagliflozin’s HFrEF efficacy confirmed in nondiabetics</a> Further analyses from the DAPA-HF trial showed dapagliflozin cut death and heart failure events in HFrEF patients with no diabetes. <a href="https://www.mdedge.com/cardiology/article/212513/interventional-cardiology-surgery/twilight-aspirin-post-pci-acs" rel="nofollow" target="_blank"> The TWILIGHT of aspirin post-PCI for ACS?</a> Patients do better post-PCI for non-ST-elevation ACS with ticagrelor monotherapy <a href="https://www.mdedge.com/cardiology/article/212447/hypertension/weaknesses-exposed-valsartan-recall" rel="nofollow" target="_blank"> Weaknesses exposed in valsartan recall</a> ED visits for hypertension in month after the 2018 recall spiked 55% *  *  *   For more MDedge Podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>

Long-awaited ISCHEMIA results to change practice, DAPA-HF elevates dapagliflozin for HFrEF

 Getting high heightens stroke, arrhythmia risks Cannabis use or abuse among the young was associated with adverse cardiovascular consequences in two studies. *  *  *  Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 *  *  *   Bempedoic acid cuts LDL by 15% in patients with high levels despite maximal treatment CLEAR Wisdom may fill a niche for patients who can't get levels down.  Low LDL-C and blood pressure can reduce lifetime risk of CVD by 80% The effects were seen in those with genetic variants linked with low LDL cholesterol and systolic blood pressure.  Statins in children cut long-term CVD risk in familial hypercholesterolemia There were no cardiovascular-related deaths and one event in treated patients who were followed for 20 years

<a href="https://www.mdedge.com/cardiology/article/211970/pulmonology/getting-high-heightens-stroke-arrhythmia-risks" rel="nofollow" target="_blank"> Getting high heightens stroke, arrhythmia risks</a> Cannabis use or abuse among the young was associated with adverse cardiovascular consequences in two studies. *  *  *  Help us make this podcast better! Please take our short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> *  *  *  <a href="https://www.mdedge.com/cardiology/article/212279/lipid-disorders/bempedoic-acid-cuts-ldl-15-patients-already-maximal" rel="nofollow" target="_blank"> Bempedoic acid cuts LDL by 15% in patients with high levels despite maximal treatment</a> CLEAR Wisdom may fill a niche for patients who can't get levels down. <a href="https://www.mdedge.com/cardiology/article/212027/lipid-disorders/low-ldl-c-and-blood-pressure-can-reduce-lifetime-risk-cvd" rel="nofollow" target="_blank"> Low LDL-C and blood pressure can reduce lifetime risk of CVD by 80%</a> The effects were seen in those with genetic variants linked with low LDL cholesterol and systolic blood pressure. <a href="https://www.mdedge.com/cardiology/article/212063/lipid-disorders/statins-children-cut-long-term-cvd-risk-familial" rel="nofollow" target="_blank"> Statins in children cut long-term CVD risk in familial hypercholesterolemia</a> There were no cardiovascular-related deaths and one event in treated patients who were followed for 20 years

Pot heightens stroke, arrhythmia risks; keeping low LDL and BP slashes lifetime heart risk

 Closing the missing link between childhood risk factors and adult cardiovascular outcomes Prescient childhood cohort studies launched in the 1970s are paying off.  * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * *  Metabolic signs of adult diabetes apparent in very young children Disturbed HDL cholesterol metabolism may be one of the earliest features of type 2 diabetes.  Sacubitril/valsartan suggests HFpEF benefit in neutral PARAGON-HF The primary endpoint was neutral, but desperation for a HFpEF therapy highlights a subgroup analysis.  * * * For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeTweets

<a href="https://www.mdedge.com/cardiology/article/211445/cardiology/closing-missing-link-between-childhood-risk-factors-and-adult?channel=39313" rel="nofollow" target="_blank"> Closing the missing link between childhood risk factors and adult cardiovascular outcomes</a> Prescient childhood cohort studies launched in the 1970s are paying off.  * * * Help us make this podcast better! Please take our short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> * * * <a href="https://www.mdedge.com/cardiology/article/211537/diabetes/signs-adult-diabetes-apparent-very-young-children?channel=39313" rel="nofollow" target="_blank"> Metabolic signs of adult diabetes apparent in very young children</a> Disturbed HDL cholesterol metabolism may be one of the earliest features of type 2 diabetes. <a href="https://www.mdedge.com/cardiology/article/211411/heart-failure/sacubitril/valsartan-suggests-hfpef-benefit-neutral-paragon" rel="nofollow" target="_blank"> Sacubitril/valsartan suggests HFpEF benefit in neutral PARAGON-HF</a> The primary endpoint was neutral, but desperation for a HFpEF therapy highlights a subgroup analysis.  * * * For more MDedge Podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>

How risk factors in childhood translate to CV outcomes in adulthood

 Patients frequently drive too soon after ICD implantation Many patients didn’t recall ever receiving instruction about when to drive again. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * *  One-third of CVD disease in blacks linked to hypertension A large analysis suggests intervention throughout all ages could have substantial impact.  Cancer overtakes CVD as cause of death in high-income countries The balance is shifting because cardiovascular deaths are way down in high-resource nations.  Virtual visits may cut no-show rate for follow-up HF appointment No-show rates cut by about one-third for patients who met their clinician via video.   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeTweets

<a href="https://www.mdedge.com/cardiology/article/210966/arrhythmias-ep/patients-frequently-drive-too-soon-after-icd-implantation?channel=39313" rel="nofollow" target="_blank"> Patients frequently drive too soon after ICD implantation</a> Many patients didn’t recall ever receiving instruction about when to drive again. * * * Help us make this podcast better! Please take our short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> * * * <a href="https://www.mdedge.com/cardiology/article/210983/hypertension/one-third-cvd-disease-blacks-linked-hypertension" rel="nofollow" target="_blank"> One-third of CVD disease in blacks linked to hypertension</a> A large analysis suggests intervention throughout all ages could have substantial impact. <a href="https://www.mdedge.com/cardiology/article/210963/cad-atherosclerosis/cancer-overtakes-cvd-cause-death-high-income-countries" rel="nofollow" target="_blank"> Cancer overtakes CVD as cause of death in high-income countries</a> The balance is shifting because cardiovascular deaths are way down in high-resource nations. <a href="https://www.mdedge.com/cardiology/article/210973/heart-failure/virtual-visits-may-cut-no-show-rate-follow-hf-appointment?channel=39313" rel="nofollow" target="_blank"> Virtual visits may cut no-show rate for follow-up HF appointment</a> No-show rates cut by about one-third for patients who met their clinician via video. For more MDedge Podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>

Driving while defibrillating; hypertension holds greater risk in black patients

MDedge Cardiocast is the weekly podcast from Cardiology News. The information in this podcast is provided for informational and educational purposes only.

MDedge Cardiocast

This week in cardiology news,  revised atrial fibrillation guidelines revamp anticoagulation, the SPRINT MIND results showing that  tight BP control staves off mild cognitive impairment are published, the FDA discovers that  nitrosamine-contaminated ARBs have been on the market for years, and subclinical hypothyroidism  boosts the immediate risk of heart failure.

This week in cardiology news, <a href="https://www.mdedge.com/cardiology/article/193439/arrhythmias-ep/revised-us-fib-guidelines-revamp-anticoagulation" rel="nofollow" target="_blank"> revised atrial fibrillation guidelines</a> revamp anticoagulation, the SPRINT MIND results showing that <a href="https://www.mdedge.com/cardiology/article/193398/hypertension/sprint-mind-published-extension-trial-add-2-years-follow" rel="nofollow" target="_blank"> tight BP control staves off mild cognitive impairment</a> are published, the FDA discovers that <a href="https://www.mdedge.com/cardiology/article/193320/cardiology/fda-nitrosamine-contaminated-arbs-marketed-4-years" rel="nofollow" target="_blank"> nitrosamine-contaminated ARBs</a> have been on the market for years, and subclinical hypothyroidism <a href="https://www.mdedge.com/cardiology/article/193227/heart-failure/subclinical-hypothyroidism-boosts-immediate-risk-heart" rel="nofollow" target="_blank"> boosts the immediate risk of heart failure</a>.

Atrial fib guidelines updated, SPRINT MIND published, and more  

The MDedge cardiology team is back for the second edition of their debrief on the 2018 annual congress of the European Society of Cardiology. The team includes MDedge editor Catherine Hackett and MDedge reporters Bruce Jancin and Mitchel Zoler.

The MDedge cardiology team is back for the second edition of their debrief on the 2018 annual congress of the European Society of Cardiology. The team includes MDedge editor Catherine Hackett and MDedge reporters Bruce Jancin and Mitchel Zoler.

ESC 2018: Part II

The top news in cardiology:    Meeting just 2 of 7 ‘simple’ goals lowers HF risk American Heart Association recommendations seem to lower risk even if only a couple of the 'Simple 7' are mastered.   Increased cardiovascular risk seen early on with testosterone replacement therapy Testosterone replacement therapy for low testosterone is linked to an early increase in the risk of cardiovascular and cerebrovascular events.   No increase in UTI risk with SGLT-2 inhibitors SGLT-2 inhibitors are not associated with an increased risk of severe urinary tract infections.   As patients, physicians fare nearly the same as everybody else Physicians do only slightly better than nonphysicians in adhering to guidelines "but not by much and not always."  You can contact the MDedge Cardiocast by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

The top news in cardiology: <ol> <li> <a href="https://www.mdedge.com/cardiology/article/205326/heart-failure/meeting-just-2-7-simple-goals-lowers-hf-risk?channel=39313" rel="nofollow" target="_blank"> Meeting just 2 of 7 ‘simple’ goals lowers HF risk</a> American Heart Association recommendations seem to lower risk even if only a couple of the 'Simple 7' are mastered. </li> <li><a href="https://www.mdedge.com/cardiology/article/205285/mens-health/increased-cardiovascular-risk-seen-early-testosterone" rel="nofollow" target="_blank"> Increased cardiovascular risk seen early on with testosterone replacement therapy</a> Testosterone replacement therapy for low testosterone is linked to an early increase in the risk of cardiovascular and cerebrovascular events. </li> <li><a href="https://www.mdedge.com/cardiology/article/205421/diabetes/no-increase-uti-risk-sglt-2-inhibitors" rel="nofollow" target="_blank"> No increase in UTI risk with SGLT-2 inhibitors</a> SGLT-2 inhibitors are not associated with an increased risk of severe urinary tract infections. </li> <li><a href="https://www.mdedge.com/cardiology/search?search_api_views_fulltext=As+patients%2C+physicians+fare+nearly+the+same+as+everyone+else" rel="nofollow" target="_blank"> As patients, physicians fare nearly the same as everybody else</a> Physicians do only slightly better than nonphysicians in adhering to guidelines "but not by much and not always."</li> </ol> You can contact the MDedge Cardiocast by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

Seven simple rules of heart failure risk - you only need two

This week in clinical cardiology.     PCI reduces mortality after STEMI in older adults.     Canagliflozin lowers kidney failure risk in T2D: CREDENCE.     Poor response to statins hikes risk of cardiovascular events.     Low LDL cholesterol may increase women’s risk of hemorrhagic stroke  

This week in clinical cardiology. <ol> <li> <a href="https://www.mdedge.com/cardiology/article/199094/lipid-disorders/poor-response-statins-hikes-risk-cardiovascular-events" rel="nofollow" target="_blank"> PCI reduces mortality after STEMI in older adults.</a> </li> <li> <a href="https://www.mdedge.com/internalmedicine/article/198850/diabetes/canagliflozin-lowers-kidney-failure-risk-t2d-credence" rel="nofollow" target="_blank"> Canagliflozin lowers kidney failure risk in T2D: CREDENCE.</a> </li> <li> <a href="https://www.mdedge.com/cardiology/article/199094/lipid-disorders/poor-response-statins-hikes-risk-cardiovascular-events" rel="nofollow" target="_blank"> Poor response to statins hikes risk of cardiovascular events.</a> </li> <li> <a href="https://www.mdedge.com/familymedicine/article/198800/stroke/low-ldl-cholesterol-may-increase-womens-risk-hemorrhagic-stroke" rel="nofollow" target="_blank"> Low LDL cholesterol may increase women’s risk of hemorrhagic stroke</a> </li> </ol>

PCI reduces mortality after STEMI in older adults 

 DAPA-HF results transform dapagliflozin from antidiabetic to heart failure drug   Proof that dapagliflozin significantly helped heart failure patients without diabetes recategorizes the drug as a major agent for treating heart failure.   New hypertension cases halved with community-wide salt substitution   Social marketing principles achieved near-universal salt replacement, village by village, in rural Peru.   Ticagrelor: Modest benefit, bigger bleed risk in diabetes plus stable CAD   Patients with prior PCI fared a bit better and may be a target population for long-term DAPT therapy.   In PAD, dropping statins ups death risk 43%   Statin adherence saves lives in peripheral arterial disease.

DAPA-HF results transform dapagliflozin from antidiabetic to heart failure drug <a href="https://www.mdedge.com/familymedicine/article/207368/heart-failure/dapa-hf-results-transform-dapagliflozin-antidiabetic?channel=39313" rel="nofollow" target="_blank"> Proof that dapagliflozin significantly helped heart failure patients without diabetes recategorizes the drug as a major agent for treating heart failure.</a> New hypertension cases halved with community-wide salt substitution <a href="https://www.mdedge.com/familymedicine/article/207434/hypertension/new-hypertension-cases-halved-community-wide-salt?channel=39313" rel="nofollow" target="_blank"> Social marketing principles achieved near-universal salt replacement, village by village, in rural Peru.</a> Ticagrelor: Modest benefit, bigger bleed risk in diabetes plus stable CAD <a href="https://www.mdedge.com/cardiology/article/207366/cad-atherosclerosis/ticagrelor-modest-benefit-bigger-bleed-risk-diabetes?channel=39313" rel="nofollow" target="_blank"> Patients with prior PCI fared a bit better and may be a target population for long-term DAPT therapy.</a> In PAD, dropping statins ups death risk 43% <a href="https://www.mdedge.com/familymedicine/article/207370/peripheral-vascular-disorders/pad-dropping-statins-ups-death-risk-43?channel=39313" rel="nofollow" target="_blank"> Statin adherence saves lives in peripheral arterial disease.</a>

Dapagliflozin transforms into heart failure drug

This week,  a revelation that coronary artery bypass grafting instead of percutaneous is safer as time goes by,  a new index stretches the prognostic power of cardiac CT, a weight-loss drug  cuts new-onset diabetes, and a  controversial diet score is validated.

This week, <a href="https://www.mdedge.com/ecardiologynews/article/177360/acute-coronary-syndromes/time-reveals-benefit-cabg-over-pci-left-main" rel="nofollow" target="_blank"> a revelation</a> that coronary artery bypass grafting instead of percutaneous is safer as time goes by, <a href="https://www.mdedge.com/ecardiologynews/article/177382/cad-atherosclerosis/fat-attenuation-index-boosts-coronary-ct" rel="nofollow" target="_blank"> a new index</a> stretches the prognostic power of cardiac CT, a weight-loss drug <a href="https://www.mdedge.com/ecardiologynews/article/177358/diabetes/weight-loss-drug-lorcaserins-glycemic-effects-revealed" rel="nofollow" target="_blank"> cuts new-onset diabetes</a>, and a <a href="https://www.mdedge.com/ecardiologynews/article/177331/preventive-care/pure-healthy-diet-score-validated" rel="nofollow" target="_blank"> controversial diet score</a> is validated.

CABG vs PCI, new index enhances cardiac CT, and more

 Strong showing for TAVR after 5 years in PARTNER 2ATranscatheter and surgical aortic valve replacement had similar rates of death or disabling stroke. *   *   * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 *   *   *  Patiromer allows more CKD patients to continue on spironolactone After 12 weeks, 86% of the patiromer patients remained on spironolactone, vs. 66% of the placebo patients.  Native Americans appear to be at increased risk for AFib Atrial fibrillation was significantly more common among Native Americans than in other racial and ethnic groups.  Certain diabetes drugs may thwart dementia Intriguing findings from a Danish national registry study   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeTweets

<a href="https://www.mdedge.com/cardiology/article/210835/interventional-cardiology-surgery/strong-showing-tavr-after-5-years" rel="nofollow" target="_blank"> Strong showing for TAVR after 5 years in PARTNER 2A</a>Transcatheter and surgical aortic valve replacement had similar rates of death or disabling stroke. *   *   * Help us make this podcast better! Please take our short listener survey: <a href="https://www.surveymonkey.com/r/podcastsurveyOct2019" rel="nofollow" target="_blank">https://www.surveymonkey.com/r/podcastsurveyOct2019</a> *   *   * <a href="https://www.mdedge.com/cardiology/article/210529/heart-failure/patiromer-allows-more-ckd-patients-continue-spironolactone?channel=39313" rel="nofollow" target="_blank"> Patiromer allows more CKD patients to continue on spironolactone</a> After 12 weeks, 86% of the patiromer patients remained on spironolactone, vs. 66% of the placebo patients. <a href="https://www.mdedge.com/cardiology/article/210602/cardiology/native-americans-appear-be-increased-risk-afib?channel=39313" rel="nofollow" target="_blank"> Native Americans appear to be at increased risk for AFib</a> Atrial fibrillation was significantly more common among Native Americans than in other racial and ethnic groups. <a href="https://www.mdedge.com/cardiology/article/210520/diabetes/certain-diabetes-drugs-may-thwart-dementia?channel=39313" rel="nofollow" target="_blank"> Certain diabetes drugs may thwart dementia</a> Intriguing findings from a Danish national registry study For more MDedge Podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>

AFib hits Native Americans hard; TAVR shown durable, safe after 5 years

Cardiovascular  prevention guidelines downgrade aspirin, high coronary  artery calcium scores carry greater risks, an  Apple Watch algorithm predicts AFib, and  TAVR overtakes surgery in "historic" trials.

Cardiovascular <a href="https://www.mdedge.com/cardiology/article/196511/preventive-care/acc-aha-release-first-cardiovascular-disease-primary" rel="nofollow" target="_blank"> prevention guidelines</a> downgrade aspirin, high coronary <a href="https://www.mdedge.com/cardiology/article/196486/cad-atherosclerosis/cac-score-over-1000-carries-higher-risks" rel="nofollow" target="_blank"> artery calcium scores</a> carry greater risks, an <a href="https://www.mdedge.com/cardiology/article/196502/arrhythmias-ep/apple-watch-algorithm-showed-84-positive-predictive-value" rel="nofollow" target="_blank"> Apple Watch algorithm</a> predicts AFib, and <a href="https://www.mdedge.com/cardiology/article/196593/interventional-cardiology-surgery/tavr-tops-surgery-low-risk-patients" rel="nofollow" target="_blank"> TAVR overtakes surgery</a> in "historic" trials.

Top News from ACC 19

This week in MDedge Cardiocast: Most tPA-eligible stroke patients  now get treated within an hour,  LAA closure can be treated safely in patients with prior hemorrhagic stroke, SGLT2 inhibitors are quickly  morphing from diabetes to heart failure drugs, and the  MESA cardiovascular disease risk calculator can be an improvement on the ACC/AHA version.

This week in MDedge Cardiocast: Most tPA-eligible stroke patients <a href="https://www.mdedge.com/cardiology/article/194199/stroke/most-us-tpa-eligible-stroke-patients-now-get-treated-within-hour" rel="nofollow" target="_blank"> now get treated within an hour</a>, <a href="https://www.mdedge.com/cardiology/article/193321/stroke/laa-closure-safely-treated-af-patients-prior-ich" rel="nofollow" target="_blank"> LAA closure can be treated safely</a> in patients with prior hemorrhagic stroke, SGLT2 inhibitors are quickly <a href="https://www.mdedge.com/cardiology/article/194124/heart-failure/sglt2-inhibitors-morph-hf-drugs" rel="nofollow" target="_blank"> morphing from diabetes to heart failure drugs</a>, and the <a href="https://www.mdedge.com/cardiology/article/194214/cad-atherosclerosis/consider-adopting-mesa-10-year-chd-risk-calculator" rel="nofollow" target="_blank"> MESA cardiovascular disease risk calculator</a> can be an improvement on the ACC/AHA version.

What comes first with SGLT2 inhibitors – diabetes or heart failure?

The top stories in cardiology:   Artificial intelligence technology meets AFib detection An AI-enabled ECG model suggests clinical implications for early identification of atrial fibrillation.  Older patients who stop statins may be increasing their cardiovascular risk Discontinuation of statins was associated with an increased risk of hospital admission for a cardiovascular event.  Psoriasis patients on biologics show improved heart health Novel imaging biomarker identifies reduced coronary inflammation in psoriasis patients on biologics. Acupuncture cuts attacks in chronic angina Chronic stable angina patients showed significant improvement with acupuncture over patients given shame or no acupuncture.  You can contact the MDedge Cardiocast by emailing us at podcasts@mdedge.com or following us on Twitter @MDedgeTweets

The top stories in cardiology: <ol> <li><a href="https://www.mdedge.com/cardiology/search?search_api_views_fulltext=AI+technology+meets+AFib+detection+" rel="nofollow" target="_blank"> Artificial intelligence technology meets AFib detection</a> An AI-enabled ECG model suggests clinical implications for early identification of atrial fibrillation.</li> <li><a href="https://www.mdedge.com/cardiology/article/205840/lipid-disorders/older-patients-who-stop-statins-may-be-increasing-their" rel="nofollow" target="_blank"> Older patients who stop statins may be increasing their cardiovascular risk</a> Discontinuation of statins was associated with an increased risk of hospital admission for a cardiovascular event.</li> <li><a href="https://www.mdedge.com/cardiology/article/206012/psoriasis/psoriasis-patients-biologics-show-improved-heart-health" rel="nofollow" target="_blank"> Psoriasis patients on biologics show improved heart health</a> Novel imaging biomarker identifies reduced coronary inflammation in psoriasis patients on biologics.</li> <li>Acupuncture cuts attacks in chronic angina Chronic stable angina patients showed significant improvement with acupuncture over patients given shame or no acupuncture.</li> </ol> You can contact the MDedge Cardiocast by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter @MDedgeTweets

AI for AFib and acupuncture for angina

MDedge reporters discuss the latest in practice-changing data from the 2019 annual congress of the European Society of Cardiology in Paris. Join Mitchel L. Zoler, Bruce Jancin, Kari Oakes, and MDedge Cardiology editor Catherine Hackett as they discuss what they reported from the annual meeting.

MDedge reporters discuss the latest in practice-changing data from the <a href="http://bit.ly/2lSd8fd" rel="noopener nofollow" target="_blank">2019 annual congress of the European Society of Cardiology</a> in Paris. Join <a href="http://bit.ly/2NXzw33" rel="noopener nofollow" target="_blank">Mitchel L. Zoler</a>, <a href="http://bit.ly/2Dimbyo" rel="noopener nofollow" target="_blank">Bruce Jancin</a>, <a href="http://bit.ly/2mirrdi" rel="noopener nofollow" target="_blank">Kari Oakes</a>, and MDedge Cardiology editor Catherine Hackett as they discuss what they reported from the annual meeting.

Practice changing prevention data from ESC 2019 Part II

This week's top stories in clinical medicine:   Single-center study outlines stoke risk, DOAC type in nonvalvular A-fib patients  ACOG guidance addresses cardiac contributors to maternal mortality  Higher serum leptin levels associated with PAD  Employed physicians now outnumber independent doctors 

This week's top stories in clinical medicine: <ol> <li><a href="https://www.mdedge.com/cardiology/article/200298/stroke/single-center-study-outlines-stroke-risk-doac-type-nonvalvular-afib" rel="nofollow" target="_blank"> Single-center study outlines stoke risk, DOAC type in nonvalvular A-fib patients</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/200216/obstetrics/acog-guidance-addresses-cardiac-contributors-maternal" rel="nofollow" target="_blank"> ACOG guidance addresses cardiac contributors to maternal mortality</a></li> <li><a href="https://www.mdedge.com/cardiology/article/200456/pad-and-claudication/higher-serum-leptin-levels-associated-pad" rel="nofollow" target="_blank"> Higher serum leptin levels associated with PAD</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/200319/practice-management/employed-physicians-now-outnumber-independent" rel="nofollow" target="_blank"> Employed physicians now outnumber independent doctor</a>s</li> </ol>

Stroke risk, DOAC type in nonvalvular A-Fib patients

This week, a  breakthrough for heart failure patients with mitral regurgitation emerges, prosthesis-patient mismatch raises the risk of death following TAVR, a new study  challenges anticoagulation guidelines, and a possible  blessing in disguise for rivaroxaban comes from the massive COMPASS trial. Subscribe to Cardiocast wherever you get your podcasts.  Amazon Alexa  Apple Podcasts

This week, a <a href="https://www.mdedge.com/ecardiologynews/article/175499/interventional-cardiology-surgery/coapt-mitraclip-prolongs-life" rel="nofollow" target="_blank"> breakthrough for heart failure patients</a> with mitral regurgitation emerges, prosthesis-patient mismatch raises the risk of death following TAVR, a new study <a href="https://www.mdedge.com/ecardiologynews/article/175660/arrhythmias-ep/atrial-fib-guidelines-may-fall-short-oral" rel="nofollow" target="_blank"> challenges anticoagulation guidelines</a>, and a possible <a href="https://www.mdedge.com/ecardiologynews/article/175660/arrhythmias-ep/atrial-fib-guidelines-may-fall-short-oral" rel="nofollow" target="_blank"> blessing in disguise</a> for rivaroxaban comes from the massive COMPASS trial. Subscribe to Cardiocast wherever you get your podcasts. <a href="https://www.mdedge.com/ecardiologynews/article/175660/arrhythmias-ep/atrial-fib-guidelines-may-fall-short-oral" rel="nofollow" target="_blank"> Amazon Alexa</a> <a href="https://itunes.apple.com/us/podcast/mdedge-cardiocast/id1401503147?mt=2&amp;oc_slh=a7482f93bd99544ddc765686d517d1ca0fff832a6a34a61f1ef2efc823545e60" rel="nofollow" target="_blank"> Apple Podcasts</a>

Top news from TCT, anticoagulation guidelines, and more

You can find more of our podcasts at http://www.mdedge.com/podcasts This week in cardiology:  FFR changes coronary management in one-third of patients MADIT-CHIC: CRT aids patients with chemotherapy-induced cardiomyopathy Lipoprotein(a) levels can guide CV risk assessment and treatment Cannabis: Doctors tell FDA to get out of the weeds  Contact the show at podcasts@mdedge.com or interact with MDedge Cardiology on Twitter at @MDedgeCardio.

You can find more of our podcasts at <a href="http://www.mdedge.com/podcasts" rel="nofollow" target="_blank">http://www.mdedge.com/podcasts</a> This week in cardiology: <ol> <li>FFR changes coronary management in one-third of patients</li> <li>MADIT-CHIC: CRT aids patients with chemotherapy-induced cardiomyopathy</li> <li>Lipoprotein(a) levels can guide CV risk assessment and treatment</li> <li>Cannabis: Doctors tell FDA to get out of the weeds</li> </ol> Contact the show at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or interact with MDedge Cardiology on Twitter at <a href="http://bit.ly/2TYvkPI" rel="nofollow" target="_blank">@MDedgeCardio</a>.

FFR changes coronary management; doctors want FDA out of the weeds

This week's top stories in cardiology:  Lipoprotein(a) levels, genes boost ischemic stroke risk  Could some elderly skip statins based on negative risk markers?  Cardiac events jump after COPD exacerbation  CAROLINA findings reaffirm linagliptin’s safety, free glimepiride of CV-risk stigma  You can contact the MDedge Cardiocast by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

This week's top stories in cardiology: <ol> <li><a href="https://www.mdedge.com/cardiology/article/203834/stroke" rel="nofollow" target="_blank">Lipoprotein(a) levels, genes boost ischemic stroke risk</a></li> <li><a href="https://www.mdedge.com/cardiology/article/203871/lipid-disorders/could-some-elderly-skip-statins-based-negative-risk?channel=239" rel="nofollow" target="_blank"> Could some elderly skip statins based on negative risk markers?</a></li> <li><a href="https://www.mdedge.com/cardiology/article/203994/copd/risk-cardiac-events-jumps-after-copd-exacerbation" rel="nofollow" target="_blank"> Cardiac events jump after COPD exacerbation</a></li> <li><a href="https://www.mdedge.com/cardiology/article/203923/diabetes/carolina-findings-reaffirm-linagliptins-safety-free-glimepiride" rel="nofollow" target="_blank"> CAROLINA findings reaffirm linagliptin’s safety, free glimepiride of CV-risk stigma</a></li> </ol> You can contact the MDedge Cardiocast by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter at <a href="https://twitter.com/mdedgetweets?lang=en" rel="nofollow" target="_blank">@MDedgeTweets</a>.

Lipoprotein(a) levels and genes boost ischemic stroke risk

 Statin use linked to risk of skin and soft tissue infections Use of statins was associated with increased risk of SSTIs at an average of 91, 182, and 365 days.  Rivaroxaban trends toward higher thrombotic risk than vitamin K antagonists in APS Patients who took rivaroxaban experienced almost two times as many thrombotic events as patients who took dose-adjusted vitamin K antagonists.  HHS floats Stark/anti-kickback revisions to support value-based care Health law attorneys say reforms should remove some of the risk in value-based care arrangements that exist under current law. * * * Card Talk: Cardiologist brothers Jim and Jerry Dwyer welcome Jennifer N. Avari Silva, MD, and Berk Tas, to talk about an investigational system for electrophysiology procedures that displays holograms of patients’ anatomies in real time. The SentiAR system uses an augmented-reality head-mounted display that allows physicians to manipulate the data and enhance their understanding of the case.  Dr. Avari Silva, MD,  is assistant professor of pediatrics at Washington University in St. Louis and director of pediatric cardiac electrophysiology at St. Louis Children’s Hospital, where she leads the largest pediatric electrophysiology program in the midwest. Dr. Avari Silva has published numerous papers bringing new technologies to pediatric patients. Berk Tas is CEO and president of SentiAR. He has led development of emerging technologies and companies in Fortune 500, private equity, venture capital funded and privately held organizations.   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeCardio

<a href="https://www.mdedge.com/cardiology/article/209948/infectious-diseases/short-term-statin-use-linked-risk-skin-and-soft-tissue?channel=39313" rel="nofollow" target="_blank"> Statin use linked to risk of skin and soft tissue infections</a> Use of statins was associated with increased risk of SSTIs at an average of 91, 182, and 365 days. <a href="https://www.mdedge.com/cardiology/article/210109/cardiology/rivaroxaban-trends-toward-higher-thrombotic-risk-vitamin-k?channel=39313" rel="nofollow" target="_blank"> Rivaroxaban trends toward higher thrombotic risk than vitamin K antagonists in APS</a> Patients who took rivaroxaban experienced almost two times as many thrombotic events as patients who took dose-adjusted vitamin K antagonists. <a href="https://www.mdedge.com/cardiology/article/209936/business-medicine/hhs-floats-stark/anti-kickback-revisions-support-value?channel=39313" rel="nofollow" target="_blank"> HHS floats Stark/anti-kickback revisions to support value-based care</a> Health law attorneys say reforms should remove some of the risk in value-based care arrangements that exist under current law. * * * Card Talk: Cardiologist brothers Jim and Jerry Dwyer welcome <a href="http://pediatrics.wustl.edu/Faculty/silva_j" rel="nofollow" target="_blank">Jennifer N. Avari Silva, MD</a>, and <a href="https://rocketreach.co/berk-tas-email_98086985" rel="nofollow" target="_blank">Berk Tas</a>, to talk about an investigational system for electrophysiology procedures that displays holograms of patients’ anatomies in real time. The <a href="https://sentiar.com/" rel="nofollow" target="_blank">SentiAR</a> system uses an augmented-reality head-mounted display that allows physicians to manipulate the data and enhance their understanding of the case.  Dr. Avari Silva, MD,  is assistant professor of pediatrics at Washington University in St. Louis and director of pediatric cardiac electrophysiology at St. Louis Children’s Hospital, where she leads the largest pediatric electrophysiology program in the midwest. Dr. Avari Silva has published numerous papers bringing new technologies to pediatric patients. Berk Tas is CEO and president of SentiAR. He has led development of emerging technologies and companies in Fortune 500, private equity, venture capital funded and privately held organizations. For more MDedge Podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="https://twitter.com/mdedgecardio" rel="nofollow" target="_blank">@MDedgeCardio</a>

Statins tied to skin, soft tissue infections; new Card Talk episode

This week's top stories in clinical cardiology:    Has radial access PCI been overhyped?    Hospital TAVR volume matters to patient survival.    Studies link TMAO to microbiome, reveal new heart disease target.    More chest compression–only CPR leads to increased survival rates.   You can contact the show by emailing us at podcasts@mdedge.com or you can follow MDedge Cardiology on Twitter at @MDedgeCardio.

This week's top stories in clinical cardiology: <ol> <li> <a href="http://bit.ly/2Vu51Ck" rel="nofollow" target="_blank">Has radial access PCI been overhyped?</a> </li> <li> <a href="http://bit.ly/2FSHoyb" rel="nofollow" target="_blank">Hospital TAVR volume matters to patient survival.</a> </li> <li> <a href="http://bit.ly/2IeYaJl" rel="nofollow" target="_blank">Studies link TMAO to microbiome, reveal new heart disease target.</a> </li> <li> <a href="http://bit.ly/2ON5Gwl" rel="nofollow" target="_blank">More chest compression–only CPR leads to increased survival rates.</a> </li> </ol> You can contact the show by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or you can follow MDedge Cardiology on Twitter at <a href="http://bit.ly/2TYvkPI" rel="nofollow" target="_blank">@MDedgeCardio</a>.

Too much hype for radial access PCI?

The best podcast episodes of the most interesting stories and things. From skyping someone while they're in space, to tracking down and meeting a telephone scammer in person, to the story of a Galapagos. These episodes will keep you and all your friends entertained and captivated for hours. Learn something new in every episode! Add episodes you're interested into your queue below!

Best Episodes: Interesting Stories & Things

The best philosophy podcast episodes. Asking questions about how to live a better life, what it means to be and do good, to the idea of God. This topic includes episodes that bring about important questions that everyone should be asking themselves. Add episodes you're interested into your queue below!