Rank #1: Episode 23 - If At First You Don't Succeed
This week - Evidence that viruses drive the evolution of their hosts - who would have guessed? Matt struggles to remember how evolution works, and Kate and Kevin yell past each other about open peer review.
We initially recorded this episode a month ago, but Kevin messed up his audio settings and his recording was unusable. So sorry as always for the delay, but we hope you enjoy!
Paper (open access): Viruses are a dominant driver of protein adaptation in mammals
SIT'N Listen - A Podcast from Science in the News
Classic McDonald-Kreitman Test (wikipedia)
Kevin's many posts and podcasts about science publication
Jun 17 2016
Rank #2: Episode 13 - GATACA
Finally! This episode was recorded back in June, but I (Kevin) have been super busy (/super lazy) and only now got it posted. For those of you that are still subscribed, thanks for not abandoning us! Though it took some time, I think this conversation was worth the wait.
In this episode, we discuss the moral implications of doing experiments on babies without brains, and editing the genomes of unborn humans. I reveal my nature as a moral monster, and Kate can't resist bringing up Kim Kardashian's artificial selection of her own offspring.
Oct 01 2015
Public Health United
Talkin Immunology with BioLegend
PeerVoice Immunology & Infectious Disease Audio
The Journal of Immunology ImmunoCasts
This Week in Neuroscience
PeerView Immunology & Transplantation CME/CNE/CPE Audio Podcast
This Week in Evolution
This Week in Virology
Science Signaling Podcast
Rank #3: Episode 24 - The Devil Went Down to... awww, C'mon Matt
Path of Devil Facial Tumor Disease. Figure 1 from doi:10.1038/ncomms12684
Audiommunity loves Tasmanian devils, so we bite the shit out of them... In this episode, we're talking about a contagious tumor that couldn't happen to a nicer species. No seriously, it really couldn't. Tasmanian devils bite each other on the face to say hello. WTF devils?
And we answer audience e-mail that's been in the inbox for months! I know, I know... we're going to record more frequently going forward - honest!
Sep 30 2016
Rank #4: Episode 16 - Jimmy Carter's Brain on Drugs
Taking the breaks off of the immune system can get it to attack cancer cells
In this episode, Matt and Kevin discuss checkpoint blockade cancer immunotherapy (wow, that's a mouthful). When cancer stamps down the breaks of the immune system, cutting the break line can allow T-cells to do their job.
Meanwhile, Kate's teeth are falling out of her head, and Matt can't even remember what scotch he's drinking.
This episode was recorded Friday, Jan 8th... we're getting better folks.
Jan 13 2016
Most Popular Podcasts
Rank #5: Episode 27 - Macaque Prison Gangs
In this episode, we're talking cure for the common cold... or at least, a vaccine for it. Also, Kevin and Matt read the wrong paper, Chadene corrects Kevin's pronunciation of her name (again!) and we give a big round of applause for Dr. Kate Franz (though she's still too busy for us).
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The Paper: A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
Guardian article about the effort to develop a rhinovirus vaccine
Chadene's Blog - The SciMinded Idealist (and her post about episode 26)
Kevin's Beer - Left Hand Milk Stout
Dec 23 2017
Rank #6: Episode 12 – Bee pollen is one of those hippy things
Welcome to spring from everyone at Audiommunity! To celebrate the return of the warm(ish) weather, we discuss a paper looking at immune responses to bee venom, and the underlying causes of environmental allergy. In doing so, we focus in on the mast cell – the immune mediators of allergy and anaphylaxis – and why they may actually be helpful in helping you (or your more worm-exposed ancestors) fight off intestinal parasites. Ever wonder where histamines come from? Why your skin turns red when you scratch it? Why you should never take bee pollen as a supplement? What eosinophils and basophils are? Well we can't answer that last one, but for the rest, give a listen!
This is in no way related to the episode, but it's the figure Kate made for a recent review. It's so good, you almost can't tell it was done in PowerPoint
Apr 16 2015
Rank #7: Episode 14 - Matt got married, and we're talking about pregnancy
Non of this swelling is due to inflammation or microbes. Source: wikipedia
We're back! And I know what you're thinking - it's about damn time. We have excuses, but we won't bore you with them.
In this episode, we're talking about the placental microbiome - that is, the bacteria that hang around a developing fetus in the womb. Wait, there are bacteria hanging around a developing fetus? Apparently!
Matt also waxes poetic on the immunology of pregnancy, and Kate tells us why family planning might someday involve infecting yourself with worms.
PS - We actually have a facebook page now... go like it!
Papers in this episode:
Dec 09 2015
Rank #8: Episode 19 - J Lo Poop Pills
By SuSanA Secretariat - https://www.flickr.com/photos/gtzecosan/16424898321/, CC BY 2.0
In this episode, how parasitic worms alter in immunomodulatory effects of the gut microbiome. Also, Kate expresses her distaste for large datasets and animal experiments, and Matt proposes a weight loss company that will only market to identical twins.
The company that Kevin couldn't remember: Seres Therapeutics
Mar 17 2016
Rank #9: Episode 15 - The other DRACO
Nope... not that Draco. Source
This week, we're discussing DRACOs - not the Harry Potter character, a "new" class of antiviral therapeutics that links up the double-stranded RNA-binding part of one protein to the cell-death (apoPtosis)-activating part of a different protein.
The paper we're discussing was published over 4 years ago, but the idea hasn't seemed to take off - we'll discuss the promise of the idea, but also our concerns and skepticism, the later of which is particularly important since the original author is now embarking on a crowd funding campaign to get more money to study it.
The Paper: Broad-Spectrum Antiviral Therapeutics (Open Access)
Rachel Rynick upcoming performance in Dedham, MA
Dec 21 2015
Rank #10: Episode 11 - No, Not Seminol
Image from wikipedia
This episode brought to you by Kevin's malfunctioning audio equipment and Matt's computer meltdown... seriously, this episode was cursed!
But in the end, we had a great discussion about sCD38, a molecule that's secreted in mouse and human sperm, and may play a role in suppressing a mother's immune response to a new fetus.
Kevin, podcasting in the dark
A review on the immune system and pregnancy
What's a sith lord?
Mar 11 2015