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FoundMyFitness

Updated 2 months ago

Rank #7 in Medicine category

Health & Fitness
Medicine
Nutrition
Science
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Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

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Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

iTunes Ratings

4120 Ratings
Average Ratings
3755
212
69
37
47

Fantastic and full of information

By sogomangovaroy92 - May 27 2020
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Really detailed, scientific information. I absolutely love listening to this podcast.

Rhonda, you’re seriously the best.

By djartin - Apr 17 2020
Read more
Rhonda, you’re seriously the best.

iTunes Ratings

4120 Ratings
Average Ratings
3755
212
69
37
47

Fantastic and full of information

By sogomangovaroy92 - May 27 2020
Read more
Really detailed, scientific information. I absolutely love listening to this podcast.

Rhonda, you’re seriously the best.

By djartin - Apr 17 2020
Read more
Rhonda, you’re seriously the best.
Cover image of FoundMyFitness

FoundMyFitness

Latest release on Jun 10, 2020

All 52 episodes from oldest to newest

COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

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This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things.

Some of the topics that came up as a result of the questions submitted include:

  • 00:04:03 - Data surrounding SARS-CoV-2 duration
  • 00:06:37 - SARS-CoV-2 and potential immunity
  • 00:11:35 - Some of the main factors known to play a role in immune variation
  • 00:12:05 - What role genetics may play in immune function
  • 00:14:27 - How previous viral exposure regulates immunity
  • 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2
  • 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance
  • 00:21:50 - How sleep is a key regulator of immune function
  • 00:23:44 - Microbiome composition and immune function
  • 00:28:31 - The differential effects of exercise intensity and duration on immune regulation
  • 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation
  • 00:47:20 - The effect of sex hormones on immune function
  • 00:48:55 - How biological age age may play a role in immune regulation
  • 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19
  • 00:53:15 - ARDS and long-term lung damage

Get our detailed summary, timeline, references and more on the FoundMyFitness episode page.

This episode mentions a number of genetic polymorphisms that affect viral entry into the host cell, viral replication, host immune response ranging from cytokine production to viral-induced inflammation, SNPs that affect vitamin D levels and more. If you have used any consumer-based genetic testing services like 23andMe or Ancestry DNA we have a free viral report with these SNPs that you can check out.

If you enjoy this content or any of the associated content, I can promise you that not only does the premium membership help bring MORE of it into the world in a broadly accessible format, that membership also comes with some really great benefits just for members. Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line.

Jun 10 2020

55mins

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Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

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In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!

Episode Timeline (abridged)

  • 00:07:33 - Background on vitamin C
  • 00:17:09 - Bioavailability of vitamin C [including dosing frequency]
  • 00:22:53 - Vitamin C in the context of the common cold
  • 00:28:09 - Vitamin C and lung function
  • 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation]
  • 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity
  • 00:48:44 - Vitamin C and the brain
  • 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection
  • 00:55:33 - Intravenous Vitamin C and cancer
  • 00:57:40 - Effect of Vitamin C on fertility and reproduction
  • 00:58:36 - Intravenous vitamin C and cardiovascular health
  • 01:00:42 - Vitamin C and inflammation
  • 01:02:38 - Vitamin C’s mechanisms of action
  • 01:08:34 - Intravenous and Oral vitamin C safety
  • 01:10:20 - Vitamin C intake and kidney stone risk
  • 01:13:57 - Conclusions

Get the full timeline, show summary, and all references for this episode by clicking here.

View our new 28-page vitamin C overview article with over 190 references by clicking here.

Premium membership: Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line. Click here to learn more about premium membership.

May 13 2020

1hr 19mins

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COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

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This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon.

Some of the questions we selected from the batch to cover in this episode include:

  • 00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission?
  • 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore?
  • 00:17:58 - Can you talk about quercetin's role as a zinc ionophore?
  • 00:20:51 - Is there any indication blood type influences COVID-19 risk?
  • 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection?
  • 00:43:45 - Can you discuss whether sauna use might help prevent COVID19?
  • 00:52:55 - Is it true that high dose intravenous vitamin C might help treat COVID-19?
  • 01:04:35 - What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress?

To supplement this podcast Q&A, we’ve also made a video, summary, timeline, and references. You can view all of these on the episodes page on my website at foundmyfitness.com/episodes/covid-19-qa-1.

If you enjoy this question & answer format, consider joining my premium membership community! Non-COVID-19 related Q&As happen monthly, you get access to an an exclusive bi-weekly science digest email, and much more more! Click here to learn about premium.

Apr 14 2020

1hr 14mins

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New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

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This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, we discuss...

  • 00:08:00 - Omega-3
  • 00:27:23 - Metformin
  • 00:50:05 - Sulforaphane
  • 01:06:57 - Magnesium L-Threonate
  • 01:13:44 - Sauna
  • 01:23:48 - New FMF Membership

Learn more about the new premium membership.

Learn more about sauna on our overview page.

Learn more about metformin on our overview page.

Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts:

Jan 06 2020

1hr 36mins

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Is Resveratrol a Longevity Compound?

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In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

Learn more about resveratrol at our comprehensive overview

Relevant timepoints...

  • 00:03:39 - Clinical effects of resveratrol in humans
  • 00:04:10 - Effects on cardiovascular health biomarkers in humans
  • 00:06:54 - Reduction of inflammatory biomarkers in humans
  • 00:08:11 - Improved cognition and memory in clinical studies
  • 00:11:23 - Healthspan improvements in animals
  • 00:12:28 - Induction of longevity genes via xenohormesis
  • 00:16:19 - Contradictory effects on exercise-associated benefits
  • 00:20:34 - Various factors that affect resveratrol bioavailability
  • 00:23:09 - Unintentional effects on drug metabolism

Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to learn about premium.

Click here to sign-up for a three issue trial of the bi-monthly science digest.

Dec 30 2019

28mins

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NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

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In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts.

Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.

Nov 13 2019

35mins

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Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

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David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.

Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.

In this episode, we discuss...

  • 00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity.
  • 00:21:47 - How NAD+ levels and sirtuin activities decrease with age, and how animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger.
  • 00:23:03 - How resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period.
  • 00:27:36 - We also discuss Steve Horvath's epigenetic aging clock, which measures DNA methylation groups, and how they may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock.
  • 00:31:54 - How the signal that resets the epigenetic clock in mice involves the Yamanaka factors -- a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type.
  • 00:46:48 - How resveratrol is a xenohormetic compound and is produced when grape plants are stressed either in response to fungus or lack of water.
  • 00:55:35 - How a phase 2 clinical trial involving people with Alzheimer's disease showed resveratrol improved cognitive function, improved cerebrospinal fluid amyloid beta levels, lowered markers of activated microglia, and more.
  • 00:58:03 - How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer's disease.
  • 01:06:19 - How older mice that were given nicotinamide mononucleotide experienced delayed aging in the liver, muscle, immune cells, eyes, and bones, but those that took a lower dose had improved mitochondrial function and enhanced physical performance.
  • 01:01:22 - How there may be challenges in translating animal studies on nicotinamide riboside and nicotinamide mononucleotide to humans particularly due to the need to determine the dose required to promote health benefits.
  • And so much more!

Click here to get this episode's show notes and transcript

Watch this episode's highlights on the FMF Clips channel

Get early access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.

Submit your raw genetic data to get the latest version of the genetic report at foundmyfitness.com/genetics.

Nov 06 2019

1hr 22mins

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Sauna Use as an Exercise Mimetic for Heart and Healthspan

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This podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more.

Click here to get the episode show notes and video.

Watch the episode with cardiologist and sauna scientist Dr. Jari Laukkanen.

Did you enjoy this podcast? It was brought to you by people like you!
Click here to visit our crowdsponsor page where you can learn more about how to support the podcast.

Sep 16 2019

46mins

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Exercise as a Treatment for Depression

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In this short episode, Dr. Patrick discusses some of the compelling science including observational studies, randomized controlled trials, and human mechanistic studies that suggests exercise is a powerful tool for preventing or managing the symptoms of depression and mental illness. Moreover, she talks about the specific types of exercise and exercise parameters that evidence suggests might be the most helpful for depression.

This podcast started its life as a video, so make sure to check out the full video or the references and episode notes on the episode page.

Click here to get this episode's show notes and video.

Click here to visit the in-depth depression topic page.

See the full interview with Dr. Charles Raison.

Did you enjoy this podcast? It was brought to you by people like you!
Click here to visit our crowdsponsor page where you can learn more about how to support the podcast and access the premium members benefits.

Aug 03 2019

17mins

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Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging

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Elissa Epel, PhD, is a Professor in the Department of Psychiatry at the University of California, San Francisco where she serves as the director of the Aging, Metabolism, and Emotions Center. Her research centers on the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health.

In this episode, we dive deep into the world of telomeres, the length of which is one of the useful biomarkers scientists have for getting a sense of the differences between how individuals or groups of individuals age. Telomere shortening is both a cause and a symptom of aging and plays key roles in not only how long we live, but in how well. Lifestyle factors such as poor nutrition and smoking can accelerate telomere shortening by generating oxidative stress and inflammation.

Click here to get this episode's show notes and transcript.

Watch this episode's highlights on the FMF Clips channel.

Did you enjoy this podcast? It was brought to you by people like you!
Click here to visit our crowdsponsor page where you can learn more about how to support the podcast for as little or as much as you like.

Submit your raw genetic data. You can find the Telomere report at foundmyfitness.com/genetics.

Jun 10 2019

1hr 13mins

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