Therapeutic Monoclonal Antibodies in the Clinical Laboratory
14 Dec 2017
Effect of Preanalytical Factors on the Stability of Maternal Serum Biomarkers and Calculated Risk for Trisomy 21, Trisomy 18, and Open Neural Tube Defect
30 May 2017
Serum Free Light Chain (FLC) Analysis: A Guiding Light in Monoclonal Gammopathy Management
19 Jul 2017
Automated Laboratories: When Technology Needs a Human Touch
Laboratory automation holds the promise of enhanced workflows, improved efficiency, and decreased turnaround time while mitigating an environment of rising costs, constrained resources, and staffing shortages. Many publications tout improved outcomes from laboratory automation but realizing these results may not come easily. Automated Laboratories: When Technology Needs a Human Touch was published in the May 2018 issue of the Journal of Applied Laboratory Medicine. This work reflects on one lab’s experience with a challenging implementation of laboratory automation. Several unanticipate outcomes were encountered that required investigation to improve laboratory turnaround time.
31 May 2018
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Point-of-Care vs Central Lab "Discrepancies"
3 Mar 2017
AUC-Based Monitoring of Vancomycin: Closing the Therapeutic Window
Measuring vancomycin levels has long been an important component of laboratory therapeutic drug monitoring. Such measurements are important for obtaining optimal targets serum concentrations for drug dosing, while avoiding vancomycin induced nephrotoxicity. “AUC-Based Monitoring of Vancomycin: Closing the Therapeutic Window” was published in the January 2019 issue of The Journal of Applied Laboratory Medicine. This review evaluates shifting the conventional therapeutic drug monitoring approach of vancomycin from trough monitoring, to an area under the curve approach for more appropriate drug dosing.
9 Jan 2019
The Importance of Effective Communication
1 Jan 2017
Interventions That Can Help Reduce Diagnostic Errors
Diagnostic errors in medicine continue to be a large problem for effective healthcare delivery. As a result, moderate and severe consequences from the errors, including death, account for 75% of diagnostic errors in the United States. “Interventions That Can Help Reduce Diagnostic Errors” was published in the July 2018 issue of The Journal of Applied Laboratory Medicine. The editorial discusses the associated JALM Review “The Definition and Scope of Diagnostic Error in the US and How Diagnostic Error is Enabled” by Dr. Michael Laposata. The authors of the editorial are Dr. Michael Astion and Dr. Jane Dickerson.
10 Jul 2018
D-dimer: Common Assay, Challenges Abound, Caution Advised
Venous thromboembolism, or VTE, is a serious medical condition characterized by a blood clot in a vein, also known as deep vein thrombosis. If the clot breaks free from the vein, it can cause a life-threatening pulmonary embolism by blocking blood supply to the lungs. Over 100,000 Americans may die from VTE per year. If recognized quickly, VTE may be effectively treated with anticoagulant therapy; however, it can be difficult to detect when VTE is occurring and when treatment is warranted, thus the clinical laboratory plays an important role in performing diagnostic tests for VTE.
19 Mar 2019
Bad Tests Die Slowly: The Myelin Basic Protein Example
22 Jan 2020
High-Throughput LC-MS/MS Method for Determination of the Alcohol Use Biomarker Phosphatidylethanol in Clinical Samples by Use of a Simple Automated Extraction Procedure—Preanalytical and Analytical Conditions
A high throughput LC-MS/MS method for the determination of phosphatidylethanol (PEth) in clinical samples using a simple automated extraction procedure was published in the May 2018 issue of The Journal of Applied Laboratory Medicine. This work describes an improved automated approach to analysis of the alcohol marker phosphatidylethanol that uses liquid chromatography mass spectrometry instead of conventional HPLC.
18 May 2018
Analytical Concordance of Diverse Point-of-Care and Central Laboratory Troponin I Assays
Cardiac troponin is the supreme biomarker for the diagnosis of acute myocardial infarction. The ability of the clinical laboratory to provide rapid and reliable troponin results is critical for patient management in the emergency room. In clinics and environments far from a laboratory, point-of-care troponin testing may be necessary for timely results and patient triage. However, questions remain about the concordance among point of care and laboratory-based methods and whether the same result cut-offs should be used for clinical decision making. A study published in the March 2019 issue of The Journal of Applied Laboratory Medicine investigates the analytical concordance of three point-of-care cardiac troponin I assays against the added high sensitivity troponin I assay.
7 Mar 2019
A Multicenter Assessment of the Sensitivity and Specificity for a Single High-Sensitivity Cardiac Troponin Test at Emergency Department Presentation for Hospital Admission
An original research article published in the September 2019 issue of the Journal of Applied Laboratory Medicine describes the validation of a clinical chemistry score which incorporates high sensitivity troponin with other laboratory results of glucose and estimated glomerular filtration rate as an alternative assessment strategy for emergency room patients with possible myocardial infarction.
8 Oct 2019
Thrombophilia: Women-Specific Reference Ranges Can Prevent Misdiagnosis in Women
“Thrombophilia: Women-Specific Reference Ranges Can Prevent Misdiagnosis in Women” was published in the March 2018 issue of The Journal of Applied Laboratory Medicine. This work presents the establishment and impact of female-specific reference intervals for a variety of coagulation markers during pregnancy.
31 May 2018
Medical Cannabis and Pain Management
7 Mar 2018
Clinical Effect of Expedited Pathogen Identification and Susceptibility Testing for Gram-Negative Bacteremia and Candidemia by Use of the Accelerate PhenoTM System
“Clinical Effect of Expedited Pathogen Identification and Susceptibility Testing for Gram-Negative Bacteremia and Candidemia by Use of the Accelerate PhenoTM System” was published in the January 2019 issue of The Journal of Applied Laboratory Medicine. This work evaluates the clinical impact on a new device for pathogen identification and antimicrobial susceptibility testing.
2 Jan 2019
It’s Not Just a Needlestick: Exploring Phlebotomists’ Knowledge, Training, And Use of Comfort Measures in Pediatric Care to Improve the Patient Experience
7 Mar 2019
Clinical Laboratory Detection of a High-Level Hemoglobin Abnormality in a Patient with Suspected Recreational Drug Ingestion
3 Apr 2020
α-Glutathione S-Transferase: A New Biomarker for Liver Injury?
27 Sep 2016
Reproducible Research and Reports with R
27 Nov 2019