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Health & Fitness
Medicine
Science

HUMAN PROOF OF CONCEPT

Updated 2 days ago

Health & Fitness
Medicine
Science
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The Biotech Venture Capital Podcast

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The Biotech Venture Capital Podcast

iTunes Ratings

13 Ratings
Average Ratings
11
1
1
0
0

Deconstructing biotech

By this custard - Jan 12 2016
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Enjoyed the first few podcasts. Janelle has a defusing style that makes her guests relatable, and offers valuable insight into a complex field.

iTunes Ratings

13 Ratings
Average Ratings
11
1
1
0
0

Deconstructing biotech

By this custard - Jan 12 2016
Read more
Enjoyed the first few podcasts. Janelle has a defusing style that makes her guests relatable, and offers valuable insight into a complex field.
Cover image of HUMAN PROOF OF CONCEPT

HUMAN PROOF OF CONCEPT

Latest release on Oct 01, 2017

The Best Episodes Ranked Using User Listens

Updated by OwlTail 2 days ago

Rank #1: Colin Cahill’s Venrock Diagram

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Colin Cahill swears he didn’t grow up wanting to be a life science venture capitalist. But you would think he had planned it from his very first job cleaning glassware. His path from there to Venrock may appear linear after the fact, but at the time it was based on serendipity plus a hunch he should stay close to both science and business for as long as possible.

In this episode, Colin deconstructs some of the great VC mysteries:
How do they decide which deals to do, since “there’s no rules-based decision paradigm for venture investing”?
Why, when other VCs have run screaming from med devices, has Venrock retained its breadth?
And what does “falling in love” mean when a venture capitalist says it?

Apr 30 2016

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Rank #2: Stacey Seltzer on VC: Timing Timing Timing

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If the mantra in real estate is location location location, for venture capital it might just be timing timing timing. Stacey Seltzer made the move from big pharma into venture capital during a financial crisis and has gone on to build a wildly diverse portfolio of healthcare companies at Aisling Capital. She takes us on a tour of some of the highlights, and reveals what venture capitalists do for fun.

Feb 28 2017

31mins

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Rank #3: The Art of Pappas

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Art Pappas had an extensive, international career in the pharma industry before going on to form his eponymous VC firm in the 90s. Pappas Ventures has been partnering with pharma ever since: licensing assets from them, selling portfolio companies to them, syndicating with them, and managing venture funds for them. But perhaps most notable is the list of pharma and strategic limited partners they brought together to invest in their newest fund — Pappas V — it’s a record, even for them. 

Mar 31 2017

35mins

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Rank #4: Bill Newell: Sutro has an Unfair Advantage

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Bill Newell is a lawyer turned large molecule wrangler. He’s CEO of Sutro Biopharma, and their special sauce - literally - lets them manipulate and manufacture antibodies with the kind of control scientists have had over small molecules for decades.

Where other biotechs find scientific challenges can threaten their survival, with Sutro it comes down to strategic challenges. And Bill has led them to enviable partnerships, capital, and optionality.

Sutro has an unfair advantage: Bill Newell.

Aug 31 2016

34mins

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Rank #5: Stéphane Bancel: The Messenger is the Medium

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Moderna is the Kendall Square startup developing a variety of drugs made of messenger RNA, leaving your cells to translate them into proteins. Forging a new ecosystem doesn’t come cheap: in only 5 years, Moderna has raised nearly $2B and is valued around $5B.
Its financial position may be the envy of its biotech neighbors, but it is also polarizing. It has generated intrigue and invited scrutiny, including in a recent article that questioned both the science and culture under its CEO, Stéphane Bancel. Quite the juxtaposition since it was just announced that Moderna is - again - one of Science’s Top Employers, and has even moved up in the ranks. What is going on over there?
In this episode, Stéphane is the messenger. He takes us inside the how and why of Moderna.

Oct 31 2016

34mins

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Rank #6: Brian Bloom: Hockey Sticks and Cheerleaders Do Not Go Together

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Home or away, Brian Bloom is recognized for his wildly successful conference and boutique investment bank.

With a mission to uncover and cultivate Canadian life sciences companies through scientific focus and range of services, Bloom Burton & Co., which he co-founded in 2008, has risen swiftly to be profitable and globally unique.

And its Bloom Burton Healthcare Investor Conference achieved actual hockey stick growth since it broke onto the Canadian biotech scene 5 years ago.

But hockey and cheerleaders do not go together. Brian’s knowledge of the Canadian biotech scene, and his seat on umpteen boards, leads him to a frank, no-apologies stance on the industry.

Jul 31 2016

33mins

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Rank #7: Glen de Vries has his Head in the Cloud

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In 1999 Glen de Vries started a tech company in his 5th floor walkup - very much the NYC equivalent of a garage in Silicon Valley. Today Medidata Solutions continues to transform human drug studies with their clinical cloud platform. They are approaching 3M patients and a $3B market cap.
Glen explains how he plans to reach escape velocity with no exit strategy.  
And how he keeps his feet on the dance floor and head in the cloud.

Dec 08 2016

32mins

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Rank #8: Barry Kappel and Gerard Honig – Live!

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Barry Kappel of Sapience Therapeutics and Gerard Honig of Symbiotic Health joined me for a fireside chat at the Foundation2016 conference.  
Held at Cold Spring Harbor Labs, it was a beautiful day in pre-election times. If you listen closely you can hear local wildlife in the background: birds chirping and (the) James Watson roaring around campus in his Porsche. 
I asked them about their startup companies, and after they critiqued the VC industry, I gave them a pop quiz.

Nov 17 2016

28mins

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Rank #9: Greg Verdine will not take “undruggable” for an answer

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Greg Verdine has evolved from merely being a Harvard prof, to consulting for big pharma, to starting biotech companies, to being a Venture Partner, and even to co-founding a non-profit institute – not just sequentially, but largely in parallel.

He has teamed up with Third Rock Ventures, TPG Biotech, AppleTree Partners, and he unveils his brand new gig with WuXi Ventures.

Greg co-founded the biotechs Enanta (ENTA), Tokai (TKAI), Gloucester (now Celgene), Aileron, Warp Drive, WaVe (WVE), and Fog. His day job today, if forced to list just one, is CSO of Warp Drive Bio. He reveals a couple of secrets about Warp Drive strategy and lifts the fog off of Fog Pharma, his latest – and still stealth – newco.

As different as these companies are, a common theme runs through them: to cure the incurable by drugging the undruggable.  With apologies to Star Trek, that is Greg’s personal mission: to boldly go where no drug has gone before.

In fact Greg wants to blow up the conventional meaning for the word "drug". He sees beyond the pharma industry’s small molecules plus the biotech industry’s biologics, because they seem positively “puny” in the context of human biology. And he has clever tricks and other modalities at his disposal – not to mention the blueprints: 135,000 bacterial genomes, where the answers cannot hide.

Mar 16 2016

30mins

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Rank #10: Ron Cohen: Founder & Confounder (Part 1)

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Ron Cohen has defied Venture Capital wisdom by founding Acorda Therapeutics over 20 years ago and remaining the CEO to this day.  Originally hearing "no" from 70 VCs, he nevertheless grew the company into a public biotech worth nearly $2B today.  As unlikely as that has been, there would've been no Acorda had he found more success on Broadway.
Ron discusses his road from Jeopardy! champion to entrepreneur, the role played by his flat head and great hair, and what on earth could motivate someone to invest in drug development. He also explains how upstate NY does not start at 96th St.
The two-part interview continues in the following episode, Part 2.

Jan 06 2016

30mins

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