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Siddhartha Mukherjee

29 Podcast Episodes

Latest 16 Oct 2021 | Updated Daily

Weekly hand curated podcast episodes for learning

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The Gene | An Intimate History of Genetics Science | Siddhartha Mukherjee | Bookcast #188

A Book A Day

The Gene: An Intimate History is a book written by Siddhartha Mukherjee, an Indian-born American physician and oncologist.

16mins

12 Jun 2021

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Atul Gawande and Siddhartha Mukherjee on the State of the Pandemic

The New Yorker: Politics and More

After a year of battling COVID-19, parts of the United States are celebrating a gradual turn toward normalcy, but the pandemic isn’t over—and it may never be over, exactly. Atul Gawande tells David Remnick that a hard core of vaccine resisters, along with reservoirs of the virus in domestic animals, may make herd immunity elusive. Rather, he says, the correct goal is to bring the impact of COVID-19 down to that of something like the flu. Meanwhile, India is now overwhelmed by a devastating death toll, reported at around four thousand per day but likely much higher. Siddhartha Mukherjee, who reported on the pandemic in developing nations, says that commitments from the West such as extra doses of the AstraZeneca vaccine will barely scratch the surface. A national mobilization will be required to even begin to flatten the curve.

18mins

10 May 2021

Similar People

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Atul Gawande and Siddhartha Mukherjee on the State of the Pandemic

The New Yorker Radio Hour

After a year of battling COVID-19, parts of the United States are celebrating a gradual turn toward normalcy, but the pandemic isn’t over—and it may never be over, exactly. Atul Gawande tells David Remnick that a hard core of vaccine resisters, along with reservoirs of the virus in domestic animals, may make herd immunity elusive. Rather, he says, the correct goal is to bring the impact of COVID-19 down to that of something like the flu. Meanwhile, India is now overwhelmed by a devastating death toll, reported at around four thousand per day but likely much higher. Siddhartha Mukherjee, who reported on the pandemic in developing nations, says that commitments from the West such as extra doses of the AstraZeneca vaccine will barely scratch the surface. A national mobilization will be required to even begin to flatten the curve.

19mins

7 May 2021

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The Gene, by Siddhartha Mukherjee (genetics, biology, evolution)

Bookey App 30 mins Book Summaries Knowledge Notes and More

Thanks to today's rapid development of gene sequencing, cloning, and other genetic technologies, the Human Genome Project has completed the sequencing of all human genes. The quest to decipher the human genetic code seems to have been achieved. However, for many people, the term “gene” is still a mysterious concept. This popular science book about genes not only digs into the past, present, and future of genetic research, but also reveals how genes work and sheds light on the mysteries of life.

13mins

14 Apr 2021

Most Popular

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Siddhartha Mukherjee, U.S. Response to Covid-19

Q&A

Physician and Pulitzer Prize-winning author Siddhartha Mukherjee talks about the U.S. response to the COVID-19 pandemic and the medical science that is being used to combat it.   Learn more about your ad choices. Visit megaphone.fm/adchoices

59mins

6 Jul 2020

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Corona Chronicles: The Past, Present and Future of Pandemics: Siddhartha Mukherjee and Peter Frankopan in conversation

JLF Brave New World

See omnystudio.com/listener for privacy information.

40mins

2 May 2020

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Episode 20: Siddhartha Mukherjee on COVID-19, genes and physician sacrifice

Coronavirus: The Truth with Dr. Robert Pearl and Jeremy Corr

Welcome to the first episode of season 4. This season of the Fixing Healthcare podcast focuses on finding big ideas and the people behind them. The journey begins with Dr. Siddhartha Mukherjee. He is a physician, virologist, oncologist and Pulitzer Prize-winning author of The Emperor of All Maladies: A Biography of Cancer. In 2016, he published the New York Times bestseller, The Gene: An Intimate History. And this month, PBS released a Ken Burns two-part documentary based on Mukherjee’s work. In this interview, Dr. Mukherjee discusses the ethics of gene therapy, his hopes for an effective coronavirus medication, why doctors are struggling, and how he’d grade Trump’s response to COVID-19. Dr. Mukherjee’s highlights from episode 20 On the role of physicians during the COVID-19 pandemic Our job as doctors is to tip the equilibrium towards the host, towards the human, and tip the equilibrium away from the virus. And there are various ways one can do this. Vaccination is essentially one way that we tip the equilibrium towards the host, right? … Another strategy is to limit the amount, the dose, or the exposure to the virus, which is by wearing protective equipment. On the real purpose of social distancing The most important thing to do—and the reason that we’re saying that we should be distancing during this time—is to buy us time. And I’m going to repeat that again and again: We need to buy time. We need to buy time so that the hospitals are not overwhelmed and the healthcare workers can be adequately protected and adequately supplied with the equipment that they need to deal with the sickest patients. On hopes for an effective COVID-19 medication I’m confident that there are going to be antibodies that will decrease the effects of this severe disease in patients, they will just take time to make. Chloroquine is a completely different story. Chloroquine is a repurposed drug, it has probably some mild effect against the entry of the virus and the evidence that it changes the course of disease is pretty mild. On the U.S. government’s response to the pandemic I would give the administration a D- grade in the preparation for this pandemic. We knew about this in December, in a globalized world, it is a travesty that medical workers in the frontline, in the wealthiest nation of the world, don’t have the equipment that they need to handle patients. It is a travesty. On the ethics of gene therapy Gene therapy is alive again. There were mistakes made, ethical mistakes, medical mistakes made in the 1990s and 2000s, when we tried to use gene therapy in humans, replacing genes, altering genes in cells, such as blood cells, a little too quickly. And that froze the field for about 10 years, 15 years, but it is alive again. And for diseases such as sickle cell anemia, such as hemophilia, these gene therapies have turned out to be transformational. On the mission-driven spirit of doctors during a pandemic I’m moved to tears every time I hear of a doctor or a nurse on the front lines without protective equipment, who has been infected and is dying because they put the lives of others in front of their lives. A society which does that is fundamentally wrong. There’s something wrong with us. And there will be an autopsy, there will be a dissection, a biopsy, of what has gone wrong, what went wrong with us as human beings, as a society, once the storm blows over. And I hope that one of the elements of that autopsy reminds us that medicine is an occupation that demands a level of sacrifice. And these men and women perform that sacrifice for you, for us, for our parents, for our children, for our loved ones. They did it during the HIV pandemic, they’ve done it during this pandemic. We need to restore their spirits. We need to respect them. On learning from our nation’s failed COVID-19 response Every system that was supposed to work broke in the early days of the pandemic. We need to figure out, as we recover, how to fix those. And only if we fix those, can we become the superpower and the global leader of economy that we once were, and we hope to be again? All I can say is that, this pandemic has been an X-ray or an MRI that we performed on the American medical system. And all the silent aneurysms and the hidden malignancies that were hidden for some people have become apparent. READ: Full transcript of our discussion with Siddhartha Mukherjee * * * Fixing Healthcare is a co-production of Dr. Robert Pearl and Jeremy Corr. Subscribe to the show via Apple Podcasts or wherever you find podcasts. Join the conversation or suggest a guest by following the show on Twitter and LinkedIn. The post Episode 20: Siddhartha Mukherjee on COVID-19, genes and physician sacrifice appeared first on Fixing Healthcare.

55mins

13 Apr 2020

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Episode 20: Siddhartha Mukherjee on COVID-19, genes and physician sacrifice

Fixing Healthcare Podcast

Welcome to the first episode of season 4. This season of the Fixing Healthcare podcast focuses on finding big ideas and the people behind them. The journey begins with Dr. Siddhartha Mukherjee. He is a physician, virologist, oncologist and Pulitzer Prize-winning author of The Emperor of All Maladies: A Biography of Cancer. In 2016, he published the New York Times bestseller, The Gene: An Intimate History. And this month, PBS released a Ken Burns two-part documentary based on Mukherjee’s work. In this interview, Dr. Mukherjee discusses the ethics of gene therapy, his hopes for an effective coronavirus medication, why doctors are struggling, and how he’d grade Trump’s response to COVID-19. Dr. Mukherjee’s highlights from episode 20 On the role of physicians during the COVID-19 pandemic Our job as doctors is to tip the equilibrium towards the host, towards the human, and tip the equilibrium away from the virus. And there are various ways one can do this. Vaccination is essentially one way that we tip the equilibrium towards the host, right? … Another strategy is to limit the amount, the dose, or the exposure to the virus, which is by wearing protective equipment. On the real purpose of social distancing The most important thing to do—and the reason that we’re saying that we should be distancing during this time—is to buy us time. And I’m going to repeat that again and again: We need to buy time. We need to buy time so that the hospitals are not overwhelmed and the healthcare workers can be adequately protected and adequately supplied with the equipment that they need to deal with the sickest patients. On hopes for an effective COVID-19 medication I’m confident that there are going to be antibodies that will decrease the effects of this severe disease in patients, they will just take time to make. Chloroquine is a completely different story. Chloroquine is a repurposed drug, it has probably some mild effect against the entry of the virus and the evidence that it changes the course of disease is pretty mild. On the U.S. government’s response to the pandemic I would give the administration a D- grade in the preparation for this pandemic. We knew about this in December, in a globalized world, it is a travesty that medical workers in the frontline, in the wealthiest nation of the world, don’t have the equipment that they need to handle patients. It is a travesty. On the ethics of gene therapy Gene therapy is alive again. There were mistakes made, ethical mistakes, medical mistakes made in the 1990s and 2000s, when we tried to use gene therapy in humans, replacing genes, altering genes in cells, such as blood cells, a little too quickly. And that froze the field for about 10 years, 15 years, but it is alive again. And for diseases such as sickle cell anemia, such as hemophilia, these gene therapies have turned out to be transformational. On the mission-driven spirit of doctors during a pandemic I’m moved to tears every time I hear of a doctor or a nurse on the front lines without protective equipment, who has been infected and is dying because they put the lives of others in front of their lives. A society which does that is fundamentally wrong. There’s something wrong with us. And there will be an autopsy, there will be a dissection, a biopsy, of what has gone wrong, what went wrong with us as human beings, as a society, once the storm blows over. And I hope that one of the elements of that autopsy reminds us that medicine is an occupation that demands a level of sacrifice. And these men and women perform that sacrifice for you, for us, for our parents, for our children, for our loved ones. They did it during the HIV pandemic, they’ve done it during this pandemic. We need to restore their spirits. We need to respect them. On learning from our nation’s failed COVID-19 response Every system that was supposed to work broke in the early days of the pandemic. We need to figure out, as we recover, how to fix those. And only if we fix those, can we become the superpower and the global leader of economy that we once were, and we hope to be again? All I can say is that, this pandemic has been an X-ray or an MRI that we performed on the American medical system. And all the silent aneurysms and the hidden malignancies that were hidden for some people have become apparent. READ: Full transcript of our discussion with Siddhartha Mukherjee * * * Fixing Healthcare is a co-production of Dr. Robert Pearl and Jeremy Corr. Subscribe to the show via Apple Podcasts or wherever you find podcasts. Join the conversation or suggest a guest by following the show on Twitter and LinkedIn. The post Episode 20: Siddhartha Mukherjee on COVID-19, genes and physician sacrifice appeared first on Fixing Healthcare.

55mins

13 Apr 2020

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Siddhartha Mukherjee on Getting Personal with Our Genes

Clear+Vivid with Alan Alda

Dr. Siddhartha Mukherjee is the author of the best-selling book, “The Emperor of All Maladies: A Biography of Cancer." The book won a Pulitzer Prize and became the basis for a Ken Burns documentary series on the subject of cancer for PBS. In this fascinating conversation with Alan Alda, Dr. Mukherjee talks about the extraordinary power scientists like him have now to edit our genes using the tool known as CRISPR. Dr. Mukherjee uses CRISPR in his own laboratory at Columbia University to pioneer innovative ways to treat cancer. Dr. Mukherjee is a masterful storyteller and he possesses an obvious command of the science behind his books. He has a special ability to make science both personal and intimate, as you'll experience in this episode. Support the show: https://www.patreon.com/clearandvividSee omnystudio.com/listener for privacy information.

43mins

28 Jan 2020

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Siddhartha Mukherjee Speech: 3 Forms of Listening

English Speeches | Learn English

Learn English with Siddhartha Mukherjee. Siddhartha has a word of advice for this year’s graduates: Listen. Mukherjee is best known for his 2011 Pulitzer Prize-winning book, The Emperor of All Maladies: A Biography of Cancer. It was turned into a three-part documentary by Ken Burns and included among Time magazine’s 100 best nonfiction books of the past century. He is the author of five books, including Start With Why. In this Speech, he also quotes: “Go get out of your heads and go out into the world and listen to it. And most importantly: make us listen to you.” For more, visit: https://www.englishspeecheschannel.com

20mins

8 Nov 2019

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