#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
Lex Fridman Podcast
David Sinclair is a geneticist at Harvard and author of Lifespan. Please support this podcast by checking out our sponsors: – Onnit: https://lexfridman.com/onnit to get up to 10% off – Clear: https://clearme.com/lexpod and use code LexPod to get 2 months free – National Instruments (NI): https://www.ni.com/perspectives – SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera – Linode: https://linode.com/lex to get $100 free credit EPISODE LINKS: David’s Twitter: https://twitter.com/davidasinclair David’s Website: https://lifespanbook.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/lexfridman – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (09:34) – Staying young at heart (13:31) – Bringing people back to life (19:05) – Wearables and tracking health data (28:18) – How to solve aging (38:23) – Why do we age? (43:50) – Genetic reset switch that reverses aging (46:20) – AI in biology (48:52) – Health data (56:58) – Fasting (1:04:29) – Diet (1:12:41) – Exercise (1:18:01) – Sleep (1:26:29) – Data (1:32:00) – Extending lifespan (1:34:42) – Immortality (1:40:28) – Denial of death (1:43:45) – Meaning of life without death
135. Dr. David Sinclair with Dr. Lee Hood: Why We Age—And Why We Don’t Have To
Town Hall Seattle Science Series
Is aging a disease? How old does your body say it is? How can we live longer, healthier lives? Dr. David Sinclair, Harvard professor of genetics and bestselling author, joins ISB co-founder and genomics pioneer Dr. Lee Hood for a conversation about the very latest in aging research. David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics, Blavatnik Insitute, and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He has published over 200 scientific papers, is a co-inventor on over 50 patents, and is the New York Times bestselling author of Lifespan. He serves as co-chief editor of the scientific journal Aging. In 2018, he became an Officer of the Order of Australia (AO). Lee Hood, MD, PhD is a world-renowned scientist. Dr. Lee Hood co-founded Seattle’s Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000-2017. In 2016, ISB affiliated with Providence, and Dr. Hood became Providence’s Senior Vice President and Chief Science Officer. He is also Chief Strategy Officer and Professor at ISB. He is a member of the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine. Presented by Town Hall Seattle and KUOW.
Dr. David Sinclair on How to Reverse Aging & Live to 150!
The Mindset Mentor
On this week's episode of Mindset Mentor, Expert Series! Dr. David Sinclair, biologist, professor of genetics, and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, drops by to discuss the wonders of the body and his pivotal studies on the human aging process.See omnystudio.com/listener for privacy information.
Included in the Time 100 as one of the hundred most influential people in the world, David Sinclair parachutes in to learn us some things. Dr. Sinclair is an award-winning Biologist, Professor of Genetics, and highly-regarded for his profound work in the Ageing & Anti-Ageing field. Listen folks, he’s reversed the age of an eye in a mouse and made the mouse see again. So grab a green-juice and listen up.
Dr. David Sinclair on Unlocking the Secrets of Aging and Prolonging the Health Span of Our Lives
The Keep Going Podcast – Powered by TB12
Our guest for today's episode is Dr. David Sinclair. David is a long time friend of TB12 and a tenured Professor of Genetics at Harvard Medical School. His book, Lifespan, which we sell at our Performance & Recovery Centers, became a NY Times Bestseller in 2019. While David is best known for his work on genes that delay and reverse aging, he has also published over 200 scientific papers and has co-founded a variety of biotechnology companies in the areas of metabolic diseases, inflammation, infectious disease detection, and more. What we appreciate most in our conversations with David is his unique ability to simplify these complex concepts in a way that's easy for everyone to understand. In our discussion today, we focus on the types of food David believes we should all be eating, how to time your food intake to minimize the stress it puts on your body, and the importance of sleep and the circadian rhythm – something we focus on with all of our clients at TB12.
040 - Dr. David Sinclair PhD - The Secret to Reverse Aging.
Dr. David Sinclair is a Harvard Medical School Professor for the Department of Genetics, who focuses on the Biology of Aging. He is known for his contributions on slowing down the effects of aging. Besides his contributions to medical education, he has co-founded multiple medical technology companies and written a variety of books and contributed in films. To follow Dr. Sinclair and his endeavors, follow him on Twitter @davidasinclair.
Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we’ve seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called “free radicals,” changes in the function of our mitochondria, and so many others. Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state. David A. Sinclair, PhD, AO is Professor of Genetics at Harvard Medical School, and is the author of Lifespan: Why We Age–and Why We Don’t Have To. He is the Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. One of the leading innovators of his generation, he is listed by TIME magazine as one of the “100 most influential people in the world” (2014) and top 50 most important people in healthcare (2018). He is a board member of the American Federation for Aging Research, a Founding Editor of the journal Aging, and has received more than 35 awards for his research on resveratrol, NAD, and reprogramming to reverse aging, which have been widely hailed as major scientific breakthroughs and are topics we discuss in our time together. In 2018, Dr. Sinclair became an Officer of the Order of Australia, the equivalent of a knighthood, for his work on national security matters and human longevity. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. In closing, I really need to say that Lifespan ranks as one of the most influential books I have ever read. Please enjoy today’s interview. To stay current on Dr. Sinclair, follow him on Twitter and Instagram.
ICYMI: David Sinclair, Ph.D, On The Science of Aging, Turning Back Our Biological Clocks, & Living Long Healthy Lives
Marni on the Move
In case you missed it, we are bringing back episodes from the archives all week, January 4 thru January 8th, in addition to our weekly episode. This week we launched our 2021 Exercise and Wellness Trends, a guide to the Top 16 ideas, rituals, and routines you should be adding to your life in 2021! HINT: David Sinclair,PhD, explains a few of the key longevity supplements, Resveratrol, NMN and NR we can be taking as we age and why. This is a replay of MOTM EP # 80. David is also on the pod MOTM EP #102 where he sheds light on COVID, Immune System Building and more.David Sinclair, Ph.D., A.O., is a globally renowned biologist and leading world authority on genetics and longevity. If you haven’t already read his incredible eye opening New York Times Best Selling book Lifespan, you are going to be ordering it for sure after this conversation. His revolutionary theory and idea’s on aging and why we don’t have to, which he presents in his Information Theory of Aging and writes about in the book, is based upon his research and studies over the past twenty five years. It is truly groundbreaking. This book is going to change your life, the way you think about aging, and your overall approach to health and the future of your healthcare.David and Marni caught up at Harvard Medical School where he is a Professor of Genetics and Co-Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. On today’s episode David and Marni talk about the inspiration behind David's quest and path into science, genetics, epigenetics, and longevity, the hallmarks of aging, reversing the aging process and turning back your biological clock, activating your vitality genes and pathways, and easy to implement ways you can do this through intermittent fasting, exercise, and cold exposure and more.You will discover the science and emerging technology behind his Information Theory of Aging, Come to understand boosting Mitochondria, increasing NAD levels, and activating Sirtuin’s, learn how to Live healthier and stay younger thanks to his roadmap for taking charge of your health and destiny. David talks about his theory that aging is a disease and by reversing its effects, you can possibly prevent such as age related diabetes, heart disease, Altheimers, infertility and more.David Sinclair’s obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He is also the co-founder of several biotechnology companies and is on the boards of several others. co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 25 awards and honors including being one of Time Magazine’s Top 100 most influential people in the world (in 2014) and Top 50 People in Healthcare (2018).We hope you enjoy. If you like what you here, leave us a review on Apple.Connect@Lifespan on Instagram, Twitter and Facebook@MarniOnTheMove Instagram, Facebook, or LinkedIn
#40 Dr. David Sinclair on The Secrets of Longevity Genes
The Darin Olien Show
If you had the chance to slow down the aging process, would you take it? This sci-fi concept may sound like something from a Star Trek episode. But with new research coming to light, anti-aging fiction could very soon be a reality. Maybe it’s all in the genes. WELCOME TO THE DARIN OLIEN SHOW. On this podcast, you’ll hear me, Darin Olien, “the superfood hunter,” have honest conversations with the extraordinary people that inspire me. I hope that through their knowledge and unique perspectives, they’ll inspire you, too. Although our ideas and approaches to life may differ, our ultimate goal is the same- to save the planet one conversation at a time. So, if you’re interested in expanding your view of the world by learning new perspectives on health, nutrition, and healing the planet, this podcast is for you. Dr. David Sinclair is trying to put a stopper in the aging process. In fact, he’s the one leading the charge. David is the Australian-born Harvard Medical School professor of genetics. He’s also co-director of the Paul F. Glenn Center for the Biology of Aging Research at Harvard Medical School. On top of all that, he’s also a Professor and Head of the Aging Labs at UNSW, Sydney, and an honorary Professor at the University of Sydney. Like many pioneering scientists, he hasn’t been immune to controversy. But, if you Google his name, you’ll see a laundry list of accolades. Especially within the area he’s best known for is, which are genes and small molecules that delay aging. He is currently spearheading the research into gene function in the aging process, with a really heavy focus on the Sirtuin genes. Dr. Sinclair and his team are also trying to lift the lid on exactly what roles resveratrol and NAD precursors play in the anti-aging process. Alongside this, David has published over a whopping 170 scientific papers, is a co-inventor on over 50 patents, and co-founded multiple biotech companies in the areas of aging and biodefense. Oh yeah, and he’s the author of Lifespan: Why We Age and Why We Don’t Have To, which shot him to number 11 on the New York Times bestseller list in just over a week. One of David’s most recent claims to fame was his selection to be one of Time Magazine’s 100 Most Influential People In The World. Now that is impressive. In this conversation, Dr. Sinclair and I get right into the fantastic family of proteins known as Sirtuins and their role in the aging process. We also look at how Intermittent Fasting could turn back the clock. We get into how it all started with yeast cells, and why David is so interested in the NMN molecule. Other great topics we cover: The role Sirtuin genes play and why they’re so bossy Epigenetics and why biological stress isn’t such a bad thing Intermittent fasting and what skipping a meal can do for your body What is Resveratrol and how does it affect the body? Why the NAD molecule is so vital for every living organism The Zombie cells that wreak havoc on your health What David is so excited about for the future of anti-aging science Epigenetic reprogramming and reversing the ticking clock inside us all David’s take on stem cells and how they contribute to the aging process When you should really start taking care of your body Links: David on Facebook David on Twitter David on Instagram – @davidsinclairphd David Sinclair Lab – Harvard Medical School Lifespan Website - Be sure to sign up for Dr. Sinclair’s Newsletter! Paper on Olive Oil and SIRT-1 Activation Netflix’ Down To Earth’ Official Trailer Want amazing skin using all-natural wild-harvested ingredients? Get Caldera Lab’s “The Good” - Use code “DARIN” for 20% off your first order. The Darin Olien Show is produced by the team at Must Amplify. If you’re looking to give a voice to your brand, and make sure that it’s heard by the right people, head to www.mustamplify.com/darin to see what Amplify can do for you.