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David Sinclair

51 Podcast Episodes

Latest 19 Jan 2022 | Updated Daily

Weekly hand curated podcast episodes for learning

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Does Red Meat Accelerate Aging, with David Sinclair PhD - UPDATE and REPOST

Fundamental Health with Paul Saladino, MD

David Andrew Sinclair, PhD is an Australian biologist and professor of genetics. He is also a co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and is known for his research on aging with a focus on epigenetics. Time Stamps: 0:35:27 Podcast begins with David Sinclair 0:36:25 Is when we eat more important than what we eat? 0:38:45 What is the connection between time restrictive eating and longevity? 0:43:54 What causes us to age? 0:45:46 Epigenetic change. 0:52:03 What causes DNA breaks? 0:55:28 What plant foods create DNA breaks? 0:57:13 PARP enzymes  1:00:46 Where does NAD come from? How do we make it? What enzymes use it? 1:04:50 NAD recycling pathway. 1:12:13 Sirtuins. 1:24:14 What are the other longevity genes? (AMP kinase and mTOR) How are they connected to sirtuins? 1:31:50 Does being in a ketogenic state increase NAD? 1:40:30 Xenohormesis and plant molecules. 1:45:50 Resveratrol trials. 1:51:55 mTOR. 1:57:25 David’s thoughts on animal protein. 2:04:03 Meat consumption in relation to the environment and regenerative agriculture. 2:11:28 Where to find David Sinclair. David’s info: https://genetics.med.harvard.edu/sinc... https://lifespanbook.com/ Instagram: @davidsinclairphd Twitter: @davidasinclair Sponsors: Heart & Soil: www.heartandsoil.co White Oak Pastures: www.Whiteoakpastures.com, use code: CarnivoreMD for 10% off your first order The Cold Plunge: TheColdPlunge.com, use code CarnivoreMD for $111 off your cold plunge Eight Sleep: https://www.eightsleep.com/carnivoremd use code “CARNIVOREMD” to save $150 Sacred Hunting: www.sacredhunting.com/Paul for $250 off your hunt

2hr 15mins

17 Jan 2022

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LIFESPAN: The Science Behind Why We Age | Lifespan with Dr. David Sinclair | Episode 1

Huberman Lab

I am honored to share the first episode of the new podcast, Lifespan with Dr. David Sinclair.  Dr. Sinclair is a professor of genetics Harvard Medical School. He is also the co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research.  David is both a friend and a colleague, and I am delighted to have helped him in the creation of this new podcast. It will be an 8-episode series that provides a deep dive into the science behind why we age and the newest research on what we can do to slow, stop and even reverse aging.  While we have Episode 1 of the Lifespan podcast here, please be sure to navigate over to the Lifespan with Dr. David Sinclair podcast channel to subscribe. New episodes will come out every Wednesday for the next 8 weeks. I am certain that you will both enjoy it and learn from it. Show notes for this episode can be found on the Lifespan with Dr. David Sinclair podcast channel. More on that here: https://lifespanpodcast.com 

1hr 3mins

5 Jan 2022

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#58 - Lifespan Book Club (Casey Means & David Sinclair)

LEVELS – A Whole New Level

Levels advisor and author of Lifespan, David Sinclair, sat down with Levels Chief Medical Officer, Casey Means, Head of Growth, Ben Grynol and Head of Research & Development, Taylor Sittler, during our Levels Book Club on December 16, 2021 to take questions from our team and our members.Become a Levels Member – levelshealth.comLearn about Metabolic Health – levelshealth.com/blogFollow Levels on Social – @Levels on Instagram and Twitter

1hr 13mins

3 Jan 2022

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Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Episode 52

Huberman Lab

In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.  In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it. Thank you to our sponsors: ROKA - https://www.roka.com - code "huberman" InsideTracker - https://www.insidetracker.com/huberman Magic Spoon - https://www.magicspoon.com/huberman Dr. David Sinclair Links: Lifespan Podcast: https://lifespanpodcast.com Twitter: https://twitter.com/davidasinclair Instagram: https://www.instagram.com/davidsinclairphd/ YouTube: https://www.youtube.com/davidsinclairpodcast Lifespan (book): https://amzn.to/3mAZQjF Aging Test Waitlist: https://www.doctorsinclair.com Harvard Lab Website: https://sinclair.hms.harvard.edu Our Patreon page: https://www.patreon.com/andrewhuberman Supplements from Thorne: http://www.thorne.com/u/huberman Social: Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network Timestamps: 00:00:00 Dr. David Sinclair, Harvard Medical School 00:03:30 ROKA, InsideTracker, Magic Spoon 00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging 00:10:23 What Causes Aging? The Epigenome 00:15:53 Cosmetic Aging  00:17:15 Development Never Stops, Horvath Clock 00:20:12 Puberty Rate as a Determinant of Aging Rate 00:23:00 Fasting, Hunger & Food Choices 00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy 00:34:50 Caffeine, Electrolytes  00:35:56 Blood Glucose & the Sirtuins; mTOR 00:37:55 Amino Acids: Leucine, “Pulsing” 00:44:35 Metformin, Berberine 00:50:29 Resveratrol, Wine 00:53:20 What Breaks a Fast? 00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing 01:09:10 Are Artificial Sweeteners Bad for Us? 01:12:04 Iron Load & Aging 01:15:05 Blood Work Analysis 01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary 01:26:02 Amino Acids, Plants, Antioxidants 01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen 01:40:35 Neuroplasticity & Neural Repair 01:46:19 Ice Baths, Cold Showers, “Metabolic Winter” 01:48:07 Obesity & How It Accelerates Aging, GnRH  01:52:10 Methylation, Methylene Blue, Cigarettes  01:56:17 X-Rays   01:59:00 Public Science Education, Personal Health 02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com 02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram  Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com 

2hr 10mins

27 Dec 2021

Most Popular

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David Sinclair || Why We Age and Why We Don’t Have To

The Psychology Podcast

In this episode, I talk to world-renowned biologist David Sinclair about aging and longevity. David rejects the notion that the deterioration of health is a natural part of growing old and asserts that aging is a disease itself that we need to reverse. But how will a reset of our biological clocks affect our interactions, responses to adversity, morality, and how we live our lives? We discuss the ethical implications of limitless lifespans and also touch on the topics of death, evolution, genetics, medicine, and data tracking.BioDr. David Sinclair is a professor in the department of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and co-founder of the scientific journal Aging. He is best known for his work on understanding why we age and how to slow its effects. In addition to being a co-founder of several biotechnology companies, he's the author of the book Lifespan: Why We Age – and Why We Don't Have To. Dr. Sinclair was listed by TIME magazine as one of the “100 most influential people in the world”.Website: sinclair.hms.harvard.eduTwitter: @davidasinclair Topics00:02:26 David’s “sticky beak” personality00:05:08 David’s childhood and upbringing00:10:21 The torment of inevitable death 00:15:13 David’s life purpose00:22:06 Intergenerational interactions 00:28:59 Aging is a disease we can reverse 00:32:20 Accelerating human evolution 00:36:24 The SIR2 gene and the NMN+ pill00:40:04 Reverse brain aging and Alzheimer’s00:42:50 Gene therapy in pills00:48:45 Will we be happier with longer lifespans? 00:52:49 Inside Tracker00:55:31 The future of data tracking and medicine01:00:47 The Information Theory of Aging01:09:08 Is there a biological limit to our lifespans?01:14:21 Mental states can produce epigenetic changes01:20:39 David’s future projects

1hr 21mins

2 Dec 2021

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#208 Why We Age and Why We Don’t Have To, with Professor David Sinclair

Feel Better, Live More with Dr Rangan Chatterjee

My guest today is a revolutionary thinker and ground-breaking scientist who’s on a mission to make you younger. And if that sounds promising, you’ll be pleased to know this podcast contains practical advice you can start to follow today. He’s Australian biologist and Harvard professor David Sinclair, author of Lifespan: Why We Age – And Why We Don’t Have To. David is one of the world’s leading scientific authorities on longevity, ageing and how to slow its effects. His research interest is the epigenetics of ageing and how we can reprogramme our genes to stop and even reverse it. That’s right – reverse the ageing process. And when you listen to him explain the science, it’s not as crazy as it sounds. The key to staying young, he explains, is inducing hormesis, a state of survival in our bodies, and you don’t need a lab to do it. Simple habits like skipping meals, eating more plants and less meat, certain types of exercise, and hot/cold therapies can create just enough adversity to switch on our bodies’ longevity genes. David’s goal is not vanity. It’s not to make us young for the sake of it. Instead, he’s shining a spotlight on ageing as the root cause of all the major chronic diseases that ultimately kill us. Heart disease, stroke, cancer, diabetes, dementia – his research suggests they could all be eliminated if we looked at the common cause, instead of treating the end symptoms. Of course, this would result in a population who spent significantly more time on earth, so we discuss the ethical questions this raises in the light of our climate and economic crises. Would ageing really be better described as a disease than a natural, inevitable process? This conversation contains so many thinking points and lots of practical tips that we can all start to apply immediately. Would you want to live to 150, if you could do so in full health? CAUTION: If you have type-2 diabetes or are on any blood sugar lowering medications, talk to a healthcare professional before you go for prolonged periods without eating. Thanks to our sponsors: https://www.zendium.com/livemore https://vivobarefoot.com/livemore http://www.athleticgreens.com/livemore Show notes available at https://drchatterjee.com/208 Support the podcast: Members get ad-free episodes and exclusive content including my take on the topics most requested by the FBLM community https://drchatterjee.com/membership Follow me on https://www.instagram.com/drchatterjeeDISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or other qualified health care provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website. See acast.com/privacy for privacy and opt-out information.

2hr 19mins

12 Oct 2021

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David Sinclair: Reverse Aging & Extend Your Lifespan

Mayim Bialik's Breakdown

David Sinclair (biologist, Professor of Genetics at Harvard Medical School, and author of Lifespan: Why We Age and Why We Don’t Have To) discusses ways we can extend our lifespan and the work he’s doing to slow and reverse aging brain cells. He details the best lifestyle changes and emerging technologies available now to prevent most diseases until our 80’s, increase longevity, and even reverse the effects of aging. David opens up about his mental health struggles stemming from his own insecurities and frustrations with the planet, how his mother’s passing changed his outlook on life, and the dream he had that influenced his research and became a turning point in his career. After debating about intermittent fasting, Mayim and David examine the thread between solving problems in medicine, economics, and sociology, the effects of stress on the aging process, and mental health components tied to the aging brain. Mayim considers the amount of resources needed if humans lived longer, and the impact western culture’s attitude about aging might have on an increased lifespan.David Sinclair's Book: https://lifespanbook.com/?utm_medium=social&utm_source=linktress&utm_campaign=get%20the%20bookBialikBreakdown.comYouTube.com/mayimbialik

1hr 9mins

9 Sep 2021

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David Sinclair: How To Live Longer & Delay Aging

Master Your Mind With Marisa

In this episode Marisa speaks with Harvard Medical School professor of genetics, David Sinclair. His award-winning research into why we age and how we can slow it down has established him as a highly-respected leader in his field and a New York Times bestselling author.In this episode, Marisa and David discuss his fascinating scientific findings that contradict the mainstream belief that "aging is inevitable”. Their conversation covers:Why delaying aging is not so much about what you eat, rather it’s when you eat.The impact of stress on your body and how you can best manage your response to stressful circumstances. The specific types of exercise that help to delay biological aging.Why our bodies need to experience some “adversity” if we want our health to thrive, and how we can achieve this.The role of our thoughts and visualization in staying physically healthy.See more from David Sinclair here: https://lifespanbook.comPlease subscribe and rate the podcast, and catch up with Marisa’s longer videos on YouTube here: https://www.youtube.com/user/MarisaPeer1Stay up to date with Marisa on Social Media:Instagram: @marisapeertherapy https://www.instagram.com/marisapeertherapyFacebook: @marisa.peer.therapy https://www.facebook.com/marisa.peer.therapyTwitter: @marisapeer  https://twitter.com/marisapeerResource Links:➡ Download Marisa’s FREE ‘I Am Enough’ meditation: https://bit.ly/MP-Audio-iamenough➡ Explore audio hypnosis shop, for issues from smoking, to weight loss to low confidence: https://bit.ly/MP-Audio-Hypnosis➡ Boost your self-esteem with Marisa’s FREE workbook: http://bit.ly/Self-Esteem-workbook-download➡ Discover how you can train with Marisa Peer in Rapid Transformational Therapy®️: http://bit.ly/rtt-masterclass-watch


2 Sep 2021

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#343 - Dr David Sinclair - Defeating Ageing & Living Longer

Modern Wisdom

Dr David Sinclair is a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul Glenn Centre for the Biological Mechanisms of Ageing. The longevity movement is huge, people all around the globe are trying to discover how to live longer and slow down ageing. It's been 2 years since Dr Sinclair was last on the show, so I figured it was time to invite him back on and find out what he's been up to. Expect to learn why having a dog can make you live longer, how fasting can slow down ageing, what the longevity research says about loneliness, what Dr Sinclair's new supplement regime looks like, whether he's worried about 5G phones or Bluetooth headphones and much more... Sponsors: Get 5 Free Travel Packs, Free Liquid Vitamin D and Free Shipping from Athletic Greens at https://athleticgreens.com/modernwisdom (discount automatically applied) Get 20% discount on the highest quality CBD Products from Pure Sport at https://puresportcbd.com/modernwisdom (use code: MW20) Extra Stuff: Buy Lifespan - https://amzn.to/3xaFIrQ Sign up to Dr Sinclair's waitlist - https://www.doctorsinclair.com/ Follow David on Twitter - https://twitter.com/davidasinclair Get my free Ultimate Life Hacks List to 10x your daily productivity → https://chriswillx.com/lifehacks/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Join the discussion with me and other like minded listeners in the episode comments on the MW YouTube Channel or message me... Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/ModernWisdomPodcast Email: https://www.chriswillx.com/contact

1hr 6mins

5 Jul 2021

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David Sinclair

Good For You

Dr. David Sinclair is a world-renowned biologist and professor of genetics at Harvard Medical school and author of the book Lifespan: Why We Age and Why We Don't Have To.  Dr. Sinclair tells us how we can live forever and Whitney almost electrocutes him by spilling coffee on his biochip.  Plus, Whitney and Benton talk about meeting her lover's family in a slutty dress, a rogue pube, and announce her fall stand-up tour.   Check out David's website: www.doctorsinclair.comSee omnystudio.com/listener for privacy information.

3hr 57mins

17 Jun 2021