Kevin Eggan's guest appearances

Kevin Eggan

The Stem Cell Podcast

StemCells@Lunch Digested

Michael Levin

Alejo Rodriguez-Fraticelli

Ludovic Vallier

Nicolas Rivron

Ophir Klein

Janet Rossant

Peter Zandstra

Jürgen Knoblich

Sandrine Thuret

Kaytlyn Gerbin

Chuck Murry

Sarthak Sinha

Judith Kerr

Andrew Cohen

Camilla Forsberg

OwlTail

Today, Professor Kevin Eggan from the Department of Stem Cell and Regenerative Biology at Harvard University, is interviewed by PhD student Peter Harley. Kevin talks about the difficulties of studying neurodegenerative disorders and applying stem cell technologies to study motor neuron disease/ALS. He discusses why highlighting and understanding contradictory findings is an essential part of scientific research and the reliability of using mouse models to study ALS.   To find out more about Kevin’s work please visit the following website: https://hsci.harvard.edu/people/kevin-c-eggan-phd

Today, Professor Kevin Eggan from the Department of Stem Cell and Regenerative Biology at Harvard University, is interviewed by PhD student Peter Harley. Kevin talks about the difficulties of studying neurodegenerative disorders and applying stem cell technologies to study motor neuron disease/ALS. He discusses why highlighting and understanding contradictory findings is an essential part of scientific research and the reliability of using mouse models to study ALS. To find out more about Kevin’s work please visit the following website: <a href="https://hsci.harvard.edu/people/kevin-c-eggan-phd" rel="nofollow" target="_blank">https://hsci.harvard.edu/people/kevin-c-eggan-phd</a>

Episode 121 - Prof Kevin Eggan - "Science progresses through replication, validation, extension"

Michael Wells

Guest:Dr. Eggan is a Professor in the Department of Stem Cell and Regenerative Biology, Harvard University. On this show he joins us, along with a post-doctoral fellow from his lab, Dr. Michael Wells, to discuss their latest publication on investigating mechanisms of infection in Zika virus.Resources and LinksMicrocephaly Cases Surge in Colombia following Rise in Zika Infections – Colombia saw a surge on 2016 in babies with microcephaly — more than four times the number reported in the previous year caused by Zika virus infections.Having an Extra Chromosome Slows Cancer Cell Growth – This article reveals that smaller tumors, less cancer-driving proteins are seen with cells with an extra copy of a chromosome — known as trisomic cells.Gut Microbes Mix May Regulate Motor Deficits in Parkinson’s – Gut impulse signals from gut microbes can activate immune cells called microglia in the mouse brain, causing inflammation that’s characteristic of Parkinson’s disease.Solar Panels Are Almost Truly Green – This article reports that solar panels are about to break even on their energy usage and greenhouse gas emissions.Telomere Balance between Elongation and Trimming in Stem Cells – Researchers report that telomere length is determined by the balance between telomere elongation, which is mediated by telomerase, and telomere trimming, which is controlled by XRCC3 and Nbs1, homologous recombination proteins that generate single-stranded C-rich telomeric DNA and double-stranded telomeric circular DNA, respectively.Long-Term Self-Renewing Human Epicardial Cells Generated from Pluripotent Stem Cells under Defined Xeno-Free Conditions – Scientists show that the temporal modulation of canonical Wnt signaling is sufficient for epicardial induction from six different human pluripotent stem cell lines, including a WT1-2A-eGFP knock-in reporter line, under chemically defined, xeno-free conditions.Development of a Rapid Screen for the Endodermal Differentiation Potential of Human Pluripotent Stem Cell Lines – Researchers developed a rapid small molecule based screen to assess the endodermal potential of human pluripotent stem cells, based solely on definitive endoderm morphology.Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection – Dr. Kevin Eggan and his team of researchers show that genetic ablation of AXL has no effect on Zika virus (ZIKV) entry or ZIKV-mediated cell death in human induced pluripotent stem cell-derived neural progenitor cells or cerebral organoids.Photo Reference: Courtesy of Dr. Kevin Eggan#footable_5807  {    font-family: inherit;    font-size: 14px;    }#footable_parent_5807 thead{    display: none;}#footable_parent_5807 a.nt_edit_link{    display: none;}#footable_parent_5807 td{    border-color: #fff;}#footable_parent_5807 img{    margin-top: 0px;}.semantic_ui .ui.table{  border: 0px solid !important;  }.semantic_ui .ui.table td {    padding: 0em;}                                                                        #footable_5808  {    font-family: inherit;    font-size: 14px;    }thead{    display: none;}#footable_parent_5808 a.nt_edit_link{    display: none;}#footable_parent_5808 td{    border-color: #fff;}#footable_parent_5808 img{    margin-top: 0px;}.semantic_ui .ui.table{  border: 0px solid !important;  }.semantic_ui .ui.table td {    padding: 0em;}                                                                        #footable_5807  {    font-family: inherit;    font-size: 14px;    }#footable_parent_5807 thead{    display: none;}#footable_parent_5807 a.nt_edit_link{    display: none;}#footable_parent_5807 td{    border-color: #fff;}

Guest: Dr. Eggan is a Professor in the Department of Stem Cell and Regenerative Biology, Harvard University. On this show he joins us, along with a post-doctoral fellow from his lab, Dr. Michael Wells, to discuss their latest publication on investigating mechanisms of infection in Zika virus. Resources and Links Microcephaly Cases Surge in Colombia following Rise in Zika Infections – Colombia saw a surge on 2016 in babies with microcephaly — more than four times the number reported in the previous year caused by Zika virus infections. Having an Extra Chromosome Slows Cancer Cell Growth – This article reveals that smaller tumors, less cancer-driving proteins are seen with cells with an extra copy of a chromosome — known as trisomic cells. Gut Microbes Mix May Regulate Motor Deficits in Parkinson’s – Gut impulse signals from gut microbes can activate immune cells called microglia in the mouse brain, causing inflammation that’s characteristic of Parkinson’s disease. Solar Panels Are Almost Truly Green – This article reports that solar panels are about to break even on their energy usage and greenhouse gas emissions. Telomere Balance between Elongation and Trimming in Stem Cells – Researchers report that telomere length is determined by the balance between telomere elongation, which is mediated by telomerase, and telomere trimming, which is controlled by XRCC3 and Nbs1, homologous recombination proteins that generate single-stranded C-rich telomeric DNA and double-stranded telomeric circular DNA, respectively. Long-Term Self-Renewing Human Epicardial Cells Generated from Pluripotent Stem Cells under Defined Xeno-Free Conditions – Scientists show that the temporal modulation of canonical Wnt signaling is sufficient for epicardial induction from six different human pluripotent stem cell lines, including a WT1-2A-eGFP knock-in reporter line, under chemically defined, xeno-free conditions. Development of a Rapid Screen for the Endodermal Differentiation Potential of Human Pluripotent Stem Cell Lines – Researchers developed a rapid small molecule based screen to assess the endodermal potential of human pluripotent stem cells, based solely on definitive endoderm morphology. Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection – Dr. Kevin Eggan and his team of researchers show that genetic ablation of AXL has no effect on Zika virus (ZIKV) entry or ZIKV-mediated cell death in human induced pluripotent stem cell-derived neural progenitor cells or cerebral organoids. Photo Reference: Courtesy of Dr. Kevin Eggan #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; }

Ep. 81: “Organoids and Zika” Featuring Drs. Kevin Eggan and Michael Wells

Lou Gehrig

Guest:Dr. Kevin Eggan from Harvard University joins the show to talk about his latest work using stem cells to cure ALS/Lou Gehrig’s disease.Resources and LinksFate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous TubulesHope for Aging Brains, Skeletal MusclePain Curbs Sex Drive in Female Mice, but Not in MalesNew Virus Related To Smallpox Is Found in Republic Of GeorgiaMale Researchers Stress Out RodentsScripps Florida Scientists Find Connection Between Gene Mutation, Key Symptoms of AutismSoy-Dairy Protein Blend and Whey Protein Ingestion After Resistance Exercise Increases Amino Acid Transport and Transporter Expression in Human Skeletal MusclePush Comes to Shove: Gilead's $1,000 Pill Could Hurt Insurer EarningsDeath Rates From Pancreatic Cancer Predicted to Rise in Europe in 2014Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System FunctionY chromosome is Not Disappearing, Researchers SayLoss Of Memory Reversed in Alzheimer's Mice ModelsMRSA Spreads in HouseholdsREDD1 is Essential for Stress-Induced Synaptic Loss and Depressive BehaviorAmyloid Precursor Protein Regulates Neurogenesis by Antagonizing Mir-574-5p in the Developing Cerebral CortexJapanese Nobel Winner Latest to Apologize Over Stem-Cell ResearchRIKEN to Check 20,000 Papers for Doctored Images and PlagiarismStem Cells and the "Staircase of Shame"Stem Cells May Be Key to Long Life: Research on Body of 115-Year-Old WomanHow Silly Putty May Advance Stem Cell ResearchFirst Stem Cells Cloned From Diabetes Patient, Thanks to Egg DonorsHuman Oocytes Reprogram Adult Somatic Nuclei of a Type 1 Diabetic to Diploid Pluripotent Stem CellsHuman Embryonic-Stem-Cell-Derived Cardiomyocytes Regenerate Non-Human Primate HeartsInfertility: Stem Cell-Based Sperm Created From Infertile Mens SkinReprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined FactorsA 3D Sphere Culture System Containing Functional Polymers for Large-Scale Human Pluripotent Stem Cell Production3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem CellsPhoto Reference: Courtesy of Dr. Kevin Eggan#footable_5807  {    font-family: inherit;    font-size: 14px;    }#footable_parent_5807 thead{    display: none;}#footable_parent_5807 a.nt_edit_link{    display: none;}#footable_parent_5807 td{    border-color: #fff;}#footable_parent_5807 img{    margin-top: 0px;}.semantic_ui .ui.table{  border: 0px solid !important;  }.semantic_ui .ui.table td {    padding: 0em;}                                                                        #footable_5808  {    font-family: inherit;    font-size: 14px;    }thead{    display: none;}#footable_parent_5808 a.nt_edit_link{    display: none;}#footable_parent_5808 td{    border-color: #fff;}#footable_parent_5808 img{    margin-top: 0px;}.semantic_ui .ui.table{  border: 0px solid !important;  }.semantic_ui .ui.table td {    padding: 0em;}                                                                        #footable_5807  {    font-family: inherit;    font-size: 14px;    }#footable_parent_5807 thead{    display: none;}#footable_parent_5807 a.nt_edit_link{    display: none;}#footable_parent_5807 td{    border-color: #fff;}#footable_parent_5807 img{    margin-top: 0px;}.semantic_ui .ui.table{  border: 0px solid !important;  }.semantic_ui .ui.table td {    padding: 0em;}                                                                        #footable_5808  {    font-family: inherit;    font-size: 14px;    }thead{    display: none;

Guest: Dr. Kevin Eggan from Harvard University joins the show to talk about his latest work using stem cells to cure ALS/Lou Gehrig’s disease. Resources and Links Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules Hope for Aging Brains, Skeletal Muscle Pain Curbs Sex Drive in Female Mice, but Not in Males New Virus Related To Smallpox Is Found in Republic Of Georgia Male Researchers Stress Out Rodents Scripps Florida Scientists Find Connection Between Gene Mutation, Key Symptoms of Autism Soy-Dairy Protein Blend and Whey Protein Ingestion After Resistance Exercise Increases Amino Acid Transport and Transporter Expression in Human Skeletal Muscle Push Comes to Shove: Gilead's $1,000 Pill Could Hurt Insurer Earnings Death Rates From Pancreatic Cancer Predicted to Rise in Europe in 2014 Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function Y chromosome is Not Disappearing, Researchers Say Loss Of Memory Reversed in Alzheimer's Mice Models MRSA Spreads in Households REDD1 is Essential for Stress-Induced Synaptic Loss and Depressive Behavior Amyloid Precursor Protein Regulates Neurogenesis by Antagonizing Mir-574-5p in the Developing Cerebral Cortex Japanese Nobel Winner Latest to Apologize Over Stem-Cell Research RIKEN to Check 20,000 Papers for Doctored Images and Plagiarism Stem Cells and the "Staircase of Shame" Stem Cells May Be Key to Long Life: Research on Body of 115-Year-Old Woman How Silly Putty May Advance Stem Cell Research First Stem Cells Cloned From Diabetes Patient, Thanks to Egg Donors Human Oocytes Reprogram Adult Somatic Nuclei of a Type 1 Diabetic to Diploid Pluripotent Stem Cells Human Embryonic-Stem-Cell-Derived Cardiomyocytes Regenerate Non-Human Primate Hearts Infertility: Stem Cell-Based Sperm Created From Infertile Mens Skin Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors A 3D Sphere Culture System Containing Functional Polymers for Large-Scale Human Pluripotent Stem Cell Production 3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Photo Reference: Courtesy of Dr. Kevin Eggan #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none;

Ep. 18: Lou Gehrig’s Update Featuring Dr. Kevin Eggan