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Steve Horvath

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Latest 20 Feb 2021 | Updated Daily

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Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

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Found My Fitness - Rhonda Patrick Podcast Notes Key Takeaways The Horvath Aging Clock is collected through DNA sample and currently the most accurate estimate of chronological ageThe epigenetic clock is under genetic control – evidence strongly suggests the epigenetic clock is a continuous readout that links prenatal tissue directly to disease and healthspan in older ageSome people inherit DNA which allows their epigenetic clock to progress slowerEarly studies show DNA GrimAge is a good predictor of time to heart disease and chronic disease before clinical markers appearCompared to the epigenetic clock, telomere length is a weak predictor of agingIn healthy people, even a “perfect” lifestyle won’t make a big dent in epigenetic ageThe weakness of the epigenetic clocks is that we don’t understand the specific regulators of these clocks Read the full notes @ podcastnotes.orgConsistent patterns of age-based alterations in DNA methylation can be harnessed to estimate age, serving as a sort of "clock," the premise of which is truly remarkable: Predict a person's age (or even lifespan), based on chemical modifications to their DNA that reflect the biological life history of the organism. Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan. In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging. Get this show's notes, timeline, and transcript: https://www.foundmyfitness.com/episodes/steve-horvath Dr. Horvath's faculty bio page: https://ph.ucla.edu/faculty/horvath Dr. Horvath's Wikipedia page: https://en.wikipedia.org/wiki/Steve_Horvath Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: https://www.foundmyfitness.com/episodes/epigenetic-clock The FoundMyFitness overview article of epigenetic clocks: https://www.foundmyfitness.com/topics/epigenetic-clocks

1hr 33mins

6 Jan 2021