Corrado Spadafora's guest appearances

Corrado Spadafora

Finding Genius Podcast

FutureTech Podcast

Laura Potterat

Marc Guell

Paul Turner

Jan Vijg

Eleftherios Mylonakis

Cory Kidd

Charles C.J

Helius Medical Technologies

Patrick McKeown

Michael G. Surette

Katelyn Parsons

John Tucker

Jake Kushner

Erik Gunther

Kim Kush

OwlTail

Sperm-mediated gene transfer is a process by which mature sperm cells take up exogenous DNA (DNA from outside of the sperm) and bring it to oocytes during fertilization. This can only happen when sperm is still in the epididymous because once ejaculated, sperm is surrounded by a protective glycoprotein in seminal fluid that prevents its interaction with the exogenous material.   Corrado Spadafora discusses the potential evolutionary implications of this finding, and shares the hypothesis that this phenomenon could result in the formation of a new species; that is, if environmental conditions and stressors are strong enough and the amount, quality, and nature of the RNA that reaches the epididymous is significantly different, then it could have the power to redirect embryo development and create something new. Learn more about Spadafora’s research by pressing play. He has also authored and co-authored several papers, which can be found by searching his name at https://www.ncbi.nlm.nih.gov/pubmed.

Sperm-mediated gene transfer is a process by which mature sperm cells take up exogenous DNA (DNA from outside of the sperm) and bring it to oocytes during fertilization. This can only happen when sperm is still in the epididymous because once ejaculated, sperm is surrounded by a protective glycoprotein in seminal fluid that prevents its interaction with the exogenous material.   Corrado Spadafora discusses the potential evolutionary implications of this finding, and shares the hypothesis that this phenomenon could result in the formation of a new species; that is, if environmental conditions and stressors are strong enough and the amount, quality, and nature of the RNA that reaches the epididymous is significantly different, then it could have the power to redirect embryo development and create something new. Learn more about Spadafora’s research by pressing play. He has also authored and co-authored several papers, which can be found by searching his name at <a href="https://www.ncbi.nlm.nih.gov/pubmed" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed</a>.

Evolutionary Implications of Sperm-Mediated Gene Transfer—Corrado Spadafora—Institute of Translational Pharmacology; Italian National Research Council

In this episode, we are joined by Corrado Spadafora of the Institute of Translational Pharmacology and the Italian National Research Council. Spadafora gives us an inside look at how his laboratory discovered that mature sperm cells of several species can take up DNA molecules from outside themselves and bring that DNA to oocytes during fertilization. Because this can compromise the genetic identity of the resulting embryo, the seminal fluid that surrounds sperm protects it from exogenous DNA upon ejaculation.     However, the sperm cells are not protected when still in the epididymous. While Spadafora is more focused on the evolutionary implications of these findings, he does note some possible medical consequences; particularly the suggestion that the father’s lifestyle and environmental conditions could be reflected in the makeup of his children, potentially predisposing them to certain metabolic conditions.   Press play to hear more. If you are interested in reading about his research, you can find his papers on Medline by searching at https://www.ncbi.nlm.nih.gov/pubmed.

In this episode, we are joined by Corrado Spadafora of the Institute of Translational Pharmacology and the Italian National Research Council. Spadafora gives us an inside look at how his laboratory discovered that mature sperm cells of several species can take up DNA molecules from outside themselves and bring that DNA to oocytes during fertilization. Because this can compromise the genetic identity of the resulting embryo, the seminal fluid that surrounds sperm protects it from exogenous DNA upon ejaculation.   However, the sperm cells are not protected when still in the epididymous. While Spadafora is more focused on the evolutionary implications of these findings, he does note some possible medical consequences; particularly the suggestion that the father’s lifestyle and environmental conditions could be reflected in the makeup of his children, potentially predisposing them to certain metabolic conditions. Press play to hear more. If you are interested in reading about his research, you can find his papers on Medline by searching at <a href="https://www.ncbi.nlm.nih.gov/pubmed" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed</a>.

Why You Might Have More Than Just Your Father’s Eyes—Corrado Spadafora—Institute of Translational Pharmacology; Italian National Research Council