Graham Hatfull's guest appearances

Graham Hatfull

Finding Genius Podcast

This Week in Virology

iBiology: Subtitled versions

microTalk

Mya Breitbart

Jeff Miller

Mark Denison

Eugene Koonin

Mahmoud Ghannoum

Daniel Griffin

Paul Offit

Forest Rohwer

Ross Taylor

Scott Smith

Andrew Smith

Steven C. Hayes

Mark Bertin

Elisha Goldstein

Scott Nelson

OwlTail

Professor Graham Hatfull studies bacteriophages in the human body; these are viruses that infect bacteria. Interested in both "the exploration and exploitation of these" bacteriophages infecting bacteria, he explains  Why his lab has focused on mycobacterium characteristics and the mycobacteria phages that target this group, How the coevolution of bacteria and phages have created a complex relationship affecting the molecular genetics of bacteria, and What happened in a case study utilizing a combination of phages to kill a particular strain of Mycobacterium abscessus in a Cystic Fibrosis patient.  Graham Hatfull is the Eberly Family Professor of Biotechnology in the Department of Biological Sciences at the University of Pittsburgh and an HHMI Professor. He tells listeners about the basics and the complexities of phages and potential therapies that might utilize them.   He explains that his lab has focused mainly on the mycobacterium group because it contains important human pathogens like  Mycobacterium tuberculosis, which is responsible for the symptoms and spread of tuberculosis. Tuberculosis causes around 1.7 billion deaths a year. Studying the phages that infect this group of mycobacterium helps understand such pathogens as well as potential treatments. In order to study these phages, his lab uses bacterium related to these more dangerous bacteria as safer surrogates. This work puts us them a good position to figure out which phages infect TB and which ones don't. He also describes phage biology and coevolution with bacteria, which has led to a complex relationship.  For example, he discusses phages that are "temperate," and what that means in relationship to bacteria development. Finally, he talks about a successful case study in which they were able to use a cocktail of phages to successfully kill a particular strain of Mycobacterium abscessus in a Cystic Fibrosis patient. For more, see his lab's website at hatfull.org.  Available on Apple Podcasts: apple.co/2Os0myK 

Professor Graham Hatfull studies bacteriophages in the human body; these are viruses that infect bacteria. Interested in both "the exploration and exploitation of these" bacteriophages infecting bacteria, he explains <ul> <li>Why his lab has focused on mycobacterium characteristics and the mycobacteria phages that target this group,</li> <li>How the coevolution of bacteria and phages have created a complex relationship affecting the molecular genetics of bacteria, and</li> <li>What happened in a case study utilizing a combination of phages to kill a particular strain of Mycobacterium abscessus in a Cystic Fibrosis patient.</li> </ul> Graham Hatfull is the Eberly Family Professor of Biotechnology in the Department of Biological Sciences at the University of Pittsburgh and an HHMI Professor. He tells listeners about the basics and the complexities of phages and potential therapies that might utilize them.  He explains that his lab has focused mainly on the mycobacterium group because it contains important human pathogens like <a href="https://www.findinggeniuspodcast.com/podcasts/tb-or-not-to-be-sharee-basdeo-research-fellow-clinical-medicine-trinity-college-dublin/" rel="nofollow" target="_blank"> Mycobacterium tuberculosis</a>, which is responsible for the symptoms and spread of tuberculosis. Tuberculosis causes around 1.7 billion deaths a year. Studying the phages that infect this group of mycobacterium helps understand such pathogens as well as potential treatments. In order to study these phages, his lab uses bacterium related to these more dangerous bacteria as safer surrogates. This work puts us them a good position to figure out which phages infect TB and which ones don't. He also describes phage biology and coevolution with bacteria, which has led to a complex relationship. For example, he discusses phages that are "temperate," and what that means in relationship to bacteria development. Finally, he talks about a successful case study in which they were able to use a cocktail of phages to successfully kill a particular strain of Mycobacterium abscessus in a Cystic Fibrosis patient. For more, see his lab's website at <a href="http://www.hatfull.org/" rel="nofollow" target="_blank">hatfull.org</a>. Available on Apple Podcasts: <a href="https://podcasts.apple.com/us/podcast/id1169016854" rel="nofollow" target="_blank">apple.co/2Os0myK</a>

Phage Cocktail for Mycobacterial Infection: Graham Hatfull Talks Phages and a Successful Intervention 

Bacteriophages (“phages”), or bacterial viruses, are the most abundant biological entity on the planet, and the microbial world is shaped by these predators and parasites. The ability of bacteriophages to specifically target and kill their prey is being explored as an alternate therapy to antibiotics against various bacterial diseases. Dr. Graham Hatfull is a professor at the University of Pittsburgh who studies Mycobacterium tuberculosis, the causative agent of tuberculosis, and the phages that infect it. Hatfull directs the Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) program along with the Howard Hughes Medical Institute. Hatfull talks about how the SEA-PHAGES program has allowed entering students at more than 100 colleges and universities around the country to discover thousands of new phages, how phages isolated from the program were used to save the life of a patient infected with Mycobacterium, what the prospects are for phage therapy being used as treatment for other diseases, how bacterial resistance to phage infection impacts phage therapy, and how important research experience can be for students. microTalk was joined by Dr. Jimmy Ballard when this podcast was recorded at the ASM Microbe 2019 conference in San Francisco, CA. The microCase for listeners to solve is about Buck Shott, an aging Western movie stunt double who comes down with a potentially fatal infection after filming an action scene for “The Old, the Ancient, and the Geriatric”.  Participants: Karl Klose, Ph.D. (UTSA) Graham Hatfull, Ph.D. (University of Pittsburgh) Jimmy Ballard, Ph.D. (University of Oklahoma) Janakiram Seshu, Ph.D. (UTSA) Mylea Echazarreta (UTSA)

Bacteriophages (“phages”), or bacterial viruses, are the most abundant biological entity on the planet, and the microbial world is shaped by these predators and parasites. The ability of bacteriophages to specifically target and kill their prey is being explored as an alternate therapy to antibiotics against various bacterial diseases. Dr. Graham Hatfull is a professor at the University of Pittsburgh who studies Mycobacterium tuberculosis, the causative agent of tuberculosis, and the phages that infect it. Hatfull directs the Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) program along with the Howard Hughes Medical Institute. Hatfull talks about how the SEA-PHAGES program has allowed entering students at more than 100 colleges and universities around the country to discover thousands of new phages, how phages isolated from the program were used to save the life of a patient infected with Mycobacterium, what the prospects are for phage therapy being used as treatment for other diseases, how bacterial resistance to phage infection impacts phage therapy, and how important research experience can be for students. microTalk was joined by Dr. Jimmy Ballard when this podcast was recorded at the ASM Microbe 2019 conference in San Francisco, CA. The microCase for listeners to solve is about Buck Shott, an aging Western movie stunt double who comes down with a potentially fatal infection after filming an action scene for “The Old, the Ancient, and the Geriatric”. Participants: Karl Klose, Ph.D. (UTSA) Graham Hatfull, Ph.D. (University of Pittsburgh) Jimmy Ballard, Ph.D. (University of Oklahoma) Janakiram Seshu, Ph.D. (UTSA) Mylea Echazarreta (UTSA)

055: The Age of Phage: Phage Therapy with Graham Hatfull 

On episode #87 of the podcast This Week in Virology,  Vincent, Alan, and Rich hear from Professor Graham Hatfull how students   in the Phage Hunters Integrating Research and Education (PHIRE) program   learn about scientific inquiry by doing research on bacteriophages. Host links Vincent Racaniello, Rich Condit, Alan Dove, and Graham HatfullLinks for this episode: Bacteriophage Research: Gateway to learning science Mycobacterium smegmatis at NCBI Prof. Steve Cresawn Scientist infected with computer virus (thanks, Jason!) The  Invisible ABCs Letters read on  TWiV 87Weekly science picks:Rich - CDC Public  Health Image LibraryVincent - March  of the Microbes by John L. IngrahamAlan – Great Microbiologists – A Lego MovieGraham – Coral  Reefs in the Microbial Seas by Forest Rohwer

On episode #87 of the podcast This Week in Virology, Vincent, Alan, and Rich hear from Professor Graham Hatfull how students in the Phage Hunters Integrating Research and Education (PHIRE) program learn about scientific inquiry by doing research on bacteriophages. Host links <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" rel="nofollow" target="_blank">Vincent Racaniello</a>, <a href="http://www.mgm.ufl.edu/faculty/rcondit.htm" rel="nofollow" target="_blank">Rich Condit</a>, <a href="http://dovdox.com/content/" rel="nofollow" target="_blank">Alan Dove</a>, and <a href="http://www.pitt.edu/%7Egfh/" rel="nofollow" target="_blank">Graham Hatfull</a>Links for this episode: <ul> <li>Bacteriophage Research: <a href="http://www.microbemagazine.org/index.php?option=com_content&amp;view=article&amp;id=1866:bacteriophage-research-gateway-to-learning-science&amp;catid=464:featured&amp;Itemid=564" rel="nofollow" target="_blank">Gateway to learning science</a></li> <li><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=genomeprj&amp;cmd=Retrieve&amp;dopt=Overview&amp;list_uids=92" rel="nofollow" target="_blank">Mycobacterium smegmatis</a> at NCBI</li> <li><a href="http://www.jmu.edu/biology/faculty/cresawn/cresawn.shtml" rel="nofollow" target="_blank">Prof. Steve Cresawn</a></li> <li>Scientist <a href="http://news.techworld.com/personal-tech/3224739/scientist-infected-with-computer-virus/?cmpid=TD1N1&amp;no1x1&amp;cmpid=sbslashdotrplant" rel="nofollow" target="_blank">infected with computer virus</a> (thanks, Jason!)</li> <li><a href="http://astore.amazon.com/virologyws-20" rel="nofollow" target="_blank">The Invisible ABCs</a></li> <li><a href="http://www.microbeworld.org/index.php?option=com_content&amp;view=article&amp;id=677" rel="nofollow" target="_blank">Letters read</a> on TWiV 87</li></ul>Weekly science picks: Rich - <a href="http://www.google.com/crisisresponse/oilspill/" rel="nofollow" target="_blank"></a><a href="http://phil.cdc.gov/phil/home.asp" rel="nofollow" target="_blank">CDC Public Health Image Library</a>Vincent - <a href="http://astore.amazon.com/virologyws-20" rel="nofollow" target="_blank">March of the Microbes</a> by John L. IngrahamAlan – <a href="http://www.youtube.com/watch?v=3ArusOqt8EM&amp;feature=player_embedded" rel="nofollow" target="_blank">Great Microbiologists – A Lego Movie</a>Graham – <a href="http://astore.amazon.com/virologyws-20" rel="nofollow" target="_blank">Coral Reefs in the Microbial Seas</a> by Forest Rohwer

TWiV #87 - A PHIREside chat with Professor Graham Hatfull